product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Rapamycin from Streptomyces hygroscopicus
catalog :
R0395
more info or order :
citations: 255
Reference
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Franco A, Más Serrano P, Perez Contreras J, Jiménez L, Rodriguez D, Olivares J. Mammalian Target of Rapamycin Inhibitor Monotherapy: Efficacy in Renal Transplantation. Transplant Proc. 2015;47:2364-7 pubmed publisher
Abbas K, Mubarak M, Zafar M, Aziz T, Abbas H, Muzaffar R, et al. Plasma cell-rich acute rejections in living-related kidney transplantation: a clinicopathological study of 50 cases. Clin Transplant. 2015;29:835-41 pubmed publisher
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Li Y, Shen C, Zhu B, Shi F, Eisen H, Chen J. Persistent Antigen and Prolonged AKT-mTORC1 Activation Underlie Memory CD8 T Cell Impairment in the Absence of CD4 T Cells. J Immunol. 2015;195:1591-8 pubmed publisher
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Holczer M, Márton M, Kurucz A, Bánhegyi G, Kapuy O. A Comprehensive Systems Biological Study of Autophagy-Apoptosis Crosstalk during Endoplasmic Reticulum Stress. Biomed Res Int. 2015;2015:319589 pubmed publisher
Wang H, Zhang L, Yang X, Jin Y, Pei S, Zhang D, et al. PUMA mediates the combinational therapy of 5-FU and NVP-BEZ235 in colon cancer. Oncotarget. 2015;6:14385-98 pubmed
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Kittipongdaja W, Wu X, Garner J, Liu X, Komas S, Hwang S, et al. Rapamycin Suppresses Tumor Growth and Alters the Metabolic Phenotype in T-Cell Lymphoma. J Invest Dermatol. 2015;135:2301-2308 pubmed publisher
Nalbandian A, Llewellyn K, Nguyen C, Yazdi P, Kimonis V. Rapamycin and chloroquine: the in vitro and in vivo effects of autophagy-modifying drugs show promising results in valosin containing protein multisystem proteinopathy. PLoS ONE. 2015;10:e0122888 pubmed publisher
Fan X, Wang J, Hou J, Lin C, Bensoussan A, Chang D, et al. Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway. J Transl Med. 2015;13:92 pubmed publisher
Rosso Fernández C, Garnacho Montero J, Antonelli M, Dimopoulos G, Cisneros J. Safety and efficacy of colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia as part of a macro-project funded by the Seventh Framework Program of the European Commission studying off-patent antibiotics: study protoc. Trials. 2015;16:102 pubmed publisher
Aizawa K, Takahari Y, Higashijima N, Serizawa K, Yogo K, Ishizuka N, et al. Nicorandil prevents sirolimus-induced production of reactive oxygen species, endothelial dysfunction, and thrombus formation. J Pharmacol Sci. 2015;127:284-91 pubmed publisher
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Ferraris V. What the Human Genome Project hasn't told us: the epigenetics of development of esophageal squamous cell cancer. J Thorac Cardiovasc Surg. 2015;149:386-7 pubmed publisher
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Olesen K, Tilsted H, Jensen L, Kaltoft A, Krusell L, Ravkilde J, et al. Long-term outcome of sirolimus-eluting and zotarolimus-eluting coronary stent implantation in patients with and without diabetes mellitus (a Danish organization for randomized trials on clinical outcome III substudy). Am J Cardiol. 2015;115:298-302 pubmed publisher
Shah M, Shankar A, Gee I, Nash K, Hoare M, Gibbs P, et al. A retrospective 15-year review: survival advantage after switching to sirolimus in hepatitis C virus infected liver graft recipients. Aliment Pharmacol Ther. 2015;41:379-92 pubmed publisher
McCormack F. Chronic sirolimus therapy for lymphangioleiomyomatosis. Am J Respir Crit Care Med. 2014;190:1332-3 pubmed publisher
Poirier N, Dilek N, Mary C, Ville S, Coulon F, Branchereau J, et al. FR104, an antagonist anti-CD28 monovalent fab' antibody, prevents alloimmunization and allows calcineurin inhibitor minimization in nonhuman primate renal allograft. Am J Transplant. 2015;15:88-100 pubmed publisher
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Karanasos A, Simsek C, Gnanadesigan M, van Ditzhuijzen N, Freire R, Dijkstra J, et al. OCT assessment of the long-term vascular healing response 5 years after everolimus-eluting bioresorbable vascular scaffold. J Am Coll Cardiol. 2014;64:2343-56 pubmed publisher
Franz D, Belousova E, Sparagana S, Bebin E, Frost M, Kuperman R, et al. Everolimus for subependymal giant cell astrocytoma in patients with tuberous sclerosis complex: 2-year open-label extension of the randomised EXIST-1 study. Lancet Oncol. 2014;15:1513-20 pubmed publisher
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Marqués L, Núñez Córdoba J, Aguado L, Pretel M, Boixeda P, Nagore E, et al. Topical rapamycin combined with pulsed dye laser in the treatment of capillary vascular malformations in Sturge-Weber syndrome: phase II, randomized, double-blind, intraindividual placebo-controlled clinical trial. J Am Acad Dermatol. 2015;72:151-8.e1 pubmed publisher
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Hsu H, Lin M, Jang Y, Kuo T, Liu C, Cheng T. The 4E-BP1/eIF4E ratio is a determinant for rapamycin response in esophageal cancer cells. J Thorac Cardiovasc Surg. 2015;149:378-85 pubmed publisher
Suarez O, Pardo M, Gonzalez S, Escobar Serna D, Castañeda D, Rodriguez D, et al. Diabetes mellitus and renal transplantation in adults: is there enough evidence for diagnosis, treatment, and prevention of new-onset diabetes after renal transplantation?. Transplant Proc. 2014;46:3015-20 pubmed publisher
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Zheng X, Xie Z, Zhu Z, Liu Z, Wang Y, Wei L, et al. Methyllycaconitine alleviates amyloid-β peptides-induced cytotoxicity in SH-SY5Y cells. PLoS ONE. 2014;9:e111536 pubmed publisher
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Zhu J, Lu T, Yue S, Shen X, Gao F, Busuttil R, et al. Rapamycin protection of livers from ischemia and reperfusion injury is dependent on both autophagy induction and mammalian target of rapamycin complex 2-Akt activation. Transplantation. 2015;99:48-55 pubmed publisher
Zemp F, McKenzie B, Lun X, Reilly K, McFadden G, Yong V, et al. Cellular factors promoting resistance to effective treatment of glioma with oncolytic myxoma virus. Cancer Res. 2014;74:7260-73 pubmed publisher
Yao J, Taveira DaSilva A, Jones A, Julien Williams P, Stylianou M, Moss J. Sustained effects of sirolimus on lung function and cystic lung lesions in lymphangioleiomyomatosis. Am J Respir Crit Care Med. 2014;190:1273-82 pubmed publisher
Ronan B, Flamand O, Vescovi L, Dureuil C, Durand L, Fassy F, et al. A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy. Nat Chem Biol. 2014;10:1013-9 pubmed publisher
Van Laecke S, Nagler E, Vanholder R. Inhibition of the mTORC pathway in the antiphospholipid syndrome. N Engl J Med. 2014;371:1553 pubmed publisher
Canaud G, Terzi F. Inhibition of the mTORC pathway in the antiphospholipid syndrome. N Engl J Med. 2014;371:1554-5 pubmed publisher
Grabiner B, Van Allen E, Amin Mansour A, Taylor Weiner A, Rosenberg M, Gray N, et al. Response and acquired resistance to everolimus in anaplastic thyroid cancer. N Engl J Med. 2014;371:1426-33 pubmed publisher
Park K, Kim H, Lee J, Lee K, Jeong I, Song C, et al. Changes in the diffusion capacity for carbon monoxide and the development of non-infectious pneumonitis in patients with metastatic renal cell carcinoma treated with everolimus. Anticancer Res. 2014;34:5723-8 pubmed
Lin H, Chang K, Hung C, Kuo C, Hwang S, Chen H, et al. Effects of the mTOR inhibitor rapamycin on monocyte-secreted chemokines. BMC Immunol. 2014;15:37 pubmed publisher
Serruys P, Chevalier B, Dudek D, Cequier A, Carrié D, Iniguez A, et al. A bioresorbable everolimus-eluting scaffold versus a metallic everolimus-eluting stent for ischaemic heart disease caused by de-novo native coronary artery lesions (ABSORB II): an interim 1-year analysis of clinical and procedural secondary outcomes . Lancet. 2015;385:43-54 pubmed publisher
Di Mario C, Caiazzo G. Biodegradable stents: the golden future of angioplasty?. Lancet. 2015;385:10-12 pubmed publisher
Chuang Y, Ruan S, Huang C. Compelling results of adjuvant therapy with sirolimus for severe H1N1 pneumonia. Crit Care Med. 2014;42:e687-8 pubmed publisher
Stojkovic S, Neskovic A, Mehmedbegovic Z, Kafedzic S, Ostojic M, Nedeljkovic M, et al. Reduced sirolimus systemic exposure and improved bioresorbable polymer properties: new allies for the treatment of patients with coronary artery disease. Fundam Clin Pharmacol. 2015;29:95-105 pubmed publisher
Ding L, Heremans Y, Pipeleers D, Ling Z, Heimberg H, Gysemans C, et al. Clinical Immunosuppressants Inhibit Inflammatory, Proliferative, and Reprogramming Potential, But Not Angiogenesis of Human Pancreatic Duct Cells. Cell Transplant. 2015;24:1585-98 pubmed publisher
Mehilli J, Massberg S. Revisiting the BIOSCIENCE of drug-eluting stent technology. Lancet. 2014;384:2086-8 pubmed publisher
Pilgrim T, Heg D, Roffi M, Tüller D, Muller O, Vuilliomenet A, et al. Ultrathin strut biodegradable polymer sirolimus-eluting stent versus durable polymer everolimus-eluting stent for percutaneous coronary revascularisation (BIOSCIENCE): a randomised, single-blind, non-inferiority trial. Lancet. 2014;384:2111-22 pubmed publisher
Taveira DaSilva A, Jones A, Julien Williams P, Stylianou M, Moss J. Retrospective review of combined sirolimus and simvastatin therapy in lymphangioleiomyomatosis. Chest. 2015;147:180-187 pubmed publisher
Van Boven N, Windecker S, Umans V, van Domburg R, Kardys I, Akkerhuis K, et al. Stent thrombosis in early-generation drug-eluting stents versus newer-generation everolimus-eluting stent assorted by LVEF. Heart. 2015;101:50-7 pubmed publisher
Emoto C, Fukuda T, Mizuno T, Cox S, Schniedewind B, Christians U, et al. Age-dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1. Ther Drug Monit. 2015;37:395-9 pubmed publisher
Wang C, Cigliano A, Jiang L, Li X, Fan B, Pilo M, et al. 4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras proto-oncogenes in mice. Hepatology. 2015;61:200-13 pubmed publisher
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Saba N, Hurwitz S, Magliocca K, Kim S, Owonikoko T, Harvey D, et al. Phase 1 and pharmacokinetic study of everolimus in combination with cetuximab and carboplatin for recurrent/metastatic squamous cell carcinoma of the head and neck. Cancer. 2014;120:3940-51 pubmed publisher
Hoerning A, Wilde B, Wang J, Tebbe B, Jing L, Wang X, et al. Pharmacodynamic monitoring of mammalian target of rapamycin inhibition by phosphoflow cytometric determination of p70S6 kinase activity. Transplantation. 2015;99:210-9 pubmed publisher
Stevens R, Foster K, Miles C, Lane J, Kalil A, Florescu D, et al. A randomized 2×2 factorial trial, part 1: single-dose rabbit antithymocyte globulin induction may improve renal transplantation outcomes. Transplantation. 2015;99:197-209 pubmed publisher
Giordano S, Dodson M, Ravi S, Redmann M, Ouyang X, Darley Usmar V, et al. Bioenergetic adaptation in response to autophagy regulators during rotenone exposure. J Neurochem. 2014;131:625-33 pubmed publisher
Ferolla P. Medical treatment of advanced thoracic neuroendocrine tumors. Thorac Surg Clin. 2014;24:351-5 pubmed publisher
Zhu A, Kudo M, Assenat E, Cattan S, Kang Y, Lim H, et al. Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of sorafenib: the EVOLVE-1 randomized clinical trial. JAMA. 2014;312:57-67 pubmed publisher
Hsieh M, Fitzhugh C, Weitzel R, Link M, Coles W, Zhao X, et al. Nonmyeloablative HLA-matched sibling allogeneic hematopoietic stem cell transplantation for severe sickle cell phenotype. JAMA. 2014;312:48-56 pubmed publisher
King A, DiPersio J. Reconsideration of age as a contraindication for curative therapy of sickle cell disease. JAMA. 2014;312:33-4 pubmed publisher
Eikelboom J, Weitz J. The mTORC pathway in the antiphospholipid syndrome. N Engl J Med. 2014;371:369-71 pubmed publisher
Canaud G, Bienaime F, Tabarin F, Bataillon G, Seilhean D, Noel L, et al. Inhibition of the mTORC pathway in the antiphospholipid syndrome. N Engl J Med. 2014;371:303-12 pubmed publisher
Ganesan S, Moussavi Nik S, Newman M, Lardelli M. Identification and expression analysis of the zebrafish orthologues of the mammalian MAP1LC3 gene family. Exp Cell Res. 2014;328:228-37 pubmed publisher
Rostaing L, Christiaans M, Kovarik J, Pascual J. The pharmacokinetics of everolimus in de novo kidney transplant patients receiving tacrolimus: an analysis from the randomized ASSET study. Ann Transplant. 2014;19:337-45 pubmed publisher
Jang S, Kang M. Improved oral absorption and chemical stability of everolimus via preparation of solid dispersion using solvent wetting technique. Int J Pharm. 2014;473:187-93 pubmed publisher
Fekete T, Pazmandi K, Szabo A, Bacsi A, Koncz G, Rajnavolgyi E. The antiviral immune response in human conventional dendritic cells is controlled by the mammalian target of rapamycin. J Leukoc Biol. 2014;96:579-89 pubmed publisher
Wang W, Yu L. Acute respiratory distress attributed to sirolimus in solid organ transplant recipients. Am J Emerg Med. 2015;33:124.e1-4 pubmed publisher
Huynh T, Santini E, Klann E. Requirement of Mammalian target of rapamycin complex 1 downstream effectors in cued fear memory reconsolidation and its persistence. J Neurosci. 2014;34:9034-9 pubmed publisher
Urbanellis P, Shyu W, Khattar R, Wang J, Zakharova A, He W, et al. The regulatory T cell effector molecule fibrinogen-like protein 2 is necessary for the development of rapamycin-induced tolerance to fully MHC-mismatched murine cardiac allografts. Immunology. 2015;144:91-106 pubmed publisher
Andre F, Gianni L. BOLERO-3 results: pharmacological activity or pharmacokinetic effect?--authors' reply. Lancet Oncol. 2014;15:e304-5 pubmed publisher
Glover T, Kew V, Reeves M. Rapamycin does not inhibit human cytomegalovirus reactivation from dendritic cells in vitro. J Gen Virol. 2014;95:2260-2266 pubmed publisher
Oh C, Huh K, Ha J, Kim Y, Kim Y, Kim Y. Safety and efficacy of the early introduction of everolimus with reduced-exposure cyclosporine a in de novo kidney recipients. Transplantation. 2015;99:180-6 pubmed publisher
Benson C, Vitfell Rasmussen J, Maruzzo M, Fisher C, Tunariu N, Mitchell S, et al. A retrospective study of patients with malignant PEComa receiving treatment with sirolimus or temsirolimus: the Royal Marsden Hospital experience. Anticancer Res. 2014;34:3663-8 pubmed
Chao T, Chang G, Chen W, Chen P, Mao F. The synergistic effect of rapamycin combined with 5-fluorouracil in BALB/cByJNarl mice bearing CT-26 tumor cells. Anticancer Res. 2014;34:3329-35 pubmed
Ceppi F, Duval M, Teira P, Therrien R, Ovetchkine P, Mallette B, et al. Calcineurin inhibitor-free graft-versus-host disease prophylaxis with sirolimus and mycophenolate mofetil in a second allogeneic stem cell transplantation for engraftment failure and rituximab-refractory Epstein-Barr virus-induced posttransplant lymp. J Pediatr Hematol Oncol. 2014;36:e319-21 pubmed publisher
Kim K, Chung B, Kim B, Cho M, Yang C. The effect of mammalian target of rapamycin inhibition on T helper type 17 and regulatory T cell differentiation in vitro and in vivo in kidney transplant recipients. Immunology. 2015;144:68-78 pubmed publisher
Schindler C, Partap U, Patchen B, Swoap S. Chronic rapamycin treatment causes diabetes in male mice. Am J Physiol Regul Integr Comp Physiol. 2014;307:R434-43 pubmed publisher
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product information
Catalog Number :
R0395
Product Name :
Rapamycin from Streptomyces hygroscopicus
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥95% (HPLC), powder
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA