This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Celecoxib
catalog :
PZ0008
citations: 197
Reference
Goldshtein H, Muhire A, Petel Légaré V, Pushett A, Rotkopf R, Shefner J, et al. Efficacy of Ciprofloxacin/Celecoxib combination in zebrafish models of amyotrophic lateral sclerosis. Ann Clin Transl Neurol. 2020;7:1883-1897 pubmed publisher
Chern C, Zhou H, Wang Y, Chang C, Chiou W, Chang W, et al. Osthole ameliorates cartilage degradation by downregulation of NF-κB and HIF-2α pathways in an osteoarthritis murine model. Eur J Pharmacol. 2020;867:172799 pubmed publisher
Gassen N, Niemeyer D, Muth D, Corman V, Martinelli S, Gassen A, et al. SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection. Nat Commun. 2019;10:5770 pubmed publisher
Sagar S, Singh D, Das R, Panchal N, Sudarsanam V, Nivsarkar M, et al. Pharmacological investigation of quinoxaline-bisthiazoles as multitarget-directed ligands for the treatment of Alzheimer's disease. Bioorg Chem. 2019;89:102992 pubmed publisher
König S, Romp E, Krauth V, Rühl M, Dörfer M, Liening S, et al. Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159. Cell Chem Biol. 2019;26:60-70.e4 pubmed publisher
Li Y, Soendergaard C, Bergenheim F, Aronoff D, Milne G, Riis L, et al. COX-2-PGE2 Signaling Impairs Intestinal Epithelial Regeneration and Associates with TNF Inhibitor Responsiveness in Ulcerative Colitis. EBioMedicine. 2018;36:497-507 pubmed publisher
Liu R, Zheng H, Li W, Guo Q, He S, Hirasaki Y, et al. Anti-tumor enhancement of Fei-Liu-Ping ointment in combination with celecoxib via cyclooxygenase-2-mediated lung metastatic inflammatory microenvironment in Lewis lung carcinoma xenograft mouse model. J Transl Med. 2015;13:366 pubmed publisher
Zhou X, Shi X, Ren K, Fan G, Wu S, Zhao J. Celecoxib inhibits cell growth and modulates the expression of matrix metalloproteinases in human osteosarcoma MG-63 cell line. Eur Rev Med Pharmacol Sci. 2015;19:4087-97 pubmed
Zhang L, Tong Y, Zhang X, Pan M, Chen S. Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth. Drug Des Devel Ther. 2015;9:5851-62 pubmed publisher
Qin G, Xu F, Qin T, Zheng Q, Shi D, Xia W, et al. Palbociclib inhibits epithelial-mesenchymal transition and metastasis in breast cancer via c-Jun/COX-2 signaling pathway. Oncotarget. 2015;6:41794-808 pubmed publisher
Wu G, Wu N, Li T, Fan Y, Yu G, Lu W. Effect of Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood on reproductive endocrine activity and immune functions in patients with primary Sjogren's syndrome. Chin J Integr Med. 2015;21:778-83 pubmed publisher
Schellhorn M, Haustein M, Frank M, Linnebacher M, Hinz B. Celecoxib increases lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. Oncotarget. 2015;6:39342-56 pubmed publisher
Rosenblat J, McIntyre R, Alves G, Fountoulakis K, Carvalho A. Beyond Monoamines-Novel Targets for Treatment-Resistant Depression: A Comprehensive Review. Curr Neuropharmacol. 2015;13:636-55 pubmed
Li N, Li H, Su F, Li J, Ma X, Gong P. Relationship between epidermal growth factor receptor (EGFR) mutation and serum cyclooxygenase-2 Level, and the synergistic effect of celecoxib and gefitinib on EGFR expression in non-small cell lung cancer cells. Int J Clin Exp Pathol. 2015;8:9010-20 pubmed
Syed H, Ikram M, Yaqinuddin A, Ahmed T. Cyclooxygenase I and II inhibitors distinctly enhance hippocampal- and cortex-dependent cognitive functions in mice. Mol Med Rep. 2015;12:7649-56 pubmed publisher
Iqbal M, Ezzeldin E, Bhat M, Raish M, Al Rashood K. Preclinical pharmacokinetics, tissue distribution and excretion studies of a novel anti-candidal agent-thiosemicarbazide derivative of isoniazid (TSC-INH) by validated UPLC-MS/MS assay. J Pharm Biomed Anal. 2016;117:109-17 pubmed publisher
Cataldi M, Shah N, Felt S, Grdzelishvili V. Breaking resistance of pancreatic cancer cells to an attenuated vesicular stomatitis virus through a novel activity of IKK inhibitor TPCA-1. Virology. 2015;485:340-54 pubmed publisher
Sobolewski C, Rhim J, Legrand N, Muller F, Cerella C, Mack F, et al. 2,5-Dimethyl-celecoxib inhibits cell cycle progression and induces apoptosis in human leukemia cells. J Pharmacol Exp Ther. 2015;355:308-28 pubmed publisher
Ma Y, Gao S, Hu M. Quantitation of celecoxib and four of its metabolites in rat blood by UPLC-MS/MS clarifies their blood distribution patterns and provides more accurate pharmacokinetics profiles. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;1001:202-11 pubmed publisher
Whitted C, Palau V, Torrenegra R, Harirforoosh S. Development of reversed-phase high performance liquid chromatography methods for quantification of two isomeric flavones and the application of the methods to pharmacokinetic studies in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;1001:150-5 pubmed publisher
Ohtori S, Orita S, Yamauchi K, Eguchi Y, Ochiai N, Kishida S, et al. Efficacy of Direct Injection of Etanercept into Knee Joints for Pain in Moderate and Severe Knee Osteoarthritis. Yonsei Med J. 2015;56:1379-83 pubmed publisher
Lee Y, Kim J, Kim W, Nam J, Jeong S, Lee S, et al. Celecoxib coupled to dextran via a glutamic acid linker yields a polymeric prodrug suitable for colonic delivery. Drug Des Devel Ther. 2015;9:4105-13 pubmed publisher
Ko H, Ahn E, Oh J. N‑trans‑ρ‑caffeoyl tyramine isolated from Tribulus terrestris exerts anti‑inflammatory effects in lipopolysaccharide‑stimulated RAW 264.7 cells. Int J Mol Med. 2015;36:1042-8 pubmed publisher
Liu D, Guo M, Hu Y, Liu T, Yan J, Luo Y, et al. Effect of sanhuangwuji powder, anti-rheumatic drugs, and ginger-partitioned acupoint stimulation on the treatment of rheumatoid arthritis with peptic ulcer: a randomized controlled study. J Tradit Chin Med. 2015;35:273-80 pubmed
Tian S, Chang W, Du H, Bai J, Sun Z, Zhang Q, et al. The interplay between GRP78 expression and Akt activation in human colon cancer cells under celecoxib treatment. Anticancer Drugs. 2015;26:964-73 pubmed publisher
Jung Y, Kim E, Choi H, Park J, Kim H, Lee Y, et al. Aspirin Targets SIRT1 and AMPK to Induce Senescence of Colorectal Carcinoma Cells. Mol Pharmacol. 2015;88:708-19 pubmed publisher
Liu N, Chen L, Cai N. Celecoxib attenuates retinal angiogenesis in a mouse model of oxygen-induced retinopathy. Int J Clin Exp Pathol. 2015;8:4990-8 pubmed
Khan N, Farooq A, Sadek B. Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists. Drug Des Devel Ther. 2015;9:3497-506 pubmed publisher
Tang J, Xiao W, Li Q, Deng Q, Chu X, Chen Y, et al. A Cyclooxygenase-2 Inhibitor Reduces Vascular Wall Thickness and Ameliorates Cognitive Impairment in a Cerebral Small Vessel Diseases Rat Model. Curr Alzheimer Res. 2015;12:704-10 pubmed
Mohammadinejad P, Arya P, Esfandbod M, Kaviani A, Najafi M, Kashani L, et al. Celecoxib Versus Diclofenac in Mild to Moderate Depression Management Among Breast Cancer Patients: A Double-Blind, Placebo-Controlled, Randomized Trial. Ann Pharmacother. 2015;49:953-61 pubmed publisher
Xu Z, Zhang R, Zhang D, Yao J, Shi R, Tang Q, et al. Peptic ulcer hemorrhage combined with acute gout: analyses of treatment in 136 cases. Int J Clin Exp Med. 2015;8:6193-9 pubmed
Hiyama A, Yokoyama K, Nukaga T, Sakai D, Mochida J. Response to tumor necrosis factor-α mediated inflammation involving activation of prostaglandin E2 and Wnt signaling in nucleus pulposus cells. J Orthop Res. 2015;33:1756-68 pubmed publisher
Ichikawa M, Sowa Y, Iizumi Y, Aono Y, Sakai T. Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells. PLoS ONE. 2015;10:e0129851 pubmed publisher
Wei G, Chen X, Wang G, Jia P, Xu Q, Ping G, et al. Inhibition of cyclooxygenase-2 prevents intra-abdominal adhesions by decreasing activity of peritoneal fibroblasts. Drug Des Devel Ther. 2015;9:3083-98 pubmed publisher
Gu J, Zhang X, Ma Y, Li N, Luo F, Cao L, et al. Quantitative modeling of dose-response and drug combination based on pathway network. J Cheminform. 2015;7:19 pubmed publisher
Olive D, Barrington M, Simone S, Kluger R. A randomised controlled trial comparing three analgesia regimens following total knee joint replacement: continuous femoral nerve block, intrathecal morphine or both. Anaesth Intensive Care. 2015;43:454-60 pubmed
Costa Nunes J, Cline B, Araújo Correia M, Valença A, Markova N, Dolgov O, et al. Animal Models of Depression and Drug Delivery with Food as an Effective Dosing Method: Evidences from Studies with Celecoxib and Dicholine Succinate. Biomed Res Int. 2015;2015:596126 pubmed publisher
Liu J, Wu J, Zhou L, Pan C, Zhou Y, Du W, et al. ZD6474, a new treatment strategy for human osteosarcoma, and its potential synergistic effect with celecoxib. Oncotarget. 2015;6:21341-52 pubmed
Nath S, Roy L, Grover P, Rao S, Mukherjee P. Mucin 1 Regulates Cox-2 Gene in Pancreatic Cancer. Pancreas. 2015;44:909-17 pubmed publisher
Jafari S, Ashrafizadeh S, Zeinoddini A, Rasoulinejad M, Entezari P, Seddighi S, et al. Celecoxib for the treatment of mild-to-moderate depression due to acute brucellosis: a double-blind, placebo-controlled, randomized trial. J Clin Pharm Ther. 2015;40:441-6 pubmed publisher
Maji S, Samal S, Pattanaik L, Panda S, Quinn B, Das S, et al. Mcl-1 is an important therapeutic target for oral squamous cell carcinomas. Oncotarget. 2015;6:16623-37 pubmed
Gjyshi O, Roy A, Dutta S, Veettil M, Dutta D, Chandran B. Activated Nrf2 Interacts with Kaposi's Sarcoma-Associated Herpesvirus Latency Protein LANA-1 and Host Protein KAP1 To Mediate Global Lytic Gene Repression. J Virol. 2015;89:7874-92 pubmed publisher
Venè R, Tosetti F, Minghelli S, Poggi A, Ferrari N, Benelli R. Celecoxib increases EGF signaling in colon tumor associated fibroblasts, modulating EGFR expression and degradation. Oncotarget. 2015;6:12310-25 pubmed
Carpi S, Fogli S, Romanini A, Pellegrino M, Adinolfi B, Podestà A, et al. AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells. Anticancer Drugs. 2015;26:754-62 pubmed publisher
Li S, Gu Z, Xiao Z, Zhou T, Li J, Sun K. Anti-tumor effect and mechanism of cyclooxygenase-2 inhibitor through matrix metalloproteinase 14 pathway in PANC-1 cells. Int J Clin Exp Pathol. 2015;8:1737-42 pubmed
Tsai W, Ou T, Yen J, Wu C, Tung Y. Long-term frequent use of non-steroidal anti-inflammatory drugs might protect patients with ankylosing spondylitis from cardiovascular diseases: a nationwide case-control study. PLoS ONE. 2015;10:e0126347 pubmed publisher
Bryden L, Nicholson J, Doods H, Pekcec A. Deficits in spontaneous burrowing behavior in the rat bilateral monosodium iodoacetate model of osteoarthritis: an objective measure of pain-related behavior and analgesic efficacy. Osteoarthritis Cartilage. 2015;23:1605-12 pubmed publisher
Ambadapadi S, Wang P, Palii S, James M. Celecoxib influences steroid sulfonation catalyzed by human recombinant sulfotransferase 2A1. J Steroid Biochem Mol Biol. 2015;152:101-13 pubmed publisher
Shalbafan M, Mohammadinejad P, Shariat S, Alavi K, Zeinoddini A, Salehi M, et al. Celecoxib as an Adjuvant to Fluvoxamine in Moderate to Severe Obsessive-compulsive Disorder: A Double-blind, Placebo-controlled, Randomized Trial. Pharmacopsychiatry. 2015;48:136-40 pubmed publisher
Chen J, Jiang L, Lan K, Chen X. Celecoxib Inhibits the Lytic Activation of Kaposi's Sarcoma-Associated Herpesvirus through Down-Regulation of RTA Expression by Inhibiting the Activation of p38 MAPK. Viruses. 2015;7:2268-87 pubmed publisher
Lee S, Koo B, Park S, Kim Y. Anti-angiogenic effects of resveratrol in combination with 5-fluorouracil on B16 murine melanoma cells. Mol Med Rep. 2015;12:2777-83 pubmed publisher
Behr C, Hesketh A, Barlow M, Glick R, Symons M, Steinberg B, et al. Celecoxib inhibits Ewing sarcoma cell migration via actin modulation. J Surg Res. 2015;198:424-33 pubmed publisher
Ren J, Huang H, Liu Y, Zheng X, Zou Q. An Atomic Force Microscope Study Revealed Two Mechanisms in the Effect of Anticancer Drugs on Rate-Dependent Young's Modulus of Human Prostate Cancer Cells. PLoS ONE. 2015;10:e0126107 pubmed publisher
Vlachopoulos C, Aznaouridis K, Bratsas A, Ioakeimidis N, Dima I, Xaplanteris P, et al. Arterial stiffening and systemic endothelial activation induced by smoking: The role of COX-1 and COX-2. Int J Cardiol. 2015;189:293-8 pubmed publisher
Kaserer T, Temml V, Kutil Z, Vanek T, Landa P, Schuster D. Prospective performance evaluation of selected common virtual screening tools. Case study: Cyclooxygenase (COX) 1 and 2. Eur J Med Chem. 2015;96:445-57 pubmed publisher
Ma H, Lu T, Zhang X, Li C, Xiong J, Huang L, et al. HSPA12B: a novel facilitator of lung tumor growth. Oncotarget. 2015;6:9924-36 pubmed
Jennings C, MacDonald T, Wei L, Brown M, McConnachie L, Mackenzie I. Does offering an incentive payment improve recruitment to clinical trials and increase the proportion of socially deprived and elderly participants?. Trials. 2015;16:80 pubmed publisher
Olesch C, Sha W, Angioni C, Sha L, Açaf E, Patrignani P, et al. MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer. Oncotarget. 2015;6:10284-96 pubmed
Kwong W, Liuni A, Zhou K, Parker J. Cyclooxygenase inhibition and rosuvastatin-induced vascular protection in the setting of ischemia-reperfusion: A human in vivo study. Vascul Pharmacol. 2015;71:159-65 pubmed publisher
Chien P, Lin C, Hsiao L, Yang C. c-Src/Pyk2/EGFR/PI3K/Akt/CREB-activated pathway contributes to human cardiomyocyte hypertrophy: Role of COX-2 induction. Mol Cell Endocrinol. 2015;409:59-72 pubmed publisher
Kim J, Ahmadinia K, Li X, Hamilton J, Andrews S, Haralampus C, et al. Development of an Experimental Animal Model for Lower Back Pain by Percutaneous Injury-Induced Lumbar Facet Joint Osteoarthritis. J Cell Physiol. 2015;230:2837-47 pubmed publisher
Jeon Y, Ahn Y, Chung W, Choi H, Suh Y. Synergistic effect between celecoxib and luteolin is dependent on estrogen receptor in human breast cancer cells. Tumour Biol. 2015;36:6349-59 pubmed publisher
Murdande S, Shah D, Dave R. Impact of nanosizing on solubility and dissolution rate of poorly soluble pharmaceuticals. J Pharm Sci. 2015;104:2094-2102 pubmed publisher
Xia Q, Hu Q, Wang H, Yang H, Gao F, Ren H, et al. Induction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia. Cell Death Dis. 2015;6:e1702 pubmed publisher
Mao Y, Xu J, Seeley E, Tang X, Xu L, Zhu Y, et al. Adipose Tissue-Derived Mesenchymal Stem Cells Attenuate Pulmonary Infection Caused by Pseudomonas aeruginosa via Inhibiting Overproduction of Prostaglandin E2. Stem Cells. 2015;33:2331-42 pubmed publisher
Li B, Su K, Yang G, Feng Y, Xia L, Yin S. Assessment of the potential ototoxicity of high-dose celecoxib, a selective cyclooxygenase-2 inhibitor, in rats. Otolaryngol Head Neck Surg. 2015;152:1108-12 pubmed publisher
Yang Y, Yan J, Huang Y, Xu H, Zhang Y, Hu R, et al. The cancer pain related factors affected by celecoxib together with cetuximab in head and neck squamous cell carcinoma. Biomed Pharmacother. 2015;70:181-9 pubmed publisher
Chang C, Cheng C, Yang T, Chen Y, Lin Y, Chen S, et al. Selective and non-selective non-steroidal anti-inflammatory drugs differentially regulate pulmonary vein and atrial arrhythmogenesis. Int J Cardiol. 2015;184:559-67 pubmed publisher
Bujalska Zadrożny M, de Cordé A, Pawlik K. Influence of nitric oxide synthase or cyclooxygenase inhibitors on cannabinoids activity in streptozotocin-induced neuropathy. Pharmacol Rep. 2015;67:209-16 pubmed publisher
Chung K, Lee J, Park J, Choi C. Risk factors of delirium in patients undergoing total knee arthroplasty. Arch Gerontol Geriatr. 2015;60:443-7 pubmed publisher
Cao Y, Qu J, Li C, Yang D, Hou K, Zheng H, et al. Celecoxib sensitizes gastric cancer to rapamycin via inhibition of the Cbl-b-regulated PI3K/Akt pathway. Tumour Biol. 2015;36:5607-15 pubmed publisher
Fantappiè O, Sassoli C, Tani A, Nosi D, Marchetti S, Formigli L, et al. Mitochondria of a human multidrug-resistant hepatocellular carcinoma cell line constitutively express inducible nitric oxide synthase in the inner membrane. J Cell Mol Med. 2015;19:1410-7 pubmed publisher
Sha L, Sha W, Kuchler L, Daiber A, Giegerich A, Weigert A, et al. Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8(+) T cell function by limiting GSH and Cys availability. Free Radic Biol Med. 2015;83:77-88 pubmed publisher
Li Z, Meng D, Li G, Xu J, Tian K, Li Y. Celecoxib Combined with Diacerein Effectively Alleviates Osteoarthritis in Rats via Regulating JNK and p38MAPK Signaling Pathways. Inflammation. 2015;38:1563-72 pubmed publisher
Balansky R, Ganchev G, Iltcheva M, Nikolov M, La Maestra S, Micale R, et al. Modulation by licofelone and celecoxib of experimentally induced cancer and preneoplastic lesions in mice exposed to cigarette smoke. Curr Cancer Drug Targets. 2015;15:188-95 pubmed
Thill M, Woeste A, Reichert K, Fischer D, Rody A, Friedrich M, et al. Vitamin D inhibits ovarian cancer cell line proliferation in combination with celecoxib and suppresses cyclooxygenase-2 expression. Anticancer Res. 2015;35:1197-203 pubmed
Zhang P, Cheng J, Zou S, D Souza A, Koff J, Lu J, et al. Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation. Nat Commun. 2015;6:6221 pubmed publisher
El Mas M, Helmy M, Ali R, El Gowelli H. Celecoxib, but not indomethacin, ameliorates the hypertensive and perivascular fibrotic actions of cyclosporine in rats: role of endothelin signaling. Toxicol Appl Pharmacol. 2015;284:1-7 pubmed publisher
Aguado A, Rodriguez C, Martinez Revelles S, Avendaño M, Zhenyukh O, Orriols M, et al. HuR mediates the synergistic effects of angiotensin II and IL-1β on vascular COX-2 expression and cell migration. Br J Pharmacol. 2015;172:3028-42 pubmed publisher
Li S, Xu X, Jiang M, Bi Y, Xu J, Han M. Lipopolysaccharide induces inflammation and facilitates lung metastasis in a breast cancer model via the prostaglandin E2-EP2 pathway. Mol Med Rep. 2015;11:4454-62 pubmed publisher
Iqbal M, Ezzeldin E, Al Rashood K, Shakeel F. A validated UPLC-MS/MS assay using negative ionization mode for high-throughput determination of pomalidomide in rat plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;983-984:76-82 pubmed publisher
Kim J, Chung S, Kim S, Byun Y. Enhanced Anti-Angiogenic Effect of Low Molecular Weight Heparin-Bile Acid Conjugates by Co-Administration of a Selective COX-2 Inhibitor. Pharm Res. 2015;32:2318-27 pubmed publisher
Oh H, Kim D, Lee S, Jung B. Simultaneous quantitative determination of celecoxib and its two metabolites using liquid chromatography-tandem mass spectrometry in alternating polarity switching mode. J Pharm Biomed Anal. 2015;107:32-9 pubmed publisher
Tamura D, Saito T, Murata K, Kawashima M, Asano R. Celecoxib exerts antitumor effects in canine mammary tumor cells via COX‑2‑independent mechanisms. Int J Oncol. 2015;46:1393-404 pubmed publisher
Homayouni A, Sadeghi F, Nokhodchi A, Varshosaz J, Afrasiabi Garekani H. Preparation and characterization of celecoxib dispersions in soluplus(®): comparison of spray drying and conventional methods. Iran J Pharm Res. 2015;14:35-50 pubmed
Bannuru R, Schmid C, Kent D, Vaysbrot E, Wong J, McAlindon T. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann Intern Med. 2015;162:46-54 pubmed publisher
Zhu H, Zhuang X, Liu S, Pi Z, Song F, Lin N, et al. Ultrahigh-performance liquid chromatography/tandem mass spectrometry method for evaluating enzyme activity and screening inhibitors of cyclooxygenase-2. Rapid Commun Mass Spectrom. 2014;28:1792-800 pubmed publisher
Aziz F, Yang X, Wang X, Yan Q. Anti-LeY antibody enhances therapeutic efficacy of celecoxib against gastric cancer by downregulation of MAPKs/COX-2 signaling pathway: correlation with clinical study. J Cancer Res Clin Oncol. 2015;141:1221-35 pubmed publisher
Gjyshi O, Flaherty S, Veettil M, Johnson K, Chandran B, Bottero V. Kaposi's sarcoma-associated herpesvirus induces Nrf2 activation in latently infected endothelial cells through SQSTM1 phosphorylation and interaction with polyubiquitinated Keap1. J Virol. 2015;89:2268-86 pubmed publisher
Posada M, Bacon J, Schneck K, Tirona R, Kim R, Higgins J, et al. Prediction of renal transporter mediated drug-drug interactions for pemetrexed using physiologically based pharmacokinetic modeling. Drug Metab Dispos. 2015;43:325-34 pubmed publisher
Fink S, Dawson D, Zhang Y, Kresak A, Lawrence E, Yang P, et al. Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs. Carcinogenesis. 2015;36:291-8 pubmed publisher
Luna Munguia H, Salvamoser J, Pascher B, Pieper T, Getzinger T, Kudernatsch M, et al. Glutamate-mediated upregulation of the multidrug resistance protein 2 in porcine and human brain capillaries. J Pharmacol Exp Ther. 2015;352:368-78 pubmed publisher
Göbel C, Breitenbuecher F, Kalkavan H, Hähnel P, Kasper S, Hoffarth S, et al. Functional expression cloning identifies COX-2 as a suppressor of antigen-specific cancer immunity. Cell Death Dis. 2014;5:e1568 pubmed publisher
Shen K, Song Y, Chen I, Chong P, Liu S. Depletion of tumor-associated macrophages enhances the anti-tumor immunity induced by a Toll-like receptor agonist-conjugated peptide. Hum Vaccin Immunother. 2014;10:3241-50 pubmed publisher
Portillo J, Schwartz I, Zarini S, Bapputty R, Kern T, Gubitosi Klug R, et al. Proinflammatory responses induced by CD40 in retinal endothelial and Müller cells are inhibited by blocking CD40-Traf2,3 or CD40-Traf6 signaling. Invest Ophthalmol Vis Sci. 2014;55:8590-7 pubmed publisher
Bowers L, Brenner A, Hursting S, Tekmal R, deGraffenried L. Obesity-associated systemic interleukin-6 promotes pre-adipocyte aromatase expression via increased breast cancer cell prostaglandin E2 production. Breast Cancer Res Treat. 2015;149:49-57 pubmed publisher
Kurtova A, Xiao J, Mo Q, Pazhanisamy S, Krasnow R, Lerner S, et al. Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance. Nature. 2015;517:209-13 pubmed publisher
Ha E, Ok J, Noh J, Jeong H, Choo G, Jung Y, et al. Fabrication and evaluation of celecoxib microparticle surface modified by hydrophilic cellulose and surfactant. Int J Biol Macromol. 2015;72:1473-8 pubmed publisher
Setia S, Nehru B, Sanyal S. Celecoxib prevents colitis associated colon carcinogenesis: an upregulation of apoptosis. Pharmacol Rep. 2014;66:1083-91 pubmed publisher
Liu R, Zheng J, Li C, Pang Y, Zheng Q, Xu X, et al. Celecoxib induces epithelial-mesenchymal transition in epithelial ovarian cancer cells via regulating ZEB1 expression. Arch Gynecol Obstet. 2015;291:1361-9 pubmed publisher
Hutchison M, White P. Prostacyclin regulates bone growth via the Epac/Rap1 pathway. Endocrinology. 2015;156:499-510 pubmed publisher
Nagata N, Niikura R, Sekine K, Sakurai T, Shimbo T, Kishida Y, et al. Risk of peptic ulcer bleeding associated with Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs, low-dose aspirin, and antihypertensive drugs: a case-control study. J Gastroenterol Hepatol. 2015;30:292-8 pubmed publisher
Liu S, Jiang M, Zhao Q, Li S, Peng Y, Zhang P, et al. Vascular endothelial growth factor plays a critical role in the formation of the pre-metastatic niche via prostaglandin E2. Oncol Rep. 2014;32:2477-84 pubmed publisher
Hua K, Chou J, Ka S, Tasi Y, Chen A, Wu S, et al. Cyclooxygenase-2 regulates NLRP3 inflammasome-derived IL-1β production. J Cell Physiol. 2015;230:863-74 pubmed publisher
More A, Kim H, Khang G, Hildebrandt T, Bernlöhr C, Doods H, et al. Des-Arg9-bradykinin causes kinin B1 receptor mediated endothelium-independent contractions in endotoxin-treated porcine coronary arteries. Pharmacol Res. 2014;90:18-24 pubmed publisher
Ji Y, Seo Y, Choi W, Yeo A, Noh H, Kim E, et al. Dry eye-induced CCR7+CD11b+ cell lymph node homing is induced by COX-2 activities. Invest Ophthalmol Vis Sci. 2014;55:6829-38 pubmed publisher
Cillo J, Dattilo D. Pre-emptive analgesia with pregabalin and celecoxib decreases postsurgical pain following maxillomandibular advancement surgery: a randomized controlled clinical trial. J Oral Maxillofac Surg. 2014;72:1909-14 pubmed publisher
Li C, Li C, Zhang A, To K, Lee A, Zhu H, et al. Avian influenza A H7N9 virus induces severe pneumonia in mice without prior adaptation and responds to a combination of zanamivir and COX-2 inhibitor. PLoS ONE. 2014;9:e107966 pubmed publisher
Kim S, Ha G, Bae J, Kim G, Son C, Park Y, et al. COX-2- and endoplasmic reticulum stress-independent induction of ULBP-1 and enhancement of sensitivity to NK cell-mediated cytotoxicity by celecoxib in colon cancer cells. Exp Cell Res. 2015;330:451-9 pubmed publisher
Hsu C, Lee I, Lin C, Hsiao L, Yang C. Sphingosine-1-phosphate mediates COX-2 expression and PGE2 /IL-6 secretion via c-Src-dependent AP-1 activation. J Cell Physiol. 2015;230:702-15 pubmed publisher
More A, Kim H, Zhao R, Khang G, Hildebrandt T, Bernlöhr C, et al. COX-2 mediated induction of endothelium-independent contraction to bradykinin in endotoxin-treated porcine coronary artery. J Cardiovasc Pharmacol. 2014;64:209-17 pubmed publisher
Rabinow B, Werling J, Bendele A, Gass J, Bogseth R, Balla K, et al. Intra-articular (IA) ropivacaine microparticle suspensions reduce pain, inflammation, cytokine, and substance p levels significantly more than oral or IA celecoxib in a rat model of arthritis. Inflammation. 2015;38:40-60 pubmed publisher
Dolkart O, Liron T, Chechik O, Somjen D, Brosh T, Maman E, et al. Statins enhance rotator cuff healing by stimulating the COX2/PGE2/EP4 pathway: an in vivo and in vitro study. Am J Sports Med. 2014;42:2869-76 pubmed publisher
Gao Z, Zhang H, Liu J, Lau C, Liu P, Chen Z, et al. Cyclooxygenase-2-dependent oxidative stress mediates palmitate-induced impairment of endothelium-dependent relaxations in mouse arteries. Biochem Pharmacol. 2014;91:474-82 pubmed publisher
Yoo M, Yoo W, Kang S, Park Y, Kim S, Moon K, et al. Etoricoxib in the treatment of Korean patients with osteoarthritis in a double-blind, randomized controlled trial. Curr Med Res Opin. 2014;30:2399-408 pubmed publisher
Anwar Mohamed A, Barakat K, Bhat R, Noskov S, Tyrrell D, Tuszynski J, et al. A human ether-á-go-go-related (hERG) ion channel atomistic model generated by long supercomputer molecular dynamics simulations and its use in predicting drug cardiotoxicity. Toxicol Lett. 2014;230:382-92 pubmed publisher
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product information
Catalog Number :
PZ0008
Product Name :
Celecoxib
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA