product summary
company name :
MilliporeSigma
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, FLUKA, Sigma-Aldrich, Novabiochem, Guava, Roche Applied Science
product type :
antibody
product name :
Anti-α-Synuclein antibody, Mouse monoclonal
catalog :
S5566
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
syn211
reactivity :
human, mouse
application :
western blot, immunocytochemistry, immunoprecipitation
more info or order :
citations: 37
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 3
Umeda T, Hatanaka Y, Sakai A, Tomiyama T. Nasal Rifampicin Improves Cognition in a Mouse Model of Dementia with Lewy Bodies by Reducing α-Synuclein Oligomers. Int J Mol Sci. 2021;22: pubmed publisher
  • immunocytochemistry; mouse; 1:1000; fig 2
Feng L, Federoff H, Vicini S, Maguire Zeiss K. Alpha-synuclein mediates alterations in membrane conductance: a potential role for alpha-synuclein oligomers in cell vulnerability. Eur J Neurosci. 2010;32:10-7 pubmed publisher
Cariulo C, Martufi P, Verani M, Azzollini L, Bruni G, Weiss A, et al. Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay. Front Neurosci. 2019;13:889 pubmed publisher
Anisimov S, Takahashi M, Kakihana T, Katsuragi Y, Kitaura H, Zhang L, et al. G3BP1 inhibits ubiquitinated protein aggregations induced by p62 and USP10. Sci Rep. 2019;9:12896 pubmed publisher
Hu D, Niu J, Xiong J, Nie S, Zeng F, Zhang Z. LRRK2 G2019S Mutation Inhibits Degradation of α-Synuclein in an In Vitro Model of Parkinson's Disease. Curr Med Sci. 2018;38:1012-1017 pubmed publisher
Takahashi M, Kitaura H, Kakita A, Kakihana T, Katsuragi Y, Nameta M, et al. USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis. iScience. 2018;9:433-450 pubmed publisher
Ugras S, Daniels M, Fazelinia H, Gould N, Yocum A, Luk K, et al. Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders. EBioMedicine. 2018;31:307-319 pubmed publisher
Kim D, Hwang H, Choi S, Kwon S, Lee S, Park J, et al. D409H GBA1 mutation accelerates the progression of pathology in A53T α-synuclein transgenic mouse model. Acta Neuropathol Commun. 2018;6:32 pubmed publisher
Sethi R, Tripathi N, Pallapati A, Gaikar A, Bharatam P, Roy I. Does N-terminal huntingtin function as a 'holdase' for inhibiting cellular protein aggregation?. FEBS J. 2018;285:1791-1811 pubmed publisher
Rusconi R, Ulusoy A, Aboutalebi H, Di Monte D. Long-lasting pathological consequences of overexpression-induced α-synuclein spreading in the rat brain. Aging Cell. 2018;17: pubmed publisher
Rockenstein E, Ostroff G, Dikengil F, Rus F, Mante M, Florio J, et al. Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies. J Neurosci. 2018;38:1000-1014 pubmed publisher
Thakur P, Breger L, Lundblad M, Wan O, Mattsson B, Luk K, et al. Modeling Parkinson's disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain. Proc Natl Acad Sci U S A. 2017;114:E8284-E8293 pubmed publisher
Morabito G, Giannelli S, Ordazzo G, Bido S, Castoldi V, Indrigo M, et al. AAV-PHP.B-Mediated Global-Scale Expression in the Mouse Nervous System Enables GBA1 Gene Therapy for Wide Protection from Synucleinopathy. Mol Ther. 2017;25:2727-2742 pubmed publisher
Davtyan H, Zagorski K, Petrushina I, Kazarian K, Goldberg N, Petrosyan J, et al. MultiTEP platform-based DNA vaccines for alpha-synucleinopathies: preclinical evaluation of immunogenicity and therapeutic potency. Neurobiol Aging. 2017;59:156-170 pubmed publisher
Turriani E, Lázaro D, Ryazanov S, Leonov A, Giese A, Schön M, et al. Treatment with diphenyl-pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death. Proc Natl Acad Sci U S A. 2017;114:E4971-E4977 pubmed publisher
Cox D, Ecroyd H. The small heat shock proteins αB-crystallin (HSPB5) and Hsp27 (HSPB1) inhibit the intracellular aggregation of α-synuclein. Cell Stress Chaperones. 2017;22:589-600 pubmed publisher
Spencer B, Valera E, Rockenstein E, OVERK C, Mante M, Adame A, et al. Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy. Acta Neuropathol Commun. 2017;5:7 pubmed publisher
Pierdominici M, Maselli A, Cecchetti S, Tinari A, Mastrofrancesco A, Alfè M, et al. Diesel exhaust particle exposure in vitro impacts T lymphocyte phenotype and function. Part Fibre Toxicol. 2014;11:74 pubmed publisher
Fernandez E, García Moreno J, Martín de Pablos A, Chacon J. May the thyroid gland and thyroperoxidase participate in nitrosylation of serum proteins and sporadic Parkinson's disease?. Antioxid Redox Signal. 2014;21:2143-8 pubmed publisher
Overk C, Cartier A, Shaked G, Rockenstein E, Ubhi K, Spencer B, et al. Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies. Mol Neurodegener. 2014;9:18 pubmed publisher
Colasanti T, Vomero M, Alessandri C, Barbati C, Maselli A, Camperio C, et al. Role of alpha-synuclein in autophagy modulation of primary human T lymphocytes. Cell Death Dis. 2014;5:e1265 pubmed publisher
Sugeno N, Hasegawa T, Tanaka N, Fukuda M, Wakabayashi K, Oshima R, et al. Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized ?-synuclein. J Biol Chem. 2014;289:18137-51 pubmed publisher
Rockenstein E, Nuber S, Overk C, Ubhi K, Mante M, Patrick C, et al. Accumulation of oligomer-prone ?-synuclein exacerbates synaptic and neuronal degeneration in vivo. Brain. 2014;137:1496-513 pubmed publisher
Gelpi E, Navarro Otano J, Tolosa E, Gaig C, Compta Y, Rey M, et al. Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders. Mov Disord. 2014;29:1010-8 pubmed publisher
B ttner S, Habernig L, Broeskamp F, Ruli D, V gtle F, Vlachos M, et al. Endonuclease G mediates ?-synuclein cytotoxicity during Parkinson's disease. EMBO J. 2013;32:3041-54 pubmed publisher
Marxreiter F, Ettle B, May V, Esmer H, Patrick C, Kragh C, et al. Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice. Neurobiol Dis. 2013;59:38-51 pubmed publisher
Koehler N, Stransky E, Shing M, Gaertner S, Meyer M, Schreitmüller B, et al. Altered serum IgG levels to α-synuclein in dementia with Lewy bodies and Alzheimer's disease. PLoS ONE. 2013;8:e64649 pubmed publisher
Harms A, Cao S, Rowse A, Thome A, Li X, Mangieri L, et al. MHCII is required for ?-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration. J Neurosci. 2013;33:9592-600 pubmed publisher
Fernandez E, García Moreno J, Martín de Pablos A, Chacon J. May the evaluation of nitrosative stress through selective increase of 3-nitrotyrosine proteins other than nitroalbumin and dominant tyrosine-125/136 nitrosylation of serum α-synuclein serve for diagnosis of sporadic Parkinson's disease?. Antioxid Redox Signal. 2013;19:912-8 pubmed publisher
Cartier A, Ubhi K, Spencer B, Vázquez Roque R, Kosberg K, Fourgeaud L, et al. Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy. PLoS ONE. 2012;7:e34713 pubmed publisher
Prasad K, Beach T, Hedreen J, Richfield E. Critical role of truncated ?-synuclein and aggregates in Parkinson's disease and incidental Lewy body disease. Brain Pathol. 2012;22:811-25 pubmed publisher
Malkus K, Ischiropoulos H. Regional deficiencies in chaperone-mediated autophagy underlie ?-synuclein aggregation and neurodegeneration. Neurobiol Dis. 2012;46:732-44 pubmed publisher
Olah J, Vincze O, Virok D, Simon D, Bozso Z, Tökési N, et al. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. J Biol Chem. 2011;286:34088-100 pubmed publisher
Ubhi K, Rockenstein E, Mante M, Inglis C, Adame A, Patrick C, et al. Alpha-synuclein deficient mice are resistant to toxin-induced multiple system atrophy. Neuroreport. 2010;21:457-62 pubmed publisher
Crews L, Spencer B, Desplats P, Patrick C, Paulino A, Rockenstein E, et al. Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. PLoS ONE. 2010;5:e9313 pubmed publisher
Martin L, Pan Y, Price A, Sterling W, Copeland N, Jenkins N, et al. Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J Neurosci. 2006;26:41-50 pubmed
Giasson B, Jakes R, Goedert M, Duda J, Leight S, Trojanowski J, et al. A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease. J Neurosci Res. 2000;59:528-33 pubmed
product information
Product No. :
S5566
Product Name :
Anti-α-Synuclein antibody, Mouse monoclonal
Host :
mouse
Conjugate :
unconjugated
Antibody Type :
monoclonal
Clone Number (if monoclonal) :
Syn211
Applications/Description :
Suitable for immunohistochemistry; western blot: 0.25 μg/mL using recombinant human α·-synuclein.; immunoprecipitation (IP)
Species Reactivity :
mouse, rat human, zebra finch
Isotype :
IgG1
Concentration :
~1 mg/mL
Storage :
Store at -20°C
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA