This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
(±)-α-Lipoic acid
catalog :
T5625
citations: 39
Reference
Sharman M, Gyengesi E, Liang H, Chatterjee P, Karl T, Li Q, et al. Assessment of diets containing curcumin, epigallocatechin-3-gallate, docosahexaenoic acid and α-lipoic acid on amyloid load and inflammation in a male transgenic mouse model of Alzheimer's disease: Are combinations more effective?. Neurobiol Dis. 2019;124:505-519 pubmed publisher
Liu H, Rong P, Jia H, Yang J, Dong B, Dong Q, et al. A Wash-Free Homogeneous Colorimetric Immunoassay Method. Theranostics. 2016;6:54-64 pubmed publisher
Luboch E, Szarmach M, Buczkowska A, Wagner Wysiecka E, Kania M, Danikiewicz W. Synthesis of thiol derivatives of azobenzocrown ethers. The preliminary studies on recognition of alkali metal ions by gold nanoparticles functionalized with azobenzocrown and lipoic acid. J Incl Phenom Macrocycl Chem. 2015;83:321-334 pubmed
Li Y, Zhu H, Wang S, Qian X, Fan J, Wang Z, et al. Interplay of Oxidative Stress and Autophagy in PAMAM Dendrimers-Induced Neuronal Cell Death. Theranostics. 2015;5:1363-77 pubmed publisher
Roy S, Bacchi M, Berggren G, Artero V. A Systematic Comparative Study of Hydrogen-Evolving Molecular Catalysts in Aqueous Solutions. ChemSusChem. 2015;8:3632-8 pubmed publisher
Kang S, Bhang S, Hwang S, Yoon J, Song J, Jang H, et al. Mesenchymal Stem Cells Aggregate and Deliver Gold Nanoparticles to Tumors for Photothermal Therapy. ACS Nano. 2015;9:9678-90 pubmed publisher
Scholes K, Ence A, Strathmann F, Genzen J. Identification and Characterization of EDTA Test Strip Interfering Substances Using a Digital Color Detector. Clin Lab. 2015;61:785-91 pubmed
Ahmed M, El Awdan S. Lipoic acid and pentoxifylline mitigate nandrolone decanoate-induced neurobehavioral perturbations in rats via re-balance of brain neurotransmitters, up-regulation of Nrf2/HO-1 pathway, and down-regulation of TNFR1 expression. Horm Behav. 2015;73:186-99 pubmed publisher
Zhang X, Wu F, Liu P, Wang H, Gu N, Chen Z. Synthesis of ultrastable and multifunctional gold nanoclusters with enhanced fluorescence and potential anticancer drug delivery application. J Colloid Interface Sci. 2015;455:6-15 pubmed publisher
Bobermin L, Wartchow K, Flores M, Leite M, Quincozes Santos A, Gonçalves C. Ammonia-induced oxidative damage in neurons is prevented by resveratrol and lipoic acid with participation of heme oxygenase 1. Neurotoxicology. 2015;49:28-35 pubmed publisher
Zhao Z, Zhang Y, Woodard T, Nevin K, Lovley D. Enhancing syntrophic metabolism in up-flow anaerobic sludge blanket reactors with conductive carbon materials. Bioresour Technol. 2015;191:140-5 pubmed publisher
Debray F, Stümpfig C, Vanlander A, Dideberg V, Josse C, Caberg J, et al. Mutation of the iron-sulfur cluster assembly gene IBA57 causes fatal infantile leukodystrophy. J Inherit Metab Dis. 2015;38:1147-53 pubmed publisher
Nair L, Nazeer S, Jayasree R, Ajayaghosh A. Fluorescence Imaging Assisted Photodynamic Therapy Using Photosensitizer-Linked Gold Quantum Clusters. ACS Nano. 2015;9:5825-32 pubmed publisher
Omran O, Omer O. The effects of alpha-lipoic acid on breast of female albino rats exposed to malathion: Histopathological and immunohistochemical study. Pathol Res Pract. 2015;211:462-9 pubmed publisher
Mei H, Sun S, Bai Y, Chen Y, Chai R, Li H. Reduced mtDNA copy number increases the sensitivity of tumor cells to chemotherapeutic drugs. Cell Death Dis. 2015;6:e1710 pubmed publisher
Bastian A, Thorpe J, Disch B, Bailey Downs L, Gangjee A, Devambatla R, et al. A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer. J Pharmacol Exp Ther. 2015;353:392-404 pubmed publisher
Bacalini M, Gentilini D, Boattini A, Giampieri E, Pirazzini C, Giuliani C, et al. Identification of a DNA methylation signature in blood cells from persons with Down Syndrome. Aging (Albany NY). 2015;7:82-96 pubmed
Molina Jijón E, Rodríguez Muñoz R, Namorado M, Bautista García P, Medina Campos O, Pedraza Chaverri J, et al. All-trans retinoic acid prevents oxidative stress-induced loss of renal tight junction proteins in type-1 diabetic model. J Nutr Biochem. 2015;26:441-54 pubmed publisher
Lossos A, Stümpfig C, Stevanin G, Gaussen M, Zimmerman B, Mundwiller E, et al. Fe/S protein assembly gene IBA57 mutation causes hereditary spastic paraplegia. Neurology. 2015;84:659-67 pubmed publisher
Berkowitz B, Grady E, Khetarpal N, Patel A, Roberts R. Oxidative stress and light-evoked responses of the posterior segment in a mouse model of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2015;56:606-15 pubmed publisher
Yang Y, Nan J, Hou J, Yu B, Zhao T, Xu S, et al. Cytotoxicity of gold nanoclusters in human liver cancer cells. Int J Nanomedicine. 2014;9:5441-8 pubmed publisher
Wu P, Luo S, Chang L. Heat-shock-induced glucose transporter 4 in the slow-twitch muscle of rats. Physiol Res. 2015;64:523-30 pubmed
Ying Z, Xie X, Chen M, Yi K, Rajagopalan S. Alpha-lipoic acid activates eNOS through activation of PI3-kinase/Akt signaling pathway. Vascul Pharmacol. 2015;64:28-35 pubmed publisher
Ghezzo A, Salvioli S, Solimando M, Palmieri A, Chiostergi C, Scurti M, et al. Age-related changes of adaptive and neuropsychological features in persons with Down Syndrome. PLoS ONE. 2014;9:e113111 pubmed publisher
Xia Y, Liu Y, Xie Y, Zhu W, Guerra F, Shen S, et al. A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin. Sci Transl Med. 2014;6:263ra161 pubmed publisher
La Sala L, Pujadas G, De Nigris V, Canivell S, Novials A, Genovese S, et al. Oscillating glucose and constant high glucose induce endoglin expression in endothelial cells: the role of oxidative stress. Acta Diabetol. 2015;52:505-12 pubmed publisher
Podder B, Song K, Song H, Kim Y. Cytoprotective effect of kaempferol on paraquat-exposed BEAS-2B cells via modulating expression of MUC5AC. Biol Pharm Bull. 2014;37:1486-94 pubmed
Lane L, Smith A, Lian T, Nie S. Compact and blinking-suppressed quantum dots for single-particle tracking in live cells. J Phys Chem B. 2014;118:14140-7 pubmed publisher
Mirza A. A novel drug delivery system of gold nanorods with doxorubicin and study of drug release by single molecule spectroscopy. J Drug Target. 2015;23:52-8 pubmed publisher
Kim H, Song W, Kim J, Jin E, Kwon M, Park S. Synergic effect of exercise and lipoic acid on protection against kainic acid induced seizure activity and oxidative stress in mice. Neurochem Res. 2014;39:1579-84 pubmed publisher
Houten S, Denis S, te Brinke H, Jongejan A, van Kampen A, Bradley E, et al. Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia. Hum Mol Genet. 2014;23:5009-16 pubmed publisher
Fu Y, Nath R, Dyba M, Cruz I, Pondicherry S, Fernandez A, et al. In vivo detection of a novel endogenous etheno-DNA adduct derived from arachidonic acid and the effects of antioxidants on its formation. Free Radic Biol Med. 2014;73:12-20 pubmed publisher
Tang Y, Chen R, Huang Y, Li G, Huang Y, Chen J, et al. Natural compound Alternol induces oxidative stress-dependent apoptotic cell death preferentially in prostate cancer cells. Mol Cancer Ther. 2014;13:1526-36 pubmed publisher
Laszlo J, Evans K, Compton D. Stability of a liposomal formulation containing lipoyl or dihydrolipoyl acylglycerides. J Liposome Res. 2014;24:304-12 pubmed publisher
Rosini M, Simoni E, Bartolini M, Tarozzi A, Matera R, Milelli A, et al. Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease. Eur J Med Chem. 2011;46:5435-42 pubmed publisher
Zhang S, Ge Q, Guo D, Hu W, Liu H. Synthesis and anticancer evaluation of alpha-lipoic acid derivatives. Bioorg Med Chem Lett. 2010;20:3078-83 pubmed publisher
Marchetto M, Muotri A, Mu Y, Smith A, Cezar G, Gage F. Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell. 2008;3:649-57 pubmed publisher
Sena C, Nunes E, Louro T, Proença T, Fernandes R, Boarder M, et al. Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-fat fed rats. Br J Pharmacol. 2008;153:894-906 pubmed
Diamandis P, Wildenhain J, Clarke I, Sacher A, Graham J, Bellows D, et al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol. 2007;3:268-73 pubmed
product information
Catalog Number :
T5625
Product Name :
(±)-α-Lipoic acid
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
synthetic, ≥99% (titration), powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA