This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Radicicol from Diheterospora chlamydosporia
catalog :
R2146
citations: 35
Reference
Rodrigues I, Pereira L, Lisboa J, Pereira C, Oliveira P, dos Santos N, et al. Involvement of Hsp90 and cyclophilins in intoxication by AIP56, a metalloprotease toxin from Photobacterium damselae subsp. piscicida. Sci Rep. 2019;9:9019 pubmed publisher
Janssens G, Lin X, Millán Ariño L, Kavšek A, Sen I, Seinstra R, et al. Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging. Cell Rep. 2019;27:467-480.e6 pubmed publisher
Dorrity M, Cuperus J, Carlisle J, Fields S, Queitsch C. Preferences in a trait decision determined by transcription factor variants. Proc Natl Acad Sci U S A. 2018;115:E7997-E8006 pubmed publisher
Rohner N, Jarosz D, Kowalko J, Yoshizawa M, Jeffery W, Borowsky R, et al. Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish. Science. 2013;342:1372-5 pubmed publisher
Wang Y, Mercier R, Hobman T, LaPointe P. Regulation of RNA interference by Hsp90 is an evolutionarily conserved process. Biochim Biophys Acta. 2013;1833:2673-2681 pubmed publisher
Kudriavtsev V, Makarova I, Kabakav A. [Thermosensitization of tumor cells with inhibitors of chaperone activity and expression]. Biomed Khim. 2012;58:662-72 pubmed
Piper P, Millson S. Spotlight on the microbes that produce heat shock protein 90-targeting antibiotics. Open Biol. 2012;2:120138 pubmed publisher
Cahill P, Heasman K, Hickey A, Mountfort D, Jeffs A, Kuhajek J. Screening for negative effects of candidate ascidian antifoulant compounds on a target aquaculture species, Perna canaliculus Gmelin. Biofouling. 2013;29:29-37 pubmed publisher
Zhao Y, Huang Z, Rahman M, Luo Q, Thorlacius H. Radicicol, an Hsp90 inhibitor, inhibits intestinal inflammation and leakage in abdominal sepsis. J Surg Res. 2013;182:312-8 pubmed publisher
Dai C, Santagata S, Tang Z, Shi J, Cao J, Kwon H, et al. Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis. J Clin Invest. 2012;122:3742-54 pubmed publisher
Yang J, Myung S, Kim W, Lee C. 18β-glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway. Mol Cell Biochem. 2012;370:209-19 pubmed publisher
Higashi C, Saji C, Yamada K, Kagawa H, Ohga R, Taira T, et al. The effects of heat shock protein 90 inhibitors on apoptosis and viral replication in primary effusion lymphoma cells. Biol Pharm Bull. 2012;35:725-30 pubmed
Gorska M, Popowska U, Sielicka Dudzin A, Kuban Jankowska A, Sawczuk W, Knap N, et al. Geldanamycin and its derivatives as Hsp90 inhibitors. Front Biosci (Landmark Ed). 2012;17:2269-77 pubmed
Austin C, Pettit S, Magnolo S, Sanvoisin J, Chen W, Wood S, et al. Fragment screening using capillary electrophoresis (CEfrag) for hit identification of heat shock protein 90 ATPase inhibitors. J Biomol Screen. 2012;17:868-76 pubmed publisher
Zhang F, Snead C, Catravas J. Hsp90 regulates O-linked ?-N-acetylglucosamine transferase: a novel mechanism of modulation of protein O-linked ?-N-acetylglucosamine modification in endothelial cells. Am J Physiol Cell Physiol. 2012;302:C1786-96 pubmed publisher
Flom G, Langner E, Johnson J. Identification of an Hsp90 mutation that selectively disrupts cAMP/PKA signaling in Saccharomyces cerevisiae. Curr Genet. 2012;58:149-63 pubmed publisher
Chan J, Vuckovic D, Sleno L, Olsen J, Pogoutse O, Havugimana P, et al. Target identification by chromatographic co-elution: monitoring of drug-protein interactions without immobilization or chemical derivatization. Mol Cell Proteomics. 2012;11:M111.016642 pubmed publisher
Cahill P, Heasman K, Jeffs A, Kuhajek J, Mountfort D. Preventing ascidian fouling in aquaculture: screening selected allelochemicals for anti-metamorphic properties in ascidian larvae. Biofouling. 2012;28:39-49 pubmed publisher
Intapad S, Dimitropoulou C, Snead C, Piyachaturawat P, Catravas J. Regulation of asthmatic airway relaxation by estrogen and heat shock protein 90. J Cell Physiol. 2012;227:3036-43 pubmed publisher
Day J, Sharp S, Rowlands M, Aherne W, Hayes A, Raynaud F, et al. Targeting the Hsp90 molecular chaperone with novel macrolactams. Synthesis, structural, binding, and cellular studies. ACS Chem Biol. 2011;6:1339-47 pubmed publisher
Footz T, Dubois S, Sarfarazi M, Raymond V, Walter M. Co-variation of STI1 and WDR36/UTP21 alters cell proliferation in a glaucoma model. Mol Vis. 2011;17:1957-69 pubmed
Kim Y, Lee S, Myung S, Kim W, Lee C. Radicicol, an inhibitor of Hsp90, enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells by promoting activation of apoptosis-related proteins. Mol Cell Biochem. 2012;359:33-43 pubmed publisher
Bzowska M, Hamczyk M, Skalniak A, Guzik K. Rapid decrease of CD16 (FcγRIII) expression on heat-shocked neutrophils and their recognition by macrophages. J Biomed Biotechnol. 2011;2011:284759 pubmed publisher
Chiu W, Shen S, Yang L, Chow J, Wu C, Chen Y. Inhibition of HSP90-dependent telomerase activity in amyloid ?-induced apoptosis of cerebral endothelial cells. J Cell Physiol. 2011;226:2041-51 pubmed publisher
Matsumoto K, Minami M, Shinozaki F, Suzuki Y, Abe K, Zenno S, et al. Hsp90 is involved in the formation of P-bodies and stress granules. Biochem Biophys Res Commun. 2011;407:720-4 pubmed publisher
Luo S, Wang T, Qin H, Lei H, Xia Y. Obligatory role of heat shock protein 90 in iNOS induction. Am J Physiol Cell Physiol. 2011;301:C227-33 pubmed publisher
Toleikis Z, Cimmperman P, Petrauskas V, Matulis D. Determination of the volume changes induced by ligand binding to heat shock protein 90 using high-pressure denaturation. Anal Biochem. 2011;413:171-8 pubmed publisher
Filipeanu C, de Vries R, Danser A, Kapusta D. Modulation of ?(2C) adrenergic receptor temperature-sensitive trafficking by HSP90. Biochim Biophys Acta. 2011;1813:346-57 pubmed publisher
Benmohamed R, Arvanites A, Kim J, Ferrante R, Silverman R, Morimoto R, et al. Identification of compounds protective against G93A-SOD1 toxicity for the treatment of amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2011;12:87-96 pubmed publisher
Zhou H, Qiao K, Gao Z, Vederas J, Tang Y. Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs. J Biol Chem. 2010;285:41412-21 pubmed publisher
Pillay I, Nakano H, Sharma S. Radicicol inhibits tyrosine phosphorylation of the mitotic Src substrate Sam68 and retards subsequent exit from mitosis of Src-transformed cells. Cell Growth Differ. 1996;7:1487-99 pubmed
Chanmugam P, Feng L, Liou S, Jang B, Boudreau M, Yu G, et al. Radicicol, a protein tyrosine kinase inhibitor, suppresses the expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide and in experimental glomerulonephritis. J Biol Chem. 1995;270:5418-26 pubmed
Oikawa T, Ito H, Ashino H, Toi M, Tominaga T, Morita I, et al. Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis. Eur J Pharmacol. 1993;241:221-7 pubmed
Zhao J, Nakano H, Sharma S. Suppression of RAS and MOS transformation by radicicol. Oncogene. 1995;11:161-73 pubmed
Shimada Y, Ogawa T, Sato A, Kaneko I, Tsujita Y. Induction of differentiation of HL-60 cells by the anti-fungal antibiotic, radicicol. J Antibiot (Tokyo). 1995;48:824-30 pubmed
product information
Catalog Number :
R2146
Product Name :
Radicicol from Diheterospora chlamydosporia
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
solid
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA