This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
GSK-LSD1
catalog :
SML1072
citations: 11
Reference
Miller S, Policastro R, Savant S, Sriramkumar S, Ding N, Lu X, et al. Lysine-Specific Demethylase 1 Mediates AKT Activity and Promotes Epithelial-to-Mesenchymal Transition in PIK3CA-Mutant Colorectal Cancer. Mol Cancer Res. 2020;18:264-277 pubmed publisher
Stowers R, Shcherbina A, Israeli J, Gruber J, Chang J, Nam S, et al. Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility. Nat Biomed Eng. 2019;3:1009-1019 pubmed publisher
Romo Morales A, Aladowicz E, Blagg J, Gatz S, Shipley J. Catalytic inhibition of KDM1A in Ewing sarcoma is insufficient as a therapeutic strategy. Pediatr Blood Cancer. 2019;66:e27888 pubmed publisher
Kleszcz R, Szymanska A, Krajka Kuzniak V, Baer Dubowska W, Paluszczak J. Inhibition of CBP/β-catenin and porcupine attenuates Wnt signaling and induces apoptosis in head and neck carcinoma cells. Cell Oncol (Dordr). 2019;: pubmed publisher
Vinyard M, Su C, Siegenfeld A, Waterbury A, Freedy A, Gosavi P, et al. CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML. Nat Chem Biol. 2019;15:529-539 pubmed publisher
Lee C, Rudneva V, Erkek S, Zapatka M, Chau L, Tacheva Grigorova S, et al. Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma. Nat Commun. 2019;10:332 pubmed publisher
Smitheman K, Severson T, Rajapurkar S, McCabe M, Karpinich N, Foley J, et al. Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subtypes. Haematologica. 2019;104:1156-1167 pubmed publisher
Kirkpatrick J, Kirkwood K, Woster P. Inhibition of the histone demethylase KDM4B leads to activation of KDM1A, attenuates bacterial-induced pro-inflammatory cytokine release, and reduces osteoclastogenesis. Epigenetics. 2018;13:557-572 pubmed publisher
Wei X, Calvo Vidal M, Chen S, Wu G, Revuelta M, Sun J, et al. Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma. Cancer Res. 2018;78:2747-2759 pubmed publisher
Kumarasinghe I, Woster P. Cyclic peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis. Eur J Med Chem. 2018;148:210-220 pubmed publisher
Takagi S, Ishikawa Y, Mizutani A, Iwasaki S, Matsumoto S, Kamada Y, et al. LSD1 Inhibitor T-3775440 Inhibits SCLC Cell Proliferation by Disrupting LSD1 Interactions with SNAG Domain Proteins INSM1 and GFI1B. Cancer Res. 2017;77:4652-4662 pubmed publisher
product information
Catalog Number :
SML1072
Product Name :
GSK-LSD1
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA