product summary
company name :
MilliporeSigma
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, FLUKA, Sigma-Aldrich, Novabiochem, Guava, Roche Applied Science
product type :
antibody
product name :
Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse
catalog :
S8809
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
K58/35
reactivity :
guinea pig, human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section
more info or order :
citations: 98
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; rat; 1:200; fig 8o
Dorrego Rivas A, Ezan J, Moreau M, Poirault Chassac S, Aubailly N, De Neve J, et al. The core PCP protein Prickle2 regulates axon number and AIS maturation by binding to AnkG and modulating microtubule bundling. Sci Adv. 2022;8:eabo6333 pubmed publisher
  • immunocytochemistry; mouse; 1:100; fig 3c
Tian T, Quintana Urzainqui I, Kozi x107 Z, Pratt T, Price D. Pax6 loss alters the morphological and electrophysiological development of mouse prethalamic neurons. Development. 2022;149: pubmed publisher
  • immunocytochemistry; human; fig 6h
Clark A, Kugathasan U, Baskozos G, Priestman D, Fugger N, Lone M, et al. An iPSC model of hereditary sensory neuropathy-1 reveals L-serine-responsive deficits in neuronal ganglioside composition and axoglial interactions. Cell Rep Med. 2021;2:100345 pubmed publisher
  • immunohistochemistry; mouse; 1:400; loading ...; fig 5b
Otani Y, Ohno N, Cui J, Yamaguchi Y, Baba H. Upregulation of large myelin protein zero leads to Charcot-Marie-Tooth disease-like neuropathy in mice. Commun Biol. 2020;3:121 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 2a
Yang H, Pérez Hernández M, Sanchez Alonso J, Shevchuk A, Gorelik J, Rothenberg E, et al. Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc. elife. 2020;9: pubmed publisher
  • immunocytochemistry; rat; 1:100; loading ...; fig 3a
Aprile D, Fruscione F, Baldassari S, Fadda M, Ferrante D, Falace A, et al. TBC1D24 regulates axonal outgrowth and membrane trafficking at the growth cone in rodent and human neurons. Cell Death Differ. 2019;: pubmed publisher
  • immunocytochemistry; rat; 1:1000; loading ...; fig 1a
Alpizar S, BAKER A, Gulledge A, Hoppa M. Loss of Neurofascin-186 Disrupts Alignment of AnkyrinG Relative to Its Binding Partners in the Axon Initial Segment. Front Cell Neurosci. 2019;13:1 pubmed publisher
  • western blot; rat; 1:200; loading ...; fig 8
Pablo J, Pitt G. FGF14 is a regulator of KCNQ2/3 channels. Proc Natl Acad Sci U S A. 2017;114:154-159 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:250; loading ...; fig 4d
Yoshikawa F, Sato Y, Tohyama K, Akagi T, Furuse T, Sadakata T, et al. Mammalian-Specific Central Myelin Protein Opalin Is Redundant for Normal Myelination: Structural and Behavioral Assessments. PLoS ONE. 2016;11:e0166732 pubmed publisher
  • western blot; mouse; fig 1
Dover K, Marra C, Solinas S, Popovic M, Subramaniyam S, Zecevic D, et al. FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon. Nat Commun. 2016;7:12895 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:100; loading ...; fig 2a
Serwanski D, Jukkola P, Nishiyama A. Heterogeneity of astrocyte and NG2 cell insertion at the node of ranvier. J Comp Neurol. 2017;525:535-552 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 5a
  • immunoprecipitation; mouse; 1:200; loading ...; fig 4a
Kruger L, O Malley H, Hull J, Kleeman A, Patino G, Isom L. ?1-C121W Is Down But Not Out: Epilepsy-Associated Scn1b-C121W Results in a Deleterious Gain-of-Function. J Neurosci. 2016;36:6213-24 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:300; fig s7
Alshammari M, Alshammari T, Laezza F. Improved Methods for Fluorescence Microscopy Detection of Macromolecules at the Axon Initial Segment. Front Cell Neurosci. 2016;10:5 pubmed publisher
  • immunoprecipitation; mouse; fig 6
  • western blot; mouse; 1:1000; fig 1
Bosch M, Nerbonne J, Townsend R, Miyazaki H, Nukina N, Ornitz D, et al. Proteomic analysis of native cerebellar iFGF14 complexes. Channels (Austin). 2016;10:297-312 pubmed publisher
  • western blot; guinea pig; 1:800; fig 6
Nassal D, Wan X, Liu H, Deschenes I. Myocardial KChIP2 Expression in Guinea Pig Resolves an Expanded Electrophysiologic Role. PLoS ONE. 2016;11:e0146561 pubmed publisher
  • western blot; mouse
Cesca F, Satapathy A, Ferrea E, Nieus T, Benfenati F, Scholz Starke J. Functional Interaction between the Scaffold Protein Kidins220/ARMS and Neuronal Voltage-Gated Na+ Channels. J Biol Chem. 2015;290:18045-55 pubmed publisher
  • western blot; human; fig s6
Koenig J, Werdehausen R, Linley J, Habib A, Vernon J, Lolignier S, et al. Regulation of Nav1.7: A Conserved SCN9A Natural Antisense Transcript Expressed in Dorsal Root Ganglia. PLoS ONE. 2015;10:e0128830 pubmed publisher
  • immunocytochemistry; rat; loading ...; fig 2e
Colombelli C, Palmisano M, Eshed Eisenbach Y, Zambroni D, Pavoni E, Ferri C, et al. Perlecan is recruited by dystroglycan to nodes of Ranvier and binds the clustering molecule gliomedin. J Cell Biol. 2015;208:313-29 pubmed publisher
  • immunocytochemistry; rat; 1:100; fig 6
Chand A, Galliano E, Chesters R, Grubb M. A distinct subtype of dopaminergic interneuron displays inverted structural plasticity at the axon initial segment. J Neurosci. 2015;35:1573-90 pubmed publisher
  • immunohistochemistry; mouse; 1:100
Dumas L, Heitz Marchaland C, Fouquet S, Suter U, Livet J, Moreau Fauvarque C, et al. Multicolor analysis of oligodendrocyte morphology, interactions, and development with Brainbow. Glia. 2015;63:699-717 pubmed publisher
Forrest M, Dos Santos M, Piguel N, Wang Y, Hawkins N, Bagchi V, et al. Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub. Nat Commun. 2023;14:825 pubmed publisher
McCollum M, Larmore M, Ishihara S, Ng L, Kimura L, Guadarrama E, et al. Targeting the tamoxifen receptor within sodium channels to block osteoarthritic pain. Cell Rep. 2022;40:111248 pubmed publisher
Jentzer A, Attal A, Rou xe9 C, Raymond J, Lleix xe0 C, Illa I, et al. IgG4 Valency Modulates the Pathogenicity of Anti-Neurofascin-155 IgG4 in Autoimmune Nodopathy. Neurol Neuroimmunol Neuroinflamm. 2022;9: pubmed publisher
Lee M, Liu Y, Chen C, Lu C, Lu S, Huang T, et al. Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain. J Cell Biol. 2020;219: pubmed publisher
Xu H, Dzhashiashvili Y, Shah A, Kunjamma R, Weng Y, Elbaz B, et al. m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination. Neuron. 2020;105:293-309.e5 pubmed publisher
Kim E, Feng C, Santamaria F, Kim J. Impact of Auditory Experience on the Structural Plasticity of the AIS in the Mouse Brainstem Throughout the Lifespan. Front Cell Neurosci. 2019;13:456 pubmed publisher
Sohn P, Huang C, Yan R, Fan L, Tracy T, Camargo C, et al. Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis. Neuron. 2019;104:458-470.e5 pubmed publisher
Manso C, Querol L, Lleixà C, Poncelet M, Mekaouche M, Vallat J, et al. Anti-Neurofascin-155 IgG4 antibodies prevent paranodal complex formation in vivo. J Clin Invest. 2019;129:2222-2236 pubmed publisher
Farías G, Fréal A, Tortosa E, Stucchi R, Pan X, Portegies S, et al. Feedback-Driven Mechanisms between Microtubules and the Endoplasmic Reticulum Instruct Neuronal Polarity. Neuron. 2019;102:184-201.e8 pubmed publisher
Dembla M, Kesharwani A, Natarajan S, Fecher Trost C, Fairless R, Williams S, et al. Early auto-immune targeting of photoreceptor ribbon synapses in mouse models of multiple sclerosis. EMBO Mol Med. 2018;10: pubmed publisher
Lucas Osma A, Li Y, Lin S, Black S, Singla R, Fouad K, et al. Extrasynaptic α5GABAA receptors on proprioceptive afferents produce a tonic depolarization that modulates sodium channel function in the rat spinal cord. J Neurophysiol. 2018;120:2953-2974 pubmed publisher
Schätzle P, Esteves da Silva M, Tas R, Katrukha E, Hu H, Wierenga C, et al. Activity-Dependent Actin Remodeling at the Base of Dendritic Spines Promotes Microtubule Entry. Curr Biol. 2018;28:2081-2093.e6 pubmed publisher
Susuki K, Zollinger D, Chang K, Zhang C, Huang C, Tsai C, et al. Glial βII Spectrin Contributes to Paranode Formation and Maintenance. J Neurosci. 2018;38:6063-6075 pubmed publisher
GRIGGS R, Yermakov L, Drouet D, Nguyen D, Susuki K. Methylglyoxal Disrupts Paranodal Axoglial Junctions via Calpain Activation. ASN Neuro. 2018;10:1759091418766175 pubmed publisher
Kojima W, Hayashi K. Changes in the axo-glial junctions of the optic nerves of cuprizone-treated mice. Histochem Cell Biol. 2018;149:529-536 pubmed publisher
Stojic A, Bojcevski J, Williams S, Diem R, Fairless R. Early Nodal and Paranodal Disruption in Autoimmune Optic Neuritis. J Neuropathol Exp Neurol. 2018;77:361-373 pubmed publisher
Barron T, Saifetiarova J, Bhat M, Kim J. Myelination of Purkinje axons is critical for resilient synaptic transmission in the deep cerebellar nucleus. Sci Rep. 2018;8:1022 pubmed publisher
Bang M, Vainshtein A, Yang H, Eshed Eisenbach Y, Devaux J, Werner H, et al. Glial M6B stabilizes the axonal membrane at peripheral nodes of Ranvier. Glia. 2018;66:801-812 pubmed publisher
Höfflin F, Jack A, Riedel C, Mack Bucher J, Roos J, Corcelli C, et al. Heterogeneity of the Axon Initial Segment in Interneurons and Pyramidal Cells of Rodent Visual Cortex. Front Cell Neurosci. 2017;11:332 pubmed publisher
Burel S, Coyan F, Lorenzini M, Meyer M, Lichti C, BROWN J, et al. C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation. J Biol Chem. 2017;292:17431-17448 pubmed publisher
Feinberg K, Kolaj A, Wu C, Grinshtein N, Krieger J, Moran M, et al. A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria. J Cell Biol. 2017;216:3655-3675 pubmed publisher
York A, Zheng J. Super-Resolution Microscopy Reveals a Nanoscale Organization of Acetylcholine Receptors for Trans-Synaptic Alignment at Neuromuscular Synapses. Eneuro. 2017;4: pubmed publisher
Gonsalvez D, Tran G, Fletcher J, Hughes R, Hodgkinson S, Wood R, et al. A Brain-Derived Neurotrophic Factor-Based p75NTR Peptide Mimetic Ameliorates Experimental Autoimmune Neuritis Induced Axonal Pathology and Demyelination. Eneuro. 2017;4: pubmed publisher
Tortosa E, Adolfs Y, Fukata M, Pasterkamp R, Kapitein L, Hoogenraad C. Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization. Neuron. 2017;94:809-825.e7 pubmed publisher
Gumy L, Katrukha E, Grigoriev I, Jaarsma D, Kapitein L, Akhmanova A, et al. MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons. Neuron. 2017;94:347-362.e7 pubmed publisher
Terzenidou M, Segklia A, Kano T, Papastefanaki F, Karakostas A, Charalambous M, et al. Novel insights into SLC25A46-related pathologies in a genetic mouse model. PLoS Genet. 2017;13:e1006656 pubmed publisher
D Este E, Kamin D, Balzarotti F, Hell S. Ultrastructural anatomy of nodes of Ranvier in the peripheral nervous system as revealed by STED microscopy. Proc Natl Acad Sci U S A. 2017;114:E191-E199 pubmed publisher
Martin P, Cifuentes Diaz C, Devaux J, Garcia M, Bureau J, Thomasseau S, et al. Schwannomin-interacting Protein 1 Isoform IQCJ-SCHIP1 Is a Multipartner Ankyrin- and Spectrin-binding Protein Involved in the Organization of Nodes of Ranvier. J Biol Chem. 2017;292:2441-2456 pubmed publisher
Vilmont V, Cadot B, Ouanounou G, Gomes E. A system for studying mechanisms of neuromuscular junction development and maintenance. Development. 2016;143:2464-77 pubmed publisher
Tian C, Zou S, Hu B. Extraocular Source of Oligodendrocytes Contribute to Retinal Myelination and Optokinetic Responses in Zebrafish. Invest Ophthalmol Vis Sci. 2016;57:2129-38 pubmed publisher
Valente P, Lignani G, Medrihan L, Bosco F, Contestabile A, Lippiello P, et al. Cell adhesion molecule L1 contributes to neuronal excitability regulating the function of voltage-gated Na+ channels. J Cell Sci. 2016;129:1878-91 pubmed publisher
Jones J, Dionne L, Dell Orco J, Parent R, Krueger J, Cheng X, et al. Single amino acid deletion in transmembrane segment D4S6 of sodium channel Scn8a (Nav1.6) in a mouse mutant with a chronic movement disorder. Neurobiol Dis. 2016;89:36-45 pubmed publisher
Miyamoto Y, Torii T, Takada S, Ohno N, Saitoh Y, Nakamura K, et al. Involvement of the Tyro3 receptor and its intracellular partner Fyn signaling in Schwann cell myelination. Mol Biol Cell. 2015;26:3489-503 pubmed publisher
Herren A, Weber D, Rigor R, Margulies K, Phinney B, Bers D. CaMKII Phosphorylation of Na(V)1.5: Novel in Vitro Sites Identified by Mass Spectrometry and Reduced S516 Phosphorylation in Human Heart Failure. J Proteome Res. 2015;14:2298-311 pubmed publisher
Rudenko A, Seo J, Hu J, Su S, de Anda F, Durak O, et al. Loss of cyclin-dependent kinase 5 from parvalbumin interneurons leads to hyperinhibition, decreased anxiety, and memory impairment. J Neurosci. 2015;35:2372-83 pubmed publisher
Amor V, Feinberg K, Eshed Eisenbach Y, Vainshtein A, Frechter S, Grumet M, et al. Long-term maintenance of Na+ channels at nodes of Ranvier depends on glial contact mediated by gliomedin and NrCAM. J Neurosci. 2014;34:5089-98 pubmed publisher
King C, Lancaster E, Salomon D, Peles E, Scherer S. Kv7.2 regulates the function of peripheral sensory neurons. J Comp Neurol. 2014;522:3262-80 pubmed publisher
Gutzmann A, Ergül N, Grossmann R, Schultz C, Wahle P, Engelhardt M. A period of structural plasticity at the axon initial segment in developing visual cortex. Front Neuroanat. 2014;8:11 pubmed publisher
Persson A, Kim I, Zhao P, Estacion M, Black J, Waxman S. Sodium channels contribute to degeneration of dorsal root ganglion neurites induced by mitochondrial dysfunction in an in vitro model of axonal injury. J Neurosci. 2013;33:19250-61 pubmed publisher
Koike M, Tanida I, Nanao T, Tada N, Iwata J, Ueno T, et al. Enrichment of GABARAP relative to LC3 in the axonal initial segments of neurons. PLoS ONE. 2013;8:e63568 pubmed publisher
Higurashi N, Uchida T, Lossin C, Misumi Y, Okada Y, Akamatsu W, et al. A human Dravet syndrome model from patient induced pluripotent stem cells. Mol Brain. 2013;6:19 pubmed publisher
Hayashi T, Wakao S, Kitada M, Ose T, Watabe H, Kuroda Y, et al. Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques. J Clin Invest. 2013;123:272-84 pubmed publisher
Joucla S, Branchereau P, Cattaert D, Yvert B. Extracellular neural microstimulation may activate much larger regions than expected by simulations: a combined experimental and modeling study. PLoS ONE. 2012;7:e41324 pubmed publisher
Subramanian N, Wetzel A, Dombert B, Yadav P, Havlicek S, Jablonka S, et al. Role of Na(v)1.9 in activity-dependent axon growth in motoneurons. Hum Mol Genet. 2012;21:3655-67 pubmed publisher
Ashpole N, Herren A, Ginsburg K, Brogan J, Johnson D, Cummins T, et al. Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites. J Biol Chem. 2012;287:19856-69 pubmed publisher
O Brien J, Sharkey L, Vallianatos C, Han C, Blossom J, Yu T, et al. Interaction of voltage-gated sodium channel Nav1.6 (SCN8A) with microtubule-associated protein Map1b. J Biol Chem. 2012;287:18459-66 pubmed publisher
Bangratz M, Sarrazin N, Devaux J, Zambroni D, Echaniz Laguna A, Rene F, et al. A mouse model of Schwartz-Jampel syndrome reveals myelinating Schwann cell dysfunction with persistent axonal depolarization in vitro and distal peripheral nerve hyperexcitability when perlecan is lacking. Am J Pathol. 2012;180:2040-55 pubmed publisher
Patino G, Brackenbury W, Bao Y, Lopez Santiago L, O Malley H, Chen C, et al. Voltage-gated Na+ channel ?1B: a secreted cell adhesion molecule involved in human epilepsy. J Neurosci. 2011;31:14577-91 pubmed publisher
Beirowski B, Gustin J, Armour S, Yamamoto H, Viader A, North B, et al. Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc Natl Acad Sci U S A. 2011;108:E952-61 pubmed publisher
Lysakowski A, Gaboyard Niay S, Calin Jageman I, Chatlani S, Price S, Eatock R. Molecular microdomains in a sensory terminal, the vestibular calyx ending. J Neurosci. 2011;31:10101-14 pubmed publisher
Guo L, Abrams R, Babiarz J, Cohen J, Kameoka S, Sanders M, et al. Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci. 2011;123:281-9 pubmed publisher
Cifuentes Diaz C, Dubourg O, Irinopoulou T, Vigny M, Lachkar S, Decker L, et al. Nodes of ranvier and paranodes in chronic acquired neuropathies. PLoS ONE. 2011;6:e14533 pubmed publisher
Osadchii O, Soltysinska E, Olesen S. Na+ channel distribution and electrophysiological heterogeneities in guinea pig ventricular wall. Am J Physiol Heart Circ Physiol. 2011;300:H989-1002 pubmed publisher
Harrington E, Zhao C, Fancy S, Kaing S, Franklin R, Rowitch D. Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination. Ann Neurol. 2010;68:703-16 pubmed publisher
Mierzwa A, Arevalo J, Schiff R, Chao M, Rosenbluth J. Role of transverse bands in maintaining paranodal structure and axolemmal domain organization in myelinated nerve fibers: effect on longevity in dysmyelinated mutant mice. J Comp Neurol. 2010;518:2841-53 pubmed publisher
Feinberg K, Eshed Eisenbach Y, Frechter S, Amor V, Salomon D, Sabanay H, et al. A glial signal consisting of gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier. Neuron. 2010;65:490-502 pubmed publisher
Fried S, Lasker A, Desai N, Eddington D, Rizzo J. Axonal sodium-channel bands shape the response to electric stimulation in retinal ganglion cells. J Neurophysiol. 2009;101:1972-87 pubmed publisher
Alanne M, Pummi K, Heape A, Grenman R, Peltonen J, Peltonen S. Tight junction proteins in human Schwann cell autotypic junctions. J Histochem Cytochem. 2009;57:523-9 pubmed publisher
Lonigro A, Devaux J. Disruption of neurofascin and gliomedin at nodes of Ranvier precedes demyelination in experimental allergic neuritis. Brain. 2009;132:260-73 pubmed publisher
Jarjour A, Bull S, Almasieh M, Rajasekharan S, Baker K, Mui J, et al. Maintenance of axo-oligodendroglial paranodal junctions requires DCC and netrin-1. J Neurosci. 2008;28:11003-14 pubmed publisher
Mojumder D, Wensel T, Frishman L. Subcellular compartmentalization of two calcium binding proteins, calretinin and calbindin-28 kDa, in ganglion and amacrine cells of the rat retina. Mol Vis. 2008;14:1600-13 pubmed
Dupree J, Mason J, Marcus J, Stull M, Levinson R, Matsushima G, et al. Oligodendrocytes assist in the maintenance of sodium channel clusters independent of the myelin sheath. Neuron Glia Biol. 2004;1:179-92 pubmed publisher
Vega A, Henry D, Matthews G. Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a. Neurosci Lett. 2008;442:69-73 pubmed publisher
Alix J, Dolphin A, Fern R. Vesicular apparatus, including functional calcium channels, are present in developing rodent optic nerve axons and are required for normal node of Ranvier formation. J Physiol. 2008;586:4069-89 pubmed publisher
Yoshikawa F, Sato Y, Tohyama K, Akagi T, Hashikawa T, Nagakura Takagi Y, et al. Opalin, a transmembrane sialylglycoprotein located in the central nervous system myelin paranodal loop membrane. J Biol Chem. 2008;283:20830-40 pubmed publisher
Kress G, Dowling M, Meeks J, Mennerick S. High threshold, proximal initiation, and slow conduction velocity of action potentials in dentate granule neuron mossy fibers. J Neurophysiol. 2008;100:281-91 pubmed publisher
Karadottir R, Hamilton N, Bakiri Y, Attwell D. Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter. Nat Neurosci. 2008;11:450-6 pubmed publisher
Martínez Mármol R, David M, Sanches R, Roura Ferrer M, Villalonga N, Sorianello E, et al. Voltage-dependent Na+ channel phenotype changes in myoblasts. Consequences for cardiac repair. Cardiovasc Res. 2007;76:430-41 pubmed
Heflin S, COOK P. Narrow and wide field amacrine cells fire action potentials in response to depolarization and light stimulation. Vis Neurosci. 2007;24:197-206 pubmed
Nie D, Ma Q, Law J, Chia C, Dhingra N, Shimoda Y, et al. Oligodendrocytes regulate formation of nodes of Ranvier via the recognition molecule OMgp. Neuron Glia Biol. 2006;2:151-64 pubmed
Howell O, Palser A, Polito A, Melrose S, Zonta B, Scheiermann C, et al. Disruption of neurofascin localization reveals early changes preceding demyelination and remyelination in multiple sclerosis. Brain. 2006;129:3173-85 pubmed
Choi J, Hudmon A, Waxman S, Dib Hajj S. Calmodulin regulates current density and frequency-dependent inhibition of sodium channel Nav1.8 in DRG neurons. J Neurophysiol. 2006;96:97-108 pubmed
Platel J, Boisseau S, Dupuis A, Brocard J, Poupard A, Savasta M, et al. Na+ channel-mediated Ca2+ entry leads to glutamate secretion in mouse neocortical preplate. Proc Natl Acad Sci U S A. 2005;102:19174-9 pubmed
Drobyshevsky A, Song S, Gamkrelidze G, Wyrwicz A, Derrick M, Meng F, et al. Developmental changes in diffusion anisotropy coincide with immature oligodendrocyte progression and maturation of compound action potential. J Neurosci. 2005;25:5988-97 pubmed
Ishibashi T, Ding L, Ikenaka K, Inoue Y, Miyado K, Mekada E, et al. Tetraspanin protein CD9 is a novel paranodal component regulating paranodal junctional formation. J Neurosci. 2004;24:96-102 pubmed
Bouzidi M, Tricaud N, Giraud P, Kordeli E, Caillol G, Deleuze C, et al. Interaction of the Nav1.2a subunit of the voltage-dependent sodium channel with nodal ankyrinG. In vitro mapping of the interacting domains and association in synaptosomes. J Biol Chem. 2002;277:28996-9004 pubmed
Rasband M, Peles E, Trimmer J, Levinson S, Lux S, Shrager P. Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS. J Neurosci. 1999;19:7516-28 pubmed
Catterall W. Structure and function of voltage-gated ion channels. Annu Rev Biochem. 1995;64:493-531 pubmed
product information
Product No. :
S8809
Product Name :
Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse
Host :
mouse
Conjugate :
unconjugated
Antibody Type :
monoclonal
Clone Number (if monoclonal) :
K58/35
Applications/Description :
Suitable for immunohistochemistry (frozen sections); western blot: 1 μg/mL using crude brain membrane prep (rat); indirect immunofluorescence: 1 μg/mL using sciatic and optic nerve sections; cultured hypocampal neurons
Species Reactivity :
mammals
Isotype :
IgG1
Concentration :
~1 mg/mL
Storage :
Store at -20°C
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA