This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Saquinavir mesylate
catalog :
S8451
citations: 27
Reference
Tomaru A, Takeda Morishita M, Maeda K, Banba H, Takayama K, Kumagai Y, et al. Effects of Cremophor EL on the absorption of orally administered saquinavir and fexofenadine in healthy subjects. Drug Metab Pharmacokinet. 2015;30:221-6 pubmed publisher
Hosny K, Hassan A. Intranasal in situ gel loaded with saquinavir mesylate nanosized microemulsion: preparation, characterization, and in vivo evaluation. Int J Pharm. 2014;475:191-7 pubmed publisher
Petković F, Blaževski J, Momcilovic M, Timotijevic G, Zocca M, Mijatovic S, et al. Saquinavir-NO inhibits S6 kinase activity, impairs secretion of the encephalytogenic cytokines interleukin-17 and interferon-gamma and ameliorates experimental autoimmune encephalomyelitis. J Neuroimmunol. 2013;259:55-65 pubmed publisher
Hobbs C, Tanaka T, Muratova O, Van Vliet J, Borkowsky W, Williamson K, et al. HIV treatments have malaria gametocyte killing and transmission blocking activity. J Infect Dis. 2013;208:139-48 pubmed publisher
Park K. Transport of nanostructured lipid carriers across the intestinal barrier. J Control Release. 2013;166:195 pubmed publisher
Harada S, Yoshimura K, Yamaguchi A, Boonchawalit S, Yusa K, Matsushita S. Impact of antiretroviral pressure on selection of primary human immunodeficiency virus type 1 envelope sequences in vitro. J Gen Virol. 2013;94:933-943 pubmed publisher
Beloqui A, Solinís M, Gascón A, del Pozo Rodríguez A, des Rieux A, Préat V. Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier. J Control Release. 2013;166:115-23 pubmed publisher
Santos L, Vitório B, Branquinha M, Pedroso E Silva C, Santos A, D Ávila Levy C. Nelfinavir is effective in inhibiting the multiplication and aspartic peptidase activity of Leishmania species, including strains obtained from HIV-positive patients. J Antimicrob Chemother. 2013;68:348-53 pubmed publisher
Rasmussen L, Mathiesen E, Kronborg G, Pedersen C, Gerstoft J, Obel N. Risk of diabetes mellitus in persons with and without HIV: a Danish nationwide population-based cohort study. PLoS ONE. 2012;7:e44575 pubmed publisher
Brunet C, Reliquet V, Jovelin T, Venisse N, Winer N, Bui E, et al. Effectiveness and safety of saquinavir/ritonavir in HIV-infected pregnant women: INEMA cohort. Med Mal Infect. 2012;42:421-8 pubmed publisher
Mojic M, Mijatovic S, Maksimovic Ivanic D, Miljkovic D, Stosic Grujicic S, Stankovic M, et al. Therapeutic potential of nitric oxide-modified drugs in colon cancer cells. Mol Pharmacol. 2012;82:700-10 pubmed
Kuo Y, Wang C. Cationic solid lipid nanoparticles with primary and quaternary amines for release of saquinavir and biocompatibility with endothelia. Colloids Surf B Biointerfaces. 2013;101:101-5 pubmed publisher
Sidrim J, Perdigão Neto L, Cordeiro R, Brilhante R, Leite J, Teixeira C, et al. Viral protease inhibitors affect the production of virulence factors in Cryptococcus neoformans. Can J Microbiol. 2012;58:932-6 pubmed publisher
Esposito V, Manente L, Lucariello A, Perna A, Viglietti R, Gargiulo M, et al. Role of FAP48 in HIV-associated lipodystrophy. J Cell Biochem. 2012;113:3446-54 pubmed publisher
Donia M, Mangano K, Fagone P, De Pasquale R, Dinotta F, Coco M, et al. Unique antineoplastic profile of Saquinavir-NO, a novel NO-derivative of the protease inhibitor Saquinavir, on the in vitro and in vivo tumor formation of A375 human melanoma cells. Oncol Rep. 2012;28:682-8 pubmed publisher
Stefanidou M, Herrera C, Armanasco N, Shattock R. Saquinavir inhibits early events associated with establishment of HIV-1 infection: potential role for protease inhibitors in prevention. Antimicrob Agents Chemother. 2012;56:4381-90 pubmed publisher
Liang Z. Perspectives on addressing ionization matrix effects in LC-MS bioanalysis. Bioanalysis. 2012;4:1227-34 pubmed publisher
Wang Z, Pal D, Mitra A. Stereoselective evasion of P-glycoprotein, cytochrome P450 3A, and hydrolases by peptide prodrug modification of saquinavir. J Pharm Sci. 2012;101:3199-213 pubmed publisher
Ramana L, Sharma S, Sethuraman S, Ranga U, Krishnan U. Investigation on the stability of saquinavir loaded liposomes: implication on stealth, release characteristics and cytotoxicity. Int J Pharm. 2012;431:120-9 pubmed publisher
Palefsky J. HIV protease inhibitors to prevent progression of cervical intraepithelial neoplasia to cervical cancer: therapeutic opportunities and challenges. AIDS. 2012;26:1035-6 pubmed publisher
Wenderfer S. Can inhibition of proteasomes or NF-kappaB help control idiopathic nephrotic syndrome?. Nephrol Dial Transplant. 2012;27:1698-701 pubmed publisher
Davis D, Soule E, Davidoff K, Daniels S, Naiman N, Yarchoan R. Activity of human immunodeficiency virus type 1 protease inhibitors against the initial autocleavage in Gag-Pol polyprotein processing. Antimicrob Agents Chemother. 2012;56:3620-8 pubmed publisher
Coppo R, Camilla R, Porcellini M, Peruzzi L, Gianoglio B, Amore A, et al. Saquinavir in steroid-dependent and -resistant nephrotic syndrome: a pilot study. Nephrol Dial Transplant. 2012;27:1902-10 pubmed publisher
Maksimovic Ivanic D, Stosic Grujicic S, Nicoletti F, Mijatovic S. Resistance to TRAIL and how to surmount it. Immunol Res. 2012;52:157-68 pubmed publisher
Mojic M, Mijatovic S, Maksimovic Ivanic D, Dinić S, Grdovic N, Miljkovic D, et al. Saquinavir-NO-targeted S6 protein mediates sensitivity of androgen-dependent prostate cancer cells to TRAIL. Cell Cycle. 2012;11:1174-82 pubmed publisher
Martin R, Butterworth A, Gardiner D, Kirk K, McCarthy J, Skinner Adams T. Saquinavir inhibits the malaria parasite's chloroquine resistance transporter. Antimicrob Agents Chemother. 2012;56:2283-9 pubmed publisher
Manente L, Lucariello A, Costanzo C, Viglietti R, Parrella G, Parrella R, et al. Suppression of pre adipocyte differentiation and promotion of adipocyte death by anti-HIV drugs. In Vivo. 2012;26:287-91 pubmed
product information
Catalog Number :
S8451
Product Name :
Saquinavir mesylate
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC), powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA