This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Linezolid
catalog :
PZ0014
citations: 74
Reference
Puyskens A, Stinn A, van der Vaart M, Kreuchwig A, Protze J, Pei G, et al. Aryl Hydrocarbon Receptor Modulation by Tuberculosis Drugs Impairs Host Defense and Treatment Outcomes. Cell Host Microbe. 2020;27:238-248.e7 pubmed publisher
Xiao J, Rijal P, Schimanski L, Tharkeshwar A, Wright E, Annaert W, et al. Characterization of Influenza Virus Pseudotyped with Ebolavirus Glycoprotein. J Virol. 2018;92: pubmed publisher
Arinto Garcia R, Pinho M, Carriço J, Melo Cristino J, Ramirez M. Comparing Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry and Phenotypic and Molecular Methods for Identification of Species within the Streptococcus anginosus Group. J Clin Microbiol. 2015;53:3580-8 pubmed publisher
Karavasilis V, Zarkotou O, Panopoulou M, Kachrimanidou M, Themeli Digalaki K, Stylianakis A, et al. Wide dissemination of linezolid-resistant Staphylococcus epidermidis in Greece is associated with a linezolid-dependent ST22 clone. J Antimicrob Chemother. 2015;70:1625-9 pubmed publisher
Mutters N, Werner G, Tacconelli E, Mischnik A. [Treatment options for serious infections caused by vancomycin-resistant enterococci]. Dtsch Med Wochenschr. 2015;140:42-5 pubmed publisher
Tian Y, Li T, Zhu Y, Wang B, Zou X, Li M. Mechanisms of linezolid resistance in staphylococci and enterococci isolated from two teaching hospitals in Shanghai, China. BMC Microbiol. 2014;14:292 pubmed publisher
Holland T, Arnold C, Fowler V. Clinical management of Staphylococcus aureus bacteremia: a review. JAMA. 2014;312:1330-41 pubmed publisher
Usery J, Vo N, Finch C, Cleveland K, Gelfand M, Self T. Evaluation of the treatment of methicillin-resistant Staphylococcus aureus bacteremia. Am J Med Sci. 2015;349:36-41 pubmed publisher
Tacconelli E, Kern W. New antibiotics for skin and skin-structure infections. Lancet Infect Dis. 2014;14:659-661 pubmed publisher
Moran G, Fang E, Corey G, Das A, De Anda C, Prokocimer P. Tedizolid for 6 days versus linezolid for 10 days for acute bacterial skin and skin-structure infections (ESTABLISH-2): a randomised, double-blind, phase 3, non-inferiority trial. Lancet Infect Dis. 2014;14:696-705 pubmed publisher
Boucher H, Wilcox M, Talbot G, Puttagunta S, Das A, Dunne M. Once-weekly dalbavancin versus daily conventional therapy for skin infection. N Engl J Med. 2014;370:2169-79 pubmed publisher
Cağlayan K, Gungor B, Cinar H, Erdogan N, Koca B. Preventing intraperitoneal adhesions with linezolid and hyaluronic acid/carboxymethylcellulose: a comparative study in cecal abrasion model. Am J Surg. 2014;208:106-11 pubmed publisher
Yu Z, Chen Z, Cheng H, Zheng J, Li D, Deng X, et al. Complete genome sequencing and comparative analysis of the linezolid-resistant Enterococcus faecalis strain DENG1. Arch Microbiol. 2014;196:513-6 pubmed publisher
Drougka E, Foka A, Liakopoulos A, Doudoulakakis A, Jelastopulu E, Chini V, et al. A 12-year survey of methicillin-resistant Staphylococcus aureus infections in Greece: ST80-IV epidemic?. Clin Microbiol Infect. 2014;20:O796-803 pubmed publisher
Reznikov L, Abou Alaiwa M, Dohrn C, Gansemer N, Diekema D, Stoltz D, et al. Antibacterial properties of the CFTR potentiator ivacaftor. J Cyst Fibros. 2014;13:515-9 pubmed publisher
Oh C, Moon C, Park O, Kwon S, Jang J. Novel drug combination for Mycobacterium abscessus disease therapy identified in a Drosophila infection model. J Antimicrob Chemother. 2014;69:1599-607 pubmed publisher
Brzychczy Wloch M, Borszewska Kornacka M, Gulczynska E, Wójkowska Mach J, Sulik M, Grzebyk M, et al. Prevalence of antibiotic resistance in multi-drug resistant coagulase-negative staphylococci isolated from invasive infection in very low birth weight neonates in two Polish NICUs. Ann Clin Microbiol Antimicrob. 2013;12:41 pubmed publisher
Roongruangpitayakul C, Chuchottaworn C. Outcomes of MDR/XDR-TB patients treated with linezolid: experience in Thailand. J Med Assoc Thai. 2013;96:1273-82 pubmed
Sastre A, Roberts P, Presutti R. A practical guide to community-acquired MRSA. J Fam Pract. 2013;62:624-9 pubmed
Nie W, Chu N. [The analysis of clinical data about the treatment of linezolid against tuberculosis]. Zhonghua Jie He He Hu Xi Za Zhi. 2013;36:601-3 pubmed
Kraleti S, Soultanova I. Pancytopenia and lactic acidosis associated with linezolid use in a patient with empyema. J Ark Med Soc. 2013;110:62-3 pubmed
Sadeghi J, Mansouri S. Molecular characterization and antibiotic resistance of clinical isolates of methicillin-resistant Staphylococcus aureus obtained from Southeast of Iran (Kerman). APMIS. 2014;122:405-11 pubmed publisher
Saini J, Homeyer N, Fulle S, Gohlke H. Determinants of the species selectivity of oxazolidinone antibiotics targeting the large ribosomal subunit. Biol Chem. 2013;394:1529-41 pubmed publisher
Baietto L, D Avolio A, Ariaudo A, Corcione S, Simiele M, Cusato J, et al. Development and validation of a new UPLC-PDA method to quantify linezolid in plasma and in dried plasma spots. J Chromatogr B Analyt Technol Biomed Life Sci. 2013;936:42-7 pubmed publisher
Yoo J, Lyu J, Lee S, Kim W, Kim D, Shim T. Clinical experience of using clofazimine to treat multidrug-resistant tuberculosis [Correspondence]. Int J Tuberc Lung Dis. 2013;17:1243-4 pubmed publisher
Tsuji Y, Yukawa E, Hiraki Y, Matsumoto K, Mizoguchi A, Morita K, et al. Population pharmacokinetic analysis of linezolid in low body weight patients with renal dysfunction. J Clin Pharmacol. 2013;53:967-73 pubmed publisher
Whang D, Miller L, Partain N, McKinnell J. Systematic review and meta-analysis of linezolid and daptomycin for treatment of vancomycin-resistant enterococcal bloodstream infections. Antimicrob Agents Chemother. 2013;57:5013-8 pubmed publisher
Shukla B, Gauthier T, Correa R, Smith L, Abbo L. Treatment considerations in vancomycin-resistant enterococcal bacteremia: daptomycin or linezolid? A review. Int J Clin Pharm. 2013;35:697-703 pubmed publisher
Yue J, Dong B, Yang M, Chen X, Wu T, Liu G. Linezolid versus vancomycin for skin and soft tissue infections. Cochrane Database Syst Rev. 2013;:CD008056 pubmed publisher
Moreno R, Rives S, Justicia A, Catala A, Ruiz Llobet A, Toll T, et al. Successful port-a-cath salvage using linezolid in children with acute leukemia. Pediatr Blood Cancer. 2013;60:E103-5 pubmed publisher
Helmy S. Pharmacokinetics and relative bioavailability evaluation of linezolid suspension and tablet formulations. Drug Res (Stuttg). 2013;63:489-94 pubmed publisher
González N, Sevillano D, Alou L, Cafini F, Gimenez M, Gómez Lus M, et al. Influence of the MBC/MIC ratio on the antibacterial activity of vancomycin versus linezolid against methicillin-resistant Staphylococcus aureus isolates in a pharmacodynamic model simulating serum and soft tissue interstitial fluid concentrations rep. J Antimicrob Chemother. 2013;68:2291-5 pubmed publisher
Muzevich K, Lee K. Subtherapeutic linezolid concentrations in a patient with morbid obesity and methicillin-resistant Staphylococcus aureus pneumonia: case report and review of the literature. Ann Pharmacother. 2013;47:e25 pubmed publisher
Thilesen C, Bjørang O, Skrede T, Aronsen T, Aasnaes B, Sundsfjord A, et al. Emergence of mutation-based linezolid-resistant invasive Enterococcus faecalis in a haemodialysis patient in Norway. APMIS. 2014;122:83-4 pubmed publisher
Różalski M, Micota B, Sadowska B, Paszkiewicz M, Wieckowska Szakiel M, Rozalska B. Antimicrobial/anti-biofilm activity of expired blood platelets and their released products. Postepy Hig Med Dosw (Online). 2013;67:321-5 pubmed
Jiang H, Tang R, Wang J. Linezolid versus vancomycin or teicoplanin for nosocomial pneumonia: meta-analysis of randomised controlled trials. Eur J Clin Microbiol Infect Dis. 2013;32:1121-8 pubmed publisher
Ramsey T, Lau T, Ensom M. Serotonergic and adrenergic drug interactions associated with linezolid: a critical review and practical management approach. Ann Pharmacother. 2013;47:543-60 pubmed publisher
Diaz L, Kontoyiannis D, Panesso D, Albert N, Singh K, Tran T, et al. Dissecting the mechanisms of linezolid resistance in a Drosophila melanogaster infection model of Staphylococcus aureus. J Infect Dis. 2013;208:83-91 pubmed publisher
Diep B, Afasizheva A, Le H, Kajikawa O, Matute Bello G, Tkaczyk C, et al. Effects of linezolid on suppressing in vivo production of staphylococcal toxins and improving survival outcomes in a rabbit model of methicillin-resistant Staphylococcus aureus necrotizing pneumonia. J Infect Dis. 2013;208:75-82 pubmed publisher
Fu J, Ye X, Chen C, Chen S. The efficacy and safety of linezolid and glycopeptides in the treatment of Staphylococcus aureus infections. PLoS ONE. 2013;8:e58240 pubmed publisher
Liu X, He Y, Xiao K, White J, Fusco D, Papanicolaou G. Effect of linezolid on clinical severity and pulmonary cytokines in a murine model of influenza A and Staphylococcus aureus coinfection. PLoS ONE. 2013;8:e57483 pubmed publisher
Tu E, Jain S. Topical linezolid 0.2% for the treatment of vancomycin-resistant or vancomycin-intolerant gram-positive bacterial keratitis. Am J Ophthalmol. 2013;155:1095-1098.e1 pubmed publisher
Yang X, Chen Y, Yang Q, Qu T, Liu L, Wang H, et al. Emergence of cfr-harbouring coagulase-negative staphylococci among patients receiving linezolid therapy in two hospitals in China. J Med Microbiol. 2013;62:845-50 pubmed publisher
Cui L, Wang Y, Li Y, He T, Schwarz S, Ding Y, et al. Cfr-mediated linezolid-resistance among methicillin-resistant coagulase-negative staphylococci from infections of humans. PLoS ONE. 2013;8:e57096 pubmed publisher
Woytowish M, Maynor L. Clinical relevance of linezolid-associated serotonin toxicity. Ann Pharmacother. 2013;47:388-97 pubmed publisher
Chhibber S, Kaur T, Sandeep Kaur -. Co-therapy using lytic bacteriophage and linezolid: effective treatment in eliminating methicillin resistant Staphylococcus aureus (MRSA) from diabetic foot infections. PLoS ONE. 2013;8:e56022 pubmed publisher
Morata L, Cuesta M, Rojas J, Rodriguez S, Brunet M, Casals G, et al. Risk factors for a low linezolid trough plasma concentration in acute infections. Antimicrob Agents Chemother. 2013;57:1913-7 pubmed publisher
Wunderink R. How important is methicillin-resistant Staphylococcus aureus as a cause of community-acquired pneumonia and what is best antimicrobial therapy?. Infect Dis Clin North Am. 2013;27:177-88 pubmed publisher
Gonzalez R, Rostas J, Simmons J, Allen J, Frotan M, Brevard S. Improved outcome of ventilator-associated pneumonia caused by methicillin-resistant Staphylococcus aureus in a trauma population. Am J Surg. 2013;205:255-8; discussion 258 pubmed publisher
Kojiro M, Tsuchihashi Y, Ishida M, Furumoto A, Matsuda J, Yanagihara K, et al. [A case of pacemaker-lead infection by linezolid-resistant methicillin-resistant Staphylococcus aureus in a hemodialysis patient]. Kansenshogaku Zasshi. 2012;86:778-83 pubmed
Cai Y, Chai D, Falagas M, Karageorgopoulos D, Wang R, Bai N, et al. Weight-adjusted versus fixed dose of linezolid for Chinese healthy volunteers of higher and lower body weight: a Phase I pharmacokinetic and pharmacodynamic study. Expert Opin Investig Drugs. 2013;22:309-15 pubmed publisher
Campanile F, Mongelli G, Bongiorno D, Adembri C, Ballardini M, Falcone M, et al. Worrisome trend of new multiple mechanisms of linezolid resistance in staphylococcal clones diffused in Italy. J Clin Microbiol. 2013;51:1256-9 pubmed publisher
Sarathy J, Dartois V, Dick T, Gengenbacher M. Reduced drug uptake in phenotypically resistant nutrient-starved nonreplicating Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2013;57:1648-53 pubmed publisher
Lee D, Murakami Y, Andes D, Craig W. Inoculum effects of ceftobiprole, daptomycin, linezolid, and vancomycin with Staphylococcus aureus and Streptococcus pneumoniae at inocula of 10(5) and 10(7) CFU injected into opposite thighs of neutropenic mice. Antimicrob Agents Chemother. 2013;57:1434-41 pubmed publisher
Raghunath A. Gingival pain: an unusual side effect of ziprasidone. BMJ Case Rep. 2013;2013: pubmed publisher
Ramirez E, Gómez Gil R, Borobia A, Moreno F, Zegarra C, Munoz R, et al. Improving linezolid use decreases the incidence of resistance among Gram-positive microorganisms. Int J Antimicrob Agents. 2013;41:174-8 pubmed publisher
Watkins R, Lemonovich T, File T. An evidence-based review of linezolid for the treatment of methicillin-resistant Staphylococcus aureus (MRSA): place in therapy. Core Evid. 2012;7:131-43 pubmed publisher
Quiles Melero I, Gómez Gil R, Romero Gómez M, Sánchez Díaz A, De Pablos M, García Rodríguez J, et al. Mechanisms of linezolid resistance among Staphylococci in a tertiary hospital. J Clin Microbiol. 2013;51:998-1001 pubmed publisher
Matsumoto H, Kawabata R, Kishimoto T, Yamamoto E, Kimura Y, Imamura H, et al. [A case of refractory deep incisional surgical site infection due to methicillin-resistant Staphylococcus aureus (MRSA) and successfully treated with oral linezolid]. Gan To Kagaku Ryoho. 2012;39:2441-3 pubmed
Xu H, Xu C, Fan Z, Zhao L, Liu H. A facile synthesis, antibacterial activity of pulvinone and its derivatives. Bioorg Med Chem Lett. 2013;23:737-9 pubmed publisher
Descourouez J, Jorgenson M, Wergin J, Rose W. Fosfomycin synergy in vitro with amoxicillin, daptomycin, and linezolid against vancomycin-resistant Enterococcus faecium from renal transplant patients with infected urinary stents. Antimicrob Agents Chemother. 2013;57:1518-20 pubmed publisher
Szultka M, Krzeminski R, Szeliga J, Jackowski M, Buszewski B. A new approach for antibiotic drugs determination in human plasma by liquid chromatography-mass spectrometry. J Chromatogr A. 2013;1272:41-9 pubmed publisher
Bounthavong M, Hsu D. Cost-effectiveness of linezolid in methicillin-resistant Staphylococcus aureus skin and skin structure infections. Expert Rev Pharmacoecon Outcomes Res. 2012;12:683-98 pubmed publisher
Gu B, Kelesidis T, Tsiodras S, Hindler J, Humphries R. The emerging problem of linezolid-resistant Staphylococcus. J Antimicrob Chemother. 2013;68:4-11 pubmed publisher
He M, Jiang Y, Cai C. [Mechanisms and epidemiology of linezolid resistance in staphylococci]. Zhonghua Jie He He Hu Xi Za Zhi. 2012;35:360-2 pubmed
Sotgiu G, Centis R, D Ambrosio L, Alffenaar J, Anger H, Caminero J, et al. Efficacy, safety and tolerability of linezolid containing regimens in treating MDR-TB and XDR-TB: systematic review and meta-analysis. Eur Respir J. 2012;40:1430-42 pubmed publisher
Cox H, Ford N. Linezolid for the treatment of complicated drug-resistant tuberculosis: a systematic review and meta-analysis. Int J Tuberc Lung Dis. 2012;16:447-54 pubmed publisher
Shen T, Wu L, Geng L, Wei Z, Zheng S. Successful treatment of pulmonary Nocardia farcinica infection with linezolid: case report and literature review. Braz J Infect Dis. 2011;15:486-9 pubmed
Long K, Vester B. Resistance to linezolid caused by modifications at its binding site on the ribosome. Antimicrob Agents Chemother. 2012;56:603-12 pubmed publisher
Ross J, Farrell D, Mendes R, Sader H, Jones R. Eight-year (2002-2009) summary of the linezolid (Zyvox® Annual Appraisal of Potency and Spectrum; ZAAPS) program in European countries. J Chemother. 2011;23:71-6 pubmed
Dryden M. Linezolid pharmacokinetics and pharmacodynamics in clinical treatment. J Antimicrob Chemother. 2011;66 Suppl 4:iv7-iv15 pubmed publisher
Gould F. Linezolid: safety and efficacy in special populations. J Antimicrob Chemother. 2011;66 Suppl 4:iv3-iv6 pubmed publisher
Leach K, Brickner S, Noe M, Miller P. Linezolid, the first oxazolidinone antibacterial agent. Ann N Y Acad Sci. 2011;1222:49-54 pubmed publisher
Ijzerman M, Tack K, Huang D. Combined retrospective analysis of seven phase II and III trials of the efficacy of linezolid in the treatment of pneumonia caused by multidrug-resistant Streptococcus pneumoniae. Clin Ther. 2010;32:2198-206 pubmed publisher
product information
Catalog Number :
PZ0014
Product Name :
Linezolid
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA