This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Rapamycin
catalog :
R8781
citations: 732
Reference
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Manirarora J, Wei C. Combination Therapy Using IL-2/IL-2 Monoclonal Antibody Complexes, Rapamycin, and Islet Autoantigen Peptides Increases Regulatory T Cell Frequency and Protects against Spontaneous and Induced Type 1 Diabetes in Nonobese Diabetic Mice. J Immunol. 2015;195:5203-14 pubmed publisher
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Song G, Li Y, Lin L, Cao Y. Anti-autophagic and anti-apoptotic effects of memantine in a SH-SY5Y cell model of Alzheimer's disease via mammalian target of rapamycin-dependent and -independent pathways. Mol Med Rep. 2015;12:7615-22 pubmed publisher
Liu R, Wang W, Dai B, Liu Y, Zhang Y. Taspine derivative TAS9 regulates cell growth and metastasis of human hepatocellular carcinoma. Mol Med Rep. 2015;12:7735-41 pubmed publisher
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Song Q, Xie D, Pan S, Xu W. Rapamycin protects neurons from brain contusion‑induced inflammatory reaction via modulation of microglial activation. Mol Med Rep. 2015;12:7203-10 pubmed publisher
Salmond R, Brownlie R, Meyuhas O, Zamoyska R. Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation. J Immunol. 2015;195:4615-22 pubmed publisher
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Xiong R, Zhou W, Siegel D, Kitson R, Freed C, Moody C, et al. A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity. Mol Pharmacol. 2015;88:1045-54 pubmed publisher
Kimball S, Ravi S, Gordon B, Dennis M, Jefferson L. Amino Acid-Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet. J Nutr. 2015;145:2496-502 pubmed publisher
Martin C, Espaillat M, Santiago Schwarz F. IL-10 restricts dendritic cell (DC) growth at the monocyte-to-monocyte-derived DC interface by disrupting anti-apoptotic and cytoprotective autophagic molecular machinery. Immunol Res. 2015;63:131-43 pubmed publisher
Botbol Y, Patel B, Macian F. Common γ-chain cytokine signaling is required for macroautophagy induction during CD4+ T-cell activation. Autophagy. 2015;11:1864-77 pubmed publisher
Prakhar P, Holla S, Ghorpade D, Gilleron M, Puzo G, Udupa V, et al. Ac2PIM-responsive miR-150 and miR-143 target receptor-interacting protein kinase 2 and transforming growth factor beta-activated kinase 1 to suppress NOD2-induced immunomodulators. J Biol Chem. 2015;290:26576-86 pubmed publisher
Andrade Talavera Y, Benito I, Casañas J, Rodríguez Moreno A, Montesinos M. Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome. Neurobiol Dis. 2015;82:516-525 pubmed publisher
Gul R, Mahmood A, Lück C, Lum Naihe K, Alfadda A, Speth R, et al. Regulation of cardiac miR-208a, an inducer of obesity, by rapamycin and nebivolol. Obesity (Silver Spring). 2015;23:2251-9 pubmed publisher
Stransky L, Forgac M. Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly. J Biol Chem. 2015;290:27360-9 pubmed publisher
Ryu J, Lee S, Seong J, Han H. Glutamine contributes to maintenance of mouse embryonic stem cell self-renewal through PKC-dependent downregulation of HDAC1 and DNMT1/3a. Cell Cycle. 2015;14:3292-305 pubmed publisher
Canivet C, Menasria R, Rhéaume C, Piret J, Boivin G. Valacyclovir combined with artesunate or rapamycin improves the outcome of herpes simplex virus encephalitis in mice compared to antiviral therapy alone. Antiviral Res. 2015;123:105-13 pubmed publisher
Kloos B, Chakraborty S, Lindner S, Noack K, Harre U, Schett G, et al. Pasteurella multocida toxin- induced osteoclastogenesis requires mTOR activation. Cell Commun Signal. 2015;13:40 pubmed publisher
Shuhua W, Chenbo S, Yangyang L, Xiangqian G, Shuang H, Tangyue L, et al. Autophagy-related genes Raptor, Rictor, and Beclin1 expression and relationship with multidrug resistance in colorectal carcinoma. Hum Pathol. 2015;46:1752-9 pubmed publisher
Li H, Kong X, Cui G, Ren C, Fan S, Sun L, et al. Rapamycin restores p14, p15 and p57 expression and inhibits the mTOR/p70S6K pathway in acute lymphoblastic leukemia cells. Int J Hematol. 2015;102:558-68 pubmed publisher
Hudson M, Smuder A, Nelson W, Wiggs M, Shimkus K, Fluckey J, et al. Partial Support Ventilation and Mitochondrial-Targeted Antioxidants Protect against Ventilator-Induced Decreases in Diaphragm Muscle Protein Synthesis. PLoS ONE. 2015;10:e0137693 pubmed publisher
Hsu C, Lin C, Hsiao L, Yang C. Mevastatin ameliorates sphingosine 1-phosphate-induced COX-2/PGE2-dependent cell migration via FoxO1 and CREB phosphorylation and translocation. Br J Pharmacol. 2015;172:5360-76 pubmed publisher
Vilimanovich U, Bosnjak M, Bogdanovic A, Markovic I, Isakovic A, Kravic Stevovic T, et al. Statin-mediated inhibition of cholesterol synthesis induces cytoprotective autophagy in human leukemic cells. Eur J Pharmacol. 2015;765:415-28 pubmed publisher
Obakan P, Barrero C, Coker Gurkan A, Arisan E, Merali S, Palavan Unsal N. SILAC-Based Mass Spectrometry Analysis Reveals That Epibrassinolide Induces Apoptosis via Activating Endoplasmic Reticulum Stress in Prostate Cancer Cells. PLoS ONE. 2015;10:e0135788 pubmed publisher
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Kwon B, Querfurth H. Palmitate activates mTOR/p70S6K through AMPK inhibition and hypophosphorylation of raptor in skeletal muscle cells: Reversal by oleate is similar to metformin. Biochimie. 2015;118:141-50 pubmed publisher
Li M, Yang S, Xing B, Ferguson B, Gulchina Y, Li Y, et al. LY395756, an mGluR2 agonist and mGluR3 antagonist, enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex, but fails to improve working memory and reverse MK801-induced working memory impairment. Exp Neurol. 2015;273:190-201 pubmed publisher
Hullinger R, O Riordan K, Burger C. Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k. Neurobiol Learn Mem. 2015;125:126-34 pubmed publisher
Kim N, Jeong S, Jing K, Shin S, Kim S, Heo J, et al. Docosahexaenoic Acid Induces Cell Death in Human Non-Small Cell Lung Cancer Cells by Repressing mTOR via AMPK Activation and PI3K/Akt Inhibition. Biomed Res Int. 2015;2015:239764 pubmed publisher
Jin X, Li F, Zheng X, Liu Y, Hirayama R, Liu X, et al. Carbon ions induce autophagy effectively through stimulating the unfolded protein response and subsequent inhibiting Akt phosphorylation in tumor cells. Sci Rep. 2015;5:13815 pubmed publisher
Rai R, Tate J, Shanmuganatham K, Howe M, Nelson D, Cooper T. Nuclear Gln3 Import Is Regulated by Nitrogen Catabolite Repression Whereas Export Is Specifically Regulated by Glutamine. Genetics. 2015;201:989-1016 pubmed publisher
Cabet E, Batonnet Pichon S, Delort F, Gausserès B, Vicart P, Lilienbaum A. Antioxidant Treatment and Induction of Autophagy Cooperate to Reduce Desmin Aggregation in a Cellular Model of Desminopathy. PLoS ONE. 2015;10:e0137009 pubmed publisher
Cataldi M, Shah N, Felt S, Grdzelishvili V. Breaking resistance of pancreatic cancer cells to an attenuated vesicular stomatitis virus through a novel activity of IKK inhibitor TPCA-1. Virology. 2015;485:340-54 pubmed publisher
Gilmore K, Greer K. Why is the dog an ideal model for aging research?. Exp Gerontol. 2015;71:14-20 pubmed publisher
Gao C, Cai Y, Zhang X, Huang H, Wang J, Wang Y, et al. Ischemic Preconditioning Mediates Neuroprotection against Ischemia in Mouse Hippocampal CA1 Neurons by Inducing Autophagy. PLoS ONE. 2015;10:e0137146 pubmed publisher
Joubert P, Stapleford K, Guivel Benhassine F, Vignuzzi M, Schwartz O, Albert M. Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway. PLoS Pathog. 2015;11:e1005091 pubmed publisher
Ding B, Parmigiani A, Yang C, Budanov A. Sestrin2 facilitates death receptor-induced apoptosis in lung adenocarcinoma cells through regulation of XIAP degradation. Cell Cycle. 2015;14:3231-41 pubmed publisher
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Szewczyk B, Pochwat B, Rafało A, Palucha Poniewiera A, Domin H, Nowak G. Activation of mTOR dependent signaling pathway is a necessary mechanism of antidepressant-like activity of zinc. Neuropharmacology. 2015;99:517-26 pubmed publisher
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product information
Catalog Number :
R8781
Product Name :
Rapamycin
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
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