This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
(−)-Quinpirole hydrochloride
catalog :
Q102
citations: 61
Reference
Konanur V, Hsu T, Kanoski S, Hayes M, Roitman M. Phasic dopamine responses to a food-predictive cue are suppressed by the glucagon-like peptide-1 receptor agonist Exendin-4. Physiol Behav. 2020;215:112771 pubmed publisher
Cordisco Gonzalez S, Mustafa E, Rodriguez S, Perello M, Raingo J. Dopamine Receptor Type 2 and Ghrelin Receptor Coexpression Alters CaV2.2 Modulation by G Protein Signaling Cascades. ACS Chem Neurosci. 2020;11:3-13 pubmed publisher
Gill W, Shelton H, Burgess K, Brown R. Effects of an adenosine A2A agonist on the rewarding associative properties of nicotine and neural plasticity in a rodent model of schizophrenia. J Psychopharmacol. 2020;34:137-144 pubmed publisher
Han F, Konkalmatt P, Mokashi C, Kumar M, Zhang Y, Ko A, et al. Dopamine D2 receptor modulates Wnt expression and control of cell proliferation. Sci Rep. 2019;9:16861 pubmed publisher
Lattin C, Merullo D, Riters L, Carson R. In vivo imaging of D2 receptors and corticosteroids predict behavioural responses to captivity stress in a wild bird. Sci Rep. 2019;9:10407 pubmed publisher
Perelmuter J, Wilson A, Sisneros J, Forlano P. Forebrain Dopamine System Regulates Inner Ear Auditory Sensitivity to Socially Relevant Acoustic Signals. Curr Biol. 2019;: pubmed publisher
Ruud J, Alber J, Tokarska A, Engström Ruud L, Nolte H, Biglari N, et al. The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons. Cell Rep. 2019;27:3182-3198.e9 pubmed publisher
Janikova M, Brozka H, Radostova D, Svoboda J, Stuchlik A. No effect of riluzole and memantine on learning deficit following quinpirole sensitization - An animal model of obsessive-compulsive disorder. Physiol Behav. 2019;204:241-247 pubmed publisher
Cromberg L, Saez T, Otero M, Tomasella E, Alloatti M, Damianich A, et al. Neuronal KIF5b deletion induces striatum-dependent locomotor impairments and defects in membrane presentation of dopamine D2 receptors. J Neurochem. 2019;149:362-380 pubmed publisher
Tanimura A, Du Y, Kondapalli J, Wokosin D, Surmeier D. Cholinergic Interneurons Amplify Thalamostriatal Excitation of Striatal Indirect Pathway Neurons in Parkinson's Disease Models. Neuron. 2019;101:444-458.e6 pubmed publisher
Dorfman A, Szechtman H, Eilam D. Social interaction modulates the intensity of compulsive checking in a rat model of obsessive-compulsive disorder (OCD). Behav Brain Res. 2019;359:156-164 pubmed publisher
Yee A, Forbes B, Cheung P, Martini A, Burrell M, Freestone P, et al. Action potential and calcium dependence of tonic somatodendritic dopamine release in the Substantia Nigra pars compacta. J Neurochem. 2019;148:462-479 pubmed publisher
Hashimoto T, Baba S, Ikeda H, Oda Y, Hashimoto K, Shimizu I. Lack of dopamine supersensitivity in rats after chronic administration of blonanserin: Comparison with haloperidol. Eur J Pharmacol. 2018;830:26-32 pubmed publisher
Xue B, Mao L, Jin D, Wang J. Pharmacological modulation of AMPA receptor phosphorylation by dopamine and muscarinic receptor agents in the rat medial prefrontal cortex. Eur J Pharmacol. 2018;820:45-52 pubmed publisher
Messias J, Paula J, Grutter A, Bshary R, Soares M. Dopamine disruption increases negotiation for cooperative interactions in a fish. Sci Rep. 2016;6:20817 pubmed publisher
Xue B, Mao L, Jin D, Wang J. Regulation of synaptic MAPK/ERK phosphorylation in the rat striatum and medial prefrontal cortex by dopamine and muscarinic acetylcholine receptors. J Neurosci Res. 2015;93:1592-9 pubmed publisher
Holroyd K, Adrover M, Fuino R, Bock R, Kaplan A, Gremel C, et al. Loss of feedback inhibition via D2 autoreceptors enhances acquisition of cocaine taking and reactivity to drug-paired cues. Neuropsychopharmacology. 2015;40:1495-509 pubmed publisher
Yang Y, Cuevas S, Yang S, Villar V, Escano C, Asico L, et al. Sestrin2 decreases renal oxidative stress, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of reactive oxygen species production. Hypertension. 2014;64:825-32 pubmed publisher
Fish E, Diberto J, Krouse M, Robinson J, Malanga C. Different contributions of dopamine D1 and D2 receptor activity to alcohol potentiation of brain stimulation reward in C57BL/6J and DBA/2J mice. J Pharmacol Exp Ther. 2014;350:322-9 pubmed publisher
Martelle S, Nader S, Czoty P, John W, Duke A, Garg P, et al. Further characterization of quinpirole-elicited yawning as a model of dopamine D3 receptor activation in male and female monkeys. J Pharmacol Exp Ther. 2014;350:205-11 pubmed publisher
Hatalova H, Radostova D, Pistikova A, Vales K, Stuchlik A. Spatial reversal learning in chronically sensitized rats and in undrugged sensitized rats with dopamine d2-like receptor agonist quinpirole. Front Behav Neurosci. 2014;8:122 pubmed publisher
Cardoso Cruz H, Dourado M, Monteiro C, Matos M, Galhardo V. Activation of dopaminergic D2/D3 receptors modulates dorsoventral connectivity in the hippocampus and reverses the impairment of working memory after nerve injury. J Neurosci. 2014;34:5861-73 pubmed publisher
Jeong J, Park Y, Kim D, Lee S, Kwak Y, Lee S, et al. Cdk5 phosphorylates dopamine D2 receptor and attenuates downstream signaling. PLoS ONE. 2013;8:e84482 pubmed publisher
Bayliss A, Evans P. Characterisation of AmphiAmR11, an amphioxus (Branchiostoma floridae) D2-dopamine-like G protein-coupled receptor. PLoS ONE. 2013;8:e80833 pubmed publisher
Merritt K, Bachtell R. Initial d2 dopamine receptor sensitivity predicts cocaine sensitivity and reward in rats. PLoS ONE. 2013;8:e78258 pubmed publisher
Mierzejewski P, Kolaczkowski M, Nowak N, Korkosz A, Scinska A, Sienkiewicz Jarosz H, et al. Pharmacological characteristics of zolpidem-induced catalepsy in the rat. Neurosci Lett. 2013;556:99-103 pubmed publisher
Borroto Escuela D, Ravani A, Tarakanov A, Brito I, Narvaez M, Romero Fernandez W, et al. Dopamine D2 receptor signaling dynamics of dopamine D2-neurotensin 1 receptor heteromers. Biochem Biophys Res Commun. 2013;435:140-6 pubmed publisher
Wong W, Ford K, Pagels N, McCutcheon J, Marinelli M. Adolescents are more vulnerable to cocaine addiction: behavioral and electrophysiological evidence. J Neurosci. 2013;33:4913-22 pubmed publisher
Perna M, Brown R. Adolescent nicotine sensitization and effects of nicotine on accumbal dopamine release in a rodent model of increased dopamine D2 receptor sensitivity. Behav Brain Res. 2013;242:102-9 pubmed publisher
Alkhatib A, Dvorkin Gheva A, Szechtman H. Quinpirole and 8-OH-DPAT induce compulsive checking behavior in male rats by acting on different functional parts of an OCD neurocircuit. Behav Pharmacol. 2013;24:65-73 pubmed publisher
Shao W, Zhang S, Tang M, Zhang X, Zhou Z, Yin Y, et al. Suppression of neuroinflammation by astrocytic dopamine D2 receptors via ?B-crystallin. Nature. 2013;494:90-4 pubmed publisher
Wang W, Nitulescu I, Lewis J, Lemos J, Bamford I, Posielski N, et al. Overinhibition of corticostriatal activity following prenatal cocaine exposure. Ann Neurol. 2013;73:355-69 pubmed publisher
Taylor N, Chemali J, Brown E, Solt K. Activation of D1 dopamine receptors induces emergence from isoflurane general anesthesia. Anesthesiology. 2013;118:30-9 pubmed publisher
Hnasko T, Hjelmstad G, Fields H, Edwards R. Ventral tegmental area glutamate neurons: electrophysiological properties and projections. J Neurosci. 2012;32:15076-85 pubmed publisher
Ebrahimi Ghiri M, Nasehi M, Rostami P, Mohseni Kouchesfehani H, Zarrindast M. The effect of cholestasis on rewarding and exploratory behaviors induced by opioidergic and dopaminergic agents in mice. Arch Iran Med. 2012;15:617-24 pubmed
Nimitvilai S, McElvain M, Brodie M. Reversal of dopamine D2 agonist-induced inhibition of ventral tegmental area neurons by Gq-linked neurotransmitters is dependent on protein kinase C, G protein-coupled receptor kinase, and dynamin. J Pharmacol Exp Ther. 2013;344:253-63 pubmed publisher
Nimitvilai S, Arora D, McElvain M, Brodie M. Reversal of inhibition of putative dopaminergic neurons of the ventral tegmental area: interaction of GABA(B) and D2 receptors. Neuroscience. 2012;226:29-39 pubmed publisher
Fernández Dueñas V, Gómez Soler M, Jacobson K, Kumar S, Fuxe K, Borroto Escuela D, et al. Molecular determinants of A2AR-D2R allosterism: role of the intracellular loop 3 of the D2R. J Neurochem. 2012;123:373-84 pubmed publisher
Chen H, Ruan N, Chen J, Lin T. Dopamine D2 receptor-mediated Akt/PKB signalling: initiation by the D2S receptor and role in quinpirole-induced behavioural activation. ASN Neuro. 2012;4:371-82 pubmed publisher
Miguelez C, Morin S, Martinez A, Goillandeau M, Bezard E, Bioulac B, et al. Altered pallido-pallidal synaptic transmission leads to aberrant firing of globus pallidus neurons in a rat model of Parkinson's disease. J Physiol. 2012;590:5861-75 pubmed publisher
Perez S, Lodge D. Aberrant dopamine D2-like receptor function in a rodent model of schizophrenia. J Pharmacol Exp Ther. 2012;343:288-95 pubmed publisher
Brown R, Maple A, Perna M, Sheppard A, Cope Z, Kostrzewa R. Schizophrenia and substance abuse comorbidity: nicotine addiction and the neonatal quinpirole model. Dev Neurosci. 2012;34:140-51 pubmed
Hobson B, Merritt K, Bachtell R. Stimulation of adenosine receptors in the nucleus accumbens reverses the expression of cocaine sensitization and cross-sensitization to dopamine D2 receptors in rats. Neuropharmacology. 2012;63:1172-81 pubmed publisher
Anzalone A, Lizardi Ortiz J, Ramos M, De Mei C, Hopf F, Iaccarino C, et al. Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors. J Neurosci. 2012;32:9023-34 pubmed publisher
Sharopov S, Moser J, Chen R, Kolbaev S, Bernedo V, Werhahn K, et al. Dopaminergic modulation of low-Mg²⁺-induced epileptiform activity in the intact hippocampus of the newborn mouse in vitro. J Neurosci Res. 2012;90:2020-33 pubmed publisher
Ginovart N, Tournier B, Moulin Sallanon M, Steimer T, Ibanez V, Millet P. Chronic ??-tetrahydrocannabinol exposure induces a sensitization of dopamine D?/? receptors in the mesoaccumbens and nigrostriatal systems. Neuropsychopharmacology. 2012;37:2355-67 pubmed publisher
Radke A, Gewirtz J. Increased dopamine receptor activity in the nucleus accumbens shell ameliorates anxiety during drug withdrawal. Neuropsychopharmacology. 2012;37:2405-15 pubmed publisher
Yang Y, Zhang Y, Cuevas S, Villar V, Escano C, D Asico L, et al. Paraoxonase 2 decreases renal reactive oxygen species production, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of NADPH oxidase. Free Radic Biol Med. 2012;53:437-46 pubmed publisher
Fedotova I. [Stimulation of D2-receptors improves passive avoidance learning in female rats]. Patol Fiziol Eksp Ter. 2012;:53-6 pubmed
Amato D, Müller C, Badiani A. Increased drinking after intra-striatal injection of the dopamine D2/D3 receptor agonist quinpirole in the rat. Psychopharmacology (Berl). 2012;223:457-63 pubmed
Sciamanna G, Hollis R, Ball C, Martella G, Tassone A, Marshall A, et al. Cholinergic dysregulation produced by selective inactivation of the dystonia-associated protein torsinA. Neurobiol Dis. 2012;47:416-27 pubmed publisher
Thompson D, Martini L, Whistler J. Altered ratio of D1 and D2 dopamine receptors in mouse striatum is associated with behavioral sensitization to cocaine. PLoS ONE. 2010;5:e11038 pubmed publisher
Garavaglia A, Moiana A, Camnasio S, Bolognini D, Papait R, Rigamonti D, et al. Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci. 2010;11:7 pubmed publisher
Orisme W, Li J, Goldmann T, Bolch S, Wolfrum U, Smith W. Light-dependent translocation of arrestin in rod photoreceptors is signaled through a phospholipase C cascade and requires ATP. Cell Signal. 2010;22:447-56 pubmed publisher
Bachtell R, Self D. Effects of adenosine A2A receptor stimulation on cocaine-seeking behavior in rats. Psychopharmacology (Berl). 2009;206:469-78 pubmed publisher
Diamandis P, Wildenhain J, Clarke I, Sacher A, Graham J, Bellows D, et al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol. 2007;3:268-73 pubmed
Sanger D, Depoortere R, Perrault G. Evidence for a role for dopamine D3 receptors in the effects of dopamine agonists on operant behaviour in rats. Behav Pharmacol. 1996;7:477-482 pubmed
Zaworski P, Alberts G, Pregenzer J, Im W, Slightom J, Gill G. Efficient functional coupling of the human D3 dopamine receptor to G(o) subtype of G proteins in SH-SY5Y cells. Br J Pharmacol. 1999;128:1181-8 pubmed
Sartania N, Strange P. Role of conserved serine residues in the interaction of agonists with D3 dopamine receptors. J Neurochem. 1999;72:2621-4 pubmed
Munro L, Kokkinidis L. Infusion of quinpirole and muscimol into the ventral tegmental area inhibits fear-potentiated startle: implications for the role of dopamine in fear expression. Brain Res. 1997;746:231-8 pubmed
Rosenzweig Lipson S, Barrett J. K-channel blockers attenuate the presynaptic effects of the D2/D3 agonist quinpirole in monkeys. Pharmacol Biochem Behav. 1995;51:843-8 pubmed
product information
Catalog Number :
Q102
Product Name :
(−)-Quinpirole hydrochloride
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC), solid
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA