This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Tubacin
catalog :
SML0065
citations: 25
Reference
Deskin B, Yin Q, Zhuang Y, Saito S, Shan B, Lasky J. Inhibition of HDAC6 Attenuates Tumor Growth of Non-Small Cell Lung Cancer. Transl Oncol. 2020;13:135-145 pubmed publisher
Zhu K, Zhang Y, Zhang J, Zhou F, Zhang L, Wang S, et al. Acetylation of Hsp90 reverses dexamethasone-mediated inhibition of insulin secretion. Toxicol Lett. 2020;320:19-27 pubmed publisher
Weiss A, Le Roux Bourdieu M, Zoetemelk M, Ramzy G, Rausch M, Harry D, et al. Identification of a Synergistic Multi-Drug Combination Active in Cancer Cells via the Prevention of Spindle Pole Clustering. Cancers (Basel). 2019;11: pubmed publisher
Wenzel E, Speidell A, Flowers S, Wu C, Avdoshina V, Mocchetti I. Histone deacetylase 6 inhibition rescues axonal transport impairments and prevents the neurotoxicity of HIV-1 envelope protein gp120. Cell Death Dis. 2019;10:674 pubmed publisher
Mirvis M, Siemers K, Nelson W, Stearns T. Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding. PLoS Biol. 2019;17:e3000381 pubmed publisher
Liang J, Lu F, Gan B, Wen Y, Chen J, Wang H, et al. Low-dose tubacin promotes BMSCs proliferation and morphological changes through the ERK pathway. Am J Transl Res. 2019;11:1446-1459 pubmed
Ramakrishnan V, Miller K, Macon E, Kimlinger T, Haug J, Kumar S, et al. Histone deacetylase inhibition in combination with MEK or BCL-2 inhibition in multiple myeloma. Haematologica. 2019;: pubmed publisher
Takanezawa Y, Nakamura R, Sone Y, Uraguchi S, Kiyono M. An autophagy deficiency promotes methylmercury-induced multinuclear cell formation. Biochem Biophys Res Commun. 2019;511:460-467 pubmed publisher
Singer D, Thamm K, Zhuang H, Karbanova J, Gao Y, Walker J, et al. Prominin-1 controls stem cell activation by orchestrating ciliary dynamics. EMBO J. 2019;38: pubmed publisher
Rimando M, Wu H, Liu Y, Lee C, Kuo S, Lo Y, et al. Glucocorticoid receptor and Histone deacetylase 6 mediate the differential effect of dexamethasone during osteogenesis of mesenchymal stromal cells (MSCs). Sci Rep. 2016;6:37371 pubmed publisher
Tao H, Yang J, Hu W, Shi K, Li J. HDAC6 Promotes Cardiac Fibrosis Progression through Suppressing RASSF1A Expression. Cardiology. 2016;133:18-26 pubmed publisher
Yuan L, Wang Z, Liu L, Jian X. Inhibiting histone deacetylase 6 partly protects cultured rat cortical neurons from oxygen‑glucose deprivation‑induced necroptosis. Mol Med Rep. 2015;12:2661-7 pubmed publisher
Sancisi V, Gandolfi G, Ambrosetti D, Ciarrocchi A. Histone Deacetylase Inhibitors Repress Tumoral Expression of the Proinvasive Factor RUNX2. Cancer Res. 2015;75:1868-82 pubmed publisher
Dhanyamraju P, Holz P, Finkernagel F, Fendrich V, Lauth M. Histone deacetylase 6 represents a novel drug target in the oncogenic Hedgehog signaling pathway. Mol Cancer Ther. 2015;14:727-39 pubmed publisher
Ding N, Ping L, Feng L, Zheng X, Song Y, Zhu J. Histone deacetylase 6 activity is critical for the metastasis of Burkitt's lymphoma cells. Cancer Cell Int. 2014;14:139 pubmed publisher
Chan C, Qi J, Smith W, Paranol R, Mazitschek R, West N, et al. Syntheses and discovery of a novel class of cinnamic hydroxamates as histone deacetylase inhibitors by multimodality molecular imaging in living subjects. Cancer Res. 2014;74:7475-86 pubmed publisher
Chaudhary N, Nakka K, Chavali P, Bhat J, Chatterjee S, Chattopadhyay S. SMAR1 coordinates HDAC6-induced deacetylation of Ku70 and dictates cell fate upon irradiation. Cell Death Dis. 2014;5:e1447 pubmed publisher
Siow D, Wattenberg B. The histone deacetylase-6 inhibitor tubacin directly inhibits de novo sphingolipid biosynthesis as an off-target effect. Biochem Biophys Res Commun. 2014;449:268-71 pubmed publisher
Rosik L, Niegisch G, Fischer U, Jung M, Schulz W, Hoffmann M. Limited efficacy of specific HDAC6 inhibition in urothelial cancer cells. Cancer Biol Ther. 2014;15:742-57 pubmed publisher
Salmi M, Bruneau N, Cillario J, Lozovaya N, Massacrier A, Buhler E, et al. Tubacin prevents neuronal migration defects and epileptic activity caused by rat Srpx2 silencing in utero. Brain. 2013;136:2457-73 pubmed publisher
Melchionda L, Fang M, Wang H, Fugnanesi V, Morbin M, Liu X, et al. Adult-onset Alexander disease, associated with a mutation in an alternative GFAP transcript, may be phenotypically modulated by a non-neutral HDAC6 variant. Orphanet J Rare Dis. 2013;8:66 pubmed publisher
Zuo Q, Wu W, Li X, Zhao L, Chen W. HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin. Oncol Rep. 2012;27:819-24 pubmed publisher
Aldana Masangkay G, Rodriguez Gonzalez A, Lin T, Ikeda A, Hsieh Y, Kim Y, et al. Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells. Leuk Lymphoma. 2011;52:1544-55 pubmed publisher
Kawada J, Zou P, Mazitschek R, Bradner J, Cohen J. Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis. J Biol Chem. 2009;284:17102-9 pubmed publisher
Witte H, Neukirchen D, Bradke F. Microtubule stabilization specifies initial neuronal polarization. J Cell Biol. 2008;180:619-32 pubmed publisher
product information
Catalog Number :
SML0065
Product Name :
Tubacin
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA