This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
(±)-Synephrine
catalog :
S0752
citations: 44
Reference
Chen H, Nwe P, Yang Y, Rosen C, Bielecka A, Kuchroo M, et al. A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology. Cell. 2019;177:1217-1231.e18 pubmed publisher
Song Y, Chai T, Lou S, Zhao Y, Zhang X, Yang S, et al. Determination of synephrine in feeds by a novel quick, easy, cheap, effective, rugged, and safe solid-phase extraction method combined with UHPLC-MS/MS. J Sep Sci. 2018;41:1743-1751 pubmed publisher
Rix R, Christopher Cutler G. Acute Exposure to Worst-Case Concentrations of Amitraz Does Not Affect Honey Bee Learning, Short-Term Memory, or Hemolymph Octopamine Levels. J Econ Entomol. 2017;110:127-132 pubmed publisher
Pan C, Wang W, Zhang H, Xu L, Chen X. In situ synthesis of homochiral metal-organic framework in capillary column for capillary electrochromatography enantioseparation. J Chromatogr A. 2015;1388:207-16 pubmed publisher
Roh K, Kim I, Kim Y, Lee M, Lee J, Jung E, et al. Synephrine inhibits eotaxin-1 expression via the STAT6 signaling pathway. Molecules. 2014;19:11883-95 pubmed publisher
Mariotti K, Schuh R, Ferranti P, Ortiz R, Souza D, Pechansky F, et al. Simultaneous analysis of amphetamine-type stimulants in plasma by solid-phase microextraction and gas chromatography-mass spectrometry. J Anal Toxicol. 2014;38:432-7 pubmed publisher
Wang S, Chen P, Jiang W, Wu L, Chen L, Fan X, et al. Identification of the effective constituents for anti-inflammatory activity of Ju-Zhi-Jiang-Tang, an ancient traditional Chinese medicine formula. J Chromatogr A. 2014;1348:105-24 pubmed publisher
Sun Y, Qiao L, Shen Y, Jiang P, Chen J, Ye X. Phytochemical profile and antioxidant activity of physiological drop of citrus fruits. J Food Sci. 2013;78:C37-42 pubmed publisher
Medana C, Calza P, Giancotti V, Dal Bello F, Aragno M, Baiocchi C. Study of the photocatalytic transformation of synephrine: a biogenic amine relevant in anti-doping analysis. Anal Bioanal Chem. 2013;405:1105-13 pubmed publisher
Stohs S, Preuss H, Shara M. A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine. Int J Med Sci. 2012;9:527-38 pubmed
Peixoto J, Comar J, Moreira C, Soares A, de Oliveira A, Bracht A, et al. Effects of Citrus aurantium (bitter orange) fruit extracts and p-synephrine on metabolic fluxes in the rat liver. Molecules. 2012;17:5854-69 pubmed publisher
Hansen D, George N, White G, Pellicore L, Abdel Rahman A, Fabricant D. Physiological effects following administration of Citrus aurantium for 28 days in rats. Toxicol Appl Pharmacol. 2012;261:236-47 pubmed publisher
Yi Y, Cheng X, Liu L, Hu G, Wang Z, Deng Y, et al. Simultaneous determination of synephrine, arecoline, and norisoboldine in Chinese patent medicine Si-Mo-Tang oral liquid preparation by strong cation exchange high performance liquid chromatography. Pharm Biol. 2012;50:832-8 pubmed publisher
Schmitt G, Arbo M, Lorensi A, Maciel E, Krahn C, Mariotti K, et al. Toxicological effects of a mixture used in weight loss products: p-synephrine associated with ephedrine, salicin, and caffeine. Int J Toxicol. 2012;31:184-91 pubmed publisher
Hong N, Cui Z, Kang H, Lee D, Lee Y, Park D. p-Synephrine stimulates glucose consumption via AMPK in L6 skeletal muscle cells. Biochem Biophys Res Commun. 2012;418:720-4 pubmed publisher
Fan J, Zhang L, Zhang X, Huang J, Tong S, Kong T, et al. Molecularly imprinted polymers for selective extraction of synephrine from Aurantii Fructus Immaturus. Anal Bioanal Chem. 2012;402:1337-46 pubmed publisher
Ozaki K, Ryuda M, Yamada A, Utoguchi A, Ishimoto H, Calas D, et al. A gustatory receptor involved in host plant recognition for oviposition of a swallowtail butterfly. Nat Commun. 2011;2:542 pubmed publisher
Retamero C, Rivera T, Murphy K. "Ephedra-free" diet pill-induced psychosis. Psychosomatics. 2011;52:579-82 pubmed publisher
Thevis M, Koch A, Sigmund G, Thomas A, Schanzer W. Analysis of octopamine in human doping control samples. Biomed Chromatogr. 2012;26:610-5 pubmed publisher
Stohs S, Preuss H, Shara M. A review of the receptor-binding properties of p-synephrine as related to its pharmacological effects. Oxid Med Cell Longev. 2011;2011:482973 pubmed publisher
Kang S. [Determination of synephrine and arecoline contents in Xiao'er Xiaoji Zhike oral liquid]. Zhongguo Zhong Yao Za Zhi. 2011;36:1298-300 pubmed
Ishiuchi S, Asakawa T, Mitsuda H, Miyazaki M, Chakraborty S, Fujii M. Gas-phase spectroscopy of synephrine by laser desorption supersonic jet technique. J Phys Chem A. 2011;115:10363-9 pubmed publisher
Hansen D, Juliar B, White G, Pellicore L. Developmental toxicity of Citrus aurantium in rats. Birth Defects Res B Dev Reprod Toxicol. 2011;92:216-23 pubmed publisher
Stohs S, Preuss H, Keith S, Keith P, Miller H, Kaats G. Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes. Int J Med Sci. 2011;8:295-301 pubmed
Stohs S, Preuss H, Shara M. The safety of Citrus aurantium (bitter orange) and its primary protoalkaloid p-synephrine. Phytother Res. 2011;25:1421-8 pubmed publisher
Seifert J, Nelson A, Devonish J, Burke E, Stohs S. Effect of acute administration of an herbal preparation on blood pressure and heart rate in humans. Int J Med Sci. 2011;8:192-7 pubmed
Stohs S. Synephrine: from trace concentrations to massive consumption in weight-loss. Food Chem Toxicol. 2011;49:1472-3; author reply 1474-5 pubmed publisher
Mercader J, Wanecq E, Chen J, Carpene C. Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium. J Physiol Biochem. 2011;67:443-52 pubmed publisher
Rossato L, Costa V, de Pinho P, Carvalho F, de Lourdes Bastos M, Remião F. Structural isomerization of synephrine influences its uptake and ensuing glutathione depletion in rat-isolated cardiomyocytes. Arch Toxicol. 2011;85:929-39 pubmed publisher
Rossato L, Costa V, Limberger R, Bastos M, Remião F. Synephrine: from trace concentrations to massive consumption in weight-loss. Food Chem Toxicol. 2011;49:8-16 pubmed publisher
Kim N, Pham N, Quinn R, Kwon H. R-(-)-beta-O-methylsynephrine, a natural product, inhibits VEGF-induced angiogenesis in vitro and in vivo. Biochem Biophys Res Commun. 2010;399:20-3 pubmed publisher
Stohs S. Lack of evidence that p-synephrine is responsible for STEMI. Tex Heart Inst J. 2010;37:383; author reply 383-4 pubmed
Thomas J, Munir J, McIntyre P, Ferguson M. STEMI in a 24-year-old man after use of a synephrine-containing dietary supplement: a case report and review of the literature. Tex Heart Inst J. 2009;36:586-90 pubmed
Guo K, Li L. Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome. Anal Chem. 2009;81:3919-32 pubmed publisher
Wang S, Ma A, Song S, Quan Q, Zhao X, Zheng X. Fasting serum free fatty acid composition, waist/hip ratio and insulin activity in essential hypertensive patients. Hypertens Res. 2008;31:623-32 pubmed publisher
Minuz P, Jiang H, Fava C, Turolo L, Tacconelli S, Ricci M, et al. Altered release of cytochrome p450 metabolites of arachidonic acid in renovascular disease. Hypertension. 2008;51:1379-85 pubmed publisher
Haaz S, Fontaine K, Cutter G, Limdi N, Perumean Chaney S, Allison D. Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update. Obes Rev. 2006;7:79-88 pubmed
Abdelhamid S, Blomer R, Hommel G, Haack D, Lewicka S, Fiegel P, et al. Urinary tetrahydroaldosterone as a screening method for primary aldosteronism: a comparative study. Am J Hypertens. 2003;16:522-30 pubmed
Sim M, Qui X. Angiotensins in plasma of hypertensive rats and human. Regul Pept. 2003;111:179-82 pubmed
Carpene C, Galitzky J, Fontana E, Atgie C, Lafontan M, Berlan M. Selective activation of beta3-adrenoceptors by octopamine: comparative studies in mammalian fat cells. Naunyn Schmiedebergs Arch Pharmacol. 1999;359:310-21 pubmed
Airriess C, Rudling J, Midgley J, Evans P. Selective inhibition of adenylyl cyclase by octopamine via a human cloned alpha 2A-adrenoceptor. Br J Pharmacol. 1997;122:191-8 pubmed
Andrew R, Best S, Watson D, Midgley J, Reid J, Squire I. Analysis of biogenic amines in plasma of hypertensive patients and a control group. Neurochem Res. 1993;18:1179-82 pubmed
Andrew R, Watson D, Best S, Midgley J, Wenlong H, Petty R. The determination of hydroxydopamines and other trace amines in the urine of parkinsonian patients and normal controls. Neurochem Res. 1993;18:1175-7 pubmed
Brown C, McGrath J, Midgley J, Muir A, O Brien J, Thonoor C, et al. Activities of octopamine and synephrine stereoisomers on alpha-adrenoceptors. Br J Pharmacol. 1988;93:417-29 pubmed
product information
Catalog Number :
S0752
Product Name :
(±)-Synephrine
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98%
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA