This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Amyloid Precursor Protein α, Secreted human
catalog :
S9564
citations: 10
Reference
Durand D, Turati J, Rudi M, Ramírez D, Saba J, Caruso C, et al. Unraveling the β-amyloid clearance by astrocytes: Involvement of metabotropic glutamate receptor 3, sAPPα, and class-A scavenger receptor. Neurochem Int. 2019;131:104547 pubmed publisher
Hasebe N, Fujita Y, Ueno M, Yoshimura K, Fujino Y, Yamashita T. Soluble ?-amyloid Precursor Protein Alpha binds to p75 neurotrophin receptor to promote neurite outgrowth. PLoS ONE. 2013;8:e82321 pubmed publisher
Vrotsos E, Kolattukudy P, Sugaya K. MCP-1 involvement in glial differentiation of neuroprogenitor cells through APP signaling. Brain Res Bull. 2009;79:97-103 pubmed publisher
Sankaranarayanan S, Holahan M, Colussi D, Crouthamel M, Devanarayan V, Ellis J, et al. First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates. J Pharmacol Exp Ther. 2009;328:131-40 pubmed publisher
Sankaranarayanan S, Price E, Wu G, Crouthamel M, Shi X, Tugusheva K, et al. In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1. J Pharmacol Exp Ther. 2008;324:957-69 pubmed
Santiago Garcia J, Mas Oliva J, Innerarity T, Pitas R. Secreted forms of the amyloid-beta precursor protein are ligands for the class A scavenger receptor. J Biol Chem. 2001;276:30655-61 pubmed
Barger S, Basile A. Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function. J Neurochem. 2001;76:846-54 pubmed
Pietrzik C, Hoffmann J, Stöber K, Chen C, Bauer C, Otero D, et al. From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells. Proc Natl Acad Sci U S A. 1998;95:1770-5 pubmed
Mattson M. Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol Rev. 1997;77:1081-132 pubmed
Barger S, Mattson M. Induction of neuroprotective kappa B-dependent transcription by secreted forms of the Alzheimer's beta-amyloid precursor. Brain Res Mol Brain Res. 1996;40:116-26 pubmed
product information
Catalog Number :
S9564
Product Name :
Amyloid Precursor Protein α, Secreted human
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
>90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA