This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
GSK-J4
catalog :
SML0701
citations: 37
Reference
Perrigue P, Rakoczy M, Pawlicka K, Belter A, Giel Pietraszuk M, Naskret Barciszewska M, et al. Cancer Stem Cell-Inducing Media Activates Senescence Reprogramming in Fibroblasts. Cancers (Basel). 2020;12: pubmed publisher
Malinczak C, Rasky A, Fonseca W, Schaller M, Allen R, Ptaschinski C, et al. Upregulation of H3K27 Demethylase KDM6 During Respiratory Syncytial Virus Infection Enhances Proinflammatory Responses and Immunopathology. J Immunol. 2020;204:159-168 pubmed publisher
Benedetti R, Dell aversana C, De Marchi T, Rotili D, Liu N, Novakovic B, et al. Inhibition of Histone Demethylases LSD1 and UTX Regulates ERα Signaling in Breast Cancer. Cancers (Basel). 2019;11: pubmed publisher
Yu J, Wang L, Pei P, Li X, Wu J, Qiu Z, et al. Reduced H3K27me3 leads to abnormal Hox gene expression in neural tube defects. Epigenetics Chromatin. 2019;12:76 pubmed publisher
Zou S, Zhang D, Xu Z, Wen X, Zhang Y. JMJD3 promotes the epithelial-mesenchymal transition and migration of glioma cells via the CXCL12/CXCR4 axis. Oncol Lett. 2019;18:5930-5940 pubmed publisher
Kumar B, Elsässer S. Quantitative Multiplexed ChIP Reveals Global Alterations that Shape Promoter Bivalency in Ground State Embryonic Stem Cells. Cell Rep. 2019;28:3274-3284.e5 pubmed publisher
Stowers R, Shcherbina A, Israeli J, Gruber J, Chang J, Nam S, et al. Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility. Nat Biomed Eng. 2019;3:1009-1019 pubmed publisher
Pediconi N, Salerno D, Lupacchini L, Angrisani A, Peruzzi G, De Smaele E, et al. EZH2, JMJD3, and UTX epigenetically regulate hepatic plasticity inducing retro-differentiation and proliferation of liver cells. Cell Death Dis. 2019;10:518 pubmed publisher
Katagi H, Louis N, Unruh D, Sasaki T, He X, Zhang A, et al. Radiosensitization by Histone H3 Demethylase Inhibition in Diffuse Intrinsic Pontine Glioma. Clin Cancer Res. 2019;: pubmed publisher
Lai J, Ge M, Shen S, Yang L, Jin T, Cao D, et al. Activation of NFKB-JMJD3 signaling promotes bladder fibrosis via boosting bladder smooth muscle cell proliferation and collagen accumulation. Biochim Biophys Acta Mol Basis Dis. 2019;: pubmed publisher
Kleszcz R, Szymanska A, Krajka Kuzniak V, Baer Dubowska W, Paluszczak J. Inhibition of CBP/β-catenin and porcupine attenuates Wnt signaling and induces apoptosis in head and neck carcinoma cells. Cell Oncol (Dordr). 2019;: pubmed publisher
Lin C, Hsu Y, Huang Y, Shih Y, Wang C, Chiang W, et al. A KDM6A-KLF10 reinforcing feedback mechanism aggravates diabetic podocyte dysfunction. EMBO Mol Med. 2019;11: pubmed publisher
Xiao Z, He Y, Liu C, Xiang L, Yi J, Wang M, et al. Targeting P16INK4A in uterine serous carcinoma through inhibition of histone demethylation. Oncol Rep. 2019;41:2667-2678 pubmed publisher
Yamada T, Nabe S, Toriyama K, Suzuki J, Inoue K, Imai Y, et al. Histone H3K27 Demethylase Negatively Controls the Memory Formation of Antigen-Stimulated CD8+ T Cells. J Immunol. 2019;202:1088-1098 pubmed publisher
Zhang Y, Akumuo R, Espana R, Yan C, Gao W, Li Y. The histone demethylase KDM6B in the medial prefrontal cortex epigenetically regulates cocaine reward memory. Neuropharmacology. 2018;141:113-125 pubmed publisher
Lochmann T, Powell K, Ham J, Floros K, Heisey D, Kurupi R, et al. Targeted inhibition of histone H3K27 demethylation is effective in high-risk neuroblastoma. Sci Transl Med. 2018;10: pubmed publisher
Li Y, Zhang M, Sheng M, Zhang P, Chen Z, Xing W, et al. Therapeutic potential of GSK-J4, a histone demethylase KDM6B/JMJD3 inhibitor, for acute myeloid leukemia. J Cancer Res Clin Oncol. 2018;144:1065-1077 pubmed publisher
Fontcuberta PiSunyer M, Cervantes S, Miquel E, Mora Castilla S, Laurent L, Raya A, et al. Modulation of the endocrine transcriptional program by targeting histone modifiers of the H3K27me3 mark. Biochim Biophys Acta Gene Regul Mech. 2018;1861:473-480 pubmed publisher
Park J, Cho H, Oh H, Kim J, Seo S. AURKA Suppresses Leukemic THP-1 Cell Differentiation through Inhibition of the KDM6B Pathway. Mol Cells. 2018;41:444-453 pubmed publisher
Majumder S, Thieme K, Batchu S, Alghamdi T, Bowskill B, Kabir M, et al. Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease. J Clin Invest. 2018;128:483-499 pubmed publisher
Nancy P, Siewiera J, Rizzuto G, Tagliani E, Osokine I, Manandhar P, et al. H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition. J Clin Invest. 2018;128:233-247 pubmed publisher
Mandal C, Kim S, Kang S, Chai J, Lee Y, Jung K, et al. GSK-J4-Mediated Transcriptomic Alterations in Differentiating Embryoid Bodies. Mol Cells. 2017;40:737-751 pubmed publisher
Taube J, Sphyris N, Johnson K, Reisenauer K, Nesbit T, Joseph R, et al. The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transition. Oncotarget. 2017;8:65548-65565 pubmed publisher
Morozov V, Li Y, Clowers M, Ishov A. Inhibitor of H3K27 demethylase JMJD3/UTX GSK-J4 is a potential therapeutic option for castration resistant prostate cancer. Oncotarget. 2017;8:62131-62142 pubmed publisher
Inoue S, Takahara S, Yoshikawa T, Niihori T, Yanai K, Matsubara Y, et al. Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice. Hum Mol Genet. 2017;26:4715-4727 pubmed publisher
Liu P, Wang H, Li X, Chao T, Teav T, Christen S, et al. ?-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming. Nat Immunol. 2017;18:985-994 pubmed publisher
Clancy K, Russell A, Subramanian V, Nguyen H, Qian Y, Campbell R, et al. Citrullination/Methylation Crosstalk on Histone H3 Regulates ER-Target Gene Transcription. ACS Chem Biol. 2017;12:1691-1702 pubmed publisher
Guo Y, Walsh A, Fearon U, Smith M, Wechalekar M, Yin X, et al. CD40L-Dependent Pathway Is Active at Various Stages of Rheumatoid Arthritis Disease Progression. J Immunol. 2017;198:4490-4501 pubmed publisher
Wang F, Lian W, Lee M, Weng W, Huang Y, Chen Y, et al. Histone demethylase UTX counteracts glucocorticoid deregulation of osteogenesis by modulating histone-dependent and -independent pathways. J Mol Med (Berl). 2017;95:499-512 pubmed publisher
Cárdenas H, Zhao J, Vieth E, Nephew K, Matei D. EZH2 inhibition promotes epithelial-to-mesenchymal transition in ovarian cancer cells. Oncotarget. 2016;7:84453-84467 pubmed publisher
Doñas C, Carrasco M, Fritz M, Prado C, Tejon G, Osorio Barrios F, et al. The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs. J Autoimmun. 2016;75:105-117 pubmed publisher
Palomer E, Carretero J, Benvegnù S, Dotti C, Martin M. Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation in mature neurons. Nat Commun. 2016;7:11081 pubmed publisher
Nagarsheth N, Peng D, Kryczek I, Wu K, Li W, Zhao E, et al. PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer. Cancer Res. 2016;76:275-82 pubmed publisher
Tennant B, Hurley P, Dhillon J, Gill A, Whiting C, Hoffman B. The TrxG Complex Mediates Cytokine Induced De Novo Enhancer Formation in Islets. PLoS ONE. 2015;10:e0141470 pubmed publisher
Chakroun I, Yang D, Girgis J, Gunasekharan A, Phenix H, Kærn M, et al. Genome-wide association between Six4, MyoD, and the histone demethylase Utx during myogenesis. FASEB J. 2015;29:4738-55 pubmed publisher
Kamikawa Y, Donohoe M. Histone demethylation maintains Prdm14 and Tsix expression and represses xIst in embryonic stem cells. PLoS ONE. 2015;10:e0125626 pubmed publisher
Inoue S, Moriya M, Watanabe Y, Miyagawa Tomita S, Niihori T, Oba D, et al. New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome. Hum Mol Genet. 2014;23:6553-66 pubmed publisher
product information
Catalog Number :
SML0701
Product Name :
GSK-J4
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA