Okamura M, Shizu R, Hosaka T, Sasaki T, Yoshinari K. Possible involvement of the competition for the transcriptional coactivator glucocorticoid receptor-interacting protein 1 in the inflammatory signal-dependent suppression of PXR-mediated CYP3A induction in vitro. Drug Metab Pharmacokinet. 2019;34:272-279 pubmed publisher

Rampersaud A, Lodato N, Shin A, Waxman D. Widespread epigenetic changes to the enhancer landscape of mouse liver induced by a specific xenobiotic agonist ligand of the nuclear receptor CAR. Toxicol Sci. 2019;: pubmed publisher

Yang H, Shi Z, Wang X, Cheng R, Lu M, Zhu J, et al. Phenanthrene, but not its isomer anthracene, effectively activates both human and mouse nuclear receptor constitutive androstane receptor (CAR) and induces hepatotoxicity in mice. Toxicol Appl Pharmacol. 2019;:114618 pubmed publisher

Kim K, Choi J, Li F, Dong B, Wooton Kee C, Arizpe A, et al. Constitutive Androstane Receptor Differentially Regulates Bile Acid Homeostasis in Mouse Models of Intrahepatic Cholestasis. Hepatol Commun. 2019;3:147-159 pubmed publisher

Dempsey J, Cui J. Regulation of Hepatic Long Noncoding RNAs by Pregnane X Receptor and Constitutive Androstane Receptor Agonists in Mouse Liver. Drug Metab Dispos. 2019;47:329-339 pubmed publisher

Onuki M, Watanabe M, Ishihara N, Suzuki K, Takizawa K, Hirota M, et al. A partial agonist for retinoid X receptor mitigates experimental colitis. Int Immunol. 2019;31:251-262 pubmed publisher

Chen F, Coslo D, Chen T, Zhang L, Tian Y, Smith P, et al. Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism. J Proteome Res. 2019;18:239-251 pubmed publisher

Rooney J, Oshida K, Kumar R, Baldwin W, Corton J. Chemical Activation of the Constitutive Androstane Receptor Leads to Activation of Oxidant-Induced Nrf2. Toxicol Sci. 2019;167:172-189 pubmed publisher

Yoshimaru S, Shizu R, Tsuruta S, Amaike Y, Kano M, Hosaka T, et al. Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR. J Toxicol Sci. 2018;43:443-450 pubmed publisher

Yarushkin A, Mazin M, Yunusova A, Korchagina K, Pustylnyak Y, Prokopyeva E, et al. CAR-mediated repression of Cdkn1a(p21) is accompanied by the Akt activation. Biochem Biophys Res Commun. 2018;504:361-366 pubmed publisher

Lodato N, Rampersaud A, Waxman D. Impact of CAR Agonist Ligand TCPOBOP on Mouse Liver Chromatin Accessibility. Toxicol Sci. 2018;164:115-128 pubmed publisher

Xu P, Hong F, Wang J, Dai S, Wang J, Zhai Y. The CAR agonist TCPOBOP inhibits lipogenesis and promotes fibrosis in the mammary gland of adolescent female mice. Toxicol Lett. 2018;290:29-35 pubmed publisher

Moustafa S, Karakasiliotis I, Mavromara P. Hepatitis C Virus core+1/ARF Protein Modulates the Cyclin D1/pRb Pathway and Promotes Carcinogenesis. J Virol. 2018;92: pubmed publisher

Whyte Allman S, Hoque M, Jenabian M, Routy J, Bendayan R. Xenobiotic Nuclear Receptors Pregnane X Receptor and Constitutive Androstane Receptor Regulate Antiretroviral Drug Efflux Transporters at the Blood-Testis Barrier. J Pharmacol Exp Ther. 2017;363:324-335 pubmed publisher

Lodato N, Melia T, Rampersaud A, Waxman D. Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver. Toxicol Sci. 2017;159:25-41 pubmed publisher

Kriebs A, Jordan S, Soto E, Henriksson E, Sandate C, Vaughan M, et al. Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity. Proc Natl Acad Sci U S A. 2017;114:8776-8781 pubmed publisher

Forbes K, Kouranova E, Tinker D, Janowski K, Cortner D, McCoy A, et al. Creation and Preliminary Characterization of Pregnane X Receptor and Constitutive Androstane Receptor Knockout Rats. Drug Metab Dispos. 2017;45:1068-1076 pubmed publisher

Lu W, Rettenmeier E, Paszek M, Yueh M, Tukey R, Trottier J, et al. Crypt Organoid Culture as an in Vitro Model in Drug Metabolism and Cytotoxicity Studies. Drug Metab Dispos. 2017;45:748-754 pubmed publisher

Wang X, Zheng L, Wu J, Tang B, Zhang M, Zhu D, et al. Constitutive androstane receptor activation promotes bilirubin clearance in a murine model of alcoholic liver disease. Mol Med Rep. 2017;15:3459-3466 pubmed publisher

Hudson G, Flannigan K, Erickson S, Vicentini F, Zamponi A, Hirota C, et al. Constitutive androstane receptor regulates the intestinal mucosal response to injury. Br J Pharmacol. 2017;174:1857-1871 pubmed publisher

Cheng S, Bammler T, Cui J. RNA Sequencing Reveals Age and Species Differences of Constitutive Androstane Receptor-Targeted Drug-Processing Genes in the Liver. Drug Metab Dispos. 2017;45:867-882 pubmed publisher

Abe T, Takahashi M, Kano M, Amaike Y, Ishii C, Maeda K, et al. Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid. Arch Toxicol. 2017;91:2365-2374 pubmed publisher

Orsini V, Zurbruegg S, Pikiolek M, Tchorz J, Beckmann N. MRI as Primary End Point for Pharmacologic Experiments of Liver Regeneration in a Murine Model of Partial Hepatectomy. Acad Radiol. 2016;23:1446-1453 pubmed publisher

Hardesty J, Wahlang B, Falkner K, Clair H, Clark B, Ceresa B, et al. Polychlorinated biphenyls disrupt hepatic epidermal growth factor receptor signaling. Xenobiotica. 2017;47:807-820 pubmed publisher

Li C, Cheng S, Bammler T, Cui J. Editor's Highlight: Neonatal Activation of the Xenobiotic-Sensors PXR and CAR Results in Acute and Persistent Down-regulation of PPARα-Signaling in Mouse Liver. Toxicol Sci. 2016;153:282-302 pubmed publisher

Rondini E, Duniec Dmuchowski Z, Kocarek T. Nonsterol Isoprenoids Activate Human Constitutive Androstane Receptor in an Isoform-Selective Manner in Primary Cultured Mouse Hepatocytes. Drug Metab Dispos. 2016;44:595-604 pubmed publisher

Mattu S, Fornari F, Quagliata L, Perra A, Angioni M, Petrelli A, et al. The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival. J Hepatol. 2016;64:891-8 pubmed publisher

Baker A, Guo G, Aleksunes L, Richardson J. Isoform-Specific Regulation of Mouse Carboxylesterase Expression and Activity by Prototypical Transcriptional Activators. J Biochem Mol Toxicol. 2015;29:545-51 pubmed publisher

Zhang X, Shi Z, Lyv J, He X, Englert N, Zhang S. Pyrene is a Novel Constitutive Androstane Receptor (CAR) Activator and Causes Hepatotoxicity by CAR. Toxicol Sci. 2015;147:436-45 pubmed publisher

Chen N, Nishio N, Ito S, Tanaka Y, Sun Y, Isobe K. Growth arrest and DNA damage-inducible protein (GADD34) enhanced liver inflammation and tumorigenesis in a diethylnitrosamine (DEN)-treated murine model. Cancer Immunol Immunother. 2015;64:777-89 pubmed publisher

Yueh M, Taniguchi K, Chen S, Evans R, Hammock B, Karin M, et al. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A. 2014;111:17200-5 pubmed publisher

Schaap M, Wackers P, Zwart E, Huijskens I, Jonker M, Hendriks G, et al. A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens. Arch Toxicol. 2015;89:2413-27 pubmed publisher

Ibrahim Z, Ahmed M, El Shazly S, Ishizuka M, Fujita S. Clofibric acid induces hepatic CYP 2B1/2 via constitutive androstane receptor not via peroxisome proliferator activated receptor alpha in rat. Biosci Biotechnol Biochem. 2014;78:1550-9 pubmed publisher

Timsit Y, Negishi M. Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system. PLoS ONE. 2014;9:e96092 pubmed publisher

Kazantseva Y, Yarushkin A, Pustylnyak V. CAR-mediated repression of Foxo1 transcriptional activity regulates the cell cycle inhibitor p21 in mouse livers. Toxicology. 2014;321:73-9 pubmed publisher

Reed C, Hutcheson J, Mayhew C, Witkiewicz A, Knudsen E. RB tumor suppressive function in response to xenobiotic hepatocarcinogens. Am J Pathol. 2014;184:1853-9 pubmed publisher

Scaiewicz V, Nahmias A, Chung R, Mueller T, Tirosh B, Shibolet O. CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model. PLoS ONE. 2013;8:e81065 pubmed publisher

Kubota A, Bainy A, Woodin B, Goldstone J, Stegeman J. The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers. Toxicol Appl Pharmacol. 2013;272:172-9 pubmed publisher

Kazantseva Y, Yarushkin A, Pustylnyak V. Dichlorodiphenyltrichloroethane technical mixture regulates cell cycle and apoptosis genes through the activation of CAR and ER? in mouse livers. Toxicol Appl Pharmacol. 2013;271:137-43 pubmed publisher

Braeuning A, Sanna R, Huelsken J, Schwarz M. Inducibility of drug-metabolizing enzymes by xenobiotics in mice with liver-specific knockout of Ctnnb1. Drug Metab Dispos. 2009;37:1138-45 pubmed publisher

Baskin Bey E, Huang W, Ishimura N, Isomoto H, Bronk S, Braley K, et al. Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology. 2006;44:252-62 pubmed