Kang X, Li C, Xie X, Zhan K, Yang S, Tang Y, et al. Hydrogen Sulfide Inhibits Homocysteine-Induced Neuronal Senescence by Up-Regulation of SIRT1. Int J Med Sci. 2020;17:310-319 pubmed publisher

Luo J, He T, Yang J, Yang N, Li Z, Xing Y. SIRT1 is required for the neuroprotection of resveratrol on retinal ganglion cells after retinal ischemia-reperfusion injury in mice. Graefes Arch Clin Exp Ophthalmol. 2020;258:335-344 pubmed publisher

Yu X, Hu Y, Huang W, Ye N, Yan Q, Ni W, et al. Role of AMPK/SIRT1-SIRT3 signaling pathway in affective disorders in unpredictable chronic mild stress mice. Neuropharmacology. 2020;165:107925 pubmed publisher

Ma J, Sun Y, Ming Q, Tian Z, Yang H, Liu C. Ampelopsin attenuates carbon tetrachloride-induced mouse liver fibrosis and hepatic stellate cell activation associated with the SIRT1/TGF-β1/Smad3 and autophagy pathway. Int Immunopharmacol. 2019;77:105984 pubmed publisher

Jeong H, Shin S, Lee J, Lee S, Baik J, Lim S, et al. Pan-HDAC Inhibitors Promote Tau Aggregation by Increasing the Level of Acetylated Tau. Int J Mol Sci. 2019;20: pubmed publisher

Yang K, Lauritzen K, Olsen M, Dahl T, Ranheim T, Ahmed M, et al. Low Cellular NAD+ Compromises Lipopolysaccharide-Induced Inflammatory Responses via Inhibiting TLR4 Signal Transduction in Human Monocytes. J Immunol. 2019;203:1598-1608 pubmed publisher

Sirri V, Grob A, Berthelet J, Jourdan N, Roussel P. Sirtuin 7 promotes 45S pre-rRNA cleavage at site 2 and determines the processing pathway. J Cell Sci. 2019;132: pubmed publisher

Hackett B, Dittmar M, Segrist E, Pittenger N, To J, Griesman T, et al. Sirtuin Inhibitors Are Broadly Antiviral against Arboviruses. MBio. 2019;10: pubmed publisher

Stowers R, Shcherbina A, Israeli J, Gruber J, Chang J, Nam S, et al. Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility. Nat Biomed Eng. 2019;3:1009-1019 pubmed publisher

Zhang Y, Cui G, Wang Y, Gong Y, Wang Y. SIRT1 activation alleviates brain microvascular endothelial dysfunction in peroxisomal disorders. Int J Mol Med. 2019;44:995-1005 pubmed publisher

Zhao J, Wozniak A, Adams A, Cox J, Vittal A, Voss J, et al. SIRT7 regulates hepatocellular carcinoma response to therapy by altering the p53-dependent cell death pathway. J Exp Clin Cancer Res. 2019;38:252 pubmed publisher

Nham G, Zhang X, Asou Y, Shinomura T. Expression of type II collagen and aggrecan genes is regulated through distinct epigenetic modifications of their multiple enhancer elements. Gene. 2019;704:134-141 pubmed publisher

Saeed M, Rahama M, Kuete V, Dawood M, Elbadawi M, Sugimoto Y, et al. Collateral sensitivity of drug-resistant ABCB5- and mutation-activated EGFR overexpressing cells towards resveratrol due to modulation of SIRT1 expression. Phytomedicine. 2019;59:152890 pubmed publisher

Roy S, Saha S, Gupta P, Ukil A, Das P. Crosstalk of PD-1 signaling with the SIRT1/FOXO-1 axis during the progression of visceral leishmaniasis. J Cell Sci. 2019;132: pubmed publisher

Han Y, Jin S, Lee G, Choi J, Lee H, Chung Y, et al. Stimulatory effects of platycodin D on osteoblast differentiation. J Cell Biochem. 2019;120:13085-13094 pubmed publisher

Gonçalves R, Agnes J, Delgobo M, de Souza P, Thomé M, Heimfarth L, et al. Late autophagy inhibitor chloroquine improves efficacy of the histone deacetylase inhibitor SAHA and temozolomide in gliomas. Biochem Pharmacol. 2019;163:440-450 pubmed publisher

Yadav S, Stojkov D, Feigelson S, Roncato F, Simon H, Yousefi S, et al. Chemokine-triggered microtubule polymerization promotes neutrophil chemotaxis and invasion but not transendothelial migration. J Leukoc Biol. 2019;105:755-766 pubmed publisher

Di Emidio G, Santini S, D Alessandro A, Vetuschi A, Sferra R, Artini P, et al. SIRT1 participates in the response to methylglyoxal-dependent glycative stress in mouse oocytes and ovary. Biochim Biophys Acta Mol Basis Dis. 2019;1865:1389-1401 pubmed publisher

El Hayek L, Khalifeh M, Zibara V, Abi Assaad R, Emmanuel N, Karnib N, et al. Lactate Mediates the Effects of Exercise on Learning and Memory through SIRT1-Dependent Activation of Hippocampal Brain-Derived Neurotrophic Factor (BDNF). J Neurosci. 2019;39:2369-2382 pubmed publisher

Potenza M, Sgarra L, Nacci C, Leo V, De Salvia M, Montagnani M. Activation of AMPK/SIRT1 axis is required for adiponectin-mediated preconditioning on myocardial ischemia-reperfusion (I/R) injury in rats. PLoS ONE. 2019;14:e0210654 pubmed publisher

Ryu D, Yu M, Kong K, Kim H, Kwon S, Jeon J, et al. Sirt1-hypoxia-inducible factor-1α interaction is a key mediator of tubulointerstitial damage in the aged kidney. Aging Cell. 2019;:e12904 pubmed publisher

Chen S, Tang Q, Wang Y, Xu Z, Chen S, Sun Y, et al. Evidence of metabolic memory-induced neurodegeneration and the therapeutic effects of glucagon-like peptide-1 receptor agonists via Forkhead box class O. Biochim Biophys Acta Mol Basis Dis. 2018;1865:371-377 pubmed publisher

Tae I, Park E, Dey P, Son J, Lee S, Jung J, et al. Novel SIRT1 inhibitor 15-deoxy-Δ12,14-prostaglandin J2 and its derivatives exhibit anticancer activity through apoptotic or autophagic cell death pathways in SKOV3 cells. Int J Oncol. 2018;53:2518-2530 pubmed publisher

Roh E, Park J, Kang G, Lee C, Dugu H, Gil S, et al. Exogenous nicotinamide adenine dinucleotide regulates energy metabolism via hypothalamic connexin 43. Metabolism. 2018;88:51-60 pubmed publisher

Peng Y, He P, Fan L, Xu H, Li J, Chen T, et al. Neuroprotective Effects of Magnesium Lithospermate B against Subarachnoid Hemorrhage in Rats. Am J Chin Med. 2018;46:1225-1241 pubmed publisher

Kudo H, Takeichi O, Makino K, Hatori K, Ogiso B. Expression of silent information regulator 2 homolog 1 (SIRT1) in periapical granulomas. J Oral Sci. 2018;60:411-417 pubmed publisher

Chen X, Yan J, He F, Zhong D, Yang H, Pei M, et al. Mechanical stretch induces antioxidant responses and osteogenic differentiation in human mesenchymal stem cells through activation of the AMPK-SIRT1 signaling pathway. Free Radic Biol Med. 2018;126:187-201 pubmed publisher

Ma W, Zhao X, Wang K, Liu J, Huang G. Dichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer. Cancer Biol Ther. 2018;19:835-846 pubmed publisher

Wu B, Feng J, Yu L, Wang Y, Chen Y, Wei Y, et al. Icariin protects cardiomyocytes against ischaemia/reperfusion injury by attenuating sirtuin 1-dependent mitochondrial oxidative damage. Br J Pharmacol. 2018;175:4137-4153 pubmed publisher

Lu Y, Feng Y, Liu D, Zhang Z, Gao K, Zhang W, et al. Thymoquinone Attenuates Myocardial Ischemia/Reperfusion Injury Through Activation of SIRT1 Signaling. Cell Physiol Biochem. 2018;47:1193-1206 pubmed publisher

Zhou J, Wang F, Ma Y, Wei F. Vitamin D3 contributes to enhanced osteogenic differentiation of MSCs under oxidative stress condition via activating the endogenous antioxidant system. Osteoporos Int. 2018;29:1917-1926 pubmed publisher

So D, Shin H, Kim J, Lee M, Myeong J, Chun Y, et al. Cervical cancer is addicted to SIRT1 disarming the AIM2 antiviral defense. Oncogene. 2018;37:5191-5204 pubmed publisher

Kim M, Cho H, Yoon H, Ahn Y, Park E, Jin Y, et al. JIB-04, A Small Molecule Histone Demethylase Inhibitor, Selectively Targets Colorectal Cancer Stem Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway. Sci Rep. 2018;8:6611 pubmed publisher

Jang B, Choi B, Kim S, Lee J, Kim M. Trichostatin A and Sirtinol Regulate the Expression and Nucleocytoplasmic Shuttling of Histone Deacetylases in All-Trans Retinoic Acid-Induced Differentiation of Neuroblastoma Cells. J Mol Neurosci. 2018;64:501-511 pubmed publisher

He X, Huang C, Xie B. Autophagy inhibition enhanced 5‑FU‑induced cell death in human gastric carcinoma BGC‑823 cells. Mol Med Rep. 2018;17:6768-6776 pubmed publisher

Xu L, Jia L, Wang Q, Hou J, Li S, Teng J. Salidroside attenuates hypoxia/reoxygenation-induced human brain vascular smooth muscle cell injury by activating the SIRT1/FOXO3α pathway. Exp Ther Med. 2018;15:822-830 pubmed publisher

Song N, Lee Y, Na H, Baek J, Surh Y. Leptin induces SIRT1 expression through activation of NF-E2-related factor 2: Implications for obesity-associated colon carcinogenesis. Biochem Pharmacol. 2018;153:282-291 pubmed publisher

Hwang J, Kang E, Han S, Lim D, Paek K, Lee C, et al. Formononetin inhibits lipopolysaccharide-induced release of high mobility group box 1 by upregulating SIRT1 in a PPARδ-dependent manner. Peerj. 2018;6:e4208 pubmed publisher

Bortell N, Basova L, Najera J, Morsey B, Fox H, Marcondes M. Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain. J Neuroimmune Pharmacol. 2018;13:163-178 pubmed publisher

Eriksson M, Hååg P, Brzozowska B, Lipka M, Lisowska H, Lewensohn R, et al. Analysis of Chromatin Opening in Heterochromatic Non-Small Cell Lung Cancer Tumor-Initiating Cells in Relation to DNA-Damaging Antitumor Treatment. Int J Radiat Oncol Biol Phys. 2018;100:174-187 pubmed publisher

Zhang X, Chen J, Sun L, Xu Y. SIRT1 deacetylates KLF4 to activate Claudin-5 transcription in ovarian cancer cells. J Cell Biochem. 2018;119:2418-2426 pubmed publisher

Zarone M, Misso G, Grimaldi A, Zappavigna S, Russo M, Amler E, et al. Evidence of novel miR-34a-based therapeutic approaches for multiple myeloma treatment. Sci Rep. 2017;7:17949 pubmed publisher

Saihara K, Kamikubo R, Ikemoto K, Uchida K, Akagawa M. Pyrroloquinoline Quinone, a Redox-active o-Quinone, Stimulates Mitochondrial Biogenesis by Activating SIRT1/PGC-1? Signaling Pathway. Biochemistry. 2017;: pubmed publisher

Adámková K, Yi Y, Petr J, Žalmanová T, Hošková K, Jelinkova P, et al. SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development. J Anim Sci Biotechnol. 2017;8:83 pubmed publisher

Ye Q, Zhang M, Wang Y, Fu S, Han S, Wang L, et al. Sirtinol regulates the balance of Th17/Treg to prevent allograft rejection. Cell Biosci. 2017;7:55 pubmed publisher

Qian C, Jin J, Chen J, Li J, Yu X, Mo H, et al. SIRT1 activation by resveratrol reduces brain edema and neuronal apoptosis in an experimental rat subarachnoid hemorrhage model. Mol Med Rep. 2017;16:9627-9635 pubmed publisher

Tang F, Guo S, Liao H, Yu P, Wang L, Song X, et al. Resveratrol Enhances Neurite Outgrowth and Synaptogenesis Via Sonic Hedgehog Signaling Following Oxygen-Glucose Deprivation/Reoxygenation Injury. Cell Physiol Biochem. 2017;43:852-869 pubmed publisher

Hu T, Fan X, Ma L, Liu J, Chang Y, Yang P, et al. TIM4-TIM1 interaction modulates Th2 pattern inflammation through enhancing SIRT1 expression. Int J Mol Med. 2017;40:1504-1510 pubmed publisher

Sun L, Zhi Z, Chen L, Zhou Q, Li X, Gan W, et al. SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p. Cancer Lett. 2017;409:104-115 pubmed publisher

Wang S, Wang J, Zhao A, Li J. SIRT1 activation inhibits hyperglycemia-induced apoptosis by reducing oxidative stress and mitochondrial dysfunction in human endothelial cells. Mol Med Rep. 2017;16:3331-3338 pubmed publisher

Mittal N, Muthuswami R, Madhubala R. The mitochondrial SIR2 related protein 2 (SIR2RP2) impacts Leishmania donovani growth and infectivity. PLoS Negl Trop Dis. 2017;11:e0005590 pubmed publisher

Shin J, Lee S. Genipin protects the liver from ischemia/reperfusion injury by modulating mitochondrial quality control. Toxicol Appl Pharmacol. 2017;328:25-33 pubmed publisher

Xing Z, Pan W, Zhang J, Xu X, Zhang X, He X, et al. Hydrogen Rich Water Attenuates Renal Injury and Fibrosis by Regulation Transforming Growth Factor-β Induced Sirt1. Biol Pharm Bull. 2017;40:610-615 pubmed publisher

Puddu F, Salguero I, Herzog M, Geisler N, Costanzo V, Jackson S. Chromatin determinants impart camptothecin sensitivity. EMBO Rep. 2017;18:1000-1012 pubmed publisher

Lin Q, Geng Y, Zhao M, Lin S, Zhu Q, Tian Z. MiR-21 Regulates TNF-α-Induced CD40 Expression via the SIRT1-NF-κB Pathway in Renal Inner Medullary Collecting Duct Cells. Cell Physiol Biochem. 2017;41:124-136 pubmed publisher

Zheng W, Feng Z, You S, Zhang H, Tao Z, Wang Q, et al. Fisetin inhibits IL-1?-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in mice. Int Immunopharmacol. 2017;45:135-147 pubmed publisher

Singh S, Singh A, Yadav S, Gautam V, Singh A, Sarkar A. Sirtinol, a Sir2 protein inhibitor, affects stem cell maintenance and root development in Arabidopsis thaliana by modulating auxin-cytokinin signaling components. Sci Rep. 2017;7:42450 pubmed publisher

Sadeghi A, Seyyed Ebrahimi S, Golestani A, Meshkani R. Resveratrol Ameliorates Palmitate-Induced Inflammation in Skeletal Muscle Cells by Attenuating Oxidative Stress and JNK/NF-κB Pathway in a SIRT1-Independent Mechanism. J Cell Biochem. 2017;118:2654-2663 pubmed publisher

Jablonska B, Gierdalski M, Chew L, Hawley T, Catron M, Lichauco A, et al. Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury. Nat Commun. 2016;7:13866 pubmed publisher

Park S, Kim H, Park H, Shin H, Hong K, Kim C. Concurrent Treatment with Taxifolin and Cilostazol on the Lowering of β-Amyloid Accumulation and Neurotoxicity via the Suppression of P-JAK2/P-STAT3/NF-κB/BACE1 Signaling Pathways. PLoS ONE. 2016;11:e0168286 pubmed publisher

Lin Q, Geng Y, Jiang Z, Tian Z. SIRT1 regulates lipopolysaccharide-induced CD40 expression in renal medullary collecting duct cells by suppressing the TLR4-NF-?B signaling pathway. Life Sci. 2017;170:100-107 pubmed publisher

Hwang J, Ham S, Yoo T, Lee W, Paek K, Kim J, et al. Upregulation of MKP-7 in response to rosiglitazone treatment ameliorates lipopolysaccharide-induced destabilization of SIRT1 by inactivating JNK. Pharmacol Res. 2016;114:47-55 pubmed publisher

Zhang X, Wu Q, Wu L, Ye Z, Jiang T, Li W, et al. Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats. Cell Death Dis. 2016;7:e2416 pubmed publisher

Feng J, Li S, Chen H. Tanshinone IIA inhibits myocardial remodeling induced by pressure overload via suppressing oxidative stress and inflammation: Possible role of silent information regulator 1. Eur J Pharmacol. 2016;791:632-639 pubmed publisher

Li Z, Bridges B, Olson J, Weinman S. The interaction between acetylation and serine-574 phosphorylation regulates the apoptotic function of FOXO3. Oncogene. 2017;36:1887-1898 pubmed publisher

Barjaktarovic Z, Merl Pham J, Azimzadeh O, Kempf S, Raj K, Atkinson M, et al. Low-dose radiation differentially regulates protein acetylation and histone deacetylase expression in human coronary artery endothelial cells. Int J Radiat Biol. 2017;93:156-164 pubmed publisher

Hwang J, Ham S, Yoo T, Lee W, Paek K, Lee C, et al. Sirtuin 1 Mediates the Actions of Peroxisome Proliferator-Activated Receptor ? on the Oxidized Low-Density Lipoprotein-Triggered Migration and Proliferation of Vascular Smooth Muscle Cells. Mol Pharmacol. 2016;90:522-529 pubmed

Bhalla S, Gordon L. Functional characterization of NAD dependent de-acetylases SIRT1 and SIRT2 in B-Cell Chronic Lymphocytic Leukemia (CLL). Cancer Biol Ther. 2016;17:300-9 pubmed publisher

Peleg S, Feller C, Forne I, Schiller E, Sévin D, Schauer T, et al. Life span extension by targeting a link between metabolism and histone acetylation in Drosophila. EMBO Rep. 2016;17:455-69 pubmed publisher

Han C, Srivastava A, Cui T, Wang Q, Wani A. Differential DNA lesion formation and repair in heterochromatin and euchromatin. Carcinogenesis. 2016;37:129-38 pubmed publisher

Akiyoshi T, Ota H, Iijima K, Son B, Kahyo T, Setou M, et al. A novel organ culture model of aorta for vascular calcification. Atherosclerosis. 2016;244:51-8 pubmed publisher

Ramírez Espinosa J, González Dávalos L, Shimada A, Piña E, Varela Echavarria A, Mora O. Bovine (Bos taurus) Bone Marrow Mesenchymal Cell Differentiation to Adipogenic and Myogenic Lineages. Cells Tissues Organs. 2016;201:51-64 pubmed publisher

Stoney P, Helfer G, Rodrigues D, Morgan P, McCaffery P. Thyroid hormone activation of retinoic acid synthesis in hypothalamic tanycytes. Glia. 2016;64:425-39 pubmed publisher

Kim E, Wang B, Sastry N, Masliah E, Nelson P, Cai H, et al. NEDD4-mediated HSF1 degradation underlies α-synucleinopathy. Hum Mol Genet. 2016;25:211-22 pubmed publisher

Kim M, Lim S, Lee H, Kim S, Nho C. Gomisin J Inhibits Oleic Acid-Induced Hepatic Lipogenesis by Activation of the AMPK-Dependent Pathway and Inhibition of the Hepatokine Fetuin-A in HepG2 Cells. J Agric Food Chem. 2015;63:9729-39 pubmed publisher

Zhang Y, Wei W, Li L, Tu G, Zhang Y, Yang J, et al. Sirt1 and HMGB1 Regulate the AGE-Induced Pro-Inflammatory Cytokines in Human Retinal Cells. Clin Lab. 2015;61:999-1008 pubmed

Marampon F, Gravina G, Festuccia C, Popov V, Colapietro E, Sanità P, et al. Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SirT1 axis. J Endocrinol Invest. 2016;39:411-22 pubmed publisher

Paradis F, Hales B. The Effects of Class-Specific Histone Deacetylase Inhibitors on the Development of Limbs During Organogenesis. Toxicol Sci. 2015;148:220-8 pubmed publisher

Santolla M, Avino S, Pellegrino M, De Francesco E, De Marco P, Lappano R, et al. SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer. Cell Death Dis. 2015;6:e1834 pubmed publisher

Zhang L, Ma R, Hu J, Ding X, Xu Y. Sirtuin Inhibition Adversely Affects Porcine Oocyte Meiosis. PLoS ONE. 2015;10:e0132941 pubmed publisher

Amadio P, Baldassarre D, Tarantino E, Zacchi E, Gianellini S, Squellerio I, et al. Production of prostaglandin E2 induced by cigarette smoke modulates tissue factor expression and activity in endothelial cells. FASEB J. 2015;29:4001-10 pubmed publisher

Tang H, Gao W, Chan C, Cheng Y, Deng J, Yuen K, et al. SIRT1 Suppresses Human T-Cell Leukemia Virus Type 1 Transcription. J Virol. 2015;89:8623-31 pubmed publisher

Scherzberg M, Kiehl A, Zivkovic A, Stark H, Stein J, Fürst R, et al. Structural modification of resveratrol leads to increased anti-tumor activity, but causes profound changes in the mode of action. Toxicol Appl Pharmacol. 2015;287:67-76 pubmed publisher

Zhou L, Chen X, Liu T, Gong Y, Chen S, Pan G, et al. Melatonin reverses H2 O2 -induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway. J Pineal Res. 2015;59:190-205 pubmed publisher

Ahangari F, Sood A, Ma B, Takyar S, Schuyler M, Qualls C, et al. Chitinase 3-like-1 regulates both visceral fat accumulation and asthma-like Th2 inflammation. Am J Respir Crit Care Med. 2015;191:746-57 pubmed publisher

Qiu J, Zhou Z, He Z, Zhao R, Zhang X, Yang L, et al. Plumbagin elicits differential proteomic responses mainly involving cell cycle, apoptosis, autophagy, and epithelial-to-mesenchymal transition pathways in human prostate cancer PC-3 and DU145 cells. Drug Des Devel Ther. 2015;9:349-417 pubmed publisher

Di Sante G, Wang L, Wang C, Jiao X, Casimiro M, Chen K, et al. Sirt1-deficient mice have hypogonadotropic hypogonadism due to defective GnRH neuronal migration. Mol Endocrinol. 2015;29:200-12 pubmed publisher

Rizk S, El Maraghy S, Nassar N. A novel role for SIRT-1 in L-arginine protection against STZ induced myocardial fibrosis in rats. PLoS ONE. 2014;9:e114560 pubmed publisher

Das B, Dobrowolski C, Shahir A, Feng Z, Yu X, Sha J, et al. Short chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications. Virology. 2015;474:65-81 pubmed publisher

Kim T, Kim H, Kang Y, Yoon S, Lee J, Choi W, et al. Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts. Biochim Biophys Acta. 2015;1850:401-10 pubmed publisher

Chen I, Chiang W, Huang H, Chen P, Shen Y, Chiang H. Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis. Mol Cancer. 2014;13:254 pubmed publisher

Chen H, Ruiz P, Novikov L, Casill A, Park J, Gamble M. MacroH2A1.1 and PARP-1 cooperate to regulate transcription by promoting CBP-mediated H2B acetylation. Nat Struct Mol Biol. 2014;21:981-9 pubmed publisher

Jin T, Kim O, Shin M, Choi E, Lee S, Han Y, et al. Fisetin up-regulates the expression of adiponectin in 3T3-L1 adipocytes via the activation of silent mating type information regulation 2 homologue 1 (SIRT1)-deacetylase and peroxisome proliferator-activated receptors (PPARs). J Agric Food Chem. 2014;62:10468-74 pubmed publisher

Fan Y, Meley D, Pizer B, Sée V. Mir-34a mimics are potential therapeutic agents for p53-mutated and chemo-resistant brain tumour cells. PLoS ONE. 2014;9:e108514 pubmed publisher

Song N, Na H, Baek J, Surh Y. Docosahexaenoic acid inhibits insulin-induced activation of sterol regulatory-element binding protein 1 and cyclooxygenase-2 expression through upregulation of SIRT1 in human colon epithelial cells. Biochem Pharmacol. 2014;92:142-8 pubmed publisher

Zhao L, Du Y, Chen L, Liu Z, Pan Y, Liu J, et al. Quercetin protects against high glucose-induced damage in bone marrow-derived endothelial progenitor cells. Int J Mol Med. 2014;34:1025-31 pubmed publisher

Prud homme G, Glinka Y, Udovyk O, Hasilo C, Paraskevas S, Wang Q. GABA protects pancreatic beta cells against apoptosis by increasing SIRT1 expression and activity. Biochem Biophys Res Commun. 2014;452:649-54 pubmed publisher

Zhu L, Qi J, Chiao C, Zhang Q, Porco J, Faller D, et al. Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities. Int J Oncol. 2014;45:2128-36 pubmed publisher

Guo P, Pi H, Xu S, Zhang L, Li Y, Li M, et al. Melatonin Improves mitochondrial function by promoting MT1/SIRT1/PGC-1 alpha-dependent mitochondrial biogenesis in cadmium-induced hepatotoxicity in vitro. Toxicol Sci. 2014;142:182-95 pubmed publisher

Trocme C, Deffert C, Cachat J, Donati Y, Tissot C, Papacatzis S, et al. Macrophage-specific NOX2 contributes to the development of lung emphysema through modulation of SIRT1/MMP-9 pathways. J Pathol. 2015;235:65-78 pubmed publisher

Kim Y, Hwang J, Kim K, Noh J, Gang G, Seo Y, et al. NAD(P)H:quinone oxidoreductase 1 activation reduces blood pressure through regulation of endothelial nitric oxide synthase acetylation in spontaneously hypertensive rats. Am J Hypertens. 2015;28:50-7 pubmed publisher

Valle C, Salvatori I, Gerbino V, Rossi S, Palamiuc L, Rene F, et al. Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways. Cell Death Dis. 2014;5:e1296 pubmed publisher

Jia Y, Lu J, Huang Y, Liu G, Gao P, Wan Y, et al. The involvement of NFAT transcriptional activity suppression in SIRT1-mediated inhibition of COX-2 expression induced by PMA/Ionomycin. PLoS ONE. 2014;9:e97999 pubmed publisher

Ponnusamy M, Zhou X, Yan Y, Tang J, Tolbert E, Zhao T, et al. Blocking sirtuin 1 and 2 inhibits renal interstitial fibroblast activation and attenuates renal interstitial fibrosis in obstructive nephropathy. J Pharmacol Exp Ther. 2014;350:243-56 pubmed publisher

Pérez Estrada C, Covacu R, Sankavaram S, Svensson M, Brundin L. Oxidative stress increases neurogenesis and oligodendrogenesis in adult neural progenitor cells. Stem Cells Dev. 2014;23:2311-27 pubmed publisher

Shalwala M, Zhu S, Das A, Salloum F, Xi L, Kukreja R. Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice. PLoS ONE. 2014;9:e86977 pubmed publisher

Bae H, Noh J, Kim J, Eun J, Jung K, Kim M, et al. MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma. Oncogene. 2014;33:2557-67 pubmed publisher

Orecchia A, Scarponi C, Di Felice F, Cesarini E, Avitabile S, Mai A, et al. Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cells. PLoS ONE. 2011;6:e24307 pubmed publisher

Vinciguerra M, Santini M, Claycomb W, Ladurner A, Rosenthal N. Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity. Aging (Albany NY). 2009;2:43-62 pubmed

Gracia Sancho J, Villarreal G, Zhang Y, Garcia Cardena G. Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype. Cardiovasc Res. 2010;85:514-9 pubmed publisher

Liu F, Liao C, Chang Y, Liou J, Day Y. A new insight of anti-platelet effects of sirtinol in platelets aggregation via cyclic AMP phosphodiesterase. Biochem Pharmacol. 2009;77:1364-73 pubmed publisher

Finlan L, Sproul D, Thomson I, Boyle S, Kerr E, Perry P, et al. Recruitment to the nuclear periphery can alter expression of genes in human cells. PLoS Genet. 2008;4:e1000039 pubmed publisher

Grozinger C, Chao E, Blackwell H, Moazed D, Schreiber S. Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem. 2001;276:38837-43 pubmed

Mutoh H, Ota S, Hiraishi H, Ivey K, Terano A, Sugimoto T. Reduced glutathione protects cultured gastric mucosal cells from suckling rats against acid. Am J Physiol. 1991;261:G65-70 pubmed