Sankaranarayanan S, Holahan M, Colussi D, Crouthamel M, Devanarayan V, Ellis J, et al. First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates. J Pharmacol Exp Ther. 2009;328:131-40 pubmed publisher

Sankaranarayanan S, Price E, Wu G, Crouthamel M, Shi X, Tugusheva K, et al. In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1. J Pharmacol Exp Ther. 2008;324:957-69 pubmed

Taru H, Kirino Y, Suzuki T. Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism. J Biol Chem. 2002;277:27567-74 pubmed

Skovronsky D, Moore D, Milla M, Doms R, Lee V. Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network. J Biol Chem. 2000;275:2568-75 pubmed

Selkoe D. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature. 1999;399:A23-31 pubmed

Mattson M. Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol Rev. 1997;77:1081-132 pubmed

Kang J, Lemaire H, Unterbeck A, Salbaum J, Masters C, Grzeschik K, et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature. 1987;325:733-6 pubmed

Haass C, Koo E, Mellon A, Hung A, Selkoe D. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature. 1992;357:500-3 pubmed