product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
antibody
product name :
Monoclonal Anti-Lamin A/C antibody produced in mouse
catalog :
SAB4200236
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4C11
reactivity :
hamsters, human, mouse, rat, dogs, bovine
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, western blot knockout validation
more info or order :
citations: 49
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; loading ...; fig 1d
  • immunohistochemistry; mouse; loading ...; fig 2a
Wang W, Wang J, Lin W, Kao C, Hung M, Teng Y, et al. Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis. Aging Cell. 2020;19:e13090 pubmed publisher
  • western blot; human; 1:5000; loading ...; fig 5a
Peng J, Liang S, Li L. sFRP1 exerts effects on gastric cancer cells through GSK3β/Rac1‑mediated restraint of TGFβ/Smad3 signaling. Oncol Rep. 2019;41:224-234 pubmed publisher
  • western blot; hamsters; loading ...; fig s19a
Tajik A, Zhang Y, Wei F, Sun J, Jia Q, Zhou W, et al. Transcription upregulation via force-induced direct stretching of chromatin. Nat Mater. 2016;15:1287-1296 pubmed publisher
  • western blot; mouse; 1:10,000; fig 1
Uribe M, Haro C, Ventero M, Campello L, Cruces J, Martín Nieto J. Expression pattern in retinal photoreceptors of POMGnT1, a protein involved in muscle-eye-brain disease. Mol Vis. 2016;22:658-73 pubmed
  • immunocytochemistry; mouse; 1:2000; fig 5
Thiam H, Vargas P, Carpi N, Crespo C, Raab M, Terriac E, et al. Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments. Nat Commun. 2016;7:10997 pubmed publisher
  • immunocytochemistry; mouse; fig 7
Lindenboim L, Sasson T, Worman H, Borner C, Stein R. Cellular stress induces Bax-regulated nuclear bubble budding and rupture followed by nuclear protein release. Nucleus. 2014;5:527-41 pubmed publisher
  • western blot; human; 1:1000
Jurkin J, Henkel T, Nielsen A, Minnich M, Popow J, Kaufmann T, et al. The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells. EMBO J. 2014;33:2922-36 pubmed publisher
  • western blot; human
Hamada K, Osaka M, Yoshida M. Cell density impacts epigenetic regulation of cytokine-induced E-selectin gene expression in vascular endothelium. PLoS ONE. 2014;9:e90502 pubmed publisher
Deng W, Bates J, Wei H, Bartoschek M, Conradt B, Leonhardt H. Tunable light and drug induced depletion of target proteins. Nat Commun. 2020;11:304 pubmed publisher
Senfter D, Samadaei M, Mader R, Gojo J, Peyrl A, Krupitza G, et al. High impact of miRNA-4521 on FOXM1 expression in medulloblastoma. Cell Death Dis. 2019;10:696 pubmed publisher
Tischbein M, Baron D, Lin Y, Gall K, Landers J, Fallini C, et al. The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing. J Biol Chem. 2019;: pubmed publisher
Fiserova J, Maninová M, Sieger T, Uhlířová J, Šebestová L, Efenberková M, et al. Nuclear pore protein TPR associates with lamin B1 and affects nuclear lamina organization and nuclear pore distribution. Cell Mol Life Sci. 2019;76:2199-2216 pubmed publisher
Fichtman B, Zagairy F, Biran N, Barsheshet Y, Chervinsky E, Ben Neriah Z, et al. Combined loss of LAP1B and LAP1C results in an early onset multisystemic nuclear envelopathy. Nat Commun. 2019;10:605 pubmed publisher
Kinterova V, Kanka J, Petruskova V, Toralova T. Inhibition of Skp1-Cullin-F-box complexes during bovine oocyte maturation and preimplantation development leads to delayed development of embryos†. Biol Reprod. 2019;100:896-906 pubmed publisher
Li B, Chen J, Chao B, Zheng Y, Xiao X. A Lamin-Binding Ligand Inhibits Homologous Recombination Repair of DNA Double-Strand Breaks. ACS Cent Sci. 2018;4:1201-1210 pubmed publisher
Barazeghi E, Prabhawa S, Norlén O, Hellman P, Stalberg P, Westin G. Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors. BMC Cancer. 2018;18:764 pubmed publisher
Bartova E, Legartova S, Krejci J, Řezníčková P, Kovaříková A, Suchankova J, et al. Depletion of A-type lamins and Lap2? reduces 53BP1 accumulation at UV-induced DNA lesions and Lap2? protein is responsible for compactness of irradiated chromatin. J Cell Biochem. 2018;: pubmed publisher
Li B, Chen J, Chao B, David L, Xiao X. Anticancer Pyrroloquinazoline LBL1 Targets Nuclear Lamins. ACS Chem Biol. 2018;13:1380-1387 pubmed publisher
Bossuet Greif N, Vignard J, Taïeb F, Mirey G, Dubois D, Petit C, et al. The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells. MBio. 2018;9: pubmed publisher
Iradi M, Triplett J, Thomas J, Davila R, Crown A, Brown H, et al. Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy. Sci Rep. 2018;8:4049 pubmed publisher
Bienkowska Haba M, Luszczek W, Myers J, Keiffer T, DiGiuseppe S, Polk P, et al. A new cell culture model to genetically dissect the complete human papillomavirus life cycle. PLoS Pathog. 2018;14:e1006846 pubmed publisher
Stachecka J, Walczak A, Kociucka B, Ruszczycki B, Wilczynski G, Szczerbal I. Nuclear organization during in vitro differentiation of porcine mesenchymal stem cells (MSCs) into adipocytes. Histochem Cell Biol. 2018;149:113-126 pubmed publisher
Kwon S, Chin K, NEDERLOF M, Gray J. Quantitative, in situ analysis of mRNAs and proteins with subcellular resolution. Sci Rep. 2017;7:16459 pubmed publisher
Fiorito F, Iovane V, Cantiello A, Marullo A, De Martino L, Iovane G. MG-132 reduces virus release in Bovine herpesvirus-1 infection. Sci Rep. 2017;7:13306 pubmed publisher
Pitaval A, Senger F, Letort G, Gidrol X, Guyon L, Sillibourne J, et al. Microtubule stabilization drives 3D centrosome migration to initiate primary ciliogenesis. J Cell Biol. 2017;216:3713-3728 pubmed publisher
Harhouri K, Navarro C, Depetris D, Mattei M, Nissan X, Cau P, et al. MG132-induced progerin clearance is mediated by autophagy activation and splicing regulation. EMBO Mol Med. 2017;9:1294-1313 pubmed publisher
. Muscle Pathology as a Diagnostic Clue to Allgrove Syndrome. J Neuropathol Exp Neurol. 2017;76:337-341 pubmed publisher
Chan C, Li W, Cojoc G, Guck J. Volume Transitions of Isolated Cell Nuclei Induced by Rapid Temperature Increase. Biophys J. 2017;112:1063-1076 pubmed publisher
Jansova D, Koncicka M, Tetkova A, Cerna R, Malik R, Del Llano E, et al. Regulation of 4E-BP1 activity in the mammalian oocyte. Cell Cycle. 2017;16:927-939 pubmed publisher
Stultz R, Cenker J, McDonald D. Imaging HIV-1 Genomic DNA from Entry through Productive Infection. J Virol. 2017;91: pubmed publisher
Bezine E, Malaisé Y, Loeuillet A, Chevalier M, Boutet Robinet E, Salles B, et al. Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms. Sci Rep. 2016;6:36022 pubmed publisher
Graillot V, Dormoy I, Dupuy J, Shay J, Huc L, Mirey G, et al. Genotoxicity of Cytolethal Distending Toxin (CDT) on Isogenic Human Colorectal Cell Lines: Potential Promoting Effects for Colorectal Carcinogenesis. Front Cell Infect Microbiol. 2016;6:34 pubmed publisher
Schürmann M, Scholze J, MULLER P, Guck J, Chan C. Cell nuclei have lower refractive index and mass density than cytoplasm. J Biophotonics. 2016;9:1068-1076 pubmed publisher
Leocadio D, Mitchell A, Winder S. ?-Secretase Dependent Nuclear Targeting of Dystroglycan. J Cell Biochem. 2016;117:2149-57 pubmed publisher
Casasola A, Scalzo D, Nandakumar V, Halow J, Recillas Targa F, Groudine M, et al. Prelamin A processing, accumulation and distribution in normal cells and laminopathy disorders. Nucleus. 2016;7:84-102 pubmed publisher
Versaevel M, Braquenier J, Riaz M, Grevesse T, Lantoine J, Gabriele S. Super-resolution microscopy reveals LINC complex recruitment at nuclear indentation sites. Sci Rep. 2014;4:7362 pubmed publisher
Lee S, Song C, Xie Y, Jung C, Choi H, Lee K. SMILE upregulated by metformin inhibits the function of androgen receptor in prostate cancer cells. Cancer Lett. 2014;354:390-7 pubmed publisher
Gonzalez Rodriguez A, Reibert B, Amann T, Constien R, Rondinone C, Valverde A. In vivo siRNA delivery of Keap1 modulates death and survival signaling pathways and attenuates concanavalin-A-induced acute liver injury in mice. Dis Model Mech. 2014;7:1093-100 pubmed publisher
Panda S, Vedagiri D, Viveka T, Harshan K. A unique phosphorylation-dependent eIF4E assembly on 40S ribosomes co-ordinated by hepatitis C virus protein NS5A that activates internal ribosome entry site translation. Biochem J. 2014;462:291-302 pubmed publisher
Kayman Kurekci G, Talim B, Korkusuz P, Sayar N, Sarioglu T, Oncel I, et al. Mutation in TOR1AIP1 encoding LAP1B in a form of muscular dystrophy: a novel gene related to nuclear envelopathies. Neuromuscul Disord. 2014;24:624-33 pubmed publisher
Okamoto A, Asai T, Kato H, Ando H, Minamino T, Mekada E, et al. Antibody-modified lipid nanoparticles for selective delivery of siRNA to tumors expressing membrane-anchored form of HB-EGF. Biochem Biophys Res Commun. 2014;449:460-5 pubmed publisher
Bertrand A, Ziaei S, Ehret C, Duchemin H, Mamchaoui K, Bigot A, et al. Cellular microenvironments reveal defective mechanosensing responses and elevated YAP signaling in LMNA-mutated muscle precursors. J Cell Sci. 2014;127:2873-84 pubmed publisher
Camps J, Wangsa D, Falke M, Brown M, Case C, Erdos M, et al. Loss of lamin B1 results in prolongation of S phase and decondensation of chromosome territories. FASEB J. 2014;28:3423-34 pubmed publisher
Chiu H, Hannemann H, Heesom K, Matthews D, Davidson A. High-throughput quantitative proteomic analysis of dengue virus type 2 infected A549 cells. PLoS ONE. 2014;9:e93305 pubmed publisher
Hasan A, Ohmori K, Hashimoto T, Kamitori K, Yamaguchi F, Ishihara Y, et al. Valsartan ameliorates the constitutive adipokine expression pattern in mature adipocytes: a role for inverse agonism of the angiotensin II type 1 receptor in obesity. Hypertens Res. 2014;37:621-8 pubmed publisher
Atik N, Kunii M, Avriyanti E, Furumoto N, Inami K, Yoshimura S, et al. The role of PKD in cell polarity, biosynthetic pathways, and organelle/F-actin distribution. Cell Struct Funct. 2014;39:61-77 pubmed
Drivas T, Holzbaur E, Bennett J. Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration. J Clin Invest. 2013;123:4525-39 pubmed publisher
Hirano Y, Hizume K, Kimura H, Takeyasu K, Haraguchi T, Hiraoka Y. Lamin B receptor recognizes specific modifications of histone H4 in heterochromatin formation. J Biol Chem. 2012;287:42654-63 pubmed publisher
Ruchaud S, Korfali N, Villa P, Kottke T, Dingwall C, Kaufmann S, et al. Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation. EMBO J. 2002;21:1967-77 pubmed
product information
Product No. :
SAB4200236
Product Name :
Monoclonal Anti-Lamin A/C antibody produced in mouse
Host :
mouse
Conjugate :
unconjugated
Antibody Type :
monoclonal
Clone Number (if monoclonal) :
4C11
Applications/Description :
Suitable for immunoprecipitation (IP); western blot: 0.1-0.2 μg/mL using whole extracts of human HeLa cells; indirect immunofluorescence
Species Reactivity :
human, rat, canine, hamster, mouse, bovine, monkey
Isotype :
IgG2a
Concentration :
~1.0 mg/mL
Storage :
Store at -20°C
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA