This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Abiraterone acetate
catalog :
SML1527
citations: 7
Reference
Grossebrummel H, Peter T, Mandelkow R, Weiss M, Muzzio D, Zimmermann U, et al. Cytochrome P450 17A1 inhibitor abiraterone attenuates cellular growth of prostate cancer cells independently from androgen receptor signaling by modulation of oncogenic and apoptotic pathways. Int J Oncol. 2016;48:793-800 pubmed publisher
Crawford E, Higano C, Shore N, Hussain M, Petrylak D. Treating Patients with Metastatic Castration Resistant Prostate Cancer: A Comprehensive Review of Available Therapies. J Urol. 2015;194:1537-47 pubmed publisher
Ryan C, Smith M, Fong L, Rosenberg J, Kantoff P, Raynaud F, et al. Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy. J Clin Oncol. 2010;28:1481-8 pubmed publisher
Reid A, Attard G, Danila D, Oommen N, Olmos D, Fong P, et al. Significant and sustained antitumor activity in post-docetaxel, castration-resistant prostate cancer with the CYP17 inhibitor abiraterone acetate. J Clin Oncol. 2010;28:1489-95 pubmed publisher
Danila D, Morris M, de Bono J, Ryan C, Denmeade S, Smith M, et al. Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castration-resistant prostate cancer. J Clin Oncol. 2010;28:1496-501 pubmed publisher
Attard G, Reid A, Olmos D, de Bono J. Antitumor activity with CYP17 blockade indicates that castration-resistant prostate cancer frequently remains hormone driven. Cancer Res. 2009;69:4937-40 pubmed publisher
Attard G, Reid A, A Hern R, Parker C, Oommen N, Folkerd E, et al. Selective inhibition of CYP17 with abiraterone acetate is highly active in the treatment of castration-resistant prostate cancer. J Clin Oncol. 2009;27:3742-8 pubmed publisher
product information
Catalog Number :
SML1527
Product Name :
Abiraterone acetate
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA