This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Nutlin-3a
catalog :
SML0580
citations: 100
Reference
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Sun Q, Guo Y, Liu X, Czauderna F, Carr M, Zenke F, et al. Therapeutic Implications of p53 Status on Cancer Cell Fate Following Exposure to Ionizing Radiation and the DNA-PK Inhibitor M3814. Mol Cancer Res. 2019;17:2457-2468 pubmed publisher
Timofeev O, Klimovich B, Schneikert J, Wanzel M, Pavlakis E, Noll J, et al. Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses. EMBO J. 2019;38:e102096 pubmed publisher
Han N, Moon P, Kim H, Jeong H. TSLP Exacerbates Septic Inflammation via Murine Double Minute 2 (MDM2) Signaling Pathway. J Clin Med. 2019;8: pubmed publisher
Besztercei B, Vancsik T, Benedek A, Major E, Thomas M, Schvarcz C, et al. Stress-Induced, p53-Mediated Tumor Growth Inhibition of Melanoma by Modulated Electrohyperthermia in Mouse Models without Major Immunogenic Effects. Int J Mol Sci. 2019;20: pubmed publisher
McKenzie M, Ghisi M, Oxley E, Ngo S, Cimmino L, Esnault C, et al. Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia. Cell Stem Cell. 2019;25:258-272.e9 pubmed publisher
Neitzel C, Seiwert N, Göder A, Diehl E, Weber C, Nagel G, et al. Lipoic Acid Synergizes with Antineoplastic Drugs in Colorectal Cancer by Targeting p53 for Proteasomal Degradation. Cells. 2019;8: pubmed publisher
Singh A, Bhattacharyya N, Srivastava A, Pruett N, Ripley R, Schrump D, et al. MicroRNA-215-5p Treatment Suppresses Mesothelioma Progression via the MDM2-p53-Signaling Axis. Mol Ther. 2019;: pubmed publisher
Hsu C, Altschuler S, Wu L. Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy. Cell. 2019;: pubmed publisher
Zaman S, Yu X, Bencivenga A, Blanden A, Liu Y, Withers T, et al. Combinatorial therapy of Zinc metallochaperones with mutant p53 reactivation and diminished copper binding. Mol Cancer Ther. 2019;: pubmed publisher
Matson J, House A, Grant G, Wu H, Perez J, Cook J. Intrinsic checkpoint deficiency during cell cycle re-entry from quiescence. J Cell Biol. 2019;: pubmed publisher
Bowen M, McClendon J, Long H, Sorayya A, Van Nostrand J, Wysocka J, et al. The Spatiotemporal Pattern and Intensity of p53 Activation Dictates Phenotypic Diversity in p53-Driven Developmental Syndromes. Dev Cell. 2019;: pubmed publisher
Yang Y, Dong Z, Hu H, Peng J, Sheng Y, Tong Y, et al. The facile and visualizable identification of broad-spectrum inhibitors of MDM2/p53 using co-expressed protein complexes. Analyst. 2019;144:3773-3781 pubmed publisher
Deng H, Ikeda A, Cui H, Bartlett J, Suzuki M. MDM2-Mediated p21 Proteasomal Degradation Promotes Fluoride Toxicity in Ameloblasts. Cells. 2019;8: pubmed publisher
Wang C, Jiang S, Ke L, Zhang L, Li D, Liang J, et al. Genome-wide CRISPR-based gene knockout screens reveal cellular factors and pathways essential for nasopharyngeal carcinoma. J Biol Chem. 2019;294:9734-9745 pubmed publisher
Qin Y, Sekine I, Hanazono M, Morinaga T, Fan M, Takiguchi Y, et al. AMPK activation induced in pemetrexed-treated cells is associated with development of drug resistance independently of target enzyme expression. Mol Oncol. 2019;13:1419-1432 pubmed publisher
Saito Y, Muramatsu T, Kanai Y, Ojima H, Sukeda A, Hiraoka N, et al. Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma. Cell Rep. 2019;27:1265-1276.e4 pubmed publisher
Zhou X, Li W, Wang S, Zhang P, Wang Q, Xiao J, et al. YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis. Cell Rep. 2019;27:1176-1189.e5 pubmed publisher
Ciardullo C, Aptullahoglu E, Woodhouse L, Lin W, Wallis J, Marr H, et al. Non-genotoxic MDM2 inhibition selectively induces pro-apoptotic p53 gene signature in chronic lymphocytic leukemia cells. Haematologica. 2019;: pubmed publisher
Gong H, An J, Dong Q, Li J, Yang W, Sun W, et al. Discovery of SCY45, a Natural Small-Molecule MDM2-p53 Interaction Inhibitor. Chem Biodivers. 2019;16:e1900081 pubmed publisher
Wang T, Li K, Song H, Xu D, Liao Y, Jing B, et al. p53 suppression is essential for oncogenic SPAG5 upregulation in lung adenocarcinoma. Biochem Biophys Res Commun. 2019;513:319-325 pubmed publisher
Xu X, Liu Q, Zhang C, Ren S, Xu L, Zhao Z, et al. Inhibition of DYRK1A-EGFR axis by p53-MDM2 cascade mediates the induction of cellular senescence. Cell Death Dis. 2019;10:282 pubmed publisher
Khanal S, Galloway D. High-risk human papillomavirus oncogenes disrupt the Fanconi anemia DNA repair pathway by impairing localization and de-ubiquitination of FancD2. PLoS Pathog. 2019;15:e1007442 pubmed publisher
Zhong B, Shingyoji M, Hanazono M, Nguyễn T, Morinaga T, Tada Y, et al. A p53-stabilizing agent, CP-31398, induces p21 expression with increased G2/M phase through the YY1 transcription factor in esophageal carcinoma defective of the p53 pathway. Am J Cancer Res. 2019;9:79-93 pubmed
Fischer M. Conservation and divergence of the p53 gene regulatory network between mice and humans. Oncogene. 2019;38:4095-4109 pubmed publisher
Azatyan A, Gallo Oller G, Diao Y, Selivanova G, Johnsen J, Zaphiropoulos P. RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism. Cancer Lett. 2018;442:341-350 pubmed publisher
Nagaraja M, Tiwari N, Shetty S, Marudamuthu A, Fan L, Ostrom R, et al. p53 Expression in Lung Fibroblasts Is Linked to Mitigation of Fibrotic Lung Remodeling. Am J Pathol. 2018;188:2207-2222 pubmed publisher
Sriraman A, Dickmanns A, Najafova Z, Johnsen S, Dobbelstein M. CDK4 inhibition diminishes p53 activation by MDM2 antagonists. Cell Death Dis. 2018;9:918 pubmed publisher
Fedorova O, Daks A, Petrova V, Petukhov A, Lezina L, Shuvalov O, et al. Novel isatin-derived molecules activate p53 via interference with Mdm2 to promote apoptosis. Cell Cycle. 2018;17:1917-1930 pubmed publisher
Dijkstra K, Cattaneo C, Weeber F, Chalabi M, van de Haar J, Fanchi L, et al. Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids. Cell. 2018;174:1586-1598.e12 pubmed publisher
Senapati P, Dey S, Sudarshan D, Das S, Kumar M, Kaypee S, et al. Oncogene c-fos and mutant R175H p53 regulate expression of Nucleophosmin implicating cancer manifestation. FEBS J. 2018;285:3503-3524 pubmed publisher
Marcus J, Burke R, Doak A, Park S, Orth J. Loss of p53 expression in cancer cells alters cell cycle response after inhibition of exportin-1 but does not prevent cell death. Cell Cycle. 2018;17:1329-1344 pubmed publisher
Alessandrini F, Pezzè L, Menendez D, Resnick M, Ciribilli Y. ETV7-Mediated DNAJC15 Repression Leads to Doxorubicin Resistance in Breast Cancer Cells. Neoplasia. 2018;20:857-870 pubmed publisher
Li H, Gao Q, Shao Y, Sun B, Wang F, Qiao Y, et al. Gallid Herpesvirus 1 Initiates Apoptosis in Uninfected Cells through Paracrine Repression of p53. J Virol. 2018;92: pubmed publisher
Bellanne Chantelot C, Schmaltz Panneau B, Marty C, Fenneteau O, Callebaut I, Clauin S, et al. Mutations in SRP54 gene cause severe congenital neutropenia as well as Shwachman-Diamond-like syndrome. Blood. 2018;: pubmed publisher
Haapaniemi E, Botla S, Persson J, Schmierer B, Taipale J. CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response. Nat Med. 2018;24:927-930 pubmed publisher
Charni Natan M, Solomon H, Molchadsky A, Jacob Berger A, Goldfinger N, Rotter V. Various stress stimuli rewire the profile of liver secretome in a p53-dependent manner. Cell Death Dis. 2018;9:647 pubmed publisher
Bowling S, Di Gregorio A, Sancho M, Pozzi S, Aarts M, Signore M, et al. P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development. Nat Commun. 2018;9:1763 pubmed publisher
Machado D, Pizzorno A, Hoffmann J, Traversier A, Endtz H, Lina B, et al. Role of p53/NF-κB functional balance in respiratory syncytial virus-induced inflammation response. J Gen Virol. 2018;99:489-500 pubmed publisher
Consales C, Cirotti C, Filomeni G, Panatta M, Butera A, Merla C, et al. Fifty-Hertz Magnetic Field Affects the Epigenetic Modulation of the miR-34b/c in Neuronal Cells. Mol Neurobiol. 2018;55:5698-5714 pubmed publisher
Briest F, Grass I, Sedding D, Möbs M, Christen F, Benecke J, et al. Mechanisms of Targeting the MDM2-p53-FOXM1 Axis in Well-Differentiated Intestinal Neuroendocrine Tumors. Neuroendocrinology. 2018;107:1-23 pubmed publisher
Ullah K, Rosendahl A, Izzi V, Bergmann U, Pihlajaniemi T, Maki J, et al. Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways. Sci Rep. 2017;7:17220 pubmed publisher
Brown J, Yonekubo Y, Hanson N, Sastre Perona A, Basin A, Rytlewski J, et al. TGF-β-Induced Quiescence Mediates Chemoresistance of Tumor-Propagating Cells in Squamous Cell Carcinoma. Cell Stem Cell. 2017;21:650-664.e8 pubmed publisher
Wiedenhoft H, Hayashi L, Coffin A. PI3K and Inhibitor of Apoptosis Proteins Modulate Gentamicin- Induced Hair Cell Death in the Zebrafish Lateral Line. Front Cell Neurosci. 2017;11:326 pubmed publisher
Moder M, Velimezi G, Owusu M, Mazouzi A, Wiedner M, Ferreira da Silva J, et al. Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia. Nat Commun. 2017;8:1238 pubmed publisher
Mazzucco A, Smogorzewska A, Kang C, Luo J, Schlabach M, Xu Q, et al. Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. Genes Dev. 2017;31:1933-1938 pubmed publisher
Mattes K, Berger G, Geugien M, Vellenga E, Schepers H. CITED2 affects leukemic cell survival by interfering with p53 activation. Cell Death Dis. 2017;8:e3132 pubmed publisher
Mai W, Gosa L, Daniëls V, Ta L, Tsang J, Higgins B, et al. Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. Nat Med. 2017;23:1342-1351 pubmed publisher
Lessel D, Wu D, Trujillo C, Ramezani T, Lessel I, Alwasiyah M, et al. Dysfunction of the MDM2/p53 axis is linked to premature aging. J Clin Invest. 2017;127:3598-3608 pubmed publisher
Mello S, Sinow C, Raj N, Mazur P, Bieging Rolett K, Broz D, et al. Neat1 is a p53-inducible lincRNA essential for transformation suppression. Genes Dev. 2017;31:1095-1108 pubmed publisher
Davaadelger B, Perez R, Zhou Y, Duan L, Gitelis S, Maki C. The IGF-1R/AKT pathway has opposing effects on Nutlin-3a-induced apoptosis. Cancer Biol Ther. 2017;18:895-903 pubmed publisher
Tang H, Lei C, Ye C, GAO P, Wan C, Chen S, et al. MDM2 is implicated in high-glucose-induced podocyte mitotic catastrophe via Notch1 signalling. J Cell Mol Med. 2017;21:3435-3444 pubmed publisher
Angius F, Piras E, Uda S, Madeddu C, Serpe R, Bigi R, et al. Antimicrobial sulfonamides clear latent Kaposi sarcoma herpesvirus infection and impair MDM2-p53 complex formation. J Antibiot (Tokyo). 2017;70:962-966 pubmed publisher
Urso L, Cavallari I, Silic Benussi M, Biasini L, Zago G, Calabrese F, et al. Synergistic targeting of malignant pleural mesothelioma cells by MDM2 inhibitors and TRAIL agonists. Oncotarget. 2017;8:44232-44241 pubmed publisher
Lee H, Wang H, Baladandayuthapani V, Lin H, He J, Jones R, et al. RNA Polymerase I Inhibition with CX-5461 as a Novel Therapeutic Strategy to Target MYC in Multiple Myeloma. Br J Haematol. 2017;177:80-94 pubmed publisher
Corbel C, Sartini S, Levati E, Colas P, Maillet L, Couturier C, et al. Screening for Protein-Protein Interaction Inhibitors Using a Bioluminescence Resonance Energy Transfer (BRET)-Based Assay in Yeast. SLAS Discov. 2017;22:751-759 pubmed publisher
Soares J, Espadinha M, Raimundo L, Ramos H, Gomes A, Gomes S, et al. DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties. Mol Oncol. 2017;11:612-627 pubmed publisher
Idogawa M, Ohashi T, Sasaki Y, Nakase H, Tokino T. Long non-coding RNA NEAT1 is a transcriptional target of p53 and modulates p53-induced transactivation and tumor-suppressor function. Int J Cancer. 2017;140:2785-2791 pubmed publisher
Ohashi T, Idogawa M, Sasaki Y, Tokino T. p53 mediates the suppression of cancer cell invasion by inducing LIMA1/EPLIN. Cancer Lett. 2017;390:58-66 pubmed publisher
Hideshima T, Cottini F, Nozawa Y, Seo H, Ohguchi H, Samur M, et al. p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma. Blood. 2017;129:1308-1319 pubmed publisher
Hölzer K, Drucker E, Roessler S, Dauch D, Heinzmann F, Waldburger N, et al. Proteomic Analysis Reveals GMP Synthetase as p53 Repression Target in Liver Cancer. Am J Pathol. 2017;187:228-235 pubmed publisher
Lee J, An S, Choi Y, Jung J, Li L, Meng H, et al. TRIAD1 Is a Novel Transcriptional Target of p53 and Regulates Nutlin-3a-Induced Cell Death. J Cell Biochem. 2017;118:1733-1740 pubmed publisher
Qian S, Li J, Hong M, Zhu Y, Zhao H, Xie Y, et al. TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia. J Hematol Oncol. 2016;9:128 pubmed
Zhao H, Shen R, Dong X, Shen Y. Murine Double Minute-2 Inhibition Attenuates Cardiac Dysfunction and Fibrosis by Modulating NF-?B Pathway After Experimental Myocardial Infarction. Inflammation. 2017;40:232-239 pubmed publisher
Prokesch A, Graef F, Madl T, Kahlhofer J, Heidenreich S, Schümann A, et al. Liver p53 is stabilized upon starvation and required for amino acid catabolism and gluconeogenesis. FASEB J. 2017;31:732-742 pubmed publisher
Yue X, Zhao Y, Huang G, Li J, Zhu J, Feng Z, et al. A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis. Cell Discov. 2016;2:16039 pubmed
da Mota M, Cortez A, Benfica P, Rodrigues B, Castro T, Macedo L, et al. Induction of apoptosis in Ehrlich ascites tumour cells via p53 activation by a novel small-molecule MDM2 inhibitor - LQFM030. J Pharm Pharmacol. 2016;68:1143-59 pubmed publisher
Wen J, Lee J, Malhotra A, Nahta R, Arnold A, Buss M, et al. WIP1 modulates responsiveness to Sonic Hedgehog signaling in neuronal precursor cells and medulloblastoma. Oncogene. 2016;35:5552-5564 pubmed publisher
Yeo S, Itahana Y, Guo A, Han R, Iwamoto K, Nguyen H, et al. Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation. elife. 2016;5:e07101 pubmed publisher
Johmura Y, Sun J, Kitagawa K, Nakanishi K, Kuno T, Naiki Ito A, et al. SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence. Nat Commun. 2016;7:10574 pubmed publisher
Korkmaz G, Lopes R, Ugalde A, Nevedomskaya E, Han R, Myacheva K, et al. Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9. Nat Biotechnol. 2016;34:192-8 pubmed publisher
Verhoef L, Mattioli M, Ricci F, Li Y, Wade M. Multiplex detection of protein-protein interactions using a next generation luciferase reporter. Biochim Biophys Acta. 2016;1863:284-92 pubmed publisher
Jiang H, Xu Z, Zhong P, Ren Y, Liang G, Schilling H, et al. Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons. Nat Commun. 2015;6:10100 pubmed publisher
Aiken J, Roudier E, Ciccone J, Drouin G, Stromberg A, Vojnovic J, et al. Phosphorylation of murine double minute-2 on Ser166 is downstream of VEGF-A in exercised skeletal muscle and regulates primary endothelial cell migration and FoxO gene expression. FASEB J. 2016;30:1120-34 pubmed publisher
Tonsing Carter E, Bailey B, Saadatzadeh M, Ding J, Wang H, Sinn A, et al. Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model. Mol Cancer Ther. 2015;14:2850-63 pubmed publisher
Robert F, Barbeau M, Éthier S, Dostie J, Pelletier J. Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing. Genome Med. 2015;7:93 pubmed publisher
Li P, Zhao M, Parris A, Feng X, Yang X. p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells. Biochem Biophys Res Commun. 2015;464:1267-74 pubmed publisher
Hünten S, Hermeking H. p53 directly activates cystatin D/CST5 to mediate mesenchymal-epithelial transition: a possible link to tumor suppression by vitamin D3. Oncotarget. 2015;6:15842-56 pubmed
Peng W, Hu C, Shu Z, Han T, Qin L, Zheng C. Antitumor activity of tatariside F isolated from roots of Fagopyrum tataricum (L.) Gaertn against H22 hepatocellular carcinoma via up-regulation of p53. Phytomedicine. 2015;22:730-6 pubmed publisher
Tebaldi T, Zaccara S, Alessandrini F, Bisio A, Ciribilli Y, Inga A. Whole-genome cartography of p53 response elements ranked on transactivation potential. BMC Genomics. 2015;16:464 pubmed publisher
Shai A, Dankort D, Juan J, Green S, McMahon M. TP53 Silencing Bypasses Growth Arrest of BRAFV600E-Induced Lung Tumor Cells in a Two-Switch Model of Lung Tumorigenesis. Cancer Res. 2015;75:3167-80 pubmed publisher
Zajkowicz A, Gdowicz Kłosok A, Krześniak M, Ścieglińska D, Rusin M. Actinomycin D and nutlin-3a synergistically promote phosphorylation of p53 on serine 46 in cancer cell lines of different origin. Cell Signal. 2015;27:1677-87 pubmed publisher
Joshi Y, Sória M, Quadrato G, Inak G, Zhou L, Hervera A, et al. The MDM4/MDM2-p53-IGF1 axis controls axonal regeneration, sprouting and functional recovery after CNS injury. Brain. 2015;138:1843-62 pubmed publisher
Chen L, Rousseau R, Middleton S, Nichols G, Newell D, Lunec J, et al. Pre-clinical evaluation of the MDM2-p53 antagonist RG7388 alone and in combination with chemotherapy in neuroblastoma. Oncotarget. 2015;6:10207-21 pubmed
Soares J, Raimundo L, Pereira N, dos Santos D, Pérez M, Queiroz G, et al. A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins. Pharmacol Res. 2015;95-96:42-52 pubmed publisher
Barabutis N, Dimitropoulou C, Birmpas C, Joshi A, Thangjam G, Catravas J. p53 protects against LPS-induced lung endothelial barrier dysfunction. Am J Physiol Lung Cell Mol Physiol. 2015;308:L776-87 pubmed publisher
Fraser J, Worrall E, Lin Y, Landré V, Pettersson S, Blackburn E, et al. Phosphomimetic mutation of the N-terminal lid of MDM2 enhances the polyubiquitination of p53 through stimulation of E2-ubiquitin thioester hydrolysis. J Mol Biol. 2015;427:1728-47 pubmed publisher
Overstreet J, Samarakoon R, Cardona Grau D, Goldschmeding R, Higgins P. Tumor suppressor ataxia telangiectasia mutated functions downstream of TGF-β1 in orchestrating profibrotic responses. FASEB J. 2015;29:1258-68 pubmed publisher
Wohak L, Krais A, Kucab J, Stertmann J, Øvrebø S, Seidel A, et al. Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism. Arch Toxicol. 2016;90:291-304 pubmed publisher
Ricci F, Subramanian A, Wade M. Open access to high-content clonogenic analysis. J Biomol Screen. 2015;20:391-401 pubmed publisher
Bethuyne J, De Gieter S, Zwaenepoel O, Garcia Pino A, Durinck K, Verhelle A, et al. A nanobody modulates the p53 transcriptional program without perturbing its functional architecture. Nucleic Acids Res. 2014;42:12928-38 pubmed publisher
Leão M, Gomes S, Bessa C, Soares J, Raimundo L, Monti P, et al. Studying p53 family proteins in yeast: induction of autophagic cell death and modulation by interactors and small molecules. Exp Cell Res. 2015;330:164-77 pubmed publisher
Das M, Duan W, Sahoo S. Multifunctional nanoparticle-EpCAM aptamer bioconjugates: a paradigm for targeted drug delivery and imaging in cancer therapy. Nanomedicine. 2015;11:379-89 pubmed publisher
Vandenberg C, Waring P, Strasser A, Cory S. Plasmacytomagenesis in Eμ-v-abl transgenic mice is accelerated when apoptosis is restrained. Blood. 2014;124:1099-109 pubmed publisher
Zaccara S, Tebaldi T, Pederiva C, Ciribilli Y, Bisio A, Inga A. p53-directed translational control can shape and expand the universe of p53 target genes. Cell Death Differ. 2014;21:1522-34 pubmed publisher
Buss M, Remke M, Lee J, Gandhi K, Schniederjan M, Kool M, et al. The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants. Oncogene. 2015;34:1126-40 pubmed publisher
product information
Catalog Number :
SML0580
Product Name :
Nutlin-3a
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA