This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
SB 216763
catalog :
S3442
citations: 29
Reference
Adusumilli L, Facchinello N, Teh C, Busolin G, Le M, Yang H, et al. miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation. Cells. 2020;9: pubmed publisher
Yun C, Roh E, Kim S, Han J, Lee J, Jung D, et al. Stem Cell Factor-Inducible MITF-M Expression in Therapeutics for Acquired Skin Hyperpigmentation. Theranostics. 2020;10:340-352 pubmed publisher
Li Q, Zhou X, Fang Z, Pan Z. Effect of STC2 gene silencing on colorectal cancer cells. Mol Med Rep. 2019;20:977-984 pubmed publisher
Zhou J, Wang T, Wang H, Jiang Y, Peng S. Obacunone attenuates high glucose-induced oxidative damage in NRK-52E cells by inhibiting the activity of GSK-3β. Biochem Biophys Res Commun. 2019;513:226-233 pubmed publisher
Ramos Fernández E, Tapia Rojas C, Ramirez V, Inestrosa N. Wnt-7a Stimulates Dendritic Spine Morphogenesis and PSD-95 Expression Through Canonical Signaling. Mol Neurobiol. 2019;56:1870-1882 pubmed publisher
Glaeser K, Urban M, Fenech E, Voloshanenko O, Kranz D, Lari F, et al. ERAD-dependent control of the Wnt secretory factor Evi. EMBO J. 2018;37: pubmed publisher
Wickens R, Quartarone S, Beninger R. Inhibition of glycogen synthase kinase-3 by SB 216763 affects acquisition at lower doses than expression of amphetamine-conditioned place preference in rats. Behav Pharmacol. 2017;28:262-271 pubmed publisher
Gulino G, Polimeni M, Prato M, Gazzano E, Kopecka J, Colombatto S, et al. Effects of Chrysotile Exposure in Human Bronchial Epithelial Cells: Insights into the Pathogenic Mechanisms of Asbestos-Related Diseases. Environ Health Perspect. 2016;124:776-84 pubmed publisher
Jurczyk A, Nowosielska A, Przewozniak N, Aryee K, Diiorio P, Blodgett D, et al. Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β. FASEB J. 2016;30:983-93 pubmed publisher
Zhong G, He J, Zhou R, LORENZO D, Babcock H, Bennett V, et al. Developmental mechanism of the periodic membrane skeleton in axons. elife. 2014;3: pubmed publisher
Gagliardi M, Hernandez A, McGough I, Vincent J. Inhibitors of endocytosis prevent Wnt/Wingless signalling by reducing the level of basal β-catenin/Armadillo. J Cell Sci. 2014;127:4918-26 pubmed publisher
Xu L, Long Z, Peng F, Liu Y, Xu J, Wang C, et al. Aurora kinase a suppresses metabolic stress-induced autophagic cell death by activating mTOR signaling in breast cancer cells. Oncotarget. 2014;5:7498-511 pubmed
Shi X, Miller J, Harper L, Poole R, Gould T, Unterwald E. Reactivation of cocaine reward memory engages the Akt/GSK3/mTOR signaling pathway and can be disrupted by GSK3 inhibition. Psychopharmacology (Berl). 2014;231:3109-18 pubmed publisher
Miller J, Barr J, Harper L, Poole R, Gould T, Unterwald E. The GSK3 signaling pathway is activated by cocaine and is critical for cocaine conditioned reward in mice. PLoS ONE. 2014;9:e88026 pubmed publisher
Groulx J, Giroux V, Beauséjour M, Boudjadi S, Basora N, Carrier J, et al. Integrin ?6A splice variant regulates proliferation and the Wnt/?-catenin pathway in human colorectal cancer cells. Carcinogenesis. 2014;35:1217-27 pubmed publisher
Brooks M, Neelam S, Cammarata P. Lenticular mitoprotection. Part B: GSK-3? and regulation of mitochondrial permeability transition for lens epithelial cells in atmospheric oxygen. Mol Vis. 2013;19:2451-67 pubmed
Baarsma H, Bos S, Meurs H, Visser K, Smit M, Schols A, et al. Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: I. Effects on lung remodeling and pathology. Respir Res. 2013;14:113 pubmed publisher
Brooks M, Neelam S, Fudala R, Gryczynski I, Cammarata P. Lenticular mitoprotection. Part A: Monitoring mitochondrial depolarization with JC-1 and artifactual fluorescence by the glycogen synthase kinase-3? inhibitor, SB216763. Mol Vis. 2013;19:1406-12 pubmed
Woolley J, Naughton R, Stanicka J, Gough D, Bhatt L, Dickinson B, et al. H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling. PLoS ONE. 2012;7:e34050 pubmed publisher
Dash P, Johnson D, Clark J, Orsi S, Zhang M, Zhao J, et al. Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome. PLoS ONE. 2011;6:e24648 pubmed publisher
Gouti M, Briscoe J, Gavalas A. Anterior Hox genes interact with components of the neural crest specification network to induce neural crest fates. Stem Cells. 2011;29:858-70 pubmed publisher
Kitagawa K, Kotake Y, Hiramatsu Y, Liu N, Suzuki S, Nakamura S, et al. GSK3 regulates the expressions of human and mouse c-Myb via different mechanisms. Cell Div. 2010;5:27 pubmed publisher
Benakanakere M, Zhao J, Galicia J, Martin M, Kinane D. Sphingosine kinase-1 is required for toll mediated beta-defensin 2 induction in human oral keratinocytes. PLoS ONE. 2010;5:e11512 pubmed publisher
Guo S, Arai K, Stins M, Chuang D, Lo E. Lithium upregulates vascular endothelial growth factor in brain endothelial cells and astrocytes. Stroke. 2009;40:652-5 pubmed publisher
Wolf A, Lyuksyutova A, Fenstermaker A, Shafer B, Lo C, Zou Y. Phosphatidylinositol-3-kinase-atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance. J Neurosci. 2008;28:3456-67 pubmed publisher
Deng H, Dokshin G, Lei J, Goldsmith A, Bitar K, Fingar D, et al. Inhibition of glycogen synthase kinase-3beta is sufficient for airway smooth muscle hypertrophy. J Biol Chem. 2008;283:10198-207 pubmed publisher
Gross E, Hsu A, Gross G. Delayed cardioprotection afforded by the glycogen synthase kinase 3 inhibitor SB-216763 occurs via a KATP- and MPTP-dependent mechanism at reperfusion. Am J Physiol Heart Circ Physiol. 2008;294:H1497-500 pubmed publisher
Shakoori A, Ougolkov A, Yu Z, Zhang B, Modarressi M, Billadeau D, et al. Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation. Biochem Biophys Res Commun. 2005;334:1365-73 pubmed
Cross D, Culbert A, Chalmers K, Facci L, Skaper S, Reith A. Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death. J Neurochem. 2001;77:94-102 pubmed
product information
Catalog Number :
S3442
Product Name :
SB 216763
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
>98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA