This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Strychnine
catalog :
S0532
citations: 112
Reference
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Bhattarai J, Park S, Chun S, Cho D, Han S. Activation of synaptic and extrasynaptic glycine receptors by taurine in preoptic hypothalamic neurons. Neurosci Lett. 2015;608:51-6 pubmed publisher
Murphy Baum B, Taylor W. The Synaptic and Morphological Basis of Orientation Selectivity in a Polyaxonal Amacrine Cell of the Rabbit Retina. J Neurosci. 2015;35:13336-50 pubmed publisher
Khacho P, Wang B, Ahlskog N, Hristova E, Bergeron R. Differential effects of N-acetyl-aspartyl-glutamate on synaptic and extrasynaptic NMDA receptors are subunit- and pH-dependent in the CA1 region of the mouse hippocampus. Neurobiol Dis. 2015;82:580-592 pubmed publisher
Ohashi N, Sasaki M, Ohashi M, Kamiya Y, Baba H, Kohno T. Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn. Sci Rep. 2015;5:13458 pubmed publisher
Tien N, Pearson J, Heller C, Demas J, Kerschensteiner D. Genetically Identified Suppressed-by-Contrast Retinal Ganglion Cells Reliably Signal Self-Generated Visual Stimuli. J Neurosci. 2015;35:10815-20 pubmed publisher
Lee K, Prescott S. Chloride dysregulation and inhibitory receptor blockade yield equivalent disinhibition of spinal neurons yet are differentially reversed by carbonic anhydrase blockade. Pain. 2015;156:2431-7 pubmed publisher
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Zachary S, Fuchs P. Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss. J Neurosci. 2015;35:9701-6 pubmed publisher
Imlach W, Bhola R, May L, Christopoulos A, Christie M. A Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain Model. Mol Pharmacol. 2015;88:460-8 pubmed publisher
Schall K, Holoyda K, Grant C, Levin D, Torres E, Maxwell A, et al. Adult zebrafish intestine resection: a novel model of short bowel syndrome, adaptation, and intestinal stem cell regeneration. Am J Physiol Gastrointest Liver Physiol. 2015;309:G135-45 pubmed publisher
Zhang X, Yan X, Zhang B, Yang Q, Ye M, Cao W, et al. Activity-induced synaptic delivery of the GluN2A-containing NMDA receptor is dependent on endoplasmic reticulum chaperone Bip and involved in fear memory. Cell Res. 2015;25:818-36 pubmed publisher
Ishibashi M, Gumenchuk I, Kang B, Steger C, Lynn E, Molina N, et al. Orexin Receptor Activation Generates Gamma Band Input to Cholinergic and Serotonergic Arousal System Neurons and Drives an Intrinsic Ca(2+)-Dependent Resonance in LDT and PPT Cholinergic Neurons. Front Neurol. 2015;6:120 pubmed publisher
Sethuramanujam S, Slaughter M. Properties of a Glutamatergic Synapse Controlling Information Output from Retinal Bipolar Cells. PLoS ONE. 2015;10:e0129133 pubmed publisher
Kurzawa M, Filipiak Szok A, Kłodzińska E, Szłyk E. Determination of phytochemicals, antioxidant activity and total phenolic content in Andrographis paniculata using chromatographic methods. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;995-996:101-6 pubmed publisher
Gao S, Yu Y, Ma Z, Sun H, Zhang Y, Wang X, et al. NMDAR-Mediated Hippocampal Neuronal Death is Exacerbated by Activities of ASIC1a. Neurotox Res. 2015;28:122-37 pubmed publisher
Yamasaki H, Funai Y, Funao T, Mori T, Nishikawa K. Effects of tramadol on substantia gelatinosa neurons in the rat spinal cord: an in vivo patch-clamp analysis. PLoS ONE. 2015;10:e0125147 pubmed publisher
Omori Y, Nakajima M, Nishimura K, Takahashi E, Arai T, Akahira M, et al. Analgesic effect of GT-0198, a structurally novel glycine transporter 2 inhibitor, in a mouse model of neuropathic pain. J Pharmacol Sci. 2015;127:377-81 pubmed publisher
Castilho Ã, Ambrósio A, Hartveit E, Veruki M. Disruption of a neural microcircuit in the rod pathway of the mammalian retina by diabetes mellitus. J Neurosci. 2015;35:5422-33 pubmed publisher
Shimomura H, Ito M, Nishiyama A, Tanizawa T, Takeshima Y, Nishimaru H, et al. Glycine plays a crucial role as a co-agonist of NMDA receptors in the neuronal circuit generating body movements in rat fetuses. Neurosci Res. 2015;97:13-9 pubmed publisher
Yang K, Ma R, Wang Q, Jiang P, Li Y. Optoactivation of parvalbumin neurons in the spinal dorsal horn evokes GABA release that is regulated by presynaptic GABAB receptors. Neurosci Lett. 2015;594:55-9 pubmed publisher
Liang C, Ye H, Wang R, Ni C, Rao Y, Zhang Y. Identification and quantification of 34 drugs and toxic compounds in blood, urine, and gastric content using liquid chromatography with tandem mass spectrometry. J Sep Sci. 2015;38:1680-90 pubmed publisher
Oyemitan I, Olayera O, Alabi A, Abass L, Elusiyan C, Oyedeji A, et al. Psychoneuropharmacological activities and chemical composition of essential oil of fresh fruits of Piper guineense (Piperaceae) in mice. J Ethnopharmacol. 2015;166:240-9 pubmed publisher
Zhai P, Xu L, Yang J, Jiang Z, Zhao G, Sun L, et al. Reduction of inflammatory responses by L-serine treatment leads to neuroprotection in mice after traumatic brain injury. Neuropharmacology. 2015;95:1-11 pubmed publisher
Kamii H, Kurosawa R, Taoka N, Shinohara F, Minami M, Kaneda K. Intrinsic membrane plasticity via increased persistent sodium conductance of cholinergic neurons in the rat laterodorsal tegmental nucleus contributes to cocaine-induced addictive behavior. Eur J Neurosci. 2015;41:1126-38 pubmed publisher
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Choi I, Cho J, Lee M, Jang I. Enzymatic conversion of ATP to adenosine contributes to ATP-induced inhibition of glutamate release in rat medullary dorsal horn neurons. Neuropharmacology. 2015;93:94-102 pubmed publisher
Firl A, Ke J, Zhang L, Fuerst P, Singer J, Feller M. Elucidating the role of AII amacrine cells in glutamatergic retinal waves. J Neurosci. 2015;35:1675-86 pubmed publisher
Kamiyama T, Kameda H, Murabe N, Fukuda S, Yoshioka N, Mizukami H, et al. Corticospinal tract development and spinal cord innervation differ between cervical and lumbar targets. J Neurosci. 2015;35:1181-91 pubmed publisher
Kopach O, Krotov V, Belan P, Voitenko N. Inflammatory-induced changes in synaptic drive and postsynaptic AMPARs in lamina II dorsal horn neurons are cell-type specific. Pain. 2015;156:428-38 pubmed publisher
Chumakov I, Nabirotchkin S, Cholet N, Milet A, Boucard A, Toulorge D, et al. Combining two repurposed drugs as a promising approach for Alzheimer's disease therapy. Sci Rep. 2015;5:7608 pubmed publisher
Meng Y, Xiao Q, Bai J, Xiao X, Zhang S, Zhu X, et al. Resolution and chiral recognition of muscone as well as actions on neural system. J Asian Nat Prod Res. 2014;16:1166-70 pubmed publisher
Liu Y, Huang D, Wen R, Chen X, Yi H. Glycine receptor-mediated inhibition of medial prefrontal cortical pyramidal cells. Biochem Biophys Res Commun. 2015;456:666-9 pubmed publisher
Adebesin I, Akindele A, Adeyemi O. Evaluation of neuropharmacological effects of aqueous leaf extract of Albizia glaberrima (Leguminosae) in mice. J Ethnopharmacol. 2015;160:101-8 pubmed publisher
Reyes Garcés N, Bojko B, Pawliszyn J. High throughput quantification of prohibited substances in plasma using thin film solid phase microextraction. J Chromatogr A. 2014;1374:40-49 pubmed publisher
Mehrzadi S, Sadr S, Hosseinzadeh A, Gholamine B, Shahbazi A, FallahHuseini H, et al. Anticonvulsant activity of the ethanolic extract of Punica granatum L. seed. Neurol Res. 2015;37:470-5 pubmed publisher
Zhang X, Ji F, Wang N, Chen L, Tian T, Lu W. Glycine induces bidirectional modifications in N-methyl-D-aspartate receptor-mediated synaptic responses in hippocampal CA1 neurons. J Biol Chem. 2014;289:31200-11 pubmed publisher
Stafford B, Manookin M, Singer J, Demb J. NMDA and AMPA receptors contribute similarly to temporal processing in mammalian retinal ganglion cells. J Physiol. 2014;592:4877-89 pubmed publisher
Benoist C, Kawas L, Zhu M, Tyson K, Stillmaker L, Appleyard S, et al. The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system. J Pharmacol Exp Ther. 2014;351:390-402 pubmed publisher
Mayer F, Albrecht O, Dondzillo A, Klug A. Glycinergic inhibition to the medial nucleus of the trapezoid body shows prominent facilitation and can sustain high levels of ongoing activity. J Neurophysiol. 2014;112:2901-15 pubmed publisher
Tong C, Macdermott A. Synaptic GluN2A and GluN2B containing NMDA receptors within the superficial dorsal horn activated following primary afferent stimulation. J Neurosci. 2014;34:10808-20 pubmed publisher
Huang L, Balsara R, Castellino F. Synthetic conantokin peptides potently inhibit N-methyl-D-aspartate receptor-mediated currents of retinal ganglion cells. J Neurosci Res. 2014;92:1767-74 pubmed publisher
Sodhi P, Hartwick A. Adenosine modulates light responses of rat retinal ganglion cell photoreceptors througha cAMP-mediated pathway. J Physiol. 2014;592:4201-20 pubmed publisher
Dejanovic B, Semtner M, Ebert S, Lamkemeyer T, Neuser F, Luscher B, et al. Palmitoylation of gephyrin controls receptor clustering and plasticity of GABAergic synapses. PLoS Biol. 2014;12:e1001908 pubmed publisher
Husson Z, Rousseau C, Broll I, Zeilhofer H, Dieudonné S. Differential GABAergic and glycinergic inputs of inhibitory interneurons and Purkinje cells to principal cells of the cerebellar nuclei. J Neurosci. 2014;34:9418-31 pubmed publisher
Sun J, Chen J, Shi Y. Ionic liquid-based electromembrane extraction and its comparison with traditional organic solvent based electromembrane extraction for the determination of strychnine and brucine in human urine. J Chromatogr A. 2014;1352:1-7 pubmed publisher
Zhu Y, Xu J, Hauswirth W, DeVries S. Genetically targeted binary labeling of retinal neurons. J Neurosci. 2014;34:7845-61 pubmed publisher
Dhar M, Zhu M, Impey S, Lambert T, Bland T, Karatsoreos I, et al. Leptin induces hippocampal synaptogenesis via CREB-regulated microRNA-132 suppression of p250GAP. Mol Endocrinol. 2014;28:1073-87 pubmed publisher
Salling M, Harrison N. Strychnine-sensitive glycine receptors on pyramidal neurons in layers II/III of the mouse prefrontal cortex are tonically activated. J Neurophysiol. 2014;112:1169-78 pubmed publisher
Song J, Youn D. Theta-burst stimulation induces LTP at excitatory and inhibitory synapses in the spinal trigeminal subnucleus interpolaris. Neurosci Lett. 2014;574:1-5 pubmed publisher
Dyavanapalli J, Jameson H, Dergacheva O, Jain V, Alhusayyen M, Mendelowitz D. Chronic intermittent hypoxia-hypercapnia blunts heart rate responses and alters neurotransmission to cardiac vagal neurons. J Physiol. 2014;592:2799-811 pubmed publisher
Ray T, Heath K, Hasan N, Noel J, SAMUELS I, Martemyanov K, et al. GPR179 is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells. J Neurosci. 2014;34:6334-43 pubmed publisher
White S, Carter C, Magoski N. A potentially novel nicotinic receptor in Aplysia neuroendocrine cells. J Neurophysiol. 2014;112:446-62 pubmed publisher
Arora S, Kaur T, Kaur A, Singh A. Glycine aggravates ischemia reperfusion-induced acute kidney injury through N-Methyl-D-Aspartate receptor activation in rats. Mol Cell Biochem. 2014;393:123-31 pubmed publisher
Jonsson S, Adermark L, Ericson M, Söderpalm B. The involvement of accumbal glycine receptors in the dopamine-elevating effects of addictive drugs. Neuropharmacology. 2014;82:69-75 pubmed publisher
Matsuzawa R, Fujiwara T, Nemoto K, Fukushima T, Yamaguchi S, Akagawa K, et al. Presynaptic inhibitory actions of pregabalin on excitatory transmission in superficial dorsal horn of mouse spinal cord: further characterization of presynaptic mechanisms. Neurosci Lett. 2014;558:186-91 pubmed publisher
Senior M, Williamson R, Martin G. Using HMBC and ADEQUATE NMR data to define and differentiate long-range coupling pathways: is the Crews rule obsolete?. J Nat Prod. 2013;76:2088-93 pubmed publisher
Saraswati S, Alhaider A, Agrawal S. Anticarcinogenic effect of brucine in diethylnitrosamine initiated and phenobarbital-promoted hepatocarcinogenesis in rats. Chem Biol Interact. 2013;206:214-21 pubmed publisher
Jalabi W, Kopp Scheinpflug C, Allen P, Schiavon E, DiGiacomo R, Forsythe I, et al. Sound localization ability and glycinergic innervation of the superior olivary complex persist after genetic deletion of the medial nucleus of the trapezoid body. J Neurosci. 2013;33:15044-9 pubmed publisher
Ahmed Z. Effects of cathodal trans-spinal direct current stimulation on mouse spinal network and complex multijoint movements. J Neurosci. 2013;33:14949-57 pubmed publisher
Hirata H, Ogino K, Yamada K, Leacock S, Harvey R. Defective escape behavior in DEAH-box RNA helicase mutants improved by restoring glycine receptor expression. J Neurosci. 2013;33:14638-44 pubmed publisher
Lu Y, Dong H, Gao Y, Gong Y, Ren Y, Gu N, et al. A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia. J Clin Invest. 2013;123:4050-62 pubmed publisher
Shu G, Mi X, Cai J, Zhang X, Yin W, Yang X, et al. Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: the role of hypoxia inducible factor 1 pathway. Toxicol Lett. 2013;222:91-101 pubmed publisher
Wang D, Chen J, Cai B. [Optimization and application of method to determine plasma concentration of brucine]. Zhongguo Zhong Yao Za Zhi. 2013;38:1075-8 pubmed
Rzaeva N, Dmitrienko A. [Visual cortex and its participation in retinal function regulation]. Vestn Oftalmol. 2013;129:4-8 pubmed
Janczewski W, Tashima A, Hsu P, Cui Y, Feldman J. Role of inhibition in respiratory pattern generation. J Neurosci. 2013;33:5454-65 pubmed publisher
Apostolides P, Trussell L. Rapid, activity-independent turnover of vesicular transmitter content at a mixed glycine/GABA synapse. J Neurosci. 2013;33:4768-81 pubmed publisher
Kresyun V, Polyasny V, Godovan V, Godlevsky L. Changes in brain cortex sensitivity to epileptogens under conditions of ketogenic diet. Bull Exp Biol Med. 2013;154:457-9 pubmed
Mehta B, Snellman J, Chen S, Li W, Zenisek D. Synaptic ribbons influence the size and frequency of miniature-like evoked postsynaptic currents. Neuron. 2013;77:516-27 pubmed publisher
Saraswati S, Agrawal S. Brucine, an indole alkaloid from Strychnos nux-vomica attenuates VEGF-induced angiogenesis via inhibiting VEGFR2 signaling pathway in vitro and in vivo. Cancer Lett. 2013;332:83-93 pubmed publisher
Yamanaka I, Miki M, Asakawa K, Kawakami K, Oda Y, Hirata H. Glycinergic transmission and postsynaptic activation of CaMKII are required for glycine receptor clustering in vivo. Genes Cells. 2013;18:211-24 pubmed publisher
Bifulco G, Riccio R, Martin G, Buevich A, Williamson R. Quantum chemical calculations of 1J(CC) coupling constants for the stereochemical determination of organic compounds. Org Lett. 2013;15:654-7 pubmed publisher
Chen J, Li L, Qi Y, Chen Z, Cai B. [Preparation and pharmacokinetics of brucine hydrogel patch]. Zhong Yao Cai. 2012;35:1295-8 pubmed
Born S, Levit A, Niv M, Meyerhof W, Behrens M. The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands. J Neurosci. 2013;33:201-13 pubmed publisher
Maison S, Pyott S, Meredith A, Liberman M. Olivocochlear suppression of outer hair cells in vivo: evidence for combined action of BK and SK2 channels throughout the cochlea. J Neurophysiol. 2013;109:1525-34 pubmed publisher
McCracken L, Blednov Y, Trudell J, Benavidez J, Betz H, Harris R. Mutation of a zinc-binding residue in the glycine receptor ?1 subunit changes ethanol sensitivity in vitro and alcohol consumption in vivo. J Pharmacol Exp Ther. 2013;344:489-500 pubmed publisher
Cai H, Wang D, Liu X, Chen J, Cai B. [Comparison on in vivo pharmacokinetics of brucine, total alkaloids of Strychni Semen and Strychni Semen pulveratum in rats]. Zhongguo Zhong Yao Za Zhi. 2012;37:2160-3 pubmed
Jasuja O, Kaur A, Kumar P. Fixing latent fingermarks developed by iodine fuming: a new method. Forensic Sci Int. 2012;223:e47-52 pubmed publisher
Wu G, Perlmutter S. Sensitivity of spinal neurons to GABA and glycine during voluntary movement in behaving monkeys. J Neurophysiol. 2013;109:193-201 pubmed publisher
Dutertre S, Becker C, Betz H. Inhibitory glycine receptors: an update. J Biol Chem. 2012;287:40216-23 pubmed publisher
Chu Y, Fioravante D, Thanawala M, Leitges M, Regehr W. Calcium-dependent isoforms of protein kinase C mediate glycine-induced synaptic enhancement at the calyx of Held. J Neurosci. 2012;32:13796-804 pubmed publisher
Roy N, Arpie B, Lugo J, Linney E, Levin E, Cerutti D. Brief embryonic strychnine exposure in zebrafish causes long-term adult behavioral impairment with indications of embryonic synaptic changes. Neurotoxicol Teratol. 2012;34:587-91 pubmed publisher
Williamson R, Buevich A, Martin G. Experimental and theoretical investigation of 1J(CC) and (n)J(CC) coupling constants in strychnine. Org Lett. 2012;14:5098-101 pubmed publisher
Chen Z, Liu W, Liu D, Xiao Y, Chen H, Chen J, et al. Development of brucine-loaded microsphere/thermally responsive hydrogel combination system for intra-articular administration. J Control Release. 2012;162:628-35 pubmed publisher
Saurí J, Parella T. Efficient measurement of the sign and the magnitude of long-range proton-carbon coupling constants from a spin-state-selective HSQMBC-COSY experiment. Magn Reson Chem. 2012;50:717-21 pubmed publisher
Kasumacic N, Glover J, Perreault M. Vestibular-mediated synaptic inputs and pathways to sympathetic preganglionic neurons in the neonatal mouse. J Physiol. 2012;590:5809-26 pubmed publisher
Martin G, Williamson R, Blinov K, Anklin C, Bermel W. HMBC-1,1-ADEQUATE via generalized indirect covariance: a high sensitivity alternative to n,1-ADEQUATE. Magn Reson Chem. 2012;50:691-5 pubmed publisher
Chen J, Yan G, Hu R, Gu Q, Chen M, Gu W, et al. Improved pharmacokinetics and reduced toxicity of brucine after encapsulation into stealth liposomes: role of phosphatidylcholine. Int J Nanomedicine. 2012;7:3567-77 pubmed publisher
Brustein E, Côté S, Ghislain J, Drapeau P. Spontaneous glycine-induced calcium transients in spinal cord progenitors promote neurogenesis. Dev Neurobiol. 2013;73:168-75 pubmed publisher
Johnson S, Kennedy H, Holley M, Fettiplace R, Marcotti W. The resting transducer current drives spontaneous activity in prehearing mammalian cochlear inner hair cells. J Neurosci. 2012;32:10479-83 pubmed publisher
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product information
Catalog Number :
S0532
Product Name :
Strychnine
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA