This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Echinomycin
catalog :
SML0477
citations: 30
Reference
Sala M, Chen C, Zhang Q, Do Umehara H, Wu W, Misharin A, et al. JNK2 up-regulates hypoxia-inducible factors and contributes to hypoxia-induced erythropoiesis and pulmonary hypertension. J Biol Chem. 2018;293:271-284 pubmed publisher
Fadhillah -, Yoshioka S, Nishimura R, Yamamoto Y, Kimura K, Okuda K. Hypoxia-inducible factor 1 mediates hypoxia-enhanced synthesis of progesterone during luteinization of granulosa cells. J Reprod Dev. 2017;63:75-85 pubmed publisher
Lim C, Nogawa T, Uramoto M, Okano A, Hongo Y, Nakamura T, et al. RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening. J Antibiot (Tokyo). 2014;67:323-9 pubmed publisher
Yonekura S, Itoh M, Okuhashi Y, Takahashi Y, Ono A, Nara N, et al. Effects of the HIF1 inhibitor, echinomycin, on growth and NOTCH signalling in leukaemia cells. Anticancer Res. 2013;33:3099-103 pubmed
Sato M, Nakazawa T, Tsunematsu Y, Hotta K, Watanabe K. Echinomycin biosynthesis. Curr Opin Chem Biol. 2013;17:537-45 pubmed publisher
Egger M, Huang J, Yin W, McMasters K, McNally L. Inhibition of autophagy with chloroquine is effective in melanoma. J Surg Res. 2013;184:274-81 pubmed publisher
Zhang C, Kong L, Liu Q, Lei X, Zhu T, Yin J, et al. In vitro characterization of echinomycin biosynthesis: formation and hydroxylation of L-tryptophanyl-S-enzyme and oxidation of (2S,3S) ?-hydroxytryptophan. PLoS ONE. 2013;8:e56772 pubmed publisher
Zimmermann S, Würgler Hauri C, Wanner G, Simmen H, Werner C. Echinomycin in the prevention of heterotopic ossification - an experimental antibiotic agent shows promising results in a murine model. Injury. 2013;44:570-5 pubmed publisher
Zhang J, Zhang Z, Wu Y, Chen L, Luo Q, Chen J, et al. Regulatory effect of hypoxia-inducible factor-1α on hCG-stimulated endothelin-2 expression in granulosa cells from the PMSG-treated rat ovary. J Reprod Dev. 2012;58:678-84 pubmed
Wang Z, Zhang Z, Wu Y, Chen L, Luo Q, Zhang J, et al. Effects of echinomycin on endothelin-2 expression and ovulation in immature rats primed with gonadotropins. Exp Mol Med. 2012;44:615-21 pubmed publisher
Espinosa A, Socha A, Ryke E, Rowley D. Antiamoebic properties of the actinomycete metabolites echinomycin A and tirandamycin A. Parasitol Res. 2012;111:2473-7 pubmed publisher
Branitzki Heinemann K, Okumura C, Völlger L, Kawakami Y, Kawakami T, Naim H, et al. A novel role for the transcription factor HIF-1? in the formation of mast cell extracellular traps. Biochem J. 2012;446:159-63 pubmed publisher
Tsuzuki T, Okada H, Cho H, Tsuji S, Nishigaki A, Yasuda K, et al. Hypoxic stress simultaneously stimulates vascular endothelial growth factor via hypoxia-inducible factor-1? and inhibits stromal cell-derived factor-1 in human endometrial stromal cells. Hum Reprod. 2012;27:523-30 pubmed publisher
Milesi Hallé A, McCullough S, Hinson J, Kurten R, Lamps L, Brown A, et al. Echinomycin decreases induction of vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity in mice. Basic Clin Pharmacol Toxicol. 2012;110:327-34 pubmed publisher
Maybin J, Hirani N, Jabbour H, Critchley H. Novel roles for hypoxia and prostaglandin E2 in the regulation of IL-8 during endometrial repair. Am J Pathol. 2011;178:1245-56 pubmed publisher
Jarikote D, Li W, Jiang T, Eriksson L, Murphy P. Towards echinomycin mimetics by grafting quinoxaline residues on glycophane scaffolds. Bioorg Med Chem. 2011;19:826-35 pubmed publisher
Lim C, Qiao X, Reslan O, Xia Y, Raffetto J, Paleolog E, et al. Prolonged mechanical stretch is associated with upregulation of hypoxia-inducible factors and reduced contraction in rat inferior vena cava. J Vasc Surg. 2011;53:764-73 pubmed publisher
Hirose Y, Watanabe K, Minami A, Nakamura T, Oguri H, Oikawa H. Involvement of common intermediate 3-hydroxy-L-kynurenine in chromophore biosynthesis of quinomycin family antibiotics. J Antibiot (Tokyo). 2011;64:117-22 pubmed publisher
Krishna O, Jeon O, Kim K, Byun Y, Moon H. Drug release from a chemically-anchored PEG/phospholipid monolayer onto polymer-coated metallic stents. J Biomater Sci Polym Ed. 2010;21:789-802 pubmed publisher
Regazzetti C, Bost F, Le Marchand Brustel Y, Tanti J, Giorgetti Peraldi S. Insulin induces REDD1 expression through hypoxia-inducible factor 1 activation in adipocytes. J Biol Chem. 2010;285:5157-64 pubmed publisher
Hu Y, Kirito K, Yoshida K, Mitsumori T, Nakajima K, Nozaki Y, et al. Inhibition of hypoxia-inducible factor-1 function enhances the sensitivity of multiple myeloma cells to melphalan. Mol Cancer Ther. 2009;8:2329-38 pubmed publisher
Watanabe K, Hotta K, Praseuth A, Searcey M, Wang C, Oguri H, et al. Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli. Chembiochem. 2009;10:1965-8 pubmed publisher
Pfoh R, Cuesta Seijo J, Sheldrick G. Interaction of an echinomycin-DNA complex with manganese ions. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009;65:660-4 pubmed publisher
Watanabe K, Hotta K, Nakaya M, Praseuth A, Wang C, Inada D, et al. Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product. J Am Chem Soc. 2009;131:9347-53 pubmed publisher
Kim J, Bagchi I, Bagchi M. Signaling by hypoxia-inducible factors is critical for ovulation in mice. Endocrinology. 2009;150:3392-400 pubmed publisher
Thangasamy A, Rogge J, Ammanamanchi S. Recepteur d'origine nantais tyrosine kinase is a direct target of hypoxia-inducible factor-1alpha-mediated invasion of breast carcinoma cells. J Biol Chem. 2009;284:14001-10 pubmed publisher
Watanabe K, Oguri H, Oikawa H. Diversification of echinomycin molecular structure by way of chemoenzymatic synthesis and heterologous expression of the engineered echinomycin biosynthetic pathway. Curr Opin Chem Biol. 2009;13:189-96 pubmed publisher
Foster B, Clagett Carr K, Shoemaker D, Suffness M, Plowman J, Trissel L, et al. Echinomycin: the first bifunctional intercalating agent in clinical trials. Invest New Drugs. 1985;3:403-10 pubmed
Gao X, Patel D. Antitumour drug-DNA interactions: NMR studies of echinomycin and chromomycin complexes. Q Rev Biophys. 1989;22:93-138 pubmed
Waring M. Echinomycin. Pathol Biol (Paris). 1992;40:1022-34 pubmed
product information
Catalog Number :
SML0477
Product Name :
Echinomycin
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA