product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
antibody
product name :
Monoclonal Anti-Talin antibody produced in mouse
catalog :
T3287
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
8d4
reactivity :
hamsters, guinea pig, human, mouse, rat, chicken, Xenopus laevis
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, western blot knockout validation
more info or order :
citations: 166
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:1000; fig 1
Theodosiou M, Widmaier M, Böttcher R, Rognoni E, Veelders M, Bharadwaj M, et al. Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin. elife. 2016;5:e10130 pubmed publisher
  • immunocytochemistry; Xenopus laevis; 1:100; loading ...; fig 1s2b
Chan Z, Kwan H, Wong Y, Jiang Z, Zhou Z, Tam K, et al. Site-directed MT1-MMP trafficking and surface insertion regulate AChR clustering and remodeling at developing NMJs. elife. 2020;9: pubmed publisher
  • immunohistochemistry; human; 1:250; loading ...; fig 3a
  • western blot; human; 1:2000; loading ...; fig 3d
Bayer S, Grither W, Brenot A, Hwang P, Barcus C, Ernst M, et al. DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs. elife. 2019;8: pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 5b
Song K, Gras C, Capin G, Gimber N, Lehmann M, Mohd S, et al. A SEPT1-based scaffold is required for Golgi integrity and function. J Cell Sci. 2019;132: pubmed publisher
  • western blot; mouse; loading ...; fig 4g
Lin C, Zhang Y, Zhang K, Zheng Y, Lu L, Chang H, et al. Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins. Immunity. 2019;50:137-151.e6 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1a
Sun H, Lagarrigue F, Gingras A, Fan Z, Ley K, Ginsberg M. Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development. J Cell Biol. 2018;217:1453-1465 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4f
Margraf A, Nussbaum C, Rohwedder I, Klapproth S, Kurz A, Florian A, et al. Maturation of Platelet Function During Murine Fetal Development In Vivo. Arterioscler Thromb Vasc Biol. 2017;37:1076-1086 pubmed publisher
  • western blot; mouse; loading ...; fig 4k
Georgiadou M, Lilja J, Jacquemet G, Guzmán C, Rafaeva M, Alibert C, et al. AMPK negatively regulates tensin-dependent integrin activity. J Cell Biol. 2017;216:1107-1121 pubmed publisher
  • immunohistochemistry; chicken; 1:250; loading ...; fig st14
  • immunohistochemistry; mouse; 1:250; loading ...; fig st14
  • immunohistochemistry; human; 1:250; loading ...; fig st14
  • immunohistochemistry; rat; 1:250; loading ...; fig st14
Furukawa S, Nagaike M, Ozaki K. Databases for technical aspects of immunohistochemistry. J Toxicol Pathol. 2017;30:79-107 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s1d
Bharadwaj M, Strohmeyer N, Colo G, Helenius J, Beerenwinkel N, Schiller H, et al. αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin. Nat Commun. 2017;8:14348 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 3b
Zeng F, Xie Y, Liao L, Li L, Chen B, Xie J, et al. Biological characterization of three immortalized esophageal epithelial cell lines. Mol Med Rep. 2016;14:4802-4810 pubmed publisher
  • western blot; mouse; loading ...; fig 1e
  • western blot; human; loading ...; fig 9a
Kishi T, Mayanagi T, Iwabuchi S, Akasaka T, Sobue K. Myocardin-related transcription factor A (MRTF-A) activity-dependent cell adhesion is correlated to focal adhesion kinase (FAK) activity. Oncotarget. 2016;7:72113-72130 pubmed publisher
  • immunocytochemistry; human; fig 1
Bouchet B, Gough R, Ammon Y, van de Willige D, Post H, Jacquemet G, et al. Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions. elife. 2016;5: pubmed publisher
  • immunocytochemistry; guinea pig; 1:100; fig 1
  • western blot; guinea pig; 1:1000; fig 1
Roa Espitia A, Hernández Rendón E, Baltiérrez Hoyos R, Muñoz Gotera R, Cote Vélez A, Jiménez I, et al. Focal adhesion kinase is required for actin polymerization and remodeling of the cytoskeleton during sperm capacitation. Biol Open. 2016;5:1189-99 pubmed publisher
  • immunocytochemistry; human; fig 4
Cross A, Wilson A, Guerrero M, Thomas K, Bachir A, Kubow K, et al. Breast cancer antiestrogen resistance 3-p130Cas interactions promote adhesion disassembly and invasion in breast cancer cells. Oncogene. 2016;35:5850-5859 pubmed publisher
  • western blot; mouse; 1:1000; fig s4
Elosegui Artola A, Oria R, Chen Y, Kosmalska A, Pérez González C, Castro N, et al. Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity. Nat Cell Biol. 2016;18:540-8 pubmed publisher
  • immunohistochemistry; human; 1:100; loading ...; fig 6d
  • western blot; human; 1:1000; loading ...; fig 6a
Nader G, Ezratty E, Gundersen G. FAK, talin and PIPKI? regulate endocytosed integrin activation to polarize focal adhesion assembly. Nat Cell Biol. 2016;18:491-503 pubmed publisher
  • western blot; mouse; fig s1
Atherton P, Stutchbury B, Wang D, Jethwa D, Tsang R, Meiler Rodriguez E, et al. Vinculin controls talin engagement with the actomyosin machinery. Nat Commun. 2015;6:10038 pubmed publisher
  • western blot; rat; 1:800; fig 2
Fiore V, Strane P, Bryksin A, White E, Hagood J, Barker T. Conformational coupling of integrin and Thy-1 regulates Fyn priming and fibroblast mechanotransduction. J Cell Biol. 2015;211:173-90 pubmed publisher
  • western blot; human; fig 1
Roda D, Castillo J, Telechea Fernández M, Gil A, López Rodas G, Franco L, et al. EGF-Induced Acetylation of Heterogeneous Nuclear Ribonucleoproteins Is Dependent on KRAS Mutational Status in Colorectal Cancer Cells. PLoS ONE. 2015;10:e0130543 pubmed publisher
  • immunocytochemistry; human; fig 4
Poulter N, Pollitt A, Davies A, Malinova D, Nash G, Hannon M, et al. Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex. Nat Commun. 2015;6:7254 pubmed publisher
  • immunocytochemistry; human; 1:100
  • western blot; human; 1:500
Kiss A, Gong X, Kowalewski J, Shafqat Abbasi H, Strömblad S, Lock J. Non-monotonic cellular responses to heterogeneity in talin protein expression-level. Integr Biol (Camb). 2015;7:1171-85 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Robertson J, Jacquemet G, Byron A, Jones M, Warwood S, Selley J, et al. Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling. Nat Commun. 2015;6:6265 pubmed publisher
  • western blot; human
Ng D, Humphries J, Byron A, Millon Frémillon A, Humphries M. Microtubule-dependent modulation of adhesion complex composition. PLoS ONE. 2014;9:e115213 pubmed publisher
  • immunocytochemistry; human
Uotila L, Jahan F, Soto Hinojosa L, Melandri E, Grönholm M, Gahmberg C. Specific phosphorylations transmit signals from leukocyte β2 to β1 integrins and regulate adhesion. J Biol Chem. 2014;289:32230-42 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Abramowski P, Ogrodowczyk C, Martin R, Pongs O. A truncation variant of the cation channel P2RX5 is upregulated during T cell activation. PLoS ONE. 2014;9:e104692 pubmed publisher
  • western blot; mouse; fig 1
Tseng H, Thorausch N, Ziegler T, Meves A, Fassler R, Böttcher R. Sorting nexin 31 binds multiple ? integrin cytoplasmic domains and regulates ?1 integrin surface levels and stability. J Mol Biol. 2014;426:3180-3194 pubmed publisher
  • western blot; mouse; fig 5, 7
Zemljic Harpf A, Godoy J, Platoshyn O, Asfaw E, Busija A, Domenighetti A, et al. Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes. J Cell Sci. 2014;127:1104-16 pubmed publisher
  • western blot; hamsters; 1:2,000
Honda S, Shirotani Ikejima H, Tadokoro S, Tomiyama Y, Miyata T. The integrin-linked kinase-PINCH-parvin complex supports integrin ?IIb?3 activation. PLoS ONE. 2013;8:e85498 pubmed publisher
van den Dries K, Nahidiazar L, Slotman J, Meddens M, Pandzic E, Joosten B, et al. Modular actin nano-architecture enables podosome protrusion and mechanosensing. Nat Commun. 2019;10:5171 pubmed publisher
Stubb A, Guzman C, Närvä E, Aaron J, Chew T, Saari M, et al. Superresolution architecture of cornerstone focal adhesions in human pluripotent stem cells. Nat Commun. 2019;10:4756 pubmed publisher
Wei H, Harper M. ABT-737 Triggers Caspase-Dependent Inhibition of Platelet Procoagulant Extracellular Vesicle Release during Apoptosis and Secondary Necrosis In Vitro. Thromb Haemost. 2019;119:1665-1674 pubmed publisher
Buken C, Sahana J, Corydon T, Melnik D, Bauer J, Wehland M, et al. Morphological and Molecular Changes in Juvenile Normal Human Fibroblasts Exposed to Simulated Microgravity. Sci Rep. 2019;9:11882 pubmed publisher
Sengupta S, Rothenberg K, Li H, Hoffman B, Bursac N. Altering integrin engagement regulates membrane localization of Kir2.1 channels. J Cell Sci. 2019;132: pubmed publisher
Kumar A, Shutova M, Tanaka K, Iwamoto D, Calderwood D, Svitkina T, et al. Filamin A mediates isotropic distribution of applied force across the actin network. J Cell Biol. 2019;218:2481-2491 pubmed publisher
Faust J, Balabiyev A, Heddleston J, Podolnikova N, Baluch D, Chew T, et al. An actin-based protrusion originating from a podosome-enriched region initiates macrophage fusion. Mol Biol Cell. 2019;30:2254-2267 pubmed publisher
Peterková L, Rimpelová S, Slepicka P, Krízová I, Kasalkova N, Svorcik V, et al. Argon plasma-treated fluorinated ethylene propylene: Growth of primary dermal fibroblasts and mesenchymal stem cells. Tissue Cell. 2019;58:121-129 pubmed publisher
Peterková L, Rimpelová S, Krízová I, Slepicka P, Kasalkova N, Svorcik V, et al. Biocompatibility of Ar plasma-treated fluorinated ethylene propylene: Adhesion and viability of human keratinocytes. Mater Sci Eng C Mater Biol Appl. 2019;100:269-275 pubmed publisher
Bance B, Seetharaman S, Leduc C, Boëda B, Etienne Manneville S. Microtubule acetylation but not detyrosination promotes focal adhesion dynamics and astrocyte migration. J Cell Sci. 2019;: pubmed publisher
Jacquemet G, Stubb A, Saup R, Miihkinen M, Kremneva E, Hamidi H, et al. Filopodome Mapping Identifies p130Cas as a Mechanosensitive Regulator of Filopodia Stability. Curr Biol. 2019;29:202-216.e7 pubmed publisher
Hino N, Ichikawa T, Kimura Y, Matsuda M, Ueda K, Kioka N. An amphipathic helix of vinexin α is necessary for a substrate stiffness-dependent conformational change in vinculin. J Cell Sci. 2019;132: pubmed publisher
Myllymäki S, Kämäräinen U, Liu X, Cruz S, Miettinen S, Vuorela M, et al. Assembly of the β4-Integrin Interactome Based on Proximal Biotinylation in the Presence and Absence of Heterodimerization. Mol Cell Proteomics. 2019;18:277-293 pubmed publisher
Waldt N, Seifert A, Demiray Y, Devroe E, Turk B, Reichardt P, et al. Filamin A Phosphorylation at Serine 2152 by the Serine/Threonine Kinase Ndr2 Controls TCR-Induced LFA-1 Activation in T Cells. Front Immunol. 2018;9:2852 pubmed publisher
Loh J, Lim T, Ikumi K, Matoba T, Janela B, Gunawan M, et al. Ezh2 Controls Skin Tolerance through Distinct Mechanisms in Different Subsets of Skin Dendritic Cells. iScience. 2018;10:23-39 pubmed publisher
Gan W, Do O, Cottle L, Ma W, Kosobrodova E, Cooper White J, et al. Local Integrin Activation in Pancreatic ? Cells Targets Insulin Secretion to the Vasculature. Cell Rep. 2018;24:2819-2826.e3 pubmed publisher
De Pascalis C, Pérez González C, Seetharaman S, Boëda B, Vianay B, Burute M, et al. Intermediate filaments control collective migration by restricting traction forces and sustaining cell-cell contacts. J Cell Biol. 2018;217:3031-3044 pubmed publisher
Wei H, Malcor J, Harper M. Lipid rafts are essential for release of phosphatidylserine-exposing extracellular vesicles from platelets. Sci Rep. 2018;8:9987 pubmed publisher
Atkinson S, Gontarczyk A, Alghamdi A, Ellison T, Johnson R, Fowler W, et al. The β3-integrin endothelial adhesome regulates microtubule-dependent cell migration. EMBO Rep. 2018;19: pubmed publisher
Sauveur J, Matera E, Chettab K, Valet P, Guitton J, Savina A, et al. Esophageal cancer cells resistant to T-DM1 display alterations in cell adhesion and the prostaglandin pathway. Oncotarget. 2018;9:21141-21155 pubmed publisher
Zhang W, Bhetwal B, Gunst S. Rho kinase collaborates with p21-activated kinase to regulate actin polymerization and contraction in airway smooth muscle. J Physiol. 2018;596:3617-3635 pubmed publisher
Dix C, Matthews H, Uroz M, McLaren S, Wolf L, Heatley N, et al. The Role of Mitotic Cell-Substrate Adhesion Re-modeling in Animal Cell Division. Dev Cell. 2018;45:132-145.e3 pubmed publisher
Maxson M, Naj X, O Meara T, Plumb J, Cowen L, Grinstein S. Integrin-based diffusion barrier separates membrane domains enabling the formation of microbiostatic frustrated phagosomes. elife. 2018;7: pubmed publisher
Goreczny G, Forsythe I, Turner C. Hic-5 regulates fibrillar adhesion formation to control tumor extracellular matrix remodeling through interaction with tensin1. Oncogene. 2018;37:1699-1713 pubmed publisher
Burgstaller G, Sengupta A, Vierkotten S, Preissler G, Lindner M, Behr J, et al. Distinct niches within the extracellular matrix dictate fibroblast function in (cell free) 3D lung tissue cultures. Am J Physiol Lung Cell Mol Physiol. 2018;314:L708-L723 pubmed publisher
Ruoss S, Möhl C, Benn M, von Rechenberg B, Wieser K, Meyer D, et al. Costamere protein expression and tissue composition of rotator cuff muscle after tendon release in sheep. J Orthop Res. 2018;36:272-281 pubmed publisher
Elosegui Artola A, Andreu I, Beedle A, Lezamiz A, Uroz M, Kosmalska A, et al. Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores. Cell. 2017;171:1397-1410.e14 pubmed publisher
Ichikawa T, Kita M, Matsui T, Nagasato A, Araki T, Chiang S, et al. Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation. J Cell Sci. 2017;130:3517-3531 pubmed publisher
Warnke E, Pietsch J, Kopp S, Bauer J, Sahana J, Wehland M, et al. Cytokine Release and Focal Adhesion Proteins in Normal Thyroid Cells Cultured on the Random Positioning Machine. Cell Physiol Biochem. 2017;43:257-270 pubmed publisher
Sun C, Wacquier B, Aguilar D, Carayol N, Denis K, Boucherie S, et al. The Shigella type III effector IpgD recodes Ca2+ signals during invasion of epithelial cells. EMBO J. 2017;36:2567-2580 pubmed publisher
Veß A, Blache U, Leitner L, Kurz A, Ehrenpfordt A, Sixt M, et al. A dual phenotype of MDA-MB-468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity. J Cell Sci. 2017;130:2172-2184 pubmed publisher
Tello Lafoz M, Martínez Martínez G, Rodríguez Rodríguez C, Albar J, Huse M, Gharbi S, et al. Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse. Traffic. 2017;18:491-504 pubmed publisher
Liskova J, Hadraba D, Filova E, Konarik M, Pirk J, Jelen K, et al. Valve interstitial cell culture: Production of mature type I collagen and precise detection. Microsc Res Tech. 2017;80:936-942 pubmed publisher
Lim I, Joo H, Jeong M, Kim J, Choi S, Kim C, et al. Talin Modulation by a Synthetic N-Acylurea Derivative Reduces Angiogenesis in Human Endothelial Cells. Int J Mol Sci. 2017;18: pubmed publisher
Jacquemet G, Baghirov H, Georgiadou M, Sihto H, Peuhu E, Cettour Janet P, et al. L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling. Nat Commun. 2016;7:13297 pubmed publisher
Alsebaey A, Ahmedy E. Talin-1 and Non-invasive Fibrosis Models in the Assessment of Patients with Hepatocellular Carcinoma. Asian Pac J Cancer Prev. 2016;17:4077-82 pubmed
Hammers D, Sleeper M, Forbes S, Shima A, Walter G, Sweeney H. Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts. J Am Heart Assoc. 2016;5: pubmed publisher
Godinho Santos A, Hance A, Gonçalves J, Mammano F. CIB1 and CIB2 are HIV-1 helper factors involved in viral entry. Sci Rep. 2016;6:30927 pubmed publisher
Wang X, Li J, Chen S, Shen X, Yang X, Teng Y, et al. Knockdown of HMGN2 increases the internalization of Klebsiella pneumoniae by respiratory epithelial cells through the regulation of α5β1 integrin expression. Int J Mol Med. 2016;38:737-46 pubmed publisher
Pollizzi K, Sun I, Patel C, Lo Y, Oh M, Waickman A, et al. Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8(+) T cell differentiation. Nat Immunol. 2016;17:704-11 pubmed publisher
Minns M, Teicher G, Rich C, Trinkaus Randall V. Purinoreceptor P2X7 Regulation of Ca(2+) Mobilization and Cytoskeletal Rearrangement Is Required for Corneal Reepithelialization after Injury. Am J Pathol. 2016;186:285-96 pubmed publisher
Filova E, Fojt J, Krýslová M, Moravec H, Joska L, Bacakova L. The diameter of nanotubes formed on Ti-6Al-4V alloy controls the adhesion and differentiation of Saos-2 cells. Int J Nanomedicine. 2015;10:7145-63 pubmed publisher
Austen K, Ringer P, Mehlich A, Chrostek Grashoff A, Kluger C, Klingner C, et al. Extracellular rigidity sensing by talin isoform-specific mechanical linkages. Nat Cell Biol. 2015;17:1597-606 pubmed publisher
Musílková J, Kotelnikov I, Novotná K, Pop Georgievski O, Rypacek F, Bacakova L, et al. Cell adhesion and growth enabled by biomimetic oligopeptide modification of a polydopamine-poly(ethylene oxide) protein repulsive surface. J Mater Sci Mater Med. 2015;26:253 pubmed publisher
Lagarrigue F, Vikas Anekal P, Lee H, Bachir A, Ablack J, Horwitz A, et al. A RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migration. Nat Commun. 2015;6:8492 pubmed publisher
Yamahashi Y, Cavnar P, Hind L, Berthier E, Bennin D, Beebe D, et al. Integrin associated proteins differentially regulate neutrophil polarity and directed migration in 2D and 3D. Biomed Microdevices. 2015;17:100 pubmed publisher
Kang W, Kim S, Cho H, Jin J, Lee J, Joo K, et al. Talin1 targeting potentiates anti-angiogenic therapy by attenuating invasion and stem-like features of glioblastoma multiforme. Oncotarget. 2015;6:27239-51 pubmed publisher
Xu Y, Ren X, Li Y, He Q, Tang X, Sun Y, et al. High expression of Talin-1 is associated with poor prognosis in patients with nasopharyngeal carcinoma. BMC Cancer. 2015;15:332 pubmed publisher
Bergert M, Erzberger A, Desai R, Aspalter I, Oates A, Charras G, et al. Force transmission during adhesion-independent migration. Nat Cell Biol. 2015;17:524-9 pubmed publisher
Zhang H, Chen Y, Wadham C, McCaughan G, Keane F, Gorrell M. Dipeptidyl peptidase 9 subcellular localization and a role in cell adhesion involving focal adhesion kinase and paxillin. Biochim Biophys Acta. 2015;1853:470-80 pubmed publisher
Kadaré G, Gervasi N, Brami Cherrier K, Blockus H, El Messari S, Arold S, et al. Conformational dynamics of the focal adhesion targeting domain control specific functions of focal adhesion kinase in cells. J Biol Chem. 2015;290:478-91 pubmed publisher
Rubashkin M, Cassereau L, Bainer R, DuFort C, Yui Y, Ou G, et al. Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate. Cancer Res. 2014;74:4597-611 pubmed publisher
Supinski G, Wang L, Song X, Moylan J, Callahan L. Muscle-specific calpastatin overexpression prevents diaphragm weakness in cecal ligation puncture-induced sepsis. J Appl Physiol (1985). 2014;117:921-9 pubmed publisher
Ferraris G, Schulte C, Buttiglione V, De Lorenzi V, Piontini A, Galluzzi M, et al. The interaction between uPAR and vitronectin triggers ligand-independent adhesion signalling by integrins. EMBO J. 2014;33:2458-72 pubmed publisher
Filova E, Suchy T, Sucharda Z, Supová M, Zaloudková M, Balík K, et al. Support for the initial attachment, growth and differentiation of MG-63 cells: a comparison between nano-size hydroxyapatite and micro-size hydroxyapatite in composites. Int J Nanomedicine. 2014;9:3687-706 pubmed publisher
Jungwirth U, Gojo J, Tuder T, Walko G, Holcmann M, Schöfl T, et al. Calpain-mediated integrin deregulation as a novel mode of action for the anticancer gallium compound KP46. Mol Cancer Ther. 2014;13:2436-49 pubmed publisher
Rognoni E, Widmaier M, Jakobson M, Ruppert R, Ussar S, Katsougkri D, et al. Kindlin-1 controls Wnt and TGF-? availability to regulate cutaneous stem cell proliferation. Nat Med. 2014;20:350-9 pubmed publisher
Czarnowski A, Papp S, Száraz P, Opas M. Calreticulin affects cell adhesiveness through differential phosphorylation of insulin receptor substrate-1. Cell Mol Biol Lett. 2014;19:77-97 pubmed publisher
Baranov M, ter Beest M, Reinieren Beeren I, Cambi A, Figdor C, van den Bogaart G. Podosomes of dendritic cells facilitate antigen sampling. J Cell Sci. 2014;127:1052-1064 pubmed publisher
Joshi R, Schmidt A, Das J, Pytel D, Riese M, Lester M, et al. The ? isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling. Sci Signal. 2013;6:ra102 pubmed publisher
Shen B, Zhao X, O Brien K, Stojanovic Terpo A, Delaney M, Kim K, et al. A directional switch of integrin signalling and a new anti-thrombotic strategy. Nature. 2013;503:131-5 pubmed publisher
Willenbrock F, Zicha D, Hoppe A, Hogg N. Novel automated tracking analysis of particles subjected to shear flow: kindlin-3 role in B cells. Biophys J. 2013;105:1110-22 pubmed publisher
Teräväinen T, Myllymäki S, Friedrichs J, Strohmeyer N, Moyano J, Wu C, et al. ?V-integrins are required for mechanotransduction in MDCK epithelial cells. PLoS ONE. 2013;8:e71485 pubmed publisher
Sáez de Guinoa J, Barrio L, Carrasco Y. Vinculin arrests motile B cells by stabilizing integrin clustering at the immune synapse. J Immunol. 2013;191:2742-51 pubmed publisher
Kostourou V, Lechertier T, Reynolds L, Lees D, Baker M, Jones D, et al. FAK-heterozygous mice display enhanced tumour angiogenesis. Nat Commun. 2013;4:2020 pubmed publisher
Chiang Y, Ho K, Sun C, Chiu J, Lee F, Liao F, et al. CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration. PLoS ONE. 2013;8:e61761 pubmed publisher
Roca Cusachs P, Del Rio A, Puklin Faucher E, Gauthier N, Biais N, Sheetz M. Integrin-dependent force transmission to the extracellular matrix by ?-actinin triggers adhesion maturation. Proc Natl Acad Sci U S A. 2013;110:E1361-70 pubmed publisher
Tong L, Png E, Aihua H, Yong S, Yeo H, Riau A, et al. Molecular mechanism of transglutaminase-2 in corneal epithelial migration and adhesion. Biochim Biophys Acta. 2013;1833:1304-15 pubmed publisher
Ham H, Guerrier S, Kim J, Schoon R, Anderson E, Hamann M, et al. Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity. J Immunol. 2013;190:3661-9 pubmed publisher
Shin J, Krey J, Hassan A, Metlagel Z, Tauscher A, Pagana J, et al. Molecular architecture of the chick vestibular hair bundle. Nat Neurosci. 2013;16:365-74 pubmed publisher
Brody M, Hacker T, Patel J, Feng L, Sadoshima J, Tevosian S, et al. Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy. PLoS ONE. 2012;7:e51621 pubmed publisher
Gawecka J, Young Robbins S, Sulzmaier F, Caliva M, Heikkila M, Matter M, et al. RSK2 protein suppresses integrin activation and fibronectin matrix assembly and promotes cell migration. J Biol Chem. 2012;287:43424-37 pubmed publisher
Kato H, Liao Z, Mitsios J, Wang H, Deryugina E, Varner J, et al. The primacy of β1 integrin activation in the metastatic cascade. PLoS ONE. 2012;7:e46576 pubmed publisher
Menon A, Eddinger T, Wang H, Wendell D, Toth J, LaDisa J. Altered hemodynamics, endothelial function, and protein expression occur with aortic coarctation and persist after repair. Am J Physiol Heart Circ Physiol. 2012;303:H1304-18 pubmed publisher
Beaumont K, Mrksich M. The mechanostability of isolated focal adhesions is strongly dependent on pH. Chem Biol. 2012;19:711-20 pubmed publisher
Zhang F, Saha S, Kashina A. Arginylation-dependent regulation of a proteolytic product of talin is essential for cell-cell adhesion. J Cell Biol. 2012;197:819-36 pubmed publisher
Parizek M, Douglas T, Novotná K, Kromka A, Brady M, Renzing A, et al. Nanofibrous poly(lactide-co-glycolide) membranes loaded with diamond nanoparticles as promising substrates for bone tissue engineering. Int J Nanomedicine. 2012;7:1931-51 pubmed publisher
Sequeira S, Soscia D, Oztan B, Mosier A, Jean Gilles R, Gadre A, et al. The regulation of focal adhesion complex formation and salivary gland epithelial cell organization by nanofibrous PLGA scaffolds. Biomaterials. 2012;33:3175-86 pubmed publisher
Daley W, Kohn J, Larsen M. A focal adhesion protein-based mechanochemical checkpoint regulates cleft progression during branching morphogenesis. Dev Dyn. 2011;240:2069-83 pubmed publisher
Li G, Du X, Vass W, Papageorge A, Lowy D, Qian X. Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK). Proc Natl Acad Sci U S A. 2011;108:17129-34 pubmed publisher
Tzircotis G, Braga V, Caron E. RhoG is required for both FcγR- and CR3-mediated phagocytosis. J Cell Sci. 2011;124:2897-902 pubmed publisher
Brunner M, Millon Fremillon A, Chevalier G, Nakchbandi I, Mosher D, Block M, et al. Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition. J Cell Biol. 2011;194:307-22 pubmed publisher
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product information
Product No. :
T3287
Product Name :
Monoclonal Anti-Talin antibody produced in mouse
Host :
mouse
Conjugate :
unconjugated
Antibody Type :
monoclonal
Clone Number (if monoclonal) :
8d4
Applications/Description :
Suitable for immunoprecipitation (IP); western blot: 1:100 using chicken gizzard extract; indirect immunofluorescence: 1:500 using cultured Rat2 cells
Species Reactivity :
frog, mouse, rat, human, chicken
Isotype :
IgG1
Storage :
Store at -20°C
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA