This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Valspodar
catalog :
SML0572
citations: 31
Reference
Vormann M, Gijzen L, Hutter S, Boot L, Nicolas A, van den Heuvel A, et al. Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules. AAPS J. 2018;20:90 pubmed publisher
Storck S, Hartz A, Bernard J, Wolf A, Kachlmeier A, Mahringer A, et al. The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM. Brain Behav Immun. 2018;73:21-33 pubmed publisher
Dugardin C, Briand O, Touche V, Schonewille M, Moreau F, Le May C, et al. Retrograde cholesterol transport in the human Caco-2/TC7 cell line: a model to study trans-intestinal cholesterol excretion in atherogenic and diabetic dyslipidemia. Acta Diabetol. 2017;54:191-199 pubmed publisher
Georges E, Lian J, Laberge R. A tamoxifen derivative, N,N-diethyl-2-[4-(phenylmethyl) phenoxy] ethanamine, selectively targets P-glycoprotein-positive multidrug resistant Chinese hamster cells. Biochem Pharmacol. 2014;90:107-14 pubmed publisher
Brayboy L, Oulhen N, Witmyer J, Robins J, Carson S, Wessel G. Multidrug-resistant transport activity protects oocytes from chemotherapeutic agents and changes during oocyte maturation. Fertil Steril. 2013;100:1428-35 pubmed publisher
Lee W, Chakraborty P, Thevenod F. Pituitary homeobox 2 (PITX2) protects renal cancer cell lines against doxorubicin toxicity by transcriptional activation of the multidrug transporter ABCB1. Int J Cancer. 2013;133:556-67 pubmed publisher
Morad S, Messner M, Levin J, Abdelmageed N, Park H, Merrill A, et al. Potential role of acid ceramidase in conversion of cytostatic to cytotoxic end-point in pancreatic cancer cells. Cancer Chemother Pharmacol. 2013;71:635-45 pubmed publisher
Nagao K, Maeda M, Mañucat N, Ueda K. Cyclosporine A and PSC833 inhibit ABCA1 function via direct binding. Biochim Biophys Acta. 2013;1831:398-406 pubmed publisher
Bajelan E, Haeri A, Vali A, Ostad S, Dadashzadeh S. Co-delivery of doxorubicin and PSC 833 (Valspodar) by stealth nanoliposomes for efficient overcoming of multidrug resistance. J Pharm Pharm Sci. 2012;15:568-82 pubmed
Eadie L, Saunders V, Hughes T, White D. Degree of kinase inhibition achieved in vitro by imatinib and nilotinib is decreased by high levels of ABCB1 but not ABCG2. Leuk Lymphoma. 2013;54:569-78 pubmed publisher
Okyar A, Dressler C, Hanafy A, Baktir G, Lemmer B, Spahn Langguth H. Circadian variations in exsorptive transport: in situ intestinal perfusion data and in vivo relevance. Chronobiol Int. 2012;29:443-53 pubmed publisher
Binkhathlan Z, Shayeganpour A, Brocks D, Lavasanifar A. Encapsulation of P-glycoprotein inhibitors by polymeric micelles can reduce their pharmacokinetic interactions with doxorubicin. Eur J Pharm Biopharm. 2012;81:142-8 pubmed publisher
Binkhathlan Z, Elhasi S, Brocks D, Lavasanifar A. Characterization of the self assembly of methoxy poly(ethylene oxide)-block-poly(?-benzyl carboxylate-?-caprolactone) for the solubilization and in vivo delivery of valspodar. Curr Drug Deliv. 2012;9:164-71 pubmed
Crowe A. The role of P-glycoprotein and breast cancer resistance protein (BCRP) in bacterial attachment to human gastrointestinal cells. J Crohns Colitis. 2011;5:531-42 pubmed publisher
Kurihara H, Sato T, Akimoto N, Ogura T, Ito A. Identification and characterization of ABCB1-mediated and non-apoptotic sebum secretion in differentiated hamster sebocytes. Biochim Biophys Acta. 2011;1811:1090-6 pubmed publisher
Sziráki I, Erdo F, Beéry E, Molnár P, Fazakas C, Wilhelm I, et al. Quinidine as an ABCB1 probe for testing drug interactions at the blood-brain barrier: an in vitro in vivo correlation study. J Biomol Screen. 2011;16:886-94 pubmed publisher
Kuemmerle A, Yan H, Krueger T, Buclin T, Braissant O, Henry H, et al. P-glycoprotein modulation by valspodar and cyclosporin does not increase tumor uptake of doxorubicin administered via isolated lung perfusion to rats bearing sarcoma lung metastases. Anticancer Res. 2011;31:2121-8 pubmed
Mariana B, Adrián L, Guillermo V, Juan S, Laura M, Carlos L. Gender-related differences on P-glycoprotein-mediated drug intestinal transport in rats. J Pharm Pharmacol. 2011;63:619-26 pubmed publisher
Emmink B, van Houdt W, Vries R, Hoogwater F, Govaert K, Verheem A, et al. Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan. Gastroenterology. 2011;141:269-78 pubmed publisher
Lee W, Torchalski B, Kohistani N, Thevenod F. ABCB1 protects kidney proximal tubule cells against cadmium-induced apoptosis: roles of cadmium and ceramide transport. Toxicol Sci. 2011;121:343-56 pubmed publisher
Aouali N, El Btaouri H, Dumontet C, Eddabra L, Malagarie Cazenave S, Madoulet C, et al. Accumulation of lactosylceramide and overexpression of a PSC833-resistant P-glycoprotein in multidrug-resistant human sarcoma cells. Oncol Rep. 2011;25:1161-7 pubmed publisher
Waterkotte B, Hambruch N, Doring B, Geyer J, Tinneberg H, Pfarrer C. P-glycoprotein is functionally expressed in the placenta-derived bovine caruncular epithelial cell line 1 (BCEC-1). Placenta. 2011;32:146-52 pubmed publisher
Jin L, Li J, Nation R, Nicolazzo J. Impact of p-glycoprotein inhibition and lipopolysaccharide administration on blood-brain barrier transport of colistin in mice. Antimicrob Agents Chemother. 2011;55:502-7 pubmed publisher
Robey R, Lin B, Qiu J, Chan L, Bates S. Rapid detection of ABC transporter interaction: potential utility in pharmacology. J Pharmacol Toxicol Methods. 2011;63:217-22 pubmed publisher
Smith N, Mani S, Schuetz E, Yasuda K, Sissung T, Bates S, et al. Induction of CYP3A4 by vinblastine: Role of the nuclear receptor NR1I2. Ann Pharmacother. 2010;44:1709-17 pubmed publisher
MacLean C, Moenning U, Reichel A, Fricker G. Regional absorption of fexofenadine in rat intestine. Eur J Pharm Sci. 2010;41:670-4 pubmed publisher
Kolitz J, George S, Marcucci G, Vij R, Powell B, Allen S, et al. P-glycoprotein inhibition using valspodar (PSC-833) does not improve outcomes for patients younger than age 60 years with newly diagnosed acute myeloid leukemia: Cancer and Leukemia Group B study 19808. Blood. 2010;116:1413-21 pubmed publisher
Binkhathlan Z, Hamdy D, Brocks D, Lavasanifar A. Development of a polymeric micellar formulation for valspodar and assessment of its pharmacokinetics in rat. Eur J Pharm Biopharm. 2010;75:90-5 pubmed publisher
O Brien M, Lacayo N, Lum B, Kshirsagar S, Buck S, Ravindranath Y, et al. Phase I study of valspodar (PSC-833) with mitoxantrone and etoposide in refractory and relapsed pediatric acute leukemia: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2010;54:694-702 pubmed publisher
Tai H. Technology evaluation: Valspodar, Novartis AG. Curr Opin Mol Ther. 2000;2:459-67 pubmed
Berg D, Centrilla L, Halsey J, Silvester P, Jones B, Guynn K, et al. Overcoming multidrug resistance: valspodar as a paradigm for nursing care. Oncol Nurs Forum. 1999;26:711-20 pubmed
product information
Catalog Number :
SML0572
Product Name :
Valspodar
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA