This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Resiniferatoxin
catalog :
R8756
citations: 47
Reference
Cohen J, Edwards T, Liu A, Hirai T, Jones M, Wu J, et al. Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity. Cell. 2019;178:919-932.e14 pubmed publisher
Cheng R, Feng Y, Liu D, Wang Z, Zhang J, Chen L, et al. The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes. Theranostics. 2019;9:4287-4307 pubmed publisher
Zubcevic L, Hsu A, Borgnia M, Lee S. Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes. elife. 2019;8: pubmed publisher
Chen J, Winston J, Fu Y, Guptarak J, Jensen K, Shi X, et al. Genesis of anxiety, depression, and ongoing abdominal discomfort in ulcerative colitis-like colon inflammation. Am J Physiol Regul Integr Comp Physiol. 2015;308:R18-27 pubmed publisher
Wang H, Wang W, Cornish K, Rozanski G, Zucker I. Cardiac sympathetic afferent denervation attenuates cardiac remodeling and improves cardiovascular dysfunction in rats with heart failure. Hypertension. 2014;64:745-55 pubmed publisher
Ho K, Lambert W, Calkins D. Activation of the TRPV1 cation channel contributes to stress-induced astrocyte migration. Glia. 2014;62:1435-51 pubmed publisher
Weintraub A. Prickly painkiller: An experimental plant extract may end intractable pain with a single injection. Sci Am. 2013;309:14 pubmed
Jin H, An J, Park J, Moon S, Hong S. "Chemical-pain sensor" based on nanovesicle-carbon nanotube hybrid structures. Biosens Bioelectron. 2013;49:86-91 pubmed publisher
Ren Z, Rhyu M, Phan T, Mummalaneni S, Murthy K, Grider J, et al. TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response. Am J Physiol Gastrointest Liver Physiol. 2013;305:G106-17 pubmed publisher
Abdelhamid R, Kovács K, Pasley J, Nunez M, Larson A. Forced swim-induced musculoskeletal hyperalgesia is mediated by CRF2 receptors but not by TRPV1 receptors. Neuropharmacology. 2013;72:29-37 pubmed publisher
Wu C, Lv Z, Zhao Y, Gao Y, Li J, Gao F, et al. Electroacupuncture improves thermal and mechanical sensitivities in a rat model of postherpetic neuralgia. Mol Pain. 2013;9:18 pubmed publisher
Spahn V, Fischer O, Endres Becker J, Schafer M, Stein C, Zöllner C. Opioid withdrawal increases transient receptor potential vanilloid 1 activity in a protein kinase A-dependent manner. Pain. 2013;154:598-608 pubmed publisher
Tomohiro D, Mizuta K, Fujita T, Nishikubo Y, Kumamoto E. Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves. Life Sci. 2013;92:368-78 pubmed publisher
Yokoyama H, Oguchi T, Goins W, Goss J, Nishizawa O, de Groat W, et al. Effects of herpes simplex virus vector-mediated enkephalin gene therapy on bladder overactivity and nociception. Hum Gene Ther. 2013;24:170-80 pubmed publisher
Li C, Zhu Y, Shenoy M, Pai R, Liu L, Pasricha P. Anatomical and functional characterization of a duodeno-pancreatic neural reflex that can induce acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2013;304:G490-500 pubmed publisher
Malykhina A, Qin C, Lei Q, Pan X, Greenwood Van Meerveld B, Foreman R. Differential effects of intravesical resiniferatoxin on excitability of bladder spinal neurons upon colon-bladder cross-sensitization. Brain Res. 2013;1491:213-24 pubmed publisher
Bouyer P, Tang X, Weber C, Shen L, Turner J, Matthews J. Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1. Am J Physiol Gastrointest Liver Physiol. 2013;304:G142-56 pubmed publisher
Burliński P, Burlińska A, Gonkowski S, Całka J. Resiniferatoxin and tetrodotoxin induced NPY and TH immunoreactivity changes within the paracervical ganglion neurons supplying the urinary bladder. J Mol Neurosci. 2013;49:62-7 pubmed publisher
Xiong X, Chen W, Han Y, Zhou Y, Zhang F, Gao X, et al. Enhanced adipose afferent reflex contributes to sympathetic activation in diet-induced obesity hypertension. Hypertension. 2012;60:1280-6 pubmed publisher
Yu S, Grider J, Gulick M, Xia C, Shen S, Qiao L. Up-regulation of brain-derived neurotrophic factor is regulated by extracellular signal-regulated protein kinase 5 and by nerve growth factor retrograde signaling in colonic afferent neurons in colitis. Exp Neurol. 2012;238:209-17 pubmed publisher
Trevisan G, Rossato M, Walker C, Klafke J, Rosa F, Oliveira S, et al. Identification of the plant steroid ?-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties. J Pharmacol Exp Ther. 2012;343:258-69 pubmed publisher
Lee M, Huh B, Choi S, Lee D, Lim B, Lee M. The effect of epidural resiniferatoxin in the neuropathic pain rat model. Pain Physician. 2012;15:287-96 pubmed
Szallasi A, Sheta M. Targeting TRPV1 for pain relief: limits, losers and laurels. Expert Opin Investig Drugs. 2012;21:1351-69 pubmed publisher
Bossowska A, Majewski M. The influence of resiniferatoxin on the chemical coding of neurons in dorsal root ganglia supplying the urinary bladder in the female pig. Pol J Vet Sci. 2012;15:135-42 pubmed
Tsumura M, Sobhan U, Muramatsu T, Sato M, Ichikawa H, Sahara Y, et al. TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts. Cell Calcium. 2012;52:124-36 pubmed publisher
Zhang L, Xiong X, Fan Z, Gan X, Gao X, Zhu G. Involvement of enhanced cardiac sympathetic afferent reflex in sympathetic activation in early stage of diabetes. J Appl Physiol (1985). 2012;113:47-55 pubmed publisher
Matsuoka P, Haddad J, Pacetta A, Baracat E. Intravesical treatment of painful bladder syndrome: a systematic review and meta-analysis. Int Urogynecol J. 2012;23:1147-53 pubmed publisher
Kun J, Helyes Z, Perkecz A, Bán A, Polgar B, Szolcsanyi J, et al. Effect of surgical and chemical sensory denervation on non-neural expression of the transient receptor potential vanilloid 1 (TRPV1) receptors in the rat. J Mol Neurosci. 2012;48:795-803 pubmed
Lei Q, Malykhina A. Colonic inflammation up-regulates voltage-gated sodium channels in bladder sensory neurons via activation of peripheral transient potential vanilloid 1 receptors. Neurogastroenterol Motil. 2012;24:575-85, e257 pubmed publisher
Oguchi T, Funahashi Y, Yokoyama H, Nishizawa O, Goins W, Goss J, et al. Effect of herpes simplex virus vector-mediated interleukin-4 gene therapy on bladder overactivity and nociception. Gene Ther. 2013;20:194-200 pubmed publisher
Hsieh Y, Chiang H, Lue J, Hsieh S. P2X3-mediated peripheral sensitization of neuropathic pain in resiniferatoxin-induced neuropathy. Exp Neurol. 2012;235:316-25 pubmed publisher
Yoshikawa S, Oguchi T, Funahashi Y, de Groat W, Yoshimura N. Glycine transporter type 2 (GlyT2) inhibitor ameliorates bladder overactivity and nociceptive behavior in rats. Eur Urol. 2012;62:704-12 pubmed publisher
Xia C, Gulick M, Yu S, Grider J, Murthy K, Kuemmerle J, et al. Up-regulation of brain-derived neurotrophic factor in primary afferent pathway regulates colon-to-bladder cross-sensitization in rat. J Neuroinflammation. 2012;9:30 pubmed publisher
Vij M, Srikrishna S, Cardozo L. Interstitial cystitis: diagnosis and management. Eur J Obstet Gynecol Reprod Biol. 2012;161:1-7 pubmed publisher
Kissin I, Szallasi A. Therapeutic targeting of TRPV1 by resiniferatoxin, from preclinical studies to clinical trials. Curr Top Med Chem. 2011;11:2159-70 pubmed
Iadarola M, Mannes A. The vanilloid agonist resiniferatoxin for interventional-based pain control. Curr Top Med Chem. 2011;11:2171-9 pubmed
Fosgerau K, Weber U, Gotfredsen J, Jayatissa M, Buus C, Kristensen N, et al. Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist. BMC Cardiovasc Disord. 2010;10:51 pubmed publisher
Buatois V, Fagète S, Magistrelli G, Chatel L, Fischer N, Kosco Vilbois M, et al. Pan-CC chemokine neutralization restricts splenocyte egress and reduces inflammation in a model of arthritis. J Immunol. 2010;185:2544-54 pubmed publisher
Mourtzoukou E, Iavazzo C, Falagas M. Resiniferatoxin in the treatment of interstitial cystitis: a systematic review. Int Urogynecol J Pelvic Floor Dysfunct. 2008;19:1571-6 pubmed publisher
Cruz F, Dinis P. Resiniferatoxin and botulinum toxin type A for treatment of lower urinary tract symptoms. Neurourol Urodyn. 2007;26:920-7 pubmed
el Mahrouky A, Elashry O, Emran M. The effect of intravesical capsaicin and resiniferatoxin in neurogenic bladder dysfunction. Adv Exp Med Biol. 2003;539:359-79 pubmed
Kim D, Chancellor M. Intravesical neuromodulatory drugs: capsaicin and resiniferatoxin to treat the overactive bladder. J Endourol. 2000;14:97-103 pubmed
Chancellor M, de Groat W. Intravesical capsaicin and resiniferatoxin therapy: spicing up the ways to treat the overactive bladder. J Urol. 1999;162:3-11 pubmed
Appendino G, Szallasi A. Euphorbium: modern research on its active principle, resiniferatoxin, revives an ancient medicine. Life Sci. 1997;60:681-96 pubmed
Szallasi A, Blumberg P. Specific binding of resiniferatoxin, an ultrapotent capsaicin analog, by dorsal root ganglion membranes. Brain Res. 1990;524:106-11 pubmed
Szolcsanyi J, Szallasi A, Szallasi Z, Joo F, Blumberg P. Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons. J Pharmacol Exp Ther. 1990;255:923-8 pubmed
Szallasi A, Blumberg P. Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor. Life Sci. 1990;47:1399-408 pubmed
product information
Catalog Number :
R8756
Product Name :
Resiniferatoxin
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
from Euphorbia poisonii, ~95%
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA