This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
SB 203580
catalog :
S8307
citations: 110
Reference
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Huang Y, Sun M, Yang X, Ma A, Ma Y, Zhao A. Baicalin relieves inflammation stimulated by lipopolysaccharide via upregulating TUG1 in liver cells. J Physiol Biochem. 2019;75:463-473 pubmed publisher
Chistyakov D, Azbukina N, Astakhova A, Polozhintsev A, Sergeeva M, Reiser G. Toll-like receptors control p38 and JNK MAPK signaling pathways in rat astrocytes differently, when cultured in normal or high glucose concentrations. Neurochem Int. 2019;131:104513 pubmed publisher
Nagashima H, Mahlakõiv T, Shih H, Davis F, Meylan F, Huang Y, et al. Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation. Immunity. 2019;51:682-695.e6 pubmed publisher
Tsai T, Lin J, Lin Y, Chou K, Chen H, Ho C, et al. Cisplatin contributes to programmed death-ligand 1 expression in bladder cancer through ERK1/2-AP-1 signaling pathway. Biosci Rep. 2019;39: pubmed publisher
He G, Xu W, Liao H, Jiang C, Li C, Zhang W. Silencing Huwe1 reduces apoptosis of cortical neurons exposed to oxygen-glucose deprivation and reperfusion. Neural Regen Res. 2019;14:1977-1985 pubmed publisher
Zhong Y, Huang Y, Hu Y, Xu M, Zhu L, Deng Z. SFKs/p38 Pathway is Involved in Radicular Pain by Promoting Spinal Expression of Pro-Inflammatory Cytokines in a Rat Model of Lumbar Disc Herniation. Spine (Phila Pa 1976). 2019;44:E1112-E1121 pubmed publisher
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Wang H, Cheng X, Zhang L, Xu S, Zhang Q, Lu R. A surface-layer protein from Lactobacillus acidophilus NCFM induces autophagic death in HCT116 cells requiring ROS-mediated modulation of mTOR and JNK signaling pathways. Food Funct. 2019;: pubmed publisher
Cheng M, Yang L, Fan M, An S, Li J. Proatherogenic stimuli induce HuR in atherosclerosis through MAPK/ErK pathway. Am J Transl Res. 2019;11:2317-2327 pubmed
Yan Y, Yu H, Sun L, Liu H, Wang C, Wei X, et al. Laminin α4 overexpression in the anterior lens capsule may contribute to the senescence of human lens epithelial cells in age-related cataract. Aging (Albany NY). 2019;11:2699-2723 pubmed publisher
Yamaguchi Ueda K, Akazawa Y, Kawarabayashi K, Sugimoto A, Nakagawa H, Miyazaki A, et al. Combination of ions promotes cell migration via extracellular signal‑regulated kinase 1/2 signaling pathway in human gingival fibroblasts. Mol Med Rep. 2019;19:5039-5045 pubmed publisher
Rosina M, Langone F, Giuliani G, Cerquone Perpetuini A, Reggio A, Calderone A, et al. Osteogenic differentiation of skeletal muscle progenitor cells is activated by the DNA damage response. Sci Rep. 2019;9:5447 pubmed publisher
Liu J, Wu C, Li X, Yan Q, Reaney M, Jiang Z. Xylose rich heteroglycan from flaxseed gum mediates the immunostimulatory effects on macrophages via TLR2 activation. Carbohydr Polym. 2019;213:59-69 pubmed publisher
Santra T, Herrero A, Rodriguez J, von Kriegsheim A, Iglesias Martinez L, Schwarzl T, et al. An Integrated Global Analysis of Compartmentalized HRAS Signaling. Cell Rep. 2019;26:3100-3115.e7 pubmed publisher
Graziani F, Pinton P, Olleik H, Pujol A, Nicoletti C, Sicre M, et al. Deoxynivalenol inhibits the expression of trefoil factors (TFF) by intestinal human and porcine goblet cells. Arch Toxicol. 2019;93:1039-1049 pubmed publisher
Fiedler L, Chapman K, Xie M, Maifoshie E, Jenkins M, Golforoush P, et al. MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo. Cell Stem Cell. 2019;24:579-591.e12 pubmed publisher
Park A, Koh H. NF-κB/mTOR-mediated autophagy can regulate diquat-induced apoptosis. Arch Toxicol. 2019;93:1239-1253 pubmed publisher
Ku K, Choi N, Oh S, Kim W, Suh W, Sung J. Src inhibition induces melanogenesis in human G361 cells. Mol Med Rep. 2019;19:3061-3070 pubmed publisher
Wang L, Zhou Y, Chen Z, Sun L, Wu J, Li H, et al. PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1. Nat Commun. 2019;10:746 pubmed publisher
Li L, Ning G, Yang S, Yan Y, Cao Y, Wang Q. BMP signaling is required for nkx2.3-positive pharyngeal pouch progenitor specification in zebrafish. PLoS Genet. 2019;15:e1007996 pubmed publisher
Kim J, Pajarillo E, Rizor A, Son D, Lee J, Aschner M, et al. LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. PLoS ONE. 2019;14:e0210248 pubmed publisher
Chandra S, Fulton D, Caldwell R, Caldwell R, Toque H. Hyperglycemia-impaired aortic vasorelaxation mediated through arginase elevation: Role of stress kinase pathways. Eur J Pharmacol. 2019;844:26-37 pubmed publisher
Ge D, Gao J, Han L, Li Y, Liu H, Yang W, et al. Novel effects of sphingosylphosphorylcholine on the apoptosis of breast cancer via autophagy/AKT/p38 and JNK signaling. J Cell Physiol. 2019;234:11451-11462 pubmed publisher
Chatterjee B, Ghosh K, Suresh L, Kanade S. Curcumin ameliorates PRMT5-MEP50 arginine methyltransferase expression by decreasing the Sp1 and NF-YA transcription factors in the A549 and MCF-7 cells. Mol Cell Biochem. 2019;455:73-90 pubmed publisher
Ung T, Nguyen T, Lian S, Li S, Xia Y, Kim N, et al. Nicotine stimulates IL-6 expression by activating the AP-1 and STAT-3 pathways in human endothelial EA.hy926 cells. J Cell Biochem. 2019;120:5531-5541 pubmed publisher
Kjelgaard Petersen C, Sharma N, Kayed A, Karsdal M, Mobasheri A, Hägglund P, et al. Tofacitinib and TPCA-1 exert chondroprotective effects on extracellular matrix turnover in bovine articular cartilage ex vivo. Biochem Pharmacol. 2019;165:91-98 pubmed publisher
Giannattasio S, Megiorni F, Di Nisio V, Del Fattore A, Fontanella R, Camero S, et al. Testosterone-mediated activation of androgenic signalling sustains in vitro the transformed and radioresistant phenotype of rhabdomyosarcoma cell lines. J Endocrinol Invest. 2019;42:183-197 pubmed publisher
Chen X, Du Y, Liu Y, He Y, Zhang G, Yang C, et al. Hyaluronan arrests human breast cancer cell growth by prolonging the G0/G1 phase of the cell cycle. Acta Biochim Biophys Sin (Shanghai). 2018;50:1181-1189 pubmed publisher
Guan L, Ji Y, Liu J, Kong M, Sun Z, Shen X, et al. Diazoxide induces endoplasmic reticulum stress-related neuroprotection mediated by p38 MAPK against Aβ25-35 insults. Eur Rev Med Pharmacol Sci. 2018;22:6133-6138 pubmed publisher
Grimsey N, Narala R, Rada C, Mehta S, Stephens B, Kufareva I, et al. A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling. Cell Rep. 2018;24:3312-3323.e5 pubmed publisher
Choi J, Jang A, Kim D, Park M, Lim S, Kim M, et al. PRMT1 mediates RANKL-induced osteoclastogenesis and contributes to bone loss in ovariectomized mice. Exp Mol Med. 2018;50:111 pubmed publisher
Eryilmaz I, Guney Eskiler G, Egeli U, Yurdacan B, Cecener G, Tunca B. In vitro cytotoxic and antiproliferative effects of usnic acid on hormone-dependent breast and prostate cancer cells. J Biochem Mol Toxicol. 2018;32:e22208 pubmed publisher
Yu J, Francisco A, Patel B, Cline J, Zou E, Berga S, et al. IL-1? Stimulates Brain-Derived Neurotrophic Factor Production in Eutopic Endometriosis Stromal Cell Cultures: A Model for Cytokine Regulation of Neuroangiogenesis. Am J Pathol. 2018;188:2281-2292 pubmed publisher
Zhou Y, Zhou J, Lu X, Tan T, Chng W. BET Bromodomain inhibition promotes De-repression of TXNIP and activation of ASK1-MAPK pathway in acute myeloid leukemia. BMC Cancer. 2018;18:731 pubmed publisher
Liu Y, Wang N, Zhang S, Liang Q. Autophagy protects bone marrow mesenchymal stem cells from palmitate‑induced apoptosis through the ROS‑JNK/p38 MAPK signaling pathways. Mol Med Rep. 2018;18:1485-1494 pubmed publisher
Astakhova A, Chistyakov D, Sergeeva M, Reiser G. Regulation of the ARE-binding proteins, TTP (tristetraprolin) and HuR (human antigen R), in inflammatory response in astrocytes. Neurochem Int. 2018;118:82-90 pubmed publisher
Irazoqui A, De Genaro P, Buitrago C, Bachmann H, Gonzalez Pardo V, Russo de Boland A. 1?,25(OH)2D3-glycosides from Solanum glaucophyllum leaves extract induce myoblasts differentiation through p38 MAPK and AKT activation. Biol Open. 2018;7: pubmed publisher
Dong Y, Wu Z, He M, Chen Y, Chen Y, Shen X, et al. ADAM9 mediates the interleukin-6-induced Epithelial-Mesenchymal transition and metastasis through ROS production in hepatoma cells. Cancer Lett. 2018;421:1-14 pubmed publisher
Park J, Kim H, Lim D, Kim J, Park W, Park S. Ethanol Extract of Lycopodium serratum Thunb. Attenuates Lipopolysaccharide-Induced C6 Glioma Cells Migration via Matrix Metalloproteinase-9 Expression. Chin J Integr Med. 2018;24:860-866 pubmed publisher
Hoa N, Ge L, Korach K, Levin E. Estrogen receptor beta maintains expression of KLF15 to prevent cardiac myocyte hypertrophy in female rodents. Mol Cell Endocrinol. 2018;470:240-250 pubmed publisher
Zhang W, Liu Y, Zhang X, Lin L, Yin S. The role of ?-adrenergic receptors and p38MAPK signaling pathways in physiological processes of cardiosphere-derived cells. J Cell Biochem. 2018;119:1204-1214 pubmed publisher
Shan Z, Liu X, Chen Y, Wang M, Gao Y, Xu L, et al. Chitinase 3-like-1 Promotes Intrahepatic Activation of Coagulation Through Induction of Tissue Factor in Mice. Hepatology. 2017;: pubmed publisher
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van den Akker G, van Beuningen H, Vitters E, Koenders M, van de Loo F, van Lent P, et al. Interleukin 1 β-induced SMAD2/3 linker modifications are TAK1 dependent and delay TGFβ signaling in primary human mesenchymal stem cells. Cell Signal. 2017;40:190-199 pubmed publisher
Yu J, Berga S, Zou W, Yook D, Pan J, Andrade A, et al. IL-1β Inhibits Connexin 43 and Disrupts Decidualization of Human Endometrial Stromal Cells Through ERK1/2 and p38 MAP Kinase. Endocrinology. 2017;158:4270-4285 pubmed publisher
Yang Y, Liu S, Zhang R, Luo H, Chen L, He W, et al. Association Between C1q/TNF-Related Protein-1 Levels in Human Plasma and Epicardial Adipose Tissues and Congestive Heart Failure. Cell Physiol Biochem. 2017;42:2130-2143 pubmed publisher
Sheng X, Tu H, Chien W, Kang K, Lu D, Liou H, et al. Antagonism of proteasome inhibitor-induced heme oxygenase-1 expression by PINK1 mutation. PLoS ONE. 2017;12:e0183076 pubmed publisher
Lakshminarasimhan H, Coughlin B, Darr A, Byrne J. Characterization and reversal of Doxorubicin-mediated biphasic activation of ERK and persistent excitability in sensory neurons of Aplysia californica. Sci Rep. 2017;7:4533 pubmed publisher
Xu Z, Liao B, Zhang R, Sh R, Wang L. Pretreatment with bacterial components promotes DSS-injured colonic epithelial repair through the activation of STAT-3. Mol Med Rep. 2017;16:2247-2253 pubmed publisher
Wang J, Kho D, Zhou J, Davis R, Wu G. MKP-1 suppresses PARP-1 degradation to mediate cisplatin resistance. Oncogene. 2017;36:5939-5947 pubmed publisher
Chen H, Tang X, Zhou B, Zhou Z, Xu N, Wang Y. A ROS-mediated mitochondrial pathway and Nrf2 pathway activation are involved in BDE-47 induced apoptosis in Neuro-2a cells. Chemosphere. 2017;184:679-686 pubmed publisher
Yu Y, Zhang Y, Zhang Y, Lai Y, Chen W, Xiao Z, et al. LL-37-induced human mast cell activation through G protein-coupled receptor MrgX2. Int Immunopharmacol. 2017;49:6-12 pubmed publisher
Zhao B, Hu M, Wu H, Ren C, Wang J, Cui S. Tenascin-C expression and its associated pathway in BMSCs following co-culture with mechanically stretched ligament fibroblasts. Mol Med Rep. 2017;15:2465-2472 pubmed publisher
Landeros R, Jobe S, Aranda Pino G, Lopez G, Zheng J, Magness R. Convergent ERK1/2, p38 and JNK mitogen activated protein kinases (MAPKs) signalling mediate catecholoestradiol-induced proliferation of ovine uterine artery endothelial cells. J Physiol. 2017;595:4663-4676 pubmed publisher
Calvo N, Carriere P, Martín M, Gentili C. RSK activation via ERK modulates human colon cancer cells response to PTHrP. J Mol Endocrinol. 2017;59:13-27 pubmed publisher
Fettweis G, Di Valentin E, L homme L, Lassence C, Dequiedt F, Fillet M, et al. RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death. Biochim Biophys Acta Mol Cell Res. 2017;1864:113-124 pubmed publisher
Sun L, Pham T, Cornell T, McDonough K, McHugh W, Blatt N, et al. Myeloid-Specific Gene Deletion of Protein Phosphatase 2A Magnifies MyD88- and TRIF-Dependent Inflammation following Endotoxin Challenge. J Immunol. 2017;198:404-416 pubmed
Jiang Y, Zeng Y, Huang X, Qin Y, Luo W, Xiang S, et al. Nur77 attenuates endothelin-1 expression via downregulation of NF-κB and p38 MAPK in A549 cells and in an ARDS rat model. Am J Physiol Lung Cell Mol Physiol. 2016;311:L1023-L1035 pubmed publisher
Sikora A, Hellec C, Carpentier M, Martinez P, Delos M, Denys A, et al. Tumour-necrosis factor-? induces heparan sulfate 6-O-endosulfatase 1 (Sulf-1) expression in fibroblasts. Int J Biochem Cell Biol. 2016;80:57-65 pubmed publisher
Bruns B, Hönle T, Kellermann P, Ayala A, Perl M. Divergent Effects of Neutrophils on Fas-Induced Pulmonary Inflammation, Apoptosis, and Lung Damage. Shock. 2017;47:225-235 pubmed publisher
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Lee J, Paik J, Yun M, Lee S, Yang S. The Effect of (-)-Epigallocatechin-3-Gallate on IL-1β Induced IL-8 Expression in Orbital Fibroblast from Patients with Thyroid-Associated Ophthalmopathy. PLoS ONE. 2016;11:e0148645 pubmed publisher
Nassour J, Martien S, Martin N, Deruy E, Tomellini E, Malaquin N, et al. Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells. Nat Commun. 2016;7:10399 pubmed publisher
Park J, Ko J, Hwang J, Koh H. Dynamin-related protein 1 mediates mitochondria-dependent apoptosis in chlorpyrifos-treated SH-SY5Y cells. Neurotoxicology. 2015;51:145-57 pubmed publisher
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Polettini J, Behnia F, Taylor B, Saade G, Taylor R, Menon R. Telomere Fragment Induced Amnion Cell Senescence: A Contributor to Parturition?. PLoS ONE. 2015;10:e0137188 pubmed publisher
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Wu P, Yen J, Kou M, Wu M. Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells. PLoS ONE. 2015;10:e0130599 pubmed publisher
Wang H, Hsu S, Lee W. Extra-Nuclear Signaling Pathway Involved in Progesterone-Induced Up-Regulations of p21cip1 and p27kip1 in Male Rat Aortic Smooth Muscle Cells. PLoS ONE. 2015;10:e0125903 pubmed publisher
Muñoz Caro T, Mena Huertas S, Conejeros I, Alarcón P, Hidalgo M, Burgos R, et al. Eimeria bovis-triggered neutrophil extracellular trap formation is CD11b-, ERK 1/2-, p38 MAP kinase- and SOCE-dependent. Vet Res. 2015;46:23 pubmed publisher
He J, Li Y. Ginsenoside Rg1 downregulates the shear stress induced MCP-1 expression by inhibiting MAPK signaling pathway. Am J Chin Med. 2015;43:305-17 pubmed publisher
Dan J, Sun X, Li W, Zhang Y, Li X, Xu H, et al. 5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Promotes Phenotypic Switching from Dedifferentiated to Differentiated Phenotype via Reactive Oxygen Species and p38 Mitogen-Activated Protein Kinase in Vascular Smooth Muscle Cells. Ultrasound Med Biol. 2015;41:1681-9 pubmed publisher
Liu M, Yang J, Xing X, Cui X, Li M. Interleukin-17A promotes functional activation of systemic sclerosis patient-derived dermal vascular smooth muscle cells by extracellular-regulated protein kinases signalling pathway. Arthritis Res Ther. 2014;16:4223 pubmed publisher
Silveira A, Faheina Martins G, Maia R, Araujo D. Compound A398, a novel podophyllotoxin analogue: cytotoxicity and induction of apoptosis in human leukemia cells. PLoS ONE. 2014;9:e107404 pubmed publisher
Wales S, Hashemi S, Blais A, McDermott J. Global MEF2 target gene analysis in cardiac and skeletal muscle reveals novel regulation of DUSP6 by p38MAPK-MEF2 signaling. Nucleic Acids Res. 2014;42:11349-62 pubmed publisher
Zhang C, Fang E, Zhang H, Liu L, Yun J. Momordica charantia lectin exhibits antitumor activity towards hepatocellular carcinoma. Invest New Drugs. 2015;33:1-11 pubmed publisher
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Chen G, Park C, Xie R, Berta T, Nedergaard M, Ji R. Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice. Brain. 2014;137:2193-209 pubmed publisher
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product information
Catalog Number :
S8307
Product Name :
SB 203580
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
solid, ≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA