This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
CHIR99021
catalog :
SML1046
citations: 38
Reference
Ameneiro C, Moreira T, Fuentes Iglesias A, Coego A, Garcia Outeiral V, Escudero A, et al. BMAL1 coordinates energy metabolism and differentiation of pluripotent stem cells. Life Sci Alliance. 2020;3: pubmed publisher
Zhang Y, Zhang Z, Chen P, Ma C, Li C, Au T, et al. Directed Differentiation of Notochord-like and Nucleus Pulposus-like Cells Using Human Pluripotent Stem Cells. Cell Rep. 2020;30:2791-2806.e5 pubmed publisher
Wang W, Lu G, Su X, Tang C, Li H, Xiong Z, et al. Pten-mediated Gsk3β modulates the naïve pluripotency maintenance in embryonic stem cells. Cell Death Dis. 2020;11:107 pubmed publisher
Woznicki J, Flood P, Bustamante Garrido M, Stamou P, Moloney G, Fanning A, et al. Human BCL-G regulates secretion of inflammatory chemokines but is dispensable for induction of apoptosis by IFN-γ and TNF-α in intestinal epithelial cells. Cell Death Dis. 2020;11:68 pubmed publisher
Okkelman I, Neto N, Papkovsky D, Monaghan M, Dmitriev R. A deeper understanding of intestinal organoid metabolism revealed by combining fluorescence lifetime imaging microscopy (FLIM) and extracellular flux analyses. Redox Biol. 2020;30:101420 pubmed publisher
Zhang H, Khoa L, Mao F, Xu H, Zhou B, Han Y, et al. MLL1 Inhibition and Vitamin D Signaling Cooperate to Facilitate the Expanded Pluripotency State. Cell Rep. 2019;29:2659-2671.e6 pubmed publisher
An Z, Liu P, Zheng J, Si C, Li T, Chen Y, et al. Sox2 and Klf4 as the Functional Core in Pluripotency Induction without Exogenous Oct4. Cell Rep. 2019;29:1986-2000.e8 pubmed publisher
Garland W, Comet I, Wu M, Radzisheuskaya A, Rib L, Vitting Seerup K, et al. A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2. Cell Rep. 2019;29:1800-1811.e6 pubmed publisher
Ruiz J, Chen G, Haro Mora J, Keyvanfar K, Liu C, Zou J, et al. Robust generation of erythroid and multilineage hematopoietic progenitors from human iPSCs using a scalable monolayer culture system. Stem Cell Res. 2019;41:101600 pubmed publisher
Driehuis E, Spelier S, Beltrán Hernández I, de Bree R, M Willems S, Clevers H, et al. Patient-Derived Head and Neck Cancer Organoids Recapitulate EGFR Expression Levels of Respective Tissues and Are Responsive to EGFR-Targeted Photodynamic Therapy. J Clin Med. 2019;8: pubmed publisher
Kurgan N, Whitley K, Maddalena L, Moradi F, Stoikos J, Hamstra S, et al. A Low-Therapeutic Dose of Lithium Inhibits GSK3 and Enhances Myoblast Fusion in C2C12 Cells. Cells. 2019;8: pubmed publisher
Sung T, Liu C, Huang W, Lee Y, Kumar S, Chang Y, et al. Efficient differentiation of human ES and iPS cells into cardiomyocytes on biomaterials under xeno-free conditions. Biomater Sci. 2019;7:5467-5481 pubmed publisher
Larsson A, Coucoravas C, Sandberg R, Reinius B. X-chromosome upregulation is driven by increased burst frequency. Nat Struct Mol Biol. 2019;26:963-969 pubmed publisher
Diaz Osterman C, Ozmadenci D, Kleinschmidt E, Taylor K, Barrie A, Jiang S, et al. FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. elife. 2019;8: pubmed publisher
Ritter N, Ali T, Kopitchinski N, Schuster P, Beisaw A, Hendrix D, et al. The lncRNA Locus Handsdown Regulates Cardiac Gene Programs and Is Essential for Early Mouse Development. Dev Cell. 2019;50:644-657.e8 pubmed publisher
Low J, Li P, Chew E, Zhou B, Suzuki K, Zhang T, et al. Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network. Cell Stem Cell. 2019;25:373-387.e9 pubmed publisher
Fang M, Markmiller S, Vu A, Javaherian A, Dowdle W, Jolivet P, et al. Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD. Neuron. 2019;: pubmed publisher
TRAN T, Lindström N, Ransick A, De Sena Brandine G, Guo Q, Kim A, et al. In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes. Dev Cell. 2019;50:102-116.e6 pubmed publisher
Tung Y, Peng K, Chen Y, Yen Y, Chang M, Thams S, et al. Mir-17∼92 Confers Motor Neuron Subtype Differential Resistance to ALS-Associated Degeneration. Cell Stem Cell. 2019;: pubmed publisher
Driehuis E, Kolders S, Spelier S, Lõhmussaar K, Willems S, Devriese L, et al. Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy. Cancer Discov. 2019;: pubmed publisher
Shooshtarizadeh P, Helness A, Vadnais C, Brouwer N, Beauchemin H, Chen R, et al. Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes. Nat Commun. 2019;10:1270 pubmed publisher
McDermott L, Weir G, Themistocleous A, Segerdahl A, Blesneac I, Baskozos G, et al. Defining the Functional Role of NaV1.7 in Human Nociception. Neuron. 2019;101:905-919.e8 pubmed publisher
Garreta E, Prado P, Tarantino C, Oria R, Fanlo L, Marti E, et al. Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells. Nat Mater. 2019;18:397-405 pubmed publisher
Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, et al. FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. Cell Stem Cell. 2019;24:447-461.e8 pubmed publisher
Agajanian M, Walker M, Axtman A, Ruela de Sousa R, Serafin D, Rabinowitz A, et al. WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell Rep. 2019;26:79-93.e8 pubmed publisher
Stork C, Li Z, Lin L, Zheng S. Developmental Xist induction is mediated by enhanced splicing. Nucleic Acids Res. 2019;47:1532-1543 pubmed publisher
van Mierlo G, Dirks R, De Clerck L, Brinkman A, Huth M, Kloet S, et al. Integrative Proteomic Profiling Reveals PRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency. Cell Stem Cell. 2019;24:123-137.e8 pubmed publisher
Xie X, Jankauskas R, Mazari A, Drou N, Percipalle P. β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming. PLoS Genet. 2018;14:e1007846 pubmed publisher
Chen S, Giannakou A, Wyman S, Gruzas J, Golas J, Zhong W, et al. Cancer-associated fibroblasts suppress SOX2-induced dysplasia in a lung squamous cancer coculture. Proc Natl Acad Sci U S A. 2018;115:E11671-E11680 pubmed publisher
Blázquez L, Emmett W, Faraway R, Pineda J, Bajew S, Gohr A, et al. Exon Junction Complex Shapes the Transcriptome by Repressing Recursive Splicing. Mol Cell. 2018;72:496-509.e9 pubmed publisher
Buskin A, Zhu L, Chichagova V, Basu B, Mozaffari Jovin S, Dolan D, et al. Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa. Nat Commun. 2018;9:4234 pubmed publisher
Yuan J, Ma Y, Huang T, Chen Y, Peng Y, Li B, et al. Genetic Modulation of RNA Splicing with a CRISPR-Guided Cytidine Deaminase. Mol Cell. 2018;72:380-394.e7 pubmed publisher
Nunns H, Goentoro L. Signaling pathways as linear transmitters. elife. 2018;7: pubmed publisher
Zingg D, Debbache J, Peña Hernández R, Antunes A, Schaefer S, Cheng P, et al. EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation. Cancer Cell. 2018;34:69-84.e14 pubmed publisher
Liu K, Zhang Y, Liu D, Ying Q, Ye S. TFCP2L1 represses multiple lineage commitment of mouse embryonic stem cells through MTA1 and LEF1. J Cell Sci. 2017;130:3809-3817 pubmed publisher
Li D, Secher J, Juhl M, Mashayekhi K, Nielsen T, Holst B, et al. Identification of SSEA-1 expressing enhanced reprogramming (SEER) cells in porcine embryonic fibroblasts. Cell Cycle. 2017;16:1070-1084 pubmed publisher
Bertrand J, Petit V, Hacker E, Berlin I, Hayward N, Pouteaux M, et al. UVB represses melanocyte cell migration and acts through β-catenin. Exp Dermatol. 2017;26:875-882 pubmed publisher
Shy B, MacDougall M, Clarke R, Merrill B. Co-incident insertion enables high efficiency genome engineering in mouse embryonic stem cells. Nucleic Acids Res. 2016;44:7997-8010 pubmed publisher
product information
Catalog Number :
SML1046
Product Name :
CHIR99021
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA