This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Salinomycin
catalog :
S4526
citations: 71
Reference
Fan S, Price T, Huang W, Plue M, Warren J, Sundaramoorthy P, et al. PINK1-Dependent Mitophagy Regulates the Migration and Homing of Multiple Myeloma Cells via the MOB1B-Mediated Hippo-YAP/TAZ Pathway. Adv Sci (Weinh). 2020;7:1900860 pubmed publisher
Gassen N, Niemeyer D, Muth D, Corman V, Martinelli S, Gassen A, et al. SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection. Nat Commun. 2019;10:5770 pubmed publisher
Vanneste M, Huang Q, Li M, Moose D, Zhao L, STAMNES M, et al. High content screening identifies monensin as an EMT-selective cytotoxic compound. Sci Rep. 2019;9:1200 pubmed publisher
Oh S, Noh K, Lee Y, Hong S, Song K, Lee H, et al. Targeting stemness is an effective strategy to control EML4-ALK+ non-small cell lung cancer cells. Oncotarget. 2015;6:40255-67 pubmed publisher
Chen C, Zhang H, Ying G, Zhou L, Jones K. Passive sampling: A cost-effective method for understanding antibiotic fate, behaviour and impact. Environ Int. 2015;85:284-91 pubmed publisher
An H, Kim J, Lee N, Cho Y, Oh E, Seo J. Salinomycin possesses anti-tumor activity and inhibits breast cancer stem-like cells via an apoptosis-independent pathway. Biochem Biophys Res Commun. 2015;466:696-703 pubmed publisher
Qu H, Ma B, Yuan H, Wang Z, Guo S, Zhang J. Effect of salinomycin on metastasis and invasion of bladder cancer cell line T24. Asian Pac J Trop Med. 2015;8:578-82 pubmed publisher
He M, Fu Y, Yan Y, Xiao Q, Wu H, Yao W, et al. The Hedgehog signalling pathway mediates drug response of MCF-7 mammosphere cells in breast cancer patients. Clin Sci (Lond). 2015;129:809-22 pubmed publisher
Boesch M, Zeimet A, Rumpold H, Gastl G, Sopper S, Wolf D. Drug Transporter-Mediated Protection of Cancer Stem Cells From Ionophore Antibiotics. Stem Cells Transl Med. 2015;4:1028-32 pubmed publisher
Chitescu C, Kaklamanos G, Nicolau A, Stolker A. High sensitive multiresidue analysis of pharmaceuticals and antifungals in surface water using U-HPLC-Q-Exactive Orbitrap HRMS. Application to the Danube river basin on the Romanian territory. Sci Total Environ. 2015;532:501-11 pubmed publisher
Scherzed A, Hackenberg S, Froelich K, Rak K, Ginzkey C, Hagen R, et al. Effects of salinomycin and CGP37157 on head and neck squamous cell carcinoma cell lines in vitro. Mol Med Rep. 2015;12:4455-4461 pubmed publisher
Kim Y, Lim H. Laser-induced fluorescence reader with a turbidimetric system for sandwich-type immunoassay using nanoparticles. Anal Chim Acta. 2015;883:32-6 pubmed publisher
Qin L, Jia P, Zhang Z, Zhang S. ROS-p53-cyclophilin-D signaling mediates salinomycin-induced glioma cell necrosis. J Exp Clin Cancer Res. 2015;34:57 pubmed publisher
Thakur R, Trivedi R, Rastogi N, Singh M, Mishra D. Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer. Sci Rep. 2015;5:10194 pubmed publisher
Jangamreddy J, Jain M, Hallbeck A, Roberg K, Lotfi K, Łos M. Glucose starvation-mediated inhibition of salinomycin induced autophagy amplifies cancer cell specific cell death. Oncotarget. 2015;6:10134-45 pubmed
Senkowski W, Zhang X, Olofsson M, Isacson R, Höglund U, Gustafsson M, et al. Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer. Mol Cancer Ther. 2015;14:1504-16 pubmed publisher
Kai M, Kanaya N, Wu S, Mendez C, Nguyen D, Luu T, et al. Targeting breast cancer stem cells in triple-negative breast cancer using a combination of LBH589 and salinomycin. Breast Cancer Res Treat. 2015;151:281-94 pubmed publisher
Kim K, Kim S, Yu S, Park S, Choi H, Yu H, et al. Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin. Mol Med Rep. 2015;12:1898-904 pubmed publisher
Zhang X, Lou Y, Wang H, Zheng X, Dong Q, Sun J, et al. Wnt signaling regulates the stemness of lung cancer stem cells and its inhibitors exert anticancer effect on lung cancer SPC-A1 cells. Med Oncol. 2015;32:95 pubmed publisher
Yu S, Kim S. Salinomycin causes dedifferentiation via the extracellular signal-regulated kinase (ERK) pathway in rabbit articular chondrocytes. J Pharmacol Sci. 2015;127:196-202 pubmed publisher
Jonchère B, Vétillard A, Toutain B, Lam D, Bernard A, Henry C, et al. Irinotecan treatment and senescence failure promote the emergence of more transformed and invasive cells that depend on anti-apoptotic Mcl-1. Oncotarget. 2015;6:409-26 pubmed
Wang D, Upadhyaya B, Liu Y, Knudsen D, Dey M. Phenethyl isothiocyanate upregulates death receptors 4 and 5 and inhibits proliferation in human cancer stem-like cells. BMC Cancer. 2014;14:591 pubmed publisher
Lu W, Li Y. Salinomycin suppresses LRP6 expression and inhibits both Wnt/?-catenin and mTORC1 signaling in breast and prostate cancer cells. J Cell Biochem. 2014;115:1799-807 pubmed publisher
Choi H, Lee J, Yeo S, Kaewintajuk K, Yi K, Kim S, et al. Evaluation of anti-coccidial effects of 1-[4-(4-nitrophenoxy)phenyl]propane-1-one and identification of its potential target proteins in Toxoplasma gondii. Arch Pharm Res. 2015;38:752-60 pubmed publisher
Klose J, Stankov M, Kleine M, Ramackers W, Panayotova Dimitrova D, Jäger M, et al. Inhibition of autophagic flux by salinomycin results in anti-cancer effect in hepatocellular carcinoma cells. PLoS ONE. 2014;9:e95970 pubmed publisher
Calzolari A, Saulle E, De Angelis M, Pasquini L, Boe A, Pelacchi F, et al. Salinomycin potentiates the cytotoxic effects of TRAIL on glioblastoma cell lines. PLoS ONE. 2014;9:e94438 pubmed publisher
Bissinger R, Malik A, Jilani K, Lang F. Triggering of erythrocyte cell membrane scrambling by salinomycin. Basic Clin Pharmacol Toxicol. 2014;115:396-402 pubmed publisher
Wu D, Zhang Y, Huang J, Fan Z, Shi F, Wang S. Salinomycin inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cell in vitro and suppresses tumor growth in vivo. Biochem Biophys Res Commun. 2014;443:712-7 pubmed publisher
Duong M, Akli S, Macalou S, Biernacka A, Debeb B, Yi M, et al. Hbo1 is a cyclin E/CDK2 substrate that enriches breast cancer stem-like cells. Cancer Res. 2013;73:5556-68 pubmed publisher
Zhou S, Wang F, Wong E, Fonkem E, Hsieh T, Wu J, et al. Salinomycin: a novel anti-cancer agent with known anti-coccidial activities. Curr Med Chem. 2013;20:4095-101 pubmed
Bohn P, Bak S, Björklund E, Krogh K, Hansen M. Abiotic degradation of antibiotic ionophores. Environ Pollut. 2013;182:177-83 pubmed publisher
Zhou J, Li P, Xue X, He S, Kuang Y, Zhao H, et al. Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactive oxygen species. Toxicol Lett. 2013;222:139-45 pubmed publisher
Ojo O, Bhadauria S, Rath S. Dose-dependent adverse effects of salinomycin on male reproductive organs and fertility in mice. PLoS ONE. 2013;8:e69086 pubmed publisher
Koo K, Kim H, Bae Y, Kim K, Park B, Lee C, et al. Salinomycin induces cell death via inactivation of Stat3 and downregulation of Skp2. Cell Death Dis. 2013;4:e693 pubmed publisher
Jangamreddy J, Ghavami S, Grabarek J, Kratz G, Wiechec E, Fredriksson B, et al. Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: differences between primary and cancer cells. Biochim Biophys Acta. 2013;1833:2057-69 pubmed publisher
Parajuli B, Shin S, Kwon S, Cha S, Chung R, Park W, et al. Salinomycin induces apoptosis via death receptor-5 up-regulation in cisplatin-resistant ovarian cancer cells. Anticancer Res. 2013;33:1457-62 pubmed
Steverding D, Sexton D. Trypanocidal activity of salinomycin is due to sodium influx followed by cell swelling. Parasit Vectors. 2013;6:78 pubmed publisher
Kusunoki S, Kato K, Tabu K, Inagaki T, Okabe H, Kaneda H, et al. The inhibitory effect of salinomycin on the proliferation, migration and invasion of human endometrial cancer stem-like cells. Gynecol Oncol. 2013;129:598-605 pubmed publisher
Scherzed A, Hackenberg S, Froelich K, Rak K, Technau A, Radeloff A, et al. Effects of salinomycin on human bone marrow-derived mesenchymal stem cells in vitro. Toxicol Lett. 2013;218:207-14 pubmed publisher
He L, Wang F, Dai W, Wu D, Lin C, Wu S, et al. Mechanism of action of salinomycin on growth and migration in pancreatic cancer cell lines. Pancreatology. 2013;13:72-8 pubmed publisher
Al Dhaheri Y, Attoub S, Arafat K, Abuqamar S, Eid A, Al Faresi N, et al. Salinomycin induces apoptosis and senescence in breast cancer: upregulation of p21, downregulation of survivin and histone H3 and H4 hyperacetylation. Biochim Biophys Acta. 2013;1830:3121-35 pubmed publisher
Zhang B, Wang X, Cai F, Chen W, Loesch U, Zhong X. Antitumor properties of salinomycin on cisplatin-resistant human ovarian cancer cells in vitro and in vivo: involvement of p38 MAPK activation. Oncol Rep. 2013;29:1371-8 pubmed publisher
Wang F, He L, Dai W, Xu Y, Wu D, Lin C, et al. Salinomycin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma cells in vitro and in vivo. PLoS ONE. 2012;7:e50638 pubmed publisher
Naujokat C, Steinhart R. Salinomycin as a drug for targeting human cancer stem cells. J Biomed Biotechnol. 2012;2012:950658 pubmed publisher
De Vitto H, Mendonça B, Elseth K, Onul A, Xue J, Vesper B, et al. Part III. Molecular changes induced by high nitric oxide adaptation in human breast cancer cell line BT-20 (BT-20-HNO): a switch from aerobic to anaerobic metabolism. Tumour Biol. 2013;34:403-13 pubmed publisher
Kuo S, Blair K, Rahimy E, Kiang A, Abhold E, Fan J, et al. Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt. BMC Cancer. 2012;12:556 pubmed publisher
Szkudlarek Mikho M, Saunders R, Yap S, Ngeow Y, Chin K. Salinomycin, a polyether ionophoric antibiotic, inhibits adipogenesis. Biochem Biophys Res Commun. 2012;428:487-93 pubmed publisher
Aydın R. Herceptin-decorated salinomycin-loaded nanoparticles for breast tumor targeting. J Biomed Mater Res A. 2013;101:1405-15 pubmed publisher
Huczyński A, Janczak J, Antoszczak M, Wietrzyk J, Maj E, Brzezinski B. Antiproliferative activity of salinomycin and its derivatives. Bioorg Med Chem Lett. 2012;22:7146-50 pubmed publisher
Lieke T, Ramackers W, Bergmann S, Klempnauer J, Winkler M, Klose J. Impact of Salinomycin on human cholangiocarcinoma: induction of apoptosis and impairment of tumor cell proliferation in vitro. BMC Cancer. 2012;12:466 pubmed publisher
Verdoodt B, Vogt M, Schmitz I, Liffers S, Tannapfel A, Mirmohammadsadegh A. Salinomycin induces autophagy in colon and breast cancer cells with concomitant generation of reactive oxygen species. PLoS ONE. 2012;7:e44132 pubmed publisher
Vudathala D, Murphy L. Rapid method for the simultaneous determination of six ionophores in feed by liquid chromatography/mass spectrometry. J AOAC Int. 2012;95:1016-22 pubmed
Burnett T, Lombardi K, Rodewald J, Brunelle S, MacDougall J, Coleman M. Determination of narasin and monensin in bovine, swine, and chicken tissues by liquid chromatography with tandem mass spectrometry: first action 2011.24. J AOAC Int. 2012;95:959-91 pubmed
Furtula V, Stephenson G, Olaveson K, Chambers P. Effects of the veterinary pharmaceutical salinomycin and its formulation on the plant Brassica rapa. Arch Environ Contam Toxicol. 2012;63:513-22 pubmed publisher
Economopoulou P, Kaklamani V, Siziopikou K. The role of cancer stem cells in breast cancer initiation and progression: potential cancer stem cell-directed therapies. Oncologist. 2012;17:1394-401 pubmed publisher
Peebles E, Bafundo K, Womack S, Zhai W, Pulikanti R, Bennett L. Effects of nicarbazin on the blood glucose and liver glycogen statuses of male broilers. Poult Sci. 2012;91:2183-8 pubmed publisher
Sampieri K, Fodde R. Cancer stem cells and metastasis. Semin Cancer Biol. 2012;22:187-93 pubmed
Zhang B, Wang X, Cai F, Chen W, Loesch U, Bitzer J, et al. Effects of salinomycin on human ovarian cancer cell line OV2008 are associated with modulating p38 MAPK. Tumour Biol. 2012;33:1855-62 pubmed publisher
Huczyński A, Janczak J, Stefanska J, Antoszczak M, Brzezinski B. Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin. Bioorg Med Chem Lett. 2012;22:4697-702 pubmed publisher
Czerwinski J, Højberg O, Smulikowska S, Engberg R, Mieczkowska A. Effects of sodium butyrate and salinomycin upon intestinal microbiota, mucosal morphology and performance of broiler chickens. Arch Anim Nutr. 2012;66:102-16 pubmed
Sachlos E, Risueno R, Laronde S, Shapovalova Z, Lee J, Russell J, et al. Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells. Cell. 2012;149:1284-97 pubmed publisher
. Salinomycin toxicity causes deaths of calves on two Scottish dairy farms. Vet Rec. 2012;170:118-21 pubmed
Basu D, Montone K, Wang L, Gimotty P, Hammond R, Diehl J, et al. Detecting and targeting mesenchymal-like subpopulations within squamous cell carcinomas. Cell Cycle. 2011;10:2008-16 pubmed
Jasenosky L, Neumann G, Kawaoka Y. Minigenome-based reporter system suitable for high-throughput screening of compounds able to inhibit Ebolavirus replication and/or transcription. Antimicrob Agents Chemother. 2010;54:3007-10 pubmed publisher
Fuchs D, Heinold A, Opelz G, Daniel V, Naujokat C. Salinomycin induces apoptosis and overcomes apoptosis resistance in human cancer cells. Biochem Biophys Res Commun. 2009;390:743-9 pubmed publisher
Lagas J, Sparidans R, van Waterschoot R, Wagenaar E, Beijnen J, Schinkel A. P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin. Antimicrob Agents Chemother. 2008;52:1034-9 pubmed publisher
Biftu T, Feng D, Ponpipom M, Girotra N, Liang G, Qian X, et al. Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents. Bioorg Med Chem Lett. 2005;15:3296-301 pubmed
Dubois M, Pierret G, Delahaut P. Efficient and sensitive detection of residues of nine coccidiostats in egg and muscle by liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2004;813:181-9 pubmed
Chen Pan C, Pan I, Yamamoto Y, Sakogawa T, Yamada J, Hayashi Y. Prompt recovery of damaged adrenal medullae induced by salinomycin. Toxicol Pathol. 1999;27:563-72 pubmed
Augustine P, Danforth H. Influence of betaine and salinomycin on intestinal absorption of methionine and glucose and on the ultrastructure of intestinal cells and parasite developmental stages in chicks infected with Eimeria acervulina. Avian Dis. 1999;43:89-97 pubmed
van der Linde Sipman J, van den Ingh T, Van Nes J, Verhagen H, Kersten J, Beynen A, et al. Salinomycin-induced polyneuropathy in cats: morphologic and epidemiologic data. Vet Pathol. 1999;36:152-6 pubmed
product information
Catalog Number :
S4526
Product Name :
Salinomycin
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
from Streptomyces albus, ≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA