This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Sandoz 58-035
catalog :
S9318
citations: 60
Reference
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Heybrock S, Kanerva K, Meng Y, Ing C, Liang A, Xiong Z, et al. Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export. Nat Commun. 2019;10:3521 pubmed publisher
Li J, Zhou C, Xu H, Brook R, Liu S, Yi T, et al. Ambient Air Pollution Is Associated With HDL (High-Density Lipoprotein) Dysfunction in Healthy Adults. Arterioscler Thromb Vasc Biol. 2019;39:513-522 pubmed publisher
Vaidya M, Jentsch J, Peters S, Keul P, Weske S, Gräler M, et al. Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages. J Lipid Res. 2019;60:506-515 pubmed publisher
Sun L, Mulinyawe S, Collins H, Ibrahim A, Li Q, Simon D, et al. Spatiotemporal Control of CNS Myelination by Oligodendrocyte Programmed Cell Death through the TFEB-PUMA Axis. Cell. 2018;175:1811-1826.e21 pubmed publisher
Yamashita S, Arai H, Yokote K, Araki E, Suganami H, Ishibashi S. Effects of pemafibrate (K-877) on cholesterol efflux capacity and postprandial hyperlipidemia in patients with atherogenic dyslipidemia. J Clin Lipidol. 2018;: pubmed publisher
MATHEW A, Yu J, Guo Y, Byun J, Chen Y, Wang L, et al. Effect of Ambient Fine Particulate Matter Air Pollution and Colder Outdoor Temperatures on High-Density Lipoprotein Function. Am J Cardiol. 2018;122:565-570 pubmed publisher
Talbot C, Mensink R, Smolders L, Bakeroot V, Plat J. Theobromine Does Not Affect Fasting and Postprandial HDL Cholesterol Efflux Capacity, While It Decreases Fasting miR-92a Levels in Humans. Mol Nutr Food Res. 2018;62:e1800027 pubmed publisher
Untersteller K, Meissl S, Trieb M, Emrich I, Zawada A, Holzer M, et al. HDL functionality and cardiovascular outcome among nondialysis chronic kidney disease patients. J Lipid Res. 2018;59:1256-1265 pubmed publisher
Talbot C, Plat J, Joris P, Konings M, Kusters Y, Schalkwijk C, et al. HDL cholesterol efflux capacity and cholesteryl ester transfer are associated with body mass, but are not changed by diet-induced weight loss: A randomized trial in abdominally obese men. Atherosclerosis. 2018;274:23-28 pubmed publisher
Farras M, Fernández Castillejo S, Rubio L, Arranz S, Catalán U, Subirana I, et al. Phenol-enriched olive oils improve HDL antioxidant content in hypercholesterolemic subjects. A randomized, double-blind, cross-over, controlled trial. J Nutr Biochem. 2018;51:99-104 pubmed publisher
Chengmao X, Li L, Yan L, Jie Y, Xiaoju W, Xiaohui C, et al. ABCA1 affects placental function via trophoblast and macrophage. Life Sci. 2017;191:150-156 pubmed publisher
Schilcher I, Kern S, Hrzenjak A, Eichmann T, Stojakovic T, Scharnagl H, et al. Impact of Endothelial Lipase on Cholesterol Efflux Capacity of Serum and High-density Lipoprotein. Sci Rep. 2017;7:12485 pubmed publisher
Zhang S, Glukhova S, Caldwell K, Caldwell G. NCEH-1 modulates cholesterol metabolism and protects against α-synuclein toxicity in a C. elegans model of Parkinson's disease. Hum Mol Genet. 2017;26:3823-3836 pubmed publisher
Holzer M, Kern S, Trieb M, Trakaki A, Marsche G. HDL structure and function is profoundly affected when stored frozen in the absence of cryoprotectants. J Lipid Res. 2017;58:2220-2228 pubmed publisher
Del Giudice R, Domingo Espín J, Iacobucci I, Nilsson O, Monti M, Monti D, et al. Structural determinants in ApoA-I amyloidogenic variants explain improved cholesterol metabolism despite low HDL levels. Biochim Biophys Acta Mol Basis Dis. 2017;1863:3038-3048 pubmed publisher
Hirata H, Uto Kondo H, Ogura M, Ayaori M, Shiotani K, Ota A, et al. Xanthohumol, a hop-derived prenylated flavonoid, promotes macrophage reverse cholesterol transport. J Nutr Biochem. 2017;47:29-34 pubmed publisher
Ioannou G, Subramanian S, Chait A, Haigh W, Yeh M, Farrell G, et al. Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH. J Lipid Res. 2017;58:1067-1079 pubmed publisher
Furuhashi M, Ogura M, Matsumoto M, Yuda S, Muranaka A, Kawamukai M, et al. Serum FABP5 concentration is a potential biomarker for residual risk of atherosclerosis in relation to cholesterol efflux from macrophages. Sci Rep. 2017;7:217 pubmed publisher
Mutharasan R, Thaxton C, Berry J, Daviglus M, Yuan C, Sun J, et al. HDL efflux capacity, HDL particle size, and high-risk carotid atherosclerosis in a cohort of asymptomatic older adults: the Chicago Healthy Aging Study. J Lipid Res. 2017;58:600-606 pubmed publisher
Ho Tin Noe B, Vo S, Bayles R, Ferrière S, Ladjal H, Toumi S, et al. Cholesterol crystallization in human atherosclerosis is triggered in smooth muscle cells during the transition from fatty streak to fibroatheroma. J Pathol. 2017;241:671-682 pubmed publisher
Sbiera S, Leich E, Liebisch G, Sbiera I, Schirbel A, Wiemer L, et al. Mitotane Inhibits Sterol-O-Acyl Transferase 1 Triggering Lipid-Mediated Endoplasmic Reticulum Stress and Apoptosis in Adrenocortical Carcinoma Cells. Endocrinology. 2015;156:3895-908 pubmed publisher
Gillespie M, Gold E, Ramsey S, Podolsky I, Aderem A, Ranish J. An LXR-NCOA5 gene regulatory complex directs inflammatory crosstalk-dependent repression of macrophage cholesterol efflux. EMBO J. 2015;34:1244-58 pubmed publisher
Li W, Wang R, Zhang S, Li X. DAMP, an acidotropic pH indicator, can be used as a tool to visualize non-esterified cholesterol in cells. Acta Biochim Biophys Sin (Shanghai). 2015;47:73-9 pubmed publisher
Holligan S, West S, Gebauer S, Kay C, Kris Etherton P. A moderate-fat diet containing pistachios improves emerging markers of cardiometabolic syndrome in healthy adults with elevated LDL levels. Br J Nutr. 2014;112:744-52 pubmed publisher
Smith C, Vivekanandan Giri A, Tang C, Knight J, Mathew A, Padilla R, et al. Neutrophil extracellular trap-derived enzymes oxidize high-density lipoprotein: an additional proatherogenic mechanism in systemic lupus erythematosus. Arthritis Rheumatol. 2014;66:2532-2544 pubmed publisher
Zavar Reza J, Nahangi H, Mansouri R, Dehghani A, Mojarrad M, Fathi M, et al. The Effect of Unsaturated Fatty Acids on Molecular Markers of Cholesterol Homeostasis in THP-1 Macrophages. Iran Red Crescent Med J. 2013;15:554-9 pubmed publisher
Carey A, Siebel A, Reddy Luthmoodoo M, Natoli A, D Souza W, Meikle P, et al. Skeletal muscle insulin resistance associated with cholesterol-induced activation of macrophages is prevented by high density lipoprotein. PLoS ONE. 2013;8:e56601 pubmed publisher
Son S, Goo Y, CHANG B, Paul A. Perilipin 2 (PLIN2)-deficiency does not increase cholesterol-induced toxicity in macrophages. PLoS ONE. 2012;7:e33063 pubmed publisher
Girard E, Paul J, Fournier N, Beaune P, Johannes L, Lamaze C, et al. The dynamin chemical inhibitor dynasore impairs cholesterol trafficking and sterol-sensitive genes transcription in human HeLa cells and macrophages. PLoS ONE. 2011;6:e29042 pubmed publisher
Mulas M, Abete C, Pulisci D, Pani A, Massidda B, Dessi S, et al. Cholesterol esters as growth regulators of lymphocytic leukaemia cells. Cell Prolif. 2011;44:360-71 pubmed publisher
Maekawa T, Takahashi N, Tabeta K, Aoki Y, Miyashita H, Miyauchi S, et al. Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile. PLoS ONE. 2011;6:e20240 pubmed publisher
Ouellette S, Carabeo R. A Functional Slow Recycling Pathway of Transferrin is Required for Growth of Chlamydia. Front Microbiol. 2010;1:112 pubmed publisher
Fukunaga M, Nunomura S, Nishida S, Endo K, Gon Y, Hashimoto S, et al. Mast cell death induced by 24(S),25-epoxycholesterol. Exp Cell Res. 2010;316:3272-81 pubmed publisher
Reza J, Doosti M, Salehipour M, Packnejad M, Mojarrad M, Heidari M. Modulation peroxisome proliferators activated receptor alpha (PPAR alpha) and acyl coenzyme A: cholesterol acyltransferase1 (ACAT1) gene expression by fatty acids in foam cell. Lipids Health Dis. 2009;8:38 pubmed publisher
Kedi X, Ming Y, Yongping W, Yi Y, Xiaoxiang Z. Free cholesterol overloading induced smooth muscle cells death and activated both ER- and mitochondrial-dependent death pathway. Atherosclerosis. 2009;207:123-30 pubmed publisher
Diaz G, Batetta B, Sanna F, Uda S, Reali C, Angius F, et al. Lipid droplet changes in proliferating and quiescent 3T3 fibroblasts. Histochem Cell Biol. 2008;129:611-21 pubmed publisher
Peiretti E, Dessì S, Mulas C, Abete C, Norfo C, Putzolu M, et al. Modulation of cholesterol homeostasis by antiproliferative drugs in human pterygium fibroblasts. Invest Ophthalmol Vis Sci. 2007;48:3450-8 pubmed
de Medina P, Boubekeur N, Balaguer P, Favre G, Silvente Poirot S, Poirot M. The prototypical inhibitor of cholesterol esterification, Sah 58-035 [3-[decyldimethylsilyl]-n-[2-(4-methylphenyl)-1-phenylethyl]propanamide], is an agonist of estrogen receptors. J Pharmacol Exp Ther. 2006;319:139-49 pubmed
Nawabi P, Lykidis A, Ji D, Haldar K. Neutral-lipid analysis reveals elevation of acylglycerols and lack of cholesterol esters in Plasmodium falciparum-infected erythrocytes. Eukaryot Cell. 2003;2:1128-31 pubmed
Batetta B, Mulas M, Sanna F, Putzolu M, Bonatesta R, Gasperi Campani A, et al. Role of cholesterol ester pathway in the control of cell cycle in human aortic smooth muscle cells. FASEB J. 2003;17:746-8 pubmed
Burgess J, Frank P, Franklin V, Liang P, McManus D, Desforges M, et al. Deletion of the C-terminal domain of apolipoprotein A-I impairs cell surface binding and lipid efflux in macrophage. Biochemistry. 1999;38:14524-33 pubmed
Rodriguez A, Bachorik P, Wee S. Novel effects of the acyl-coenzyme A:Cholesterol acyltransferase inhibitor 58-035 on foam cell development in primary human monocyte-derived macrophages. Arterioscler Thromb Vasc Biol. 1999;19:2199-206 pubmed
Hrboticky N, Becker A, Kruse H, Weber P. Increased cellular triglyceride levels in human monocytic and rat smooth muscle cells after lovastatin. Biochim Biophys Acta. 1997;1349:211-21 pubmed
Ooyen C, Zecca A, Zanelli T, Catapano A. Decreased intracellular degradation and increased secretion of apo B-100 in Hep G2 cells after inhibition of cholesteryl ester synthesis. Atherosclerosis. 1997;130:143-52 pubmed
Liza M, Romero J, Chico Y, Fresnedo O, Ochoa B. Application of 2-hydroxypropyl-beta-cyclodextrin in the assay of acyl-CoA:cholesterol acyltransferase and neutral and acid cholesterol ester hydrolases. Lipids. 1996;31:323-9 pubmed
Maziere C, Barbu V, Auclair M, Maziere J. Interleukin 1 stimulates cholesterol esterification and cholesterol deposition in J774 monocytes-macrophages. Biochim Biophys Acta. 1996;1300:30-4 pubmed
Sviridov D, Safonova I, Nano J, Pavlov M, Rampal P, Repin V, et al. New model to study cholesterol uptake in the human intestine in vitro. J Lipid Res. 1993;34:331-9 pubmed
Wu X, Sakata N, Lui E, Ginsberg H. Evidence for a lack of regulation of the assembly and secretion of apolipoprotein B-containing lipoprotein from HepG2 cells by cholesteryl ester. J Biol Chem. 1994;269:12375-82 pubmed
Cianflone K, Vu H, Zhang Z, Sniderman A. Effects of albumin on lipid synthesis, apo B-100 secretion, and LDL catabolism in HepG2 cells. Atherosclerosis. 1994;107:125-35 pubmed
Hakamata H, Miyazaki A, Sakai M, Suginohara Y, Sakamoto Y, Horiuchi S. Species difference in cholesteryl ester cycle and HDL-induced cholesterol efflux from macrophage foam cells. Arterioscler Thromb. 1994;14:1860-5 pubmed
Yancey P, St Clair R. Mechanism of the defect in cholesteryl ester clearance from macrophages of atherosclerosis-susceptible White Carneau pigeons. J Lipid Res. 1994;35:2114-29 pubmed
Mazzone T, Krishna M, Lange Y. Progesterone blocks intracellular translocation of free cholesterol derived from cholesteryl ester in macrophages. J Lipid Res. 1995;36:544-51 pubmed
Clark S, Tercyak A. Reduced cholesterol transmucosal transport in rats with inhibited mucosal acyl CoA:cholesterol acyltransferase and normal pancreatic function. J Lipid Res. 1984;25:148-59 pubmed
Ross A, Go K, Heider J, Rothblat G. Selective inhibition of acyl coenzyme A:cholesterol acyltransferase by compound 58-035. J Biol Chem. 1984;259:815-9 pubmed
Williams R, McCarthy A, Sutherland C. Esterification and absorption of cholesterol: in vitro and in vivo observations in the rat. Biochim Biophys Acta. 1989;1003:213-6 pubmed
Salter A, Ekins N, Al Seeni M, Brindley D, Middleton B. Cholesterol esterification plays a major role in determining low-density-lipoprotein receptor activity in primary monolayer cultures of rat hepatocytes. Biochem J. 1989;263:255-60 pubmed
Shimasaki O, Mineo C, Mowri H, Ohkuma S, Takano T. Accumulation of oleate-rich cholesteryl esters by acetyl-LDL in macrophages in the presence of an acyl-CoA: cholesterol acyltransferase inhibitor (Sandoz 58-035). Biochem Int. 1990;20:389-96 pubmed
Metherall J, Ridgway N, Dawson P, Goldstein J, Brown M. A 25-hydroxycholesterol-resistant cell line deficient in acyl-CoA: cholesterol acyltransferase. J Biol Chem. 1991;266:12734-40 pubmed
product information
Catalog Number :
S9318
Product Name :
Sandoz 58-035
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
>98% (HPLC), powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA