This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Tyrphostin AG 1478
catalog :
T4182
citations: 37
Reference
Palamidessi A, Malinverno C, Frittoli E, Corallino S, Barbieri E, Sigismund S, et al. Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinoma. Nat Mater. 2019;18:1252-1263 pubmed publisher
McKinney A, Lindberg O, Engler J, Chen K, Kumar A, Gong H, et al. Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM. Mol Cancer Ther. 2019;18:1565-1576 pubmed publisher
Kuo D, Ding J, Cohn I, Zhang F, Wei K, Rao D, et al. HBEGF+ macrophages in rheumatoid arthritis induce fibroblast invasiveness. Sci Transl Med. 2019;11: pubmed publisher
Janssens G, Lin X, Millán Ariño L, Kavšek A, Sen I, Seinstra R, et al. Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging. Cell Rep. 2019;27:467-480.e6 pubmed publisher
Fontenas L, Welsh T, Piller M, Coughenour P, Gandhi A, Prober D, et al. The Neuromodulator Adenosine Regulates Oligodendrocyte Migration at Motor Exit Point Transition Zones. Cell Rep. 2019;27:115-128.e5 pubmed publisher
Al Nabhani Z, Dulauroy S, Marques R, Cousu C, Al Bounny S, Déjardin F, et al. A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult. Immunity. 2019;50:1276-1288.e5 pubmed publisher
Iijima M, Araki K, Liu Q, Somiya M, Kuroda S. Oriented immobilization to nanoparticles enhanced the therapeutic efficacy of antibody drugs. Acta Biomater. 2019;86:373-380 pubmed publisher
Endo Y, Shen Y, Youssef L, Mohan N, Wu W. T-DM1-resistant cells gain high invasive activity via EGFR and integrin cooperated pathways. MAbs. 2018;10:1003-1017 pubmed publisher
El Daly M, Pulakazhi Venu V, Saifeddine M, Mihara K, Kang S, Fedak P, et al. Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress. Vascul Pharmacol. 2018;109:56-71 pubmed publisher
Di Bari M, Bevilacqua V, De Jaco A, Laneve P, Piovesana R, Trobiani L, et al. Mir-34a-5p Mediates Cross-Talk between M2 Muscarinic Receptors and Notch-1/EGFR Pathways in U87MG Glioblastoma Cells: Implication in Cell Proliferation. Int J Mol Sci. 2018;19: pubmed publisher
Missinato M, Saydmohammed M, Zuppo D, Rao K, Opie G, Kuhn B, et al. Dusp6 attenuates Ras/MAPK signaling to limit zebrafish heart regeneration. Development. 2018;145: pubmed publisher
Freudenblum J, Iglesias J, Hermann M, Walsen T, Wilfinger A, Meyer D, et al. In vivo imaging of emerging endocrine cells reveals a requirement for PI3K-regulated motility in pancreatic islet morphogenesis. Development. 2018;145: pubmed publisher
Rayego Mateos S, Morgado Pascual J, Rodrigues Díez R, Rodrígues Díez R, Falke L, Mezzano S, et al. Connective tissue growth factor induces renal fibrosis via epidermal growth factor receptor activation. J Pathol. 2017;: pubmed publisher
Li L, Zhu L, Hao B, Gao W, Wang Q, Li K, et al. iNOS-derived nitric oxide promotes glycolysis by inducing pyruvate kinase M2 nuclear translocation in ovarian cancer. Oncotarget. 2017;8:33047-33063 pubmed publisher
Kochel T, Reader J, Ma X, Kundu N, Fulton A. Multiple drug resistance-associated protein (MRP4) exports prostaglandin E2 (PGE2) and contributes to metastasis in basal/triple negative breast cancer. Oncotarget. 2017;8:6540-6554 pubmed publisher
Tevis K, Cecchi R, Colson Y, Grinstaff M. Mimicking the tumor microenvironment to regulate macrophage phenotype and assessing chemotherapeutic efficacy in embedded cancer cell/macrophage spheroid models. Acta Biomater. 2017;50:271-279 pubmed publisher
Gong Z, Zhou J, Zhao S, Tian C, Wang P, Xu C, et al. Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis. Oncotarget. 2016;7:83951-83963 pubmed publisher
Sun J, Xu M, Ortsäter H, Lundeberg E, Juntti Berggren L, Chen Y, et al. Cathelicidins positively regulate pancreatic β-cell functions. FASEB J. 2016;30:884-94 pubmed publisher
Chen I, Shih H, Hsieh P, Chang F, Wu Y, Wu C. HPW-RX40 restores anoikis sensitivity of human breast cancer cells by inhibiting integrin/FAK signaling. Toxicol Appl Pharmacol. 2015;289:330-40 pubmed publisher
Wang P, Yang A, Cong M, Liu T, Zhang D, Huang J, et al. EGF Suppresses the Initiation and Drives the Reversion of TGF-β1-induced Transition in Hepatic Oval Cells Showing the Plasticity of Progenitor Cells. J Cell Physiol. 2015;230:2362-70 pubmed publisher
Aguado A, Rodriguez C, Martinez Revelles S, Avendaño M, Zhenyukh O, Orriols M, et al. HuR mediates the synergistic effects of angiotensin II and IL-1β on vascular COX-2 expression and cell migration. Br J Pharmacol. 2015;172:3028-42 pubmed publisher
Cheung L, Yu D, Neiron Z, Failes T, Arndt G, Fletcher J. Identification of new MRP4 inhibitors from a library of FDA approved drugs using a high-throughput bioluminescence screen. Biochem Pharmacol. 2015;93:380-8 pubmed publisher
Gao X, Yu L, Moore A, Kissling G, Waalkes M, Dixon D. Cadmium and proliferation in human uterine leiomyoma cells: evidence of a role for EGFR/MAPK pathways but not classical estrogen receptor pathways. Environ Health Perspect. 2015;123:331-6 pubmed publisher
Song D, Xu J, Hertz L, Peng L. Regulatory volume increase in astrocytes exposed to hypertonic medium requires β1 -adrenergic Na(+) /K(+) -ATPase stimulation and glycogenolysis. J Neurosci Res. 2015;93:130-9 pubmed publisher
Bayliss A, Evans P. Characterisation of AmphiAmR11, an amphioxus (Branchiostoma floridae) D2-dopamine-like G protein-coupled receptor. PLoS ONE. 2013;8:e80833 pubmed publisher
Ho E, Dagnino L. Epidermal growth factor induction of front-rear polarity and migration in keratinocytes is mediated by integrin-linked kinase and ELMO2. Mol Biol Cell. 2012;23:492-502 pubmed publisher
Joyner D, Jones K, Lessnick S, Schiffman J, Randall R. Potential for modulation of the fas apoptotic pathway by epidermal growth factor in sarcomas. Sarcoma. 2011;2011:847409 pubmed publisher
Müller K, Tveteraas I, Aasrum M, Ødegård J, Dawood M, Dajani O, et al. Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells. BMC Cancer. 2011;11:421 pubmed publisher
Budi E, Patterson L, Parichy D. Post-embryonic nerve-associated precursors to adult pigment cells: genetic requirements and dynamics of morphogenesis and differentiation. PLoS Genet. 2011;7:e1002044 pubmed publisher
Block E, Tolino M, Lozano J, Lathrop K, Sullenberger R, Mazie A, et al. Free edges in epithelial cell sheets stimulate epidermal growth factor receptor signaling. Mol Biol Cell. 2010;21:2172-81 pubmed publisher
Xie K, Zhang L, Cao Y, Zhu J, Feng L. Adenosine A(1) receptor-mediated transactivation of the EGF receptor produces a neuroprotective effect on cortical neurons in vitro. Acta Pharmacol Sin. 2009;30:889-98 pubmed publisher
Swat A, Dolado I, Rojas J, Nebreda A. Cell density-dependent inhibition of epidermal growth factor receptor signaling by p38alpha mitogen-activated protein kinase via Sprouty2 downregulation. Mol Cell Biol. 2009;29:3332-43 pubmed publisher
Luke T, Hexum T. UTP and ATP increase extracellular signal-regulated kinase 1/2 phosphorylation in bovine chromaffin cells through epidermal growth factor receptor transactivation. Purinergic Signal. 2008;4:323-30 pubmed publisher
Zahir N, Lakins J, Russell A, Ming W, Chatterjee C, Rozenberg G, et al. Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors. J Cell Biol. 2003;163:1397-407 pubmed
Jo M, Stolz D, Esplen J, Dorko K, Michalopoulos G, Strom S. Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells. J Biol Chem. 2000;275:8806-11 pubmed
Han Y, Caday C, Nanda A, Cavenee W, Huang H. Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors. Cancer Res. 1996;56:3859-61 pubmed
Osherov N, Levitzki A. Epidermal-growth-factor-dependent activation of the src-family kinases. Eur J Biochem. 1994;225:1047-53 pubmed
product information
Catalog Number :
T4182
Product Name :
Tyrphostin AG 1478
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98%
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA