This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Phosphodiesterase, 3′,5′-cyclic-nucleotide-specific from bovine brain
catalog :
P9529
citations: 55
Reference
Stoner R, Chow M, Boyle M, Sunkin S, Mouton P, Roy S, et al. Patches of disorganization in the neocortex of children with autism. N Engl J Med. 2014;370:1209-1219 pubmed publisher
Xin W, Li N, Cheng Q, Petkov G. BK channel-mediated relaxation of urinary bladder smooth muscle: a novel paradigm for phosphodiesterase type 4 regulation of bladder function. J Pharmacol Exp Ther. 2014;349:56-65 pubmed publisher
Koshitani Y, Tachibanaki S, Kawamura S. Quantitative aspects of cGMP phosphodiesterase activation in carp rods and cones. J Biol Chem. 2014;289:2651-7 pubmed publisher
Liu X, Luo H, Huang Y, Bao J, Tang G, Chen Y, et al. Selaginpulvilins A-D, new phosphodiesterase-4 inhibitors with an unprecedented skeleton from Selaginella pulvinata. Org Lett. 2014;16:282-5 pubmed publisher
Willis M, Baillie G. Arrestin-dependent localization of phosphodiesterases. Handb Exp Pharmacol. 2014;219:293-307 pubmed publisher
de Jonge H, Tilly B, Hogema B, Pfau D, Kelley C, Kelley M, et al. cGMP inhibition of type 3 phosphodiesterase is the major mechanism by which C-type natriuretic peptide activates CFTR in the shark rectal gland. Am J Physiol Cell Physiol. 2014;306:C343-53 pubmed publisher
Vandeput F, Szabo Fresnais N, Ahmad F, Kho C, Lee A, Krall J, et al. Selective regulation of cyclic nucleotide phosphodiesterase PDE3A isoforms. Proc Natl Acad Sci U S A. 2013;110:19778-83 pubmed publisher
Huang Z, Han Z, Cui W, Zhang F, He H, Zeng T, et al. Dynamic expression pattern of Pde4d and its relationship with CpG methylation in the promoter during mouse embryo development. Biochem Biophys Res Commun. 2013;441:982-7 pubmed publisher
Blanchard E, Zlock L, Lao A, Mika D, Namkung W, Xie M, et al. Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia. FASEB J. 2014;28:791-801 pubmed publisher
Zhmurov P, Sukhorukov A, Chupakhin V, Khomutova Y, Ioffe S, Tartakovsky V. Synthesis of PDE IV inhibitors. First asymmetric synthesis of two of GlaxoSmithKline's highly potent Rolipram analogues. Org Biomol Chem. 2013;11:8082-91 pubmed publisher
Apuhan T, Gepdiremen S, Arslan A, Aktas G. Evaluation of patients with nasal polyps about the possible association of desmosomal junctions, RORA and PDE4D gene. Eur Rev Med Pharmacol Sci. 2013;17:2680-3 pubmed
Goto T, Shiina A, Yoshino T, Mizukami K, Hirahara K, Suzuki O, et al. Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors. Bioorg Med Chem. 2013;21:7025-37 pubmed publisher
Kumar A, Sagar R, Kumar P, Sahu J, Grover A, Srivastava A, et al. Identification of genetic contribution to ischemic stroke by screening of single nucleotide polymorphisms in stroke patients by using a case control study design. BMC Neurol. 2013;13:136 pubmed publisher
Lu D, Aroonsakool N, Yokoyama U, Patel H, Insel P. Increase in cellular cyclic AMP concentrations reverses the profibrogenic phenotype of cardiac myofibroblasts: a novel therapeutic approach for cardiac fibrosis. Mol Pharmacol. 2013;84:787-93 pubmed publisher
Whitaker R, Wills L, Stallons L, Schnellmann R. cGMP-selective phosphodiesterase inhibitors stimulate mitochondrial biogenesis and promote recovery from acute kidney injury. J Pharmacol Exp Ther. 2013;347:626-34 pubmed publisher
Woodring J, Bland N, Ochiana S, Campbell R, Pollastri M. Synthesis and assessment of catechol diether compounds as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1). Bioorg Med Chem Lett. 2013;23:5971-4 pubmed publisher
Ting P, Lee J, Kuang R, Cao J, Gu D, Huang Y, et al. Discovery of oral and inhaled PDE4 inhibitors. Bioorg Med Chem Lett. 2013;23:5528-32 pubmed publisher
Bai Y, Yang J, Eisele L, Underwood A, Koestler B, Waters C, et al. Two DHH subfamily 1 proteins in Streptococcus pneumoniae possess cyclic di-AMP phosphodiesterase activity and affect bacterial growth and virulence. J Bacteriol. 2013;195:5123-32 pubmed publisher
Módis K, Panopoulos P, Coletta C, Papapetropoulos A, Szabo C. Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A. Biochem Pharmacol. 2013;86:1311-9 pubmed publisher
Wunder F, Quednau R, Geerts A, Barg M, Tersteegen A. Characterization of the cellular activity of PDE 4 inhibitors using two novel PDE 4 reporter cell lines. Mol Pharm. 2013;10:3697-705 pubmed publisher
Song R, Massenburg B, Wenderski W, Jayaraman V, Thompson L, Neves S. ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion. Proc Natl Acad Sci U S A. 2013;110:15437-42 pubmed publisher
Townsend E, Zhang Y, Xu C, Wakita R, Emala C. Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins. Am J Respir Cell Mol Biol. 2014;50:115-24 pubmed publisher
Kato Y, Kawasaki M, Nigo T, Nakamura S, Fusano A, Teranishi Y, et al. Identification of 2,3-disubstituted pyridines as potent, orally active PDE4 inhibitors. Bioorg Med Chem. 2013;21:5851-4 pubmed publisher
Baek A, Kanthi Y, Sutton N, Liao H, Pinsky D. Regulation of ecto-apyrase CD39 (ENTPD1) expression by phosphodiesterase III (PDE3). FASEB J. 2013;27:4419-28 pubmed publisher
Shen J, Cooper D. AKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complex. Biochem J. 2013;455:47-56 pubmed publisher
Pleskach H, Chumak A, Zelins ka A, Shedenko L. [Association of rs966221 phosphodiesterase 4D gene's polymorphism with risk of myocardial infarction]. Lik Sprava. 2012;:42-6 pubmed
Harrison C. Trial watch: PDE4 inhibitor leads wave of target-specific oral psoriasis drugs. Nat Rev Drug Discov. 2013;12:335 pubmed publisher
Maurice D. PDE8A runs interference to limit PKA inhibition of Raf-1. Proc Natl Acad Sci U S A. 2013;110:6248-9 pubmed publisher
Lin D, Xu L, Ding L, Sharma A, Liu L, Yang H, et al. Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers. Proc Natl Acad Sci U S A. 2013;110:6109-14 pubmed publisher
Brown K, Day J, Huston E, Zimmermann B, Hampel K, Christian F, et al. Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proc Natl Acad Sci U S A. 2013;110:E1533-42 pubmed publisher
Kraynik S, Miyaoka R, Beavo J. PDE3 and PDE4 isozyme-selective inhibitors are both required for synergistic activation of brown adipose tissue. Mol Pharmacol. 2013;83:1155-65 pubmed publisher
Li Y, Wang Y. Ras protein/cAMP-dependent protein kinase signaling is negatively regulated by a deubiquitinating enzyme, Ubp3, in yeast. J Biol Chem. 2013;288:11358-65 pubmed publisher
Cameron R, Coleman R, Day J, Yalla K, Houslay M, Adams D, et al. Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4). Biochem Pharmacol. 2013;85:1297-305 pubmed publisher
Fang C, Dong H, Zou Z, Fan L, Wang L, Zhang R, et al. High expression of cyclic nucleotide phosphodiesterase 7B mRNA predicts poor prognosis in mantle cell lymphoma. Leuk Res. 2013;37:536-40 pubmed publisher
Tanaka S, Tanaka R, Harada S, Kohda Y, Matsumura H, Shimamoto C, et al. A PKG inhibitor increases Ca(2+)-regulated exocytosis in guinea pig antral mucous cells: cAMP accumulation via PDE2A inhibition. Am J Physiol Gastrointest Liver Physiol. 2013;304:G773-80 pubmed publisher
Jansen C, Wang H, Kooistra A, de Graaf C, Orrling K, Tenor H, et al. Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure. J Med Chem. 2013;56:2087-96 pubmed publisher
Crosswhite P, Sun Z. Inhibition of phosphodiesterase-1 attenuates cold-induced pulmonary hypertension. Hypertension. 2013;61:585-92 pubmed publisher
El Elimat T, Figueroa M, Raja H, Graf T, Adcock A, Kroll D, et al. Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445). J Nat Prod. 2013;76:382-7 pubmed publisher
Mitra M, Chen Z, Ren H, Harris T, Chambers K, Hall A, et al. Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation. Proc Natl Acad Sci U S A. 2013;110:642-7 pubmed publisher
Andrés J, Buijnsters P, De Angelis M, Langlois X, Rombouts F, Trabanco A, et al. Discovery of a new series of [1,2,4]triazolo[4,3-a]quinoxalines as dual phosphodiesterase 2/phosphodiesterase 10 (PDE2/PDE10) inhibitors. Bioorg Med Chem Lett. 2013;23:785-90 pubmed publisher
Suk H, Zhou C, Yang T, Zhu H, Yu R, Olabisi O, et al. Ablation of calcineurin A? reveals hyperlipidemia and signaling cross-talks with phosphodiesterases. J Biol Chem. 2013;288:3477-88 pubmed publisher
Granfors M, Karypidis H, Hosseini F, Skjöldebrand Sparre L, Stavreus Evers A, Bremme K, et al. Phosphodiesterase 8B gene polymorphism in women with recurrent miscarriage: a retrospective case control study. BMC Med Genet. 2012;13:121 pubmed publisher
Assie G. One single signaling pathway for so many different biological functions: lessons from the cyclic adenosine monophosphate/protein kinase A pathway-related diseases. J Clin Endocrinol Metab. 2012;97:4355-7 pubmed publisher
Sassone Corsi P. The cyclic AMP pathway. Cold Spring Harb Perspect Biol. 2012;4: pubmed publisher
Ochiai K, Takita S, Kojima A, Eiraku T, Iwase K, Kishi T, et al. Phosphodiesterase inhibitors. Part 5: hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration. Bioorg Med Chem Lett. 2013;23:375-81 pubmed publisher
Cai Y, Sun Q, Huang X, Jiang J, Zhang M, Piao L, et al. cGMP-PDE3-cAMP signal pathway involved in the inhibitory effect of CNP on gastric motility in rat. Regul Pept. 2013;180:43-9 pubmed publisher
Shen Y, Sun A, Wang Y, Cha D, Wang H, Wang F, et al. Upregulation of mesencephalic astrocyte-derived neurotrophic factor in glial cells is associated with ischemia-induced glial activation. J Neuroinflammation. 2012;9:254 pubmed publisher
Beca S, Ahmad F, Shen W, Liu J, Makary S, Polidovitch N, et al. Phosphodiesterase type 3A regulates basal myocardial contractility through interacting with sarcoplasmic reticulum calcium ATPase type 2a signaling complexes in mouse heart. Circ Res. 2013;112:289-97 pubmed publisher
Humbert M, Weihbrecht K, Searby C, Li Y, Pope R, Sheffield V, et al. ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting. Proc Natl Acad Sci U S A. 2012;109:19691-6 pubmed publisher
Matveeva N, Teplov V, Nezvetskiĭ A, Orlova T, Beĭlina S. [Involvement of cyclic adenosine monophosphate in the control of motile behavior of Physarum polycephalum plasmodium]. Biofizika. 2012;57:832-9 pubmed
Fournier V, Leclerc P, Cormier N, Bailey J. Implication of calmodulin-dependent phosphodiesterase type 1 during bovine sperm capacitation. J Androl. 2003;24:104-12 pubmed
Houslay M. Adaptation in cyclic AMP signalling processes: a central role for cyclic AMP phosphodiesterases. Semin Cell Dev Biol. 1998;9:161-7 pubmed
Chock S, Huang C. An optimized continuous assay for cAMP phosphodiesterase and calmodulin. Anal Biochem. 1984;138:34-43 pubmed
Fischer U, Amrhein N. Cyclic nucleotide phosphodiesterase of Chlamydomonas reinhardtii. Biochim Biophys Acta. 1974;341:412-20 pubmed
Nair K. Purification and properties of 3',5'-cyclic nucleotide phosphodiesterase from dog heart. Biochemistry. 1966;5:150-7 pubmed
product information
Catalog Number :
P9529
Product Name :
Phosphodiesterase, 3′,5′-cyclic-nucleotide-specific from bovine brain
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
15-30 units/mg protein (in the presence of 0.03 mM Ca 2+ and a saturating level (10 units per ml) of calmodulin (P2277)), lyophilized powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA