This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Spermine
catalog :
S4264
citations: 152
Reference
Fischer M, Ruhnau J, Schulze J, Obst D, Floel A, Vogelgesang A. Spermine and spermidine modulate T-cell function in older adults with and without cognitive decline ex vivo. Aging (Albany NY). 2020;12:13716-13739 pubmed publisher
Guo Y, Ye Q, Deng P, Cao Y, He D, Zhou Z, et al. Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression. Nat Commun. 2020;11:3243 pubmed publisher
Yang Y, Chen M, Zhou J, Lv J, Song S, Fu L, et al. Interactions between Macrophages and Cyst-Lining Epithelial Cells Promote Kidney Cyst Growth in Pkd1-Deficient Mice. J Am Soc Nephrol. 2018;29:2310-2325 pubmed publisher
Shin B, Katoh T, Gutierrez E, Kim J, Suga H, Dever T. Amino acid substrates impose polyamine, eIF5A, or hypusine requirement for peptide synthesis. Nucleic Acids Res. 2017;45:8392-8402 pubmed publisher
Matsuda S, Durney A, He L, Mukaibo H. Sedimentation-induced detachment of magnetite nanoparticles from microalgal flocs. Bioresour Technol. 2016;200:914-20 pubmed publisher
Sardo C, Craparo E, Fiorica C, Giammona G, Cavallaro G. Inulin Derivatives Obtained Via Enhanced Microwave Synthesis for Nucleic Acid Based Drug Delivery. Curr Drug Targets. 2015;16:1650-9 pubmed
Zentner G, Kasinathan S, Xin B, Rohs R, Henikoff S. ChEC-seq kinetics discriminates transcription factor binding sites by DNA sequence and shape in vivo. Nat Commun. 2015;6:8733 pubmed publisher
Zhu Y, Lin G, Dai Z, Zhou T, Yuan T, Feng C, et al. Developmental changes in polyamines and autophagic marker levels in normal and growth-restricted fetal pigs. J Anim Sci. 2015;93:3503-11 pubmed publisher
Reis R, Vale E, Heringer A, Santa Catarina C, Silveira V. Putrescine induces somatic embryo development and proteomic changes in embryogenic callus of sugarcane. J Proteomics. 2016;130:170-9 pubmed publisher
Filippova E, Weigand S, Osipiuk J, Kiryukhina O, Joachimiak A, Anderson W. Substrate-Induced Allosteric Change in the Quaternary Structure of the Spermidine N-Acetyltransferase SpeG. J Mol Biol. 2015;427:3538-3553 pubmed publisher
Tang B, Luo D, Yang J, Xu X, Zhu B, Wang X, et al. Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex. Sci Rep. 2015;5:14099 pubmed publisher
Nalabothula N, Al jumaily T, Eteleeb A, Flight R, Xiaorong S, Moseley H, et al. Genome-Wide Profiling of PARP1 Reveals an Interplay with Gene Regulatory Regions and DNA Methylation. PLoS ONE. 2015;10:e0135410 pubmed publisher
Pietrini F, Iori V, Bianconi D, Mughini G, Massacci A, Zacchini M. Assessment of physiological and biochemical responses, metal tolerance and accumulation in two eucalypt hybrid clones for phytoremediation of cadmium-contaminated waters. J Environ Manage. 2015;162:221-31 pubmed publisher
Sukweenadhi J, Kim Y, Kang C, Farh M, Nguyen N, Hoang V, et al. Sphingomonas panaciterrae sp. nov., a plant growth-promoting bacterium isolated from soil of a ginseng field. Arch Microbiol. 2015;197:973-81 pubmed publisher
Singh P, Kim Y, Hoang V, Farh M, Yang D. Sphingomonas panacis sp. nov., isolated from rhizosphere of rusty ginseng. Antonie Van Leeuwenhoek. 2015;108:711-20 pubmed publisher
Wang C, Xie N, Wang Y, Li Y, Ge X, Wang M. Role of the Mitochondrial Calcium Uniporter in Rat Hippocampal Neuronal Death After Pilocarpine-Induced Status Epilepticus. Neurochem Res. 2015;40:1739-46 pubmed publisher
Kang J, Nguyen N, Kim Y, Hoang V, Bae K, Yang D. Paralcaligenes ginsengisoli sp. nov., isolated from ginseng cultivated soil. Antonie Van Leeuwenhoek. 2015;108:619-26 pubmed publisher
Chang S, Lin S, Yang H, Chou Y, Gao J, Lu S. LPS-Induced G-CSF Expression in Macrophages Is Mediated by ERK2, but Not ERK1. PLoS ONE. 2015;10:e0129685 pubmed publisher
Ray R, Bavaria M, Johnson L. Interaction of polyamines and mTOR signaling in the synthesis of antizyme (AZ). Cell Signal. 2015;27:1850-9 pubmed publisher
Pfister N, Fomin V, Regunath K, Zhou J, Zhou W, Silwal Pandit L, et al. Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells. Genes Dev. 2015;29:1298-315 pubmed publisher
Sawada S, Oberemm A, Buhrke T, Meckert C, Rozycki C, Braeuning A, et al. Proteomic analysis of 3-MCPD and 3-MCPD dipalmitate toxicity in rat testis. Food Chem Toxicol. 2015;83:84-92 pubmed publisher
Kwak H, Kim Y, Oh S, Kim S. Sulfur amino acid metabolism in Zucker diabetic fatty rats. Biochem Pharmacol. 2015;96:256-66 pubmed publisher
Rossetto M, Vianello F, Saeki M, Lima G. Polyamines in conventional and organic vegetables exposed to exogenous ethylene. Food Chem. 2015;188:218-24 pubmed publisher
Hansen U, Thünemann A. Characterization of Silver Nanoparticles in Cell Culture Medium Containing Fetal Bovine Serum. Langmuir. 2015;31:6842-52 pubmed publisher
Su H, Lee M, Lee W. Surface modification of alignment layer by ultraviolet irradiation to dramatically improve the detection limit of liquid-crystal-based immunoassay for the cancer biomarker CA125. J Biomed Opt. 2015;20:57004 pubmed publisher
Potempa M, Nalivaika E, Ragland D, Lee S, Schiffer C, Swanstrom R. A Direct Interaction with RNA Dramatically Enhances the Catalytic Activity of the HIV-1 Protease In Vitro. J Mol Biol. 2015;427:2360-78 pubmed publisher
Greenwood M, Greenwood M, Paton J, Murphy D. Control of Polyamine Biosynthesis by Antizyme Inhibitor 1 Is Important for Transcriptional Regulation of Arginine Vasopressin in the Male Rat Hypothalamus. Endocrinology. 2015;156:2905-17 pubmed publisher
Sanchez D, Bajo Grañeras R, del Caño Espinel M, Garcia Centeno R, García Mateo N, Pascua Maestro R, et al. Aging without Apolipoprotein D: Molecular and cellular modifications in the hippocampus and cortex. Exp Gerontol. 2015;67:19-47 pubmed publisher
Lopes S, Ferreira M, Sousa C, Gameiro P. A fast way to track functional OmpF reconstitution in liposomes: Escherichia coli total lipid extract. Anal Biochem. 2015;479:54-9 pubmed publisher
Kren B, Unger G, Abedin M, Vogel R, Henzler C, Ahmed K, et al. Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy. Breast Cancer Res. 2015;17:19 pubmed publisher
Restuccia D, Spizzirri U, Puoci F, Picci N. Determination of biogenic amine profiles in conventional and organic cocoa-based products. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32:1156-63 pubmed publisher
Ibáñez C, Simó C, Valdés A, Campone L, Piccinelli A, García Cañas V, et al. Metabolomics of adherent mammalian cells by capillary electrophoresis-mass spectrometry: HT-29 cells as case study. J Pharm Biomed Anal. 2015;110:83-92 pubmed publisher
Callejón S, Sendra R, Ferrer S, Pardo I. Ability of Kocuria varians LTH 1540 To Degrade Putrescine: Identification and Characterization of a Novel Amine Oxidase. J Agric Food Chem. 2015;63:4170-8 pubmed publisher
Kalaska B, Kaminski K, Sokolowska E, Czaplicki D, Kujdowicz M, Stalinska K, et al. Nonclinical evaluation of novel cationically modified polysaccharide antidotes for unfractionated heparin. PLoS ONE. 2015;10:e0119486 pubmed publisher
Geddes S, Assadzada S, Sokolovski A, Bergeron R, Haj Dahmane S, Béïque J. Time-dependent modulation of glutamate synapses onto 5-HT neurons by antidepressant treatment. Neuropharmacology. 2015;95:130-43 pubmed publisher
Sun S, Lee M, Lee Y, Lee W, Song X, Chen C. Immunoassays for the cancer biomarker CA125 based on a large-birefringence nematic liquid-crystal mixture. Biomed Opt Express. 2015;6:245-56 pubmed publisher
Shibuya N, Inoue K, Tanaka G, Akimoto K, Kubota K. Augmented pentose phosphate pathway plays critical roles in colorectal carcinomas. Oncology. 2015;88:309-19 pubmed publisher
Parodi D, Greenfield M, Evans C, Chichura A, Alpaugh A, Williams J, et al. Alteration of mammary gland development and gene expression by in utero exposure to arsenic. Reprod Toxicol. 2015;54:66-75 pubmed publisher
Su H, Chuang L, Tseng W, Lu C. Micro-scale strategy to detect spermine and spermidine by MALDI-TOF MS in foods and identification of apoptosis-related proteins by nano-flow UPLC-MS/MS after treatment with spermine and spermidine. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;978-979:131-7 pubmed publisher
Farh M, Kim Y, Van An H, Sukweenadhi J, Singh P, Huq M, et al. Burkholderia ginsengiterrae sp. nov. and Burkholderia panaciterrae sp. nov., antagonistic bacteria against root rot pathogen Cylindrocarpon destructans, isolated from ginseng soil. Arch Microbiol. 2015;197:439-47 pubmed publisher
Muhsain S, Lang M, Abu Bakar A. Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress. Toxicol Appl Pharmacol. 2015;282:77-89 pubmed publisher
Song H, Li R, Zhou C, Cai X, Huang H. Atractylodes macrocephala Koidz stimulates intestinal epithelial cell migration through a polyamine dependent mechanism. J Ethnopharmacol. 2015;159:23-35 pubmed publisher
Hu X, Gao L, Niu Y, Tian X, Wang J, Meng W, et al. Neuroprotection by Kukoamine A against oxidative stress may involve N-methyl-D-aspartate receptors. Biochim Biophys Acta. 2015;1850:287-98 pubmed publisher
Zhang F, Liu H, Jiang G, Wang H, Wang X, Wang H, et al. Changes in the proteomic profile during the differential polarization status of the human monocyte-derived macrophage THP-1 cell line. Proteomics. 2015;15:773-86 pubmed publisher
Bongers K, Fox D, Kunkel S, Stebounova L, Murry D, Pufall M, et al. Spermine oxidase maintains basal skeletal muscle gene expression and fiber size and is strongly repressed by conditions that cause skeletal muscle atrophy. Am J Physiol Endocrinol Metab. 2015;308:E144-58 pubmed publisher
Pandey V, Sultan M, Kashofer K, Ralser M, Amstislavskiy V, Starmann J, et al. Comparative analysis and modeling of the severity of steatohepatitis in DDC-treated mouse strains. PLoS ONE. 2014;9:e111006 pubmed publisher
Choi S, Smith S, Morrissey J. Polyphosphate accelerates factor V activation by factor XIa. Thromb Haemost. 2015;113:599-604 pubmed publisher
Hu F, Pan L, Zhang K, Xing F, Wang X, Lee I, et al. Elevation of extracellular Ca2+ induces store-operated calcium entry via calcium-sensing receptors: a pathway contributes to the proliferation of osteoblasts. PLoS ONE. 2014;9:e107217 pubmed publisher
Abiuso A, Berensztein E, Pagotto R, Pereyra E, Medina V, Martinel Lamas D, et al. H4 histamine receptors inhibit steroidogenesis and proliferation in Leydig cells. J Endocrinol. 2014;223:241-53 pubmed publisher
Yeon J, Ryu B, Choi S, Heo J, Kim K, Son Y, et al. Natural polyamines inhibit the migration of preosteoclasts by attenuating Ca2+-PYK2-Src-NFATc1 signaling pathways. Amino Acids. 2014;46:2605-14 pubmed publisher
Toro Funes N, Bosch Fusté J, Veciana Nogués M, Vidal Carou M. Influence of ultra-high-pressure homogenization treatment on the phytosterols, tocopherols, and polyamines of almond beverage. J Agric Food Chem. 2014;62:9539-43 pubmed publisher
Soto D, Coombs I, Gratacòs Batlle E, Farrant M, Cull Candy S. Molecular mechanisms contributing to TARP regulation of channel conductance and polyamine block of calcium-permeable AMPA receptors. J Neurosci. 2014;34:11673-83 pubmed publisher
Zhu Y, Li J, Kanvinde S, Lin Z, Hazeldine S, Singh R, et al. Self-immolative polycations as gene delivery vectors and prodrugs targeting polyamine metabolism in cancer. Mol Pharm. 2015;12:332-41 pubmed publisher
Kolhatkar V, Khambati H, Lote A, Shanine P, Insley T, Sen S, et al. Star-shaped tetraspermine enhances cellular uptake and cytotoxicity of T-oligo in prostate cancer cells. Pharm Res. 2015;32:196-210 pubmed publisher
Castellano I, Ercolesi E, Palumbo A. Nitric oxide affects ERK signaling through down-regulation of MAP kinase phosphatase levels during larval development of the ascidian Ciona intestinalis. PLoS ONE. 2014;9:e102907 pubmed publisher
Finger S, Schwieger C, Arouri A, Kerth A, Blume A. Interaction of linear polyamines with negatively charged phospholipids: the effect of polyamine charge distance. Biol Chem. 2014;395:769-78 pubmed publisher
SidAhmed Mezi M, Kurcewicz I, Rose C, Louvel J, Sokoloff P, Pumain R, et al. Mass spectrometric detection and characterization of atypical membrane-bound zinc-sensitive phosphatases modulating GABAA receptors. PLoS ONE. 2014;9:e100612 pubmed publisher
Meng K, Xu J, Zhang C, Zhang R, Yang H, Liao C, et al. Calcium sensing receptor modulates extracellular calcium entry and proliferation via TRPC3/6 channels in cultured human mesangial cells. PLoS ONE. 2014;9:e98777 pubmed publisher
Cervelli M, Angelucci E, Stano P, Leboffe L, Federico R, Antonini G, et al. The Glu²¹?/Ser²¹? pocket is a major determinant of spermine oxidase substrate specificity. Biochem J. 2014;461:453-9 pubmed publisher
Du Z, Xiang S, Zang Y, Zhou Y, Wang C, Tang H, et al. Polyspermine imine, a pH responsive polycationic siRNA carrier degradable to endogenous metabolites. Mol Pharm. 2014;11:3300-6 pubmed publisher
Krishnan N, Koveal D, Miller D, Xue B, Akshinthala S, Kragelj J, et al. Targeting the disordered C terminus of PTP1B with an allosteric inhibitor. Nat Chem Biol. 2014;10:558-66 pubmed publisher
Kubo Y, Tomise A, Tsuchiyama A, Akanuma S, Hosoya K. Involvement of the carrier-mediated process in the retina-to-blood transport of spermine at the inner blood-retinal barrier. Exp Eye Res. 2014;124:17-23 pubmed publisher
Ruan G, Zhang T, Li L, Zhang X, Shen Y, Tabata Y, et al. Hepatic-targeted gene delivery using cationic mannan vehicle. Mol Pharm. 2014;11:3322-9 pubmed publisher
Yeo W, Hosseinkhani H, Rahman S, Rosli R, Domb A, Abdullah S. Safety profile of dextran-spermine gene delivery vector in mouse lungs. J Nanosci Nanotechnol. 2014;14:3328-36 pubmed
Kraus D, Yang Q, Kong D, Banks A, Zhang L, Rodgers J, et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014;508:258-62 pubmed publisher
Huang C, Kuo C. Gating of the kir2.1 channel at the bundle crossing region by intracellular spermine and other cations. J Cell Physiol. 2014;229:1703-21 pubmed publisher
Lewis J, O Brien T, Skorupski K, Krick E, Reiter A, Jennings M, et al. Polyamine inhibitors for treatment of feline oral squamous cell carcinoma: a proof-of-concept study. J Vet Dent. 2013;30:140-5 pubmed
Goyal L, Supko J, Berlin J, Blaszkowsky L, Carpenter A, Heuman D, et al. Phase 1 study of N(1),N(11)‑diethylnorspermine (DENSPM) in patients with advanced hepatocellular carcinoma. Cancer Chemother Pharmacol. 2013;72:1305-14 pubmed
Lee B, Ma Y, Huang Y, Wang X, Otaka M, Ishikawa M, et al. Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving. Nat Neurosci. 2013;16:1644-51 pubmed publisher
Severina I, Shchegolev A, Medvedev A. [Potentiation of NO-dependent activation of soluble guanylyl cyclase by 5-nitroisatin and antiviral preparatation arbidol]. Biomed Khim. 2013;59:295-304 pubmed
Vilin Y, Nunez J, Kim R, Dake G, Kurata H. Paradoxical activation of an inwardly rectifying potassium channel mutant by spermine: "(b)locking" open the bundle crossing gate. Mol Pharmacol. 2013;84:572-81 pubmed publisher
Kim Y, Cho C, Cho M, Jiang H. Poly(ester amine) synthesized from trimethylolpropane triacrylate and spermine as an efficient siRNA carrier. J Nanosci Nanotechnol. 2013;13:5692-7 pubmed
Studniarczyk D, Coombs I, Cull Candy S, Farrant M. TARP γ-7 selectively enhances synaptic expression of calcium-permeable AMPARs. Nat Neurosci. 2013;16:1266-74 pubmed publisher
Scoccianti V, Iacobucci M, Speranza A, Antognoni F. Over-accumulation of putrescine induced by cyclohexylamine interferes with chromium accumulation and partially restores pollen tube growth in Actinidia deliciosa. Plant Physiol Biochem. 2013;70:424-32 pubmed publisher
Moreno Chacón A, Camperos Reyes J, Avila Diazgranados R, Romero H. Biochemical and physiological responses of oil palm to bud rot caused by Phytophthora palmivora. Plant Physiol Biochem. 2013;70:246-51 pubmed publisher
Sagor G, Liu T, Takahashi H, Niitsu M, Berberich T, Kusano T. Longer uncommon polyamines have a stronger defense gene-induction activity and a higher suppressing activity of Cucumber mosaic virus multiplication compared to that of spermine in Arabidopsis thaliana. Plant Cell Rep. 2013;32:1477-88 pubmed publisher
Adisa R, Alabi T, Olorunsogo O. Modulation of opening of rat liver mitochondrial membrane permeability transition pore by different fractions of the leaves of Cnestis ferruginea. D.C. Afr J Med Med Sci. 2012;41 Suppl:157-69 pubmed
Capone C, Cervelli M, Angelucci E, Colasanti M, Macone A, Mariottini P, et al. A role for spermine oxidase as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity. Free Radic Biol Med. 2013;63:99-107 pubmed publisher
Minarini A, Milelli A, Tumiatti V, Rosini M, Lenzi M, Ferruzzi L, et al. Exploiting RNA as a new biomolecular target for synthetic polyamines. Gene. 2013;524:232-40 pubmed publisher
Zhilenko V, Zalietok S, Klenov O. [Effect of fenugreek on the growth of different genesis tumors]. Lik Sprava. 2012;:133-9 pubmed
Chen W, Wennersten C, Moellering R, Regen S. Towards squalamine mimics: synthesis and antibacterial activities of head-to-tail dimeric sterol-polyamine conjugates. Chem Biodivers. 2013;10:385-93 pubmed publisher
North M, Grasemann H, Khanna N, Inman M, Gauvreau G, Scott J. Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma. Am J Respir Cell Mol Biol. 2013;48:694-702 pubmed publisher
Condon K, Ho J, Robinson C, Hanus C, Ehlers M. The Angelman syndrome protein Ube3a/E6AP is required for Golgi acidification and surface protein sialylation. J Neurosci. 2013;33:3799-814 pubmed publisher
Kuwata G, Hiramatsu K, Samejima K, Iwasaki K, Takahashi K, Koizumi K, et al. Increase of N1, N12-diacetylspermine in tissues from colorectal cancer and its liver metastasis. J Cancer Res Clin Oncol. 2013;139:925-32 pubmed publisher
Bjelakovic G, Pavlovic D, Kocic G, Stojanovic I, Jevtovic Stoimenov T, Nikolic J, et al. Dexamethasone decreases the spermidine and spermine concentrations and polyamine oxidase activity in rat thymus. J Basic Clin Physiol Pharmacol. 2013;24:67-72 pubmed publisher
Kano Y, Soda K, Konishi F. Suppression of LFA-1 expression by spermine is associated with enhanced methylation of ITGAL, the LFA-1 promoter area. PLoS ONE. 2013;8:e56056 pubmed publisher
Marina M, Sirera F, Rambla J, Gonzalez M, Blázquez M, Carbonell J, et al. Thermospermine catabolism increases Arabidopsis thaliana resistance to Pseudomonas viridiflava. J Exp Bot. 2013;64:1393-402 pubmed publisher
Mandal S, Mandal A, Johansson H, Orjalo A, Park M. Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells. Proc Natl Acad Sci U S A. 2013;110:2169-74 pubmed publisher
Makletsova M, Fedorova T, Maksimova M, Boldyrev A. Effects of carnosine on polyamine levels in red blood cells of patients with hypertonic discirculatory encephalopathy. Bull Exp Biol Med. 2012;154:210-2 pubmed
Kuroda Y, Hamaguchi R, Moriyama K, Tanimoto T, Haginaka J. Improved capillary electrophoresis method for the analysis of carbohydrate-deficient transferrin in human serum, avoiding interference by complement C3. J Pharm Biomed Anal. 2013;76:81-6 pubmed publisher
Shu S, Yuan L, Guo S, Sun J, Yuan Y. Effects of exogenous spermine on chlorophyll fluorescence, antioxidant system and ultrastructure of chloroplasts in Cucumis sativus L. under salt stress. Plant Physiol Biochem. 2013;63:209-16 pubmed publisher
Plaza Zamora J, Sabater Molina M, Rodriguez Palmero M, Rivero M, Bosch V, Nadal J, et al. Polyamines in human breast milk for preterm and term infants. Br J Nutr. 2013;110:524-8 pubmed publisher
Liew L, Kaiser M, Copp B. Discovery and preliminary structure-activity relationship analysis of 1,14-sperminediphenylacetamides as potent and selective antimalarial lead compounds. Bioorg Med Chem Lett. 2013;23:452-4 pubmed publisher
Kottakota S, Benton M, Evangelopoulos D, Guzman J, Bhakta S, McHugh T, et al. Versatile routes to marine sponge metabolites through benzylidene rhodanines. Org Lett. 2012;14:6310-3 pubmed publisher
Berger M, Pöhler T, Schadt O, Stanger M, Rebernik P, Scholze P, et al. Exploring the polyamine regulatory site of the NMDA receptor: a parallel synthesis approach. ChemMedChem. 2013;8:82-94 pubmed publisher
Michaelis J, Maruyama A, Seitz O. Promoting strand exchange in a DNA-templated transfer reaction. Chem Commun (Camb). 2013;49:618-20 pubmed publisher
Vourtsis D, Lamprou M, Sadikoglou E, Giannou A, Theodorakopoulou O, Sarrou E, et al. Effect of an all-trans-retinoic acid conjugate with spermine on viability of human prostate cancer and endothelial cells in vitro and angiogenesis in vivo. Eur J Pharmacol. 2013;698:122-30 pubmed publisher
Korovina A, Tunitskaya V, Khomutov M, Simonian A, Khomutov A, Ivanov A, et al. Biogenic polyamines spermine and spermidine activate RNA polymerase and inhibit RNA helicase of hepatitis C virus. Biochemistry (Mosc). 2012;77:1172-80 pubmed publisher
Wang S, Lee A, Lee Y, Lai Y, Chen J, Wu W, et al. Spermine attenuates the action of the DNA intercalator, actinomycin D, on DNA binding and the inhibition of transcription and DNA replication. PLoS ONE. 2012;7:e47101 pubmed publisher
Soda K, Kano Y, Chiba F. Food polyamine and cardiovascular disease--an epidemiological study. Glob J Health Sci. 2012;4:170-8 pubmed publisher
Wu M, Wang F, Zhang C, Xie Y, Han B, Huang J, et al. Heme oxygenase-1 is involved in nitric oxide- and cGMP-induced ?-Amy2/54 gene expression in GA-treated wheat aleurone layers. Plant Mol Biol. 2013;81:27-40 pubmed publisher
Benedikt J, Inyushin M, Kucheryavykh Y, Rivera Y, Kucheryavykh L, Nichols C, et al. Intracellular polyamines enhance astrocytic coupling. Neuroreport. 2012;23:1021-5 pubmed publisher
Metwally A, Blagbrough I, Mantell J. Quantitative silencing of EGFP reporter gene by self-assembled siRNA lipoplexes of LinOS and cholesterol. Mol Pharm. 2012;9:3384-95 pubmed publisher
Alarcon R. Anticancer system created by acrolein and hydroxyl radical generated in enzymatic oxidation of spermine and other biochemical reactions. Med Hypotheses. 2012;79:522-30 pubmed publisher
Chaturvedi R, de Sablet T, Peek R, Wilson K. Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk. Gut Microbes. 2012;3:48-56 pubmed publisher
Jain R, Valiante V, Remme N, Docimo T, Heinekamp T, Hertweck C, et al. The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus. Mol Microbiol. 2011;82:39-53 pubmed publisher
Durdagi S, Senturk M, Ekinci D, Balaydın H, Göksu S, Kufrevioglu O, et al. Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site. Bioorg Med Chem. 2011;19:1381-9 pubmed publisher
García Faroldi G, Rodriguez C, Urdiales J, Pérez Pomares J, Dávila J, Pejler G, et al. Polyamines are present in mast cell secretory granules and are important for granule homeostasis. PLoS ONE. 2010;5:e15071 pubmed publisher
Kucherenko Y, Lang F. Inhibition of cation channels in human erythrocytes by spermine. J Membr Biol. 2010;237:93-106 pubmed publisher
Hadjipavlou Litina D, Magoulas G, Bariamis S, Drainas D, Avgoustakis K, Papaioannou D. Does conjugation of antioxidants improve their antioxidative/anti-inflammatory potential?. Bioorg Med Chem. 2010;18:8204-17 pubmed publisher
Tomasi S, Renault J, Martin B, Duhieu S, Cerec V, Le Roch M, et al. Targeting the polyamine transport system with benzazepine- and azepine-polyamine conjugates. J Med Chem. 2010;53:7647-63 pubmed publisher
Carta F, Temperini C, Innocenti A, Scozzafava A, Kaila K, Supuran C. Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010;53:5511-22 pubmed publisher
Rook Y, Schmidtke K, Gaube F, Schepmann D, Wünsch B, Heilmann J, et al. Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. J Med Chem. 2010;53:3611-7 pubmed publisher
Mattoo A, Minocha S, Minocha R, Handa A. Polyamines and cellular metabolism in plants: transgenic approaches reveal different responses to diamine putrescine versus higher polyamines spermidine and spermine. Amino Acids. 2010;38:405-13 pubmed publisher
. Guide to Receptors and Channels (GRAC), 4th Edition. Br J Pharmacol. 2009;158 Suppl 1:S1-254 pubmed publisher
Pegg A, Michael A. Spermine synthase. Cell Mol Life Sci. 2010;67:113-21 pubmed publisher
de Medina P, Paillasse M, Payre B, Silvente Poirot S, Poirot M. Synthesis of new alkylaminooxysterols with potent cell differentiating activities: identification of leads for the treatment of cancer and neurodegenerative diseases. J Med Chem. 2009;52:7765-77 pubmed publisher
Zhu S, Ashok M, Li J, Li W, Yang H, Wang P, et al. Spermine protects mice against lethal sepsis partly by attenuating surrogate inflammatory markers. Mol Med. 2009;15:275-82 pubmed publisher
Guo K, Li L. Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome. Anal Chem. 2009;81:3919-32 pubmed publisher
Amendola R, Cervelli M, Fratini E, Polticelli F, Sallustio D, Mariottini P. Spermine metabolism and anticancer therapy. Curr Cancer Drug Targets. 2009;9:118-30 pubmed
Sreekumar A, Poisson L, Rajendiran T, Khan A, Cao Q, Yu J, et al. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009;457:910-4 pubmed publisher
Bazin M, Le Lamer A, Delcros J, Rouaud I, Uriac P, Boustie J, et al. Synthesis and cytotoxic activities of usnic acid derivatives. Bioorg Med Chem. 2008;16:6860-6 pubmed publisher
Goode D, Totten R, Heeres J, Hergenrother P. Identification of promiscuous small molecule activators in high-throughput enzyme activation screens. J Med Chem. 2008;51:2346-9 pubmed publisher
Pegg A. Spermidine/spermine-N(1)-acetyltransferase: a key metabolic regulator. Am J Physiol Endocrinol Metab. 2008;294:E995-1010 pubmed publisher
Agostinelli E, Seiler N. Lysosomotropic compounds and spermine enzymatic oxidation products in cancer therapy (review). Int J Oncol. 2007;31:473-84 pubmed
Kwon D, Lu C. Polyamine effects on antibiotic susceptibility in bacteria. Antimicrob Agents Chemother. 2007;51:2070-7 pubmed
Kawakita M, Hiramatsu K. Diacetylated derivatives of spermine and spermidine as novel promising tumor markers. J Biochem. 2006;139:315-22 pubmed
Delcros J, Tomasi S, Duhieu S, Foucault M, Martin B, Le Roch M, et al. Effect of polyamine homologation on the transport and biological properties of heterocyclic amidines. J Med Chem. 2006;49:232-45 pubmed
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product information
Catalog Number :
S4264
Product Name :
Spermine
Product Type :
CELL CULTURE REAGENT
Product Group :
Cell Biology
Product Description :
suitable for cell culture, BioReagent
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA