Sholder G, Lanz T, Moccia R, Quan J, Aparicio Prat E, Stanton R, et al. 3'Pool-seq: an optimized cost-efficient and scalable method of whole-transcriptome gene expression profiling. BMC Genomics. 2020;21:64 pubmed publisher

Moseti D, Regassa A, Chen C, O K, Kim W. 25-Hydroxycholesterol Inhibits Adipogenic Differentiation of C3H10T1/2 Pluripotent Stromal Cells. Int J Mol Sci. 2020;21: pubmed publisher

Lee S, Lee C, Hwang C, Kim D, Han Y, Hong S, et al. Network Inference Analysis Identifies SETDB1 as a Key Regulator for Reverting Colorectal Cancer Cells into Differentiated Normal-Like Cells. Mol Cancer Res. 2020;18:118-129 pubmed publisher

Mahmoud S, Svensson F, Zoufir A, Módos D, Afzal A, Bender A. Understanding Conditional Associations between ToxCast in Vitro Readouts and the Hepatotoxicity of Compounds Using Rule-Based Methods. Chem Res Toxicol. 2020;33:137-153 pubmed publisher

Perri A, Agosti V, Olivo E, Concolino A, Angelis M, Tammè L, et al. Histone proteomics reveals novel post-translational modifications in breast cancer. Aging (Albany NY). 2019;11:11722-11755 pubmed publisher

Sato T, Segawa M, Sekine S, Ito K. Mild depolarization is involved in troglitazone-induced liver mitochondrial membrane permeability transition via mitochondrial iPLA2 activation. J Toxicol Sci. 2019;44:811-820 pubmed publisher

Mourelatou R, Kostopoulou E, Rojas Gil A, Kehagias I, Linos D, Kalfarentzos F, et al. Decreased adipocyte glucose transporter 4 (GLUT4) and aquaglyceroporin-7 (AQP7) in adults with morbid obesity: possible early markers of metabolic dysfunction. Hormones (Athens). 2019;18:297-306 pubmed publisher

Lee H, Heo J, Lee G, Park S, Jang S, Kim H, et al. Ginsenoside Rc Is a New Selective UGT1A9 Inhibitor in Human Liver Microsomes and Recombinant Human UGT Isoforms. Drug Metab Dispos. 2019;47:1372-1379 pubmed publisher

Hiemstra S, Ramaiahgari S, Wink S, Callegaro G, Coonen M, Meerman J, et al. High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability. Arch Toxicol. 2019;93:2895-2911 pubmed publisher

Park W, Choe S, Park J, Um J. Black Raspberry (Rubuscoreanus Miquel) Promotes Browning of Preadipocytes and Inguinal White Adipose Tissue in Cold-Induced Mice. Nutrients. 2019;11: pubmed publisher

Beaumatin F, O Prey J, Barthet V, Zunino B, Parvy J, Bachmann A, et al. mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux. Mol Cell. 2019;76:163-176.e8 pubmed publisher

Mazaki Tovi M, Bolin S, Schenck P. Adipokines secretion in feline primary adipose tissue culture in response to dietary fatty acids. BMC Vet Res. 2019;15:324 pubmed publisher

Şen N, Canet Pons J, Halbach M, Arsovic A, Pilatus U, Chae W, et al. Generation of an Atxn2-CAG100 knock-in mouse reveals N-acetylaspartate production deficit due to early Nat8l dysregulation. Neurobiol Dis. 2019;132:104559 pubmed publisher

Tian S, Lei P, Teng C, Sun Y, Song X, Li B, et al. Targeting PLIN2/PLIN5-PPARγ: Sulforaphane Disturbs the Maturation of Lipid Droplets. Mol Nutr Food Res. 2019;:e1900183 pubmed publisher

Suzuki K, Koyanagi Aoi M, Uehara K, Hinata N, Fujisawa M, Aoi T. Directed differentiation of human induced pluripotent stem cells into mature stratified bladder urothelium. Sci Rep. 2019;9:10506 pubmed publisher

Teng C, Yu C, Chang H, Hsieh W, Wu T, Lin J, et al. Chemopreventive Effect of Phytosomal Curcumin on Hepatitis B Virus-Related Hepatocellular Carcinoma in A Transgenic Mouse Model. Sci Rep. 2019;9:10338 pubmed publisher

Zhao M, Liu T, Wang Q, Zhang R, Liu L, Gong D, et al. Fatty acids modulate the expression of pyruvate kinase and arachidonate-lipoxygenase through PPARγ/CYP2C45 pathway: a link to goose fatty liver. Poult Sci. 2019;98:4346-4358 pubmed publisher

Singh S, Yende A, Ponnusamy K, Tyagi R. A comprehensive evaluation of anti-diabetic drugs on nuclear receptor PXR platform. Toxicol In Vitro. 2019;: pubmed publisher

Sun L, Bian K. The Nuclear Export and Ubiquitin-Proteasome-Dependent Degradation of PPARγ Induced By Angiotensin II. Int J Biol Sci. 2019;15:1215-1224 pubmed publisher

Ahmed O, Avila Herrera A, Tun K, Serpa P, Peng J, Parthasarathy S, et al. Evolution of Mechanisms that Control Mating in Drosophila Males. Cell Rep. 2019;27:2527-2536.e4 pubmed publisher

Abruzzese G, Heber M, Campo Verde Arboccó F, Ferreira S, Motta A. Fetal programming by androgen excess in rats affects ovarian fuel sensors and steroidogenesis. J Dev Orig Health Dis. 2019;10:645-658 pubmed publisher

Park P, Rha C, Kim S. Theaflavin-Enriched Fraction Stimulates Adipogenesis in Human Subcutaneous Fat Cells. Int J Mol Sci. 2019;20: pubmed publisher

Park P, Cho E. Kojyl Cinnamate Ester Derivatives Increase Adiponectin Expression and Stimulate Adiponectin-Induced Hair Growth Factors in Human Dermal Papilla Cells. Int J Mol Sci. 2019;20: pubmed publisher

Bort A, Sánchez B, Mateos Gomez P, Díaz Laviada I, Rodriguez Henche N. Capsaicin Targets Lipogenesis in HepG2 Cells Through AMPK Activation, AKT Inhibition and PPARs Regulation. Int J Mol Sci. 2019;20: pubmed publisher

Kasonga A, Kruger M, Coetzee M. Activation of PPARs Modulates Signalling Pathways and Expression of Regulatory Genes in Osteoclasts Derived from Human CD14+ Monocytes. Int J Mol Sci. 2019;20: pubmed publisher

Kwon M, Lee Y, Jung H, Shin H, Kim T, Lee S, et al. The direct effect of lobeglitazone, a new thiazolidinedione, on pancreatic beta cells: A comparison with other thiazolidinediones. Diabetes Res Clin Pract. 2019;151:209-223 pubmed publisher

Saleh A, Lázaro Ibáñez E, Forsgard M, Shatnyeva O, Osteikoetxea X, Karlsson F, et al. Extracellular vesicles induce minimal hepatotoxicity and immunogenicity. Nanoscale. 2019;11:6990-7001 pubmed publisher

Tran P, Pyo Y, Kim D, Lee S, Kim J, Park J. Overview of the Manufacturing Methods of Solid Dispersion Technology for Improving the Solubility of Poorly Water-Soluble Drugs and Application to Anticancer Drugs. Pharmaceutics. 2019;11: pubmed publisher

Huttala O, Sarkanen J, Heinonen T, Ylikomi T. Presence of vasculature results in faster insulin response in adipocytes in vascularized adipose tissue model. ALTEX. 2019;36:419-434 pubmed publisher

Han Y, Shin K, Kim J, Khadka D, Kim H, Lee Y, et al. A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis. J Clin Invest. 2019;130:1684-1698 pubmed publisher

Kakutani N, Nanayama T, Nomura Y. Novel risk assessment of reactive metabolites from discovery to clinical stage. J Toxicol Sci. 2019;44:201-211 pubmed publisher

Ferro F, Spelat R, Shaw G, Duffy N, Islam M, O Shea P, et al. Survival/Adaptation of Bone Marrow-Derived Mesenchymal Stem Cells After Long-Term Starvation Through Selective Processes. Stem Cells. 2019;37:813-827 pubmed publisher

Strieder Barboza C, Contreras G. Fetuin-A modulates lipid mobilization in bovine adipose tissue by enhancing lipogenic activity of adipocytes. J Dairy Sci. 2019;102:4628-4638 pubmed publisher

Moraes C, Witt G, Kuzikov M, Ellinger B, Calogeropoulou T, Prousis K, et al. Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform. SLAS Discov. 2019;24:346-361 pubmed publisher

Sukonina V, Ma H, Zhang W, Bartesaghi S, Subhash S, Heglind M, et al. FOXK1 and FOXK2 regulate aerobic glycolysis. Nature. 2019;566:279-283 pubmed publisher

Kan W, Hwang J, Chuang L, Guh J, Ye Y, Yang Y, et al. Effect of osthole on advanced glycation end products-induced renal tubular hypertrophy and role of klotho in its mechanism of action. Phytomedicine. 2019;53:205-212 pubmed publisher

Cerone M, Uliassi E, Prati F, Ebiloma G, Lemgruber L, Bergamini C, et al. Discovery of Sustainable Drugs for Neglected Tropical Diseases: Cashew Nut Shell Liquid (CNSL)-Based Hybrids Target Mitochondrial Function and ATP Production in Trypanosoma brucei. ChemMedChem. 2019;14:621-635 pubmed publisher

Nnadi C, Ebiloma G, Black J, Nwodo N, Lemgruber L, Schmidt T, et al. Potent Antitrypanosomal Activities of 3-Aminosteroids against African Trypanosomes: Investigation of Cellular Effects and of Cross-Resistance with Existing Drugs. Molecules. 2019;24: pubmed publisher

Burban A, Sharanek A, Humbert L, Eguether T, Guguen Guillouzo C, Rainteau D, et al. Predictive Value of Cellular Accumulation of Hydrophobic Bile Acids As a Marker of Cholestatic Drug Potential. Toxicol Sci. 2019;168:474-485 pubmed publisher

Wang Q, Liu H, Slavsky M, Fitzgerald M, Lu C, O Shea T. A high-throughput glutathione trapping assay with combined high sensitivity and specificity in high-resolution mass spectrometry by applying product ion extraction and data-dependent neutral loss. J Mass Spectrom. 2019;54:158-166 pubmed publisher

Dyer D, Nebot J, Kelly C, Medina Ruiz L, Schuette F, Graham G. The chemokine receptor CXCR2 contributes to murine adipocyte development. J Leukoc Biol. 2019;105:497-506 pubmed publisher

Hikage F, Atkins S, Kahana A, Smith T, Chun T. HIF2A-LOX Pathway Promotes Fibrotic Tissue Remodeling in Thyroid-Associated Orbitopathy. Endocrinology. 2019;160:20-35 pubmed publisher

Kim S, Song N, Chang S, Bahn G, Choi Y, Rhee D, et al. Sulfuretin Prevents Obesity and Metabolic Diseases in Diet Induced Obese Mice. Biomol Ther (Seoul). 2019;27:107-116 pubmed publisher

Park J, Kim M, Song N, Kim J, Seo D, Lee J, et al. A Reciprocal Role of the Smad4-Taz Axis in Osteogenesis and Adipogenesis of Mesenchymal Stem Cells. Stem Cells. 2018;: pubmed publisher

Kim S, Han Y, Ahn S, An S, Shin J, Choi H, et al. Kojyl cinnamate esters are peroxisome proliferator-activated receptor α/γ dual agonists. Bioorg Med Chem. 2018;26:5654-5663 pubmed publisher

Oikonomou E, Kostopoulou E, Rojas Gil A, Georgiou G, Spiliotis B. Adipocyte aquaporin 7 (AQP7) expression in lean children and children with obesity. Possible involvement in molecular mechanisms of childhood obesity. J Pediatr Endocrinol Metab. 2018;31:1081-1089 pubmed publisher

Hiramitsu S, Ishikawa T, Lee W, Khan T, Crumbley C, Khwaja N, et al. Estrogen Receptor Beta-Mediated Modulation of Lung Cancer Cell Proliferation by 27-Hydroxycholesterol. Front Endocrinol (Lausanne). 2018;9:470 pubmed publisher

Cho R, Yang C, Tseng H, Hsiao L, Lin C, Yang C. Haem oxygenase-1 up-regulation by rosiglitazone via ROS-dependent Nrf2-antioxidant response elements axis or PPARγ attenuates LPS-mediated lung inflammation. Br J Pharmacol. 2018;175:3928-3946 pubmed publisher

Chen X, Zhang J, Hou L, Zhang R, Chen W, Fan H, et al. Upregulation of PD-L1 predicts poor prognosis and is associated with miR-191-5p dysregulation in colon adenocarcinoma. Int J Immunopathol Pharmacol. 2018;32:2058738418790318 pubmed publisher

Dutta D, Lai K, Reyes Ordoñez A, Chen J, van der Donk W. Lanthionine synthetase C-like protein 2 (LanCL2) is important for adipogenic differentiation. J Lipid Res. 2018;59:1433-1445 pubmed publisher

Hustler A, Eardley I, Hinley J, Pearson J, Wezel F, Radvanyi F, et al. Differential transcription factor expression by human epithelial cells of buccal and urothelial derivation. Exp Cell Res. 2018;369:284-294 pubmed publisher

Bergsma A, Ganguly S, Dick D, Williams B, Miranti C. Global deletion of tetraspanin CD82 attenuates bone growth and enhances bone marrow adipogenesis. Bone. 2018;113:105-113 pubmed publisher

Segawa M, Sekine S, Sato T, Ito K. Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model rat. J Toxicol Sci. 2018;43:339-351 pubmed publisher

Choi K, Yoo H. 3,3'-Diindolylmethane Enhances Glucose Uptake Through Activation of Insulin Signaling in 3T3-L1 Adipocytes. Obesity (Silver Spring). 2018;26:1153-1160 pubmed publisher

Sugihara H, Teramoto N, Yamanouchi K, Matsuwaki T, Nishihara M. Oxidative stress-mediated senescence in mesenchymal progenitor cells causes the loss of their fibro/adipogenic potential and abrogates myoblast fusion. Aging (Albany NY). 2018;10:747-763 pubmed publisher

Feng S, He X, Zhong P, Zhao J, Huang C, Hu Z. A Metabolism-Based Synergy for Total Coumarin Extract of Radix Angelicae Dahuricae and Ligustrazine on Migraine Treatment in Rats. Molecules. 2018;23: pubmed publisher

Le Guillou D, Bucher S, Begriche K, Hoët D, Lombes A, Labbe G, et al. Drug-Induced Alterations of Mitochondrial DNA Homeostasis in Steatotic and Nonsteatotic HepaRG Cells. J Pharmacol Exp Ther. 2018;365:711-726 pubmed publisher

Luckert C, Braeuning A, Lampen A, Hessel Pras S. PXR: Structure-specific activation by hepatotoxic pyrrolizidine alkaloids. Chem Biol Interact. 2018;288:38-48 pubmed publisher

Ke R, Vishnoi K, Viswakarma N, Santha S, Das S, Rana A, et al. Involvement of AMP-activated protein kinase and Death Receptor 5 in TRAIL-Berberine-induced apoptosis of cancer cells. Sci Rep. 2018;8:5521 pubmed publisher

Yokoyama Y, Sasaki Y, Terasaki N, Kawataki T, Takekawa K, Iwase Y, et al. Comparison of Drug Metabolism and Its Related Hepatotoxic Effects in HepaRG, Cryopreserved Human Hepatocytes, and HepG2 Cell Cultures. Biol Pharm Bull. 2018;41:722-732 pubmed publisher

Xu J, Oda S, Yokoi T. Cell-based assay using glutathione-depleted HepaRG and HepG2 human liver cells for predicting drug-induced liver injury. Toxicol In Vitro. 2018;48:286-301 pubmed publisher

Lee G, Pan Y, Scanlon M, Porter C, Nicolazzo J. Fatty Acid-Binding Protein 5 Mediates the Uptake of Fatty Acids, but not Drugs, Into Human Brain Endothelial Cells. J Pharm Sci. 2018;107:1185-1193 pubmed publisher

Cepa S, Potter D, Wong L, Schutt L, Tarrant J, Pang J, et al. Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition. Toxicol Appl Pharmacol. 2018;338:204-213 pubmed publisher

Yamaji D, Soliman M, Kamikawa A, Ito T, Ahmed M, Okamatsu Ogura Y, et al. Species-specific control of hepatocyte growth factor expression and production in adipocytes in a differentiation-dependent manner. Domest Anim Endocrinol. 2018;62:39-48 pubmed publisher

Sohlenius Sternbeck A, Meyerson G, Hagbjörk A, Juric S, Terelius Y. A strategy for early-risk predictions of clinical drug-drug interactions involving the GastroPlusTM DDI module for time-dependent CYP inhibitors. Xenobiotica. 2018;48:348-356 pubmed publisher

Phan A, Vo V, Hua T, Kim M, Jo S, Choi J, et al. PPAR? sumoylation-mediated lipid accumulation in lung cancer. Oncotarget. 2017;8:82491-82505 pubmed publisher

Luczak E, Wieczfinska J, Sokolowska M, Pniewska E, Luczynska D, Pawliczak R. Troglitazone, a PPAR-? agonist, decreases LTC4 concentration in mononuclear cells in patients with asthma. Pharmacol Rep. 2017;69:1315-1321 pubmed publisher

Mak A, Kato R, Weston K, Hayes A, Uetrecht J. An Impaired Immune Tolerance Animal Model Distinguishes the Potential of Troglitazone/Pioglitazone and Tolcapone/Entacapone to Cause IDILI. Toxicol Sci. 2017;: pubmed publisher

Sakamoto S, Watanabe T, Kohda Y, Iijima M, Sawa R, Okada M, et al. Phenazine carboxylic acid and its derivative induce osteoblast differentiation in preosteoblastic MC3T3-E1 cells but adipocyte differentiation in pluripotent mesenchymal C3H10T1/2 cells. J Antibiot (Tokyo). 2017;: pubmed publisher

Okamatsu Ogura Y, Nio Kobayashi J, Nagaya K, Tsubota A, Kimura K. Brown adipocytes postnatally arise through both differentiation from progenitors and conversion from white adipocytes in Syrian hamster. J Appl Physiol (1985). 2017;:jap.00622.2017 pubmed publisher

Dykes S, Steffan J, Cardelli J. Lysosome trafficking is necessary for EGF-driven invasion and is regulated by p38 MAPK and Na+/H+ exchangers. BMC Cancer. 2017;17:672 pubmed publisher

Okamatsu Ogura Y, Fukano K, Tsubota A, Nio Kobayashi J, Nakamura K, Morimatsu M, et al. Cell-cycle arrest in mature adipocytes impairs BAT development but not WAT browning, and reduces adaptive thermogenesis in mice. Sci Rep. 2017;7:6648 pubmed publisher

Koltes D, Spurlock M, Spurlock D. Adipose triglyceride lipase protein abundance and translocation to the lipid droplet increase during leptin-induced lipolysis in bovine adipocytes. Domest Anim Endocrinol. 2017;61:62-76 pubmed publisher

Kopinke D, Roberson E, Reiter J. Ciliary Hedgehog Signaling Restricts Injury-Induced Adipogenesis. Cell. 2017;170:340-351.e12 pubmed publisher

Ito T, Yamaji D, Kamikawa A, Abd Eldaim M, Okamatsu Ogura Y, Terao A, et al. Progesterone dose-dependently modulates hepatocyte growth factor production in 3T3-L1 mouse preadipocytes. Endocr J. 2017;64:777-785 pubmed publisher

Cheng Y, Chen S, Freeden C, Chen W, Zhang Y, Abraham P, et al. Bile Salt Homeostasis in Normal and Bsep Gene Knockout Rats with Single and Repeated Doses of Troglitazone. J Pharmacol Exp Ther. 2017;362:385-394 pubmed publisher

Whitby L, Obach R, Simon G, Hayward M, Cravatt B. Quantitative Chemical Proteomic Profiling of the in Vivo Targets of Reactive Drug Metabolites. ACS Chem Biol. 2017;12:2040-2050 pubmed publisher

Goracci L, Tortorella S, Tiberi P, Pellegrino R, Di Veroli A, Valeri A, et al. Lipostar, a Comprehensive Platform-Neutral Cheminformatics Tool for Lipidomics. Anal Chem. 2017;89:6257-6264 pubmed publisher

Ogimura E, Tokizono M, Sekine S, Nakagawa T, Bando K, Ito K. Metabolic Activation of Cholestatic Drug-Induced Bile Acid-Dependent Toxicity in Human Sandwich-Cultured Hepatocytes. J Pharm Sci. 2017;106:2509-2514 pubmed publisher

Kim M, Lee E, Shin H, Jung H, Kim T, Kim T, et al. The effect of PPAR? agonist on SGLT2 and glucagon expressions in alpha cells under hyperglycemia. J Endocrinol Invest. 2017;40:1069-1076 pubmed publisher

Ware B, McVay M, Sunada W, Khetani S. Exploring Chronic Drug Effects on Microengineered Human Liver Cultures Using Global Gene Expression Profiling. Toxicol Sci. 2017;157:387-398 pubmed publisher

Ott L, Ramachandran K, Stehno Bittel L. An Automated Multiplexed Hepatotoxicity and CYP Induction Assay Using HepaRG Cells in 2D and 3D. SLAS Discov. 2017;22:614-625 pubmed publisher

Rivera Piza A, An Y, Kim D, Lee S, Kim J, Choi J, et al. Protocatechuic Acid Enhances Osteogenesis, but Inhibits Adipogenesis in C3H10T1/2 and 3T3-L1 Cells. J Med Food. 2017;20:309-319 pubmed publisher

Lu J, Zhang Y, Sun M, Liu M, Wang X. Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein. Phytomedicine. 2017;26:1-10 pubmed publisher

Haj Yasein N, Berg O, Jernerén F, Refsum H, Nebb H, Dalen K. Cysteine deprivation prevents induction of peroxisome proliferator-activated receptor gamma-2 and adipose differentiation of 3T3-L1 cells. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:623-635 pubmed publisher

Hicks M, Salituro L, Mangion I, Schafer W, Xiang R, Gong X, et al. Assessment of coulometric array electrochemical detection coupled with HPLC-UV for the absolute quantitation of pharmaceuticals. Analyst. 2017;142:525-536 pubmed publisher

Carrer A, Parris J, Trefely S, Henry R, Montgomery D, Torres A, et al. Impact of a High-fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels. J Biol Chem. 2017;292:3312-3322 pubmed publisher

Ni X, Gao Y, Wu Z, Ma L, Chen C, Wang L, et al. Functional human induced hepatocytes (hiHeps) with bile acid synthesis and transport capacities: A novel in vitro cholestatic model. Sci Rep. 2016;6:38694 pubmed publisher

Pinkosky S, Newton R, Day E, Ford R, Lhotak S, Austin R, et al. Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis. Nat Commun. 2016;7:13457 pubmed publisher

Park H, Ko S, Lee J, Park J, Choi Y. Troglitazone Enhances the Apoptotic Response of DLD-1 Colon Cancer Cells to Photodynamic Therapy. Yonsei Med J. 2016;57:1494-9 pubmed publisher

Inoue J, Ihara Y, Tsukamoto D, Yasumoto K, Hashidume T, Kamimura K, et al. Identification of BCL11B as a regulator of adipogenesis. Sci Rep. 2016;6:32750 pubmed publisher

Tomida T, Okamura H, Yokoi T, Konno Y. A modified multiparametric assay using HepaRG cells for predicting the degree of drug-induced liver injury risk. J Appl Toxicol. 2017;37:382-390 pubmed publisher

Yu M, Jiang M, Chen Y, Zhang S, Zhang W, Yang X, et al. Inhibition of Macrophage CD36 Expression and Cellular Oxidized Low Density Lipoprotein (oxLDL) Accumulation by Tamoxifen: A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)?-DEPENDENT MECHANISM. J Biol Chem. 2016;291:16977-89 pubmed publisher

Choi M, Kim H, Ham M, Choi D, Lee T, Shin D. Amber Light (590 nm) Induces the Breakdown of Lipid Droplets through Autophagy-Related Lysosomal Degradation in Differentiated Adipocytes. Sci Rep. 2016;6:28476 pubmed publisher

Tolosa L, Gómez Lechón M, López S, Guzmán C, Castell J, Donato M, et al. Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing. Toxicol Sci. 2016;152:214-29 pubmed publisher

Pofi R, Di Mario F, Gigante A, Rosato E, Isidori A, Amoroso A, et al. Diabetic Nephropathy: Focus on Current and Future Therapeutic Strategies. Curr Drug Metab. 2016;17:497-502 pubmed

Richarson A, Scott D, Zagnitko O, Aza Blanc P, Chang C, Russler Germain D. Registered report: IDH mutation impairs histone demethylation and results in a block to cell differentiation. elife. 2016;5:e10860 pubmed publisher

Khan F, Syeda P, Nartey M, Rahman M, Islam M, Nishimura K, et al. Stimulation of fat storage by prostacyclin and selective agonists of prostanoid IP receptor during the maturation phase of cultured adipocytes. Cytotechnology. 2016;68:2417-2429 pubmed

Yousefi B, Samadi N, Baradaran B, Rameshknia V, Shafiei Irannejad V, Majidinia M, et al. Differential effects of peroxisome proliferator-activated receptor agonists on doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells. Cell Mol Biol (Noisy-le-grand). 2015;61:118-22 pubmed

Huang L, Zou S, Deng J, Dai T, Jiang J, Jia Y, et al. Development of an optimized cytotoxicity assay system for CYP3A4-mediated metabolic activation via modified piggyBac transposition. Toxicol In Vitro. 2016;32:132-7 pubmed publisher

Zhao J, Cheng Q, Ye P, Yang G, Liu S, Ao Q, et al. Atorvastatin improves pathological changes in the aged kidney by upregulating peroxisome proliferator-activated receptor expression and reducing matrix metalloproteinase-9 and transforming growth factor-β1 levels. Exp Gerontol. 2016;74:37-42 pubmed publisher

Bisikirska B, Bansal M, Shen Y, Teruya Feldstein J, Chaganti R, Califano A. Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression. Cancer Res. 2016;76:664-74 pubmed publisher

Kim S, Kim Y, Son S, Moon E, Pyo S, Um S. Fisetin induces Sirt1 expression while inhibiting early adipogenesis in 3T3-L1 cells. Biochem Biophys Res Commun. 2015;467:638-44 pubmed publisher

Fernandes P, MacSharry J, Darby T, Fanning A, Shanahan F, Houston A, et al. Differential expression of key regulators of Toll-like receptors in ulcerative colitis and Crohn's disease: a role for Tollip and peroxisome proliferator-activated receptor gamma?. Clin Exp Immunol. 2016;183:358-68 pubmed publisher

Moon S, Lee S, Jung K, Quach C, Park J, Lee J, et al. Troglitazone Stimulates Cancer Cell Uptake of 18F-FDG by Suppressing Mitochondrial Respiration and Augments Sensitivity to Glucose Restriction. J Nucl Med. 2016;57:129-35 pubmed publisher

Myneni V, Melino G, Kaartinen M. Transglutaminase 2--a novel inhibitor of adipogenesis. Cell Death Dis. 2015;6:e1868 pubmed publisher

Kaiser M, Maser P, Tadoori L, Ioset J, Brun R. Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning. PLoS ONE. 2015;10:e0135556 pubmed publisher

Vernetti L, Senutovitch N, Boltz R, DeBiasio R, Shun T, Gough A, et al. A human liver microphysiology platform for investigating physiology, drug safety, and disease models. Exp Biol Med (Maywood). 2016;241:101-14 pubmed publisher

Santha S, Viswakarma N, Das S, Rana A, Rana B. Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-Troglitazone-induced Apoptosis in Prostate Cancer Cells Involve AMP-activated Protein Kinase. J Biol Chem. 2015;290:21865-75 pubmed publisher

He Y, Ho C. Amorphous Solid Dispersions: Utilization and Challenges in Drug Discovery and Development. J Pharm Sci. 2015;104:3237-58 pubmed publisher

Nakano S, Nakamura K, Teramoto N, Yamanouchi K, Nishihara M. Basic fibroblast growth factor is pro-adipogenic in rat skeletal muscle progenitor clone, 2G11 cells. Anim Sci J. 2016;87:99-108 pubmed publisher

Lu J, Einhorn S, Venkatarangan L, Miller M, Mann D, Watkins P, et al. Morphological and Functional Characterization and Assessment of iPSC-Derived Hepatocytes for In Vitro Toxicity Testing. Toxicol Sci. 2015;147:39-54 pubmed publisher

Holobotovskyy V, Chong Y, Burchell J, He B, Phillips M, Leader L, et al. Regulator of G protein signaling 5 is a determinant of gestational hypertension and preeclampsia. Sci Transl Med. 2015;7:290ra88 pubmed publisher

Deus C, Zehowski C, Nordgren K, Wallace K, Skildum A, Oliveira P. Stimulating basal mitochondrial respiration decreases doxorubicin apoptotic signaling in H9c2 cardiomyoblasts. Toxicology. 2015;334:1-11 pubmed publisher

Ahn S, Yi S, Seo W, Lee M, Song Y, Baek S, et al. A cannabinoid receptor agonist N-arachidonoyl dopamine inhibits adipocyte differentiation in human mesenchymal stem cells. Biomol Ther (Seoul). 2015;23:218-24 pubmed publisher

Senutovitch N, Vernetti L, Boltz R, DeBiasio R, Gough A, Taylor D. Fluorescent protein biosensors applied to microphysiological systems. Exp Biol Med (Maywood). 2015;240:795-808 pubmed publisher

Sung M, Hsu H, Lee C, Lee H, Kuo Y, Hua K, et al. Krüppel-like factor 4 modulates the migration and invasion of hepatoma cells by suppressing TIMP-1 and TIMP-2. Oncol Rep. 2015;34:439-46 pubmed publisher

Tseng H, Park Y, Lee Y, Moore D. The orphan nuclear receptor small heterodimer partner is required for thiazolidinedione effects in leptin-deficient mice. J Biomed Sci. 2015;22:30 pubmed publisher

Tomida T, Okamura H, Satsukawa M, Yokoi T, Konno Y. Multiparametric assay using HepaRG cells for predicting drug-induced liver injury. Toxicol Lett. 2015;236:16-24 pubmed publisher

Than A, He H, Chua S, Xu D, Sun L, Leow M, et al. Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes. J Biol Chem. 2015;290:14679-91 pubmed publisher

Yun U, Song N, Yang D, Kwon S, Kim K, Kim S, et al. miR-195a inhibits adipocyte differentiation by targeting the preadipogenic determinator Zfp423. J Cell Biochem. 2015;116:2589-97 pubmed publisher

Declercq V, d Eon B, McLeod R. Fatty acids increase adiponectin secretion through both classical and exosome pathways. Biochim Biophys Acta. 2015;1851:1123-33 pubmed publisher

Reynolds M, Clem B. Troglitazone suppresses glutamine metabolism through a PPAR-independent mechanism. Biol Chem. 2015;396:937-47 pubmed publisher

Fortin J, Benoit Biancamano M. In vitro evaluation of hypoglycemic agents to target human islet amyloid polypeptide: a key protein involved in amyloid deposition and beta-cell loss. Can J Diabetes. 2015;39:373-82 pubmed publisher

Maschmeyer I, Hasenberg T, Jaenicke A, Lindner M, Lorenz A, Zech J, et al. Chip-based human liver-intestine and liver-skin co-cultures--A first step toward systemic repeated dose substance testing in vitro. Eur J Pharm Biopharm. 2015;95:77-87 pubmed publisher

He J, Xu C, Kuang J, Liu Q, Jiang H, Mo L, et al. Thiazolidinediones attenuate lipolysis and ameliorate dexamethasone-induced insulin resistance. Metabolism. 2015;64:826-36 pubmed publisher

Riahi Y, Kaiser N, Cohen G, Abd Elrahman I, Blum G, Shapira O, et al. Foam cell-derived 4-hydroxynonenal induces endothelial cell senescence in a TXNIP-dependent manner. J Cell Mol Med. 2015;19:1887-99 pubmed publisher

Chin L, Hsu S, Zhong W, Liang Y. Combined treatment with troglitazone and lovastatin inhibited epidermal growth factor-induced migration through the downregulation of cysteine-rich protein 61 in human anaplastic thyroid cancer cells. PLoS ONE. 2015;10:e0118674 pubmed publisher

Furuhashi M, Mita T, Moniwa N, Hoshina K, Ishimura S, Fuseya T, et al. Angiotensin II receptor blockers decrease serum concentration of fatty acid-binding protein 4 in patients with hypertension. Hypertens Res. 2015;38:252-9 pubmed publisher

Brand L, Olson M, Ravindranathan P, Guo H, Kempema A, Andrews T, et al. EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer. Oncotarget. 2015;6:3811-24 pubmed

Kim D, Ihn H, Moon C, Oh S, Park S, Kim S, et al. Ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, inhibits proliferation and differentiation of th17 cells. Biomol Ther (Seoul). 2015;23:71-6 pubmed publisher

Zhang H, Shao Z, Alibin C, Acosta C, Anderson H. Liganded peroxisome proliferator-activated receptors (PPARs) preserve nuclear histone deacetylase 5 levels in endothelin-treated Sprague-Dawley rat cardiac myocytes. PLoS ONE. 2014;9:e115258 pubmed publisher

Takahashi H, Goto T, Yamazaki Y, Kamakari K, Hirata M, Suzuki H, et al. Metabolomics reveal 1-palmitoyl lysophosphatidylcholine production by peroxisome proliferator-activated receptor α. J Lipid Res. 2015;56:254-65 pubmed publisher

Baron D, Kaindl U, Haudek Prinz V, Bayer E, Röhrl C, Gerner C, et al. Autonomous inhibition of apoptosis correlates with responsiveness of colon carcinoma cell lines to ciglitazone. PLoS ONE. 2014;9:e114158 pubmed publisher

Brink A, Fontaine F, Marschmann M, Steinhuber B, Cece E, Zamora I, et al. Post-acquisition analysis of untargeted accurate mass quadrupole time-of-flight MS(E) data for multiple collision-induced neutral losses and fragment ions of glutathione conjugates. Rapid Commun Mass Spectrom. 2014;28:2695-703 pubmed publisher

Subash Babu P, Alshatwi A. Hesperetin inhibit adipocyte differentiation and enhance Bax- and p21-mediated adipolysis in human mesenchymal stem cell adipogenesis. J Biochem Mol Toxicol. 2015;29:99-108 pubmed publisher

Sui X, Liu Y, Li Q, Liu G, Song X, Su Z, et al. Oxidized low-density lipoprotein suppresses expression of prostaglandin E receptor subtype EP3 in human THP-1 macrophages. PLoS ONE. 2014;9:e110828 pubmed publisher

Wang R, Hong J, Liu R, Chen M, Xu M, Gu W, et al. SFRP5 acts as a mature adipocyte marker but not as a regulator in adipogenesis. J Mol Endocrinol. 2014;53:405-15 pubmed publisher

Röhrborn D, Eckel J, Sell H. Shedding of dipeptidyl peptidase 4 is mediated by metalloproteases and up-regulated by hypoxia in human adipocytes and smooth muscle cells. FEBS Lett. 2014;588:3870-7 pubmed publisher

Boucher J, Husain M, Rowan Carroll A, Williams A, Yauk C, Atlas E. Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014;22:2333-43 pubmed publisher

van Noort V, Schölch S, Iskar M, Zeller G, Ostertag K, Schweitzer C, et al. Novel drug candidates for the treatment of metastatic colorectal cancer through global inverse gene-expression profiling. Cancer Res. 2014;74:5690-9 pubmed publisher

Mori T, Hidaka M, Ikuji H, Yoshizawa I, Toyohara H, Okuda T, et al. A high-throughput screen for inhibitors of the prolyl isomerase, Pin1, identifies a seaweed polyphenol that reduces adipose cell differentiation. Biosci Biotechnol Biochem. 2014;78:832-8 pubmed publisher

. Long-term chronic toxicity testing using human pluripotent stem cell-derived hepatocytes. Drug Metab Dispos. 2014;42:1401-6 pubmed publisher

Addison W, Fu M, Yang H, Lin Z, Nagano K, Gori F, et al. Direct transcriptional repression of Zfp423 by Zfp521 mediates a bone morphogenic protein-dependent osteoblast versus adipocyte lineage commitment switch. Mol Cell Biol. 2014;34:3076-85 pubmed publisher

Tan B, Cai W, Zhang J, Zhou N, Ma G, Yang P, et al. Identification of UDP-glucuronosyltransferase isoforms responsible for leonurine glucuronidation in human liver and intestinal microsomes. Xenobiotica. 2014;44:775-84 pubmed publisher

Okabe Y, Shimada T, Horikawa T, Kinoshita K, Koyama K, Ichinose K, et al. Suppression of adipocyte hypertrophy by polymethoxyflavonoids isolated from Kaempferia parviflora. Phytomedicine. 2014;21:800-6 pubmed publisher

Patel J, Butters O, Arnett T. PPAR agonists stimulate adipogenesis at the expense of osteoblast differentiation while inhibiting osteoclast formation and activity. Cell Biochem Funct. 2014;32:368-77 pubmed publisher

Shin D, Choi K, Lee Y, Kim W, Shin K, Oh S, et al. Echinacea purpurea root extract enhances the adipocyte differentiation of 3T3-L1 cells. Arch Pharm Res. 2014;37:803-12 pubmed publisher

Yan J, Yang H, Wang G, Sun L, Zhou Y, Guo Y, et al. Autophagy augmented by troglitazone is independent of EGFR transactivation and correlated with AMP-activated protein kinase signaling. Autophagy. 2010;6:67-73 pubmed

BAERGA R, Zhang Y, Chen P, Goldman S, Jin S. Targeted deletion of autophagy-related 5 (atg5) impairs adipogenesis in a cellular model and in mice. Autophagy. 2009;5:1118-30 pubmed

Lebrasseur N, Kelly M, Tsao T, Farmer S, Saha A, Ruderman N, et al. Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues. Am J Physiol Endocrinol Metab. 2006;291:E175-81 pubmed