This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Phospholipase A 2 from bovine pancreas
catalog :
P8913
citations: 145
Reference |
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Hsu P, Lee K, Lee P, Hu C, Lin C, Liu P. Biochemical characterization of a phospholipase A2 from Photobacterium damselae subsp. piscicida. Z Naturforsch C J Biosci. 2013;68:471-81 pubmed
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Zhang K, Zhang D, Jiao X, Dong C. Effect of phospholipase A2 silencing on acute experimental pancreatitis. Eur Rev Med Pharmacol Sci. 2013;17:3279-84 pubmed
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Sadaria M, Yu J, Meng X, Fullerton D, Reece T, Weyant M. Secretory phospholipase A2 mediates human esophageal adenocarcinoma cell growth and proliferation via ERK 1/2 pathway. Anticancer Res. 2013;33:1337-42 pubmed
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Khateeb S, Flusser H, Ofir R, Shelef I, Narkis G, Vardi G, et al. PLA2G6 mutation underlies infantile neuroaxonal dystrophy. Am J Hum Genet. 2006;79:942-8 pubmed
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Beausoleil S, Villen J, Gerber S, Rush J, Gygi S. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol. 2006;24:1285-92 pubmed
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Ghosh M, Loper R, Gelb M, Leslie C. Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes. J Biol Chem. 2006;281:16615-24 pubmed
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Zody M, Garber M, Sharpe T, Young S, Rowen L, O Neill K, et al. Analysis of the DNA sequence and duplication history of human chromosome 15. Nature. 2006;440:671-5 pubmed
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Sekar K, Gayathri D, Velmurugan D, Jeyakanthan J, Yamane T, Poi M, et al. Third calcium ion found in an inhibitor-bound phospholipase A2. Acta Crystallogr D Biol Crystallogr. 2006;62:392-7 pubmed
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Tao R, Yu Y, Zhang X, Shi J, Guo Y, Wang C, et al. A family based study of the genetic association between the PLA2G4D gene and schizophrenia. Prostaglandins Leukot Essent Fatty Acids. 2005;73:419-22 pubmed
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Murakami M, Masuda S, Shimbara S, Ishikawa Y, Ishii T, Kudo I. Cellular distribution, post-translational modification, and tumorigenic potential of human group III secreted phospholipase A(2). J Biol Chem. 2005;280:24987-98 pubmed
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Chiba H, Michibata H, Wakimoto K, Seishima M, Kawasaki S, Okubo K, et al. Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin. J Biol Chem. 2004;279:12890-7 pubmed
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Jenkins C, Han X, Yang J, Mancuso D, Sims H, Muslin A, et al. Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis. Biochemistry. 2003;42:11798-807 pubmed
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Murakami M, Masuda S, Shimbara S, Bezzine S, Lazdunski M, Lambeau G, et al. Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII). J Biol Chem. 2003;278:10657-67 pubmed
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Pan Y, Yu B, Singer A, Ghomashchi F, Lambeau G, Gelb M, et al. Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes. J Biol Chem. 2002;277:29086-93 pubmed
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Maury E, Prévost M, Nauze M, Redoules D, Tarroux R, Charveron M, et al. Human epidermis is a novel site of phospholipase B expression. Biochem Biophys Res Commun. 2002;295:362-9 pubmed
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Sers C, Husmann K, Nazarenko I, Reich S, Wiechen K, Zhumabayeva B, et al. The class II tumour suppressor gene H-REV107-1 is a target of interferon-regulatory factor-1 and is involved in IFNgamma-induced cell death in human ovarian carcinoma cells. Oncogene. 2002;21:2829-39 pubmed
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Siegrist S, Feral C, Chami M, Solhonne B, Mattei M, Rajpert De Meyts E, et al. hH-Rev107, a class II tumor suppressor gene, is expressed by post-meiotic testicular germ cells and CIS cells but not by human testicular germ cell tumors. Oncogene. 2001;20:5155-63 pubmed
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Sheridan A, Force T, Yoon H, O LEARY E, Choukroun G, Taheri M, et al. PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production. Mol Cell Biol. 2001;21:4470-81 pubmed
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Shakhov A, Rubtsov A, Lyakhov I, Tumanov A, Nedospasov S. SPLASH (PLA2IID), a novel member of phospholipase A2 family, is associated with lymphotoxin deficiency. Genes Immun. 2000;1:191-9 pubmed
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Valentin E, Singer A, Ghomashchi F, Lazdunski M, Gelb M, Lambeau G. Cloning and recombinant expression of human group IIF-secreted phospholipase A(2). Biochem Biophys Res Commun. 2000;279:223-8 pubmed
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Gelb M, Valentin E, Ghomashchi F, Lazdunski M, Lambeau G. Cloning and recombinant expression of a structurally novel human secreted phospholipase A2. J Biol Chem. 2000;275:39823-6 pubmed
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Valentin E, Ghomashchi F, Gelb M, Lazdunski M, Lambeau G. Novel human secreted phospholipase A(2) with homology to the group III bee venom enzyme. J Biol Chem. 2000;275:7492-6 pubmed
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Suzuki N, Ishizaki J, Yokota Y, Higashino K, Ono T, Ikeda M, et al. Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s. J Biol Chem. 2000;275:5785-93 pubmed
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Dunham I, Shimizu N, Roe B, Chissoe S, Hunt A, Collins J, et al. The DNA sequence of human chromosome 22. Nature. 1999;402:489-95 pubmed
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Scanlan M, Gordan J, Williamson B, Stockert E, Bander N, Jongeneel V, et al. Antigens recognized by autologous antibody in patients with renal-cell carcinoma. Int J Cancer. 1999;83:456-64 pubmed
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Ishizaki J, Suzuki N, Higashino K, Yokota Y, Ono T, Kawamoto K, et al. Cloning and characterization of novel mouse and human secretory phospholipase A(2)s. J Biol Chem. 1999;274:24973-9 pubmed
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Song C, Chang X, Bean K, Proia M, Knopf J, Kriz R. Molecular characterization of cytosolic phospholipase A2-beta. J Biol Chem. 1999;274:17063-7 pubmed
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Larsson Forsell P, Kennedy B, Claesson H. The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene. Eur J Biochem. 1999;262:575-85 pubmed
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Dessen A, Tang J, Schmidt H, Stahl M, Clark J, Seehra J, et al. Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism. Cell. 1999;97:349-60 pubmed
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Ma Z, Wang X, Nowatzke W, Ramanadham S, Turk J. Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromoso. J Biol Chem. 1999;274:9607-16 pubmed
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Pickard R, Strifler B, Kramer R, Sharp J. Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2. J Biol Chem. 1999;274:8823-31 pubmed
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Husmann K, Sers C, Fietze E, Mincheva A, Lichter P, Schafer R. Transcriptional and translational downregulation of H-REV107, a class II tumour suppressor gene located on human chromosome 11q11-12. Oncogene. 1998;17:1305-12 pubmed
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Underwood K, Song C, Kriz R, Chang X, Knopf J, Lin L. A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2. J Biol Chem. 1998;273:21926-32 pubmed
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Xu G, McDonagh T, Yu H, Nalefski E, Clark J, Cumming D. Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A2. J Mol Biol. 1998;280:485-500 pubmed
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Kitadokoro K, Hagishita S, Sato T, Ohtani M, Miki K. Crystal structure of human secretory phospholipase A2-IIA complex with the potent indolizine inhibitor 120-1032. J Biochem. 1998;123:619-23 pubmed
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Borsch Haubold A, Bartoli F, Asselin J, Dudler T, Kramer R, Apitz Castro R, et al. Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells. J Biol Chem. 1998;273:4449-58 pubmed
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Perisic O, Fong S, Lynch D, Bycroft M, Williams R. Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2. J Biol Chem. 1998;273:1596-604 pubmed
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Larsson P, Claesson H, Kennedy B. Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity. J Biol Chem. 1998;273:207-14 pubmed
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Cupillard L, Koumanov K, Mattei M, Lazdunski M, Lambeau G. Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2. J Biol Chem. 1997;272:15745-52 pubmed
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Pickard R, Chiou X, Strifler B, DeFelippis M, Hyslop P, Tebbe A, et al. Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine. J Biol Chem. 1996;271:19225-31 pubmed
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Huang Z, Payette P, Abdullah K, Cromlish W, Kennedy B. Functional identification of the active-site nucleophile of the human 85-kDa cytosolic phospholipase A2. Biochemistry. 1996;35:3712-21 pubmed
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Minami T, Tojo H, Shinomura Y, Matsuzawa Y, Okamoto M. Purification and characterization of a phospholipase A2 from human ileal mucosa. Biochim Biophys Acta. 1993;1170:125-30 pubmed
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Lin L, Wartmann M, Lin A, Knopf J, Seth A, Davis R. cPLA2 is phosphorylated and activated by MAP kinase. Cell. 1993;72:269-78 pubmed
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Chen J, Engle S, Seilhamer J, Tischfield J. Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2. J Biol Chem. 1994;269:2365-8 pubmed
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Sharp J, Pickard R, Chiou X, Manetta J, Kovacevic S, Miller J, et al. Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2. J Biol Chem. 1994;269:23250-4 pubmed
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Schevitz R, Bach N, Carlson D, Chirgadze N, Clawson D, Dillard R, et al. Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2. Nat Struct Biol. 1995;2:458-65 pubmed
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Grataroli R, Dijkman R, Dutilh C, van der Ouderaa F, de Haas G, Figarella C. Studies on prophospholipase A2 and its enzyme from human pancreatic juice. Catalytic properties and sequence of the N-terminal region. Eur J Biochem. 1982;122:111-7 pubmed
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Hara S, Kudo I, Matsuta K, Miyamoto T, Inoue K. Amino acid composition and NH2-terminal amino acid sequence of human phospholipase A2 purified from rheumatoid synovial fluid. J Biochem. 1988;104:326-8 pubmed
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Seilhamer J, Randall T, Yamanaka M, Johnson L. Pancreatic phospholipase A2: isolation of the human gene and cDNAs from porcine pancreas and human lung. DNA. 1986;5:519-27 pubmed
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Kramer R, Hession C, Johansen B, Hayes G, McGray P, Chow E, et al. Structure and properties of a human non-pancreatic phospholipase A2. J Biol Chem. 1989;264:5768-75 pubmed
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product information
Catalog Number :
P8913
Product Name :
Phospholipase A 2 from bovine pancreas
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
lyophilized powder, ?20 units/mg protein
company information

MilliporeSigma
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