This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Probenecid
catalog :
P8761
citations: 71
Reference
Demurtas O, de Brito Francisco R, Diretto G, Ferrante P, Frusciante S, Pietrella M, et al. ABCC Transporters Mediate the Vacuolar Accumulation of Crocins in Saffron Stigmas. Plant Cell. 2019;31:2789-2804 pubmed publisher
Alonso C, Lottero Leconte R, Luque G, Vernaz Z, Di Siervi N, Gervasi M, et al. MRP4-mediated cAMP efflux is essential for mouse spermatozoa capacitation. J Cell Sci. 2019;132: pubmed publisher
Wiebe S, Plain A, Pan W, O Neill D, Braam B, Alexander R. NHE8 attenuates Ca2+ influx into NRK cells and the proximal tubule epithelium. Am J Physiol Renal Physiol. 2019;317:F240-F253 pubmed publisher
Goddard P, Sanchez Garrido J, Slater S, Kalyan M, Ruano Gallego D, Marches O, et al. Enteropathogenic Escherichia coli Stimulates Effector-Driven Rapid Caspase-4 Activation in Human Macrophages. Cell Rep. 2019;27:1008-1017.e6 pubmed publisher
Trinklein N, Pham D, Schellenberger U, Buelow B, Boudreau A, Choudhry P, et al. Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies. MAbs. 2019;11:639-652 pubmed publisher
Müller M, Fouyssac M, Taylor C. Effective Glucose Uptake by Human Astrocytes Requires Its Sequestration in the Endoplasmic Reticulum by Glucose-6-Phosphatase-β. Curr Biol. 2018;28:3481-3486.e4 pubmed publisher
Adamiak M, Bujko K, Cymer M, Plonka M, Glaser T, Kucia M, et al. Novel evidence that extracellular nucleotides and purinergic signaling induce innate immunity-mediated mobilization of hematopoietic stem/progenitor cells. Leukemia. 2018;32:1920-1931 pubmed publisher
Guittard G, Dios Esponera A, Palmer D, Akpan I, Barr V, Manna A, et al. The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8+ T cells. Sci Rep. 2018;8:5336 pubmed publisher
Roesch F, OhAinle M, Emerman M. A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery. Retrovirology. 2018;15:26 pubmed publisher
Barría I, Güiza J, Cifuentes F, Zamorano P, Saez J, Gonzalez J, et al. Trypanosoma cruzi Infection Induces Pannexin-1 Channel Opening in Cardiac Myocytes. Am J Trop Med Hyg. 2018;98:105-112 pubmed publisher
Kawano A, Kadomatsu R, Ono M, Kojima S, Tsukimoto M, Sakamoto H. Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors. PLoS ONE. 2015;10:e0127919 pubmed publisher
Werner K, Kälble S, Wolter S, Schneider E, Buschauer A, Neumann D, et al. Flow cytometric analysis with a fluorescently labeled formyl peptide receptor ligand as a new method to study the pharmacological profile of the histamine H2 receptor. Naunyn Schmiedebergs Arch Pharmacol. 2015;388:1039-52 pubmed publisher
Quallo T, Vastani N, Horridge E, Gentry C, Parra A, Moss S, et al. TRPM8 is a neuronal osmosensor that regulates eye blinking in mice. Nat Commun. 2015;6:7150 pubmed publisher
Nauha E, Bernstein J. "Predicting" Polymorphs of Pharmaceuticals Using Hydrogen Bond Propensities: Probenecid and Its Two Single-Crystal-to-Single-Crystal Phase Transitions. J Pharm Sci. 2015;104:2056-2061 pubmed publisher
Chioukh R, Noel Hudson M, Ribes S, Fournier N, Becquemont L, Verstuyft C. Proton pump inhibitors inhibit methotrexate transport by renal basolateral organic anion transporter hOAT3. Drug Metab Dispos. 2014;42:2041-8 pubmed publisher
Jalan Sakrikar N, Field J, Klar R, Mattmann M, Gregory K, Zamorano R, et al. Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem Neurosci. 2014;5:1221-37 pubmed publisher
Tang X, Benesch M, Dewald J, Zhao Y, Patwardhan N, Santos W, et al. Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice. J Lipid Res. 2014;55:2389-400 pubmed publisher
Wang L, Wang C, Liu Q, Meng Q, Huo X, Sun P, et al. PEPT1- and OAT1/3-mediated drug-drug interactions between bestatin and cefixime in vivo and in vitro in rats, and in vitro in human. Eur J Pharm Sci. 2014;63:77-86 pubmed publisher
An G, Wang X, Morris M. Flavonoids are inhibitors of human organic anion transporter 1 (OAT1)-mediated transport. Drug Metab Dispos. 2014;42:1357-66 pubmed publisher
Saito H, Yoshimura M, Saigo C, Komori M, Nomura Y, Yamamoto Y, et al. Hepatic sulfotransferase as a nephropreventing target by suppression of the uremic toxin indoxyl sulfate accumulation in ischemic acute kidney injury. Toxicol Sci. 2014;141:206-17 pubmed publisher
Trejtnar F, Mandíková J, Kočíncová J, Volková M. Renal handling of amphotericin B and amphotericin B-deoxycholate and potential renal drug-drug interactions with selected antivirals. Antimicrob Agents Chemother. 2014;58:5650-7 pubmed publisher
Sun P, Wang C, Liu Q, Meng Q, Zhang A, Huo X, et al. OATP and MRP2-mediated hepatic uptake and biliary excretion of eprosartan in rat and human. Pharmacol Rep. 2014;66:311-9 pubmed publisher
Kong W, Fast V. The role of dye affinity in optical measurements of Cai(2+) transients in cardiac muscle. Am J Physiol Heart Circ Physiol. 2014;307:H73-9 pubmed publisher
Rekha K, Selvakumar G. Gene expression regulation of Bcl2, Bax and cytochrome-C by geraniol on chronic MPTP/probenecid induced C57BL/6 mice model of Parkinson's disease. Chem Biol Interact. 2014;217:57-66 pubmed publisher
Bam R, Yant S, Cihlar T. Tenofovir alafenamide is not a substrate for renal organic anion transporters (OATs) and does not exhibit OAT-dependent cytotoxicity. Antivir Ther. 2014;19:687-92 pubmed publisher
Penuela S, Kelly J, Churko J, Barr K, Berger A, Laird D. Panx1 regulates cellular properties of keratinocytes and dermal fibroblasts in skin development and wound healing. J Invest Dermatol. 2014;134:2026-2035 pubmed publisher
Adamczak S, de Rivero Vaccari J, Dale G, Brand F, Nonner D, Bullock M, et al. Pyroptotic neuronal cell death mediated by the AIM2 inflammasome. J Cereb Blood Flow Metab. 2014;34:621-9 pubmed publisher
Robbins N, Koch S, Rubinstein J. Targeting TRPV1 and TRPV2 for potential therapeutic interventions in cardiovascular disease. Transl Res. 2013;161:469-76 pubmed publisher
Al Jarrah M, Obaidat H, Bataineh Z, Walton L, Al Khateeb A. Endurance exercise training protects against the upregulation of nitric oxide in the striatum of MPTP/probenecid mouse model of Parkinson's disease. NeuroRehabilitation. 2013;32:141-7 pubmed publisher
Duan L, Yan Y, Sun Y, Zhao B, Hu W, Li G. Contribution of TRPV1 and multidrug resistance proteins in the permeation of capsaicin across different intestinal regions. Int J Pharm. 2013;445:134-40 pubmed publisher
Pattabiraman P, Pecen P, Rao P. MRP4-mediated regulation of intracellular cAMP and cGMP levels in trabecular meshwork cells and homeostasis of intraocular pressure. Invest Ophthalmol Vis Sci. 2013;54:1636-49 pubmed publisher
Aceves Baldó P, Anzures Cabrera J, Bentley D. In vivo evaluation of drug-drug interactions linked to UGT inhibition: the effect of probenecid on dalcetrapib pharmacokinetics. Int J Clin Pharmacol Ther. 2013;51:215-8 pubmed publisher
Watanabe H, Miyamoto Y, Honda D, Tanaka H, Wu Q, Endo M, et al. p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase. Kidney Int. 2013;83:582-92 pubmed publisher
Li L, Agarwal S, Elmquist W. Brain efflux index to investigate the influence of active efflux on brain distribution of pemetrexed and methotrexate. Drug Metab Dispos. 2013;41:659-67 pubmed publisher
Carta A, Carboni E, Spiga S. The MPTP/probenecid model of progressive Parkinson's disease. Methods Mol Biol. 2013;964:295-308 pubmed publisher
Yokooji T, Kawabe Y, Mori N, Murakami T. Effect of genistein, a natural soy isoflavone, on the pharmacokinetics and intestinal toxicity of irinotecan hydrochloride in rats. J Pharm Pharmacol. 2013;65:280-91 pubmed publisher
Lai P, Walters J. Azithromycin kills invasive Aggregatibacter actinomycetemcomitans in gingival epithelial cells. Antimicrob Agents Chemother. 2013;57:1347-51 pubmed publisher
Hagos Y, Burckhardt G, Burckhardt B. Human organic anion transporter OAT1 is not responsible for glutathione transport but mediates transport of glutamate derivatives. Am J Physiol Renal Physiol. 2013;304:F403-9 pubmed publisher
Perwitasari O, Yan X, Johnson S, White C, Brooks P, Tompkins S, et al. Targeting organic anion transporter 3 with probenecid as a novel anti-influenza a virus strategy. Antimicrob Agents Chemother. 2013;57:475-83 pubmed publisher
Momper J, Zhao Y, Shapiro R, Schonder K, Gao Y, Randhawa P, et al. Pharmacokinetics of low-dose cidofovir in kidney transplant recipients with BK virus infection. Transpl Infect Dis. 2013;15:34-41 pubmed publisher
Vorasubin N, Wu A, Day C, Suh J. Invasive sinonasal actinomycosis: case report and literature review. Laryngoscope. 2013;123:334-8 pubmed publisher
Soletsky B, Feig D. Uric acid reduction rectifies prehypertension in obese adolescents. Hypertension. 2012;60:1148-56 pubmed publisher
Xu J, Cao J, Iguchi N, Riethmacher D, Huang L. Functional characterization of bitter-taste receptors expressed in mammalian testis. Mol Hum Reprod. 2013;19:17-28 pubmed publisher
Conway R, Coughlan R, Carey J. Adherence to uric acid treatment guidelines in a rheumatology clinic. Clin Rheumatol. 2012;31:1707-11 pubmed publisher
Dahl G, Keane R. Pannexin: from discovery to bedside in 11±4 years?. Brain Res. 2012;1487:150-9 pubmed publisher
Bradshaw D, Nwokolo N. Dizziness and rash in an HIV positive man. BMJ. 2012;344:e4167 pubmed publisher
McClenaghan C, Zeng F, Verkuyl J. TRPA1 agonist activity of probenecid desensitizes channel responses: consequences for screening. Assay Drug Dev Technol. 2012;10:533-41 pubmed publisher
Anandhan A, Essa M, Manivasagam T. Therapeutic attenuation of neuroinflammation and apoptosis by black tea theaflavin in chronic MPTP/probenecid model of Parkinson's disease. Neurotox Res. 2013;23:166-73 pubmed publisher
Liu S, Wang B, Kompa A, Lekawanvijit S, Krum H. Antagonists of organic anion transporters 1 and 3 ameliorate adverse cardiac remodelling induced by uremic toxin indoxyl sulfate. Int J Cardiol. 2012;158:457-8 pubmed publisher
Hilmi B, Asmahan M, Rosman A. Use of newly available febuxostat in a case of chronic tophaceous gout contraindicated to allopurinol and probenecid. Med J Malaysia. 2012;67:125-6 pubmed
Molinas A, Sicard G, Jakob I. Functional evidence of multidrug resistance transporters (MDR) in rodent olfactory epithelium. PLoS ONE. 2012;7:e36167 pubmed publisher
Koch S, Gao X, Haar L, Jiang M, Lasko V, Robbins N, et al. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. J Mol Cell Cardiol. 2012;53:134-44 pubmed publisher
Curiel R, Guzman N. Challenges associated with the management of gouty arthritis in patients with chronic kidney disease: a systematic review. Semin Arthritis Rheum. 2012;42:166-78 pubmed publisher
Zhang X, Ke X, He L, Tian J. [Transport of limonin in rat intestine in situ and Caco-2 cells in vitro]. Yao Xue Xue Bao. 2012;47:229-32 pubmed
Gutman J, Kachur S, Slutsker L, Nzila A, Mutabingwa T. Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy. Malar J. 2012;11:39 pubmed publisher
Robbins N, Koch S, Tranter M, Rubinstein J. The history and future of probenecid. Cardiovasc Toxicol. 2012;12:1-9 pubmed publisher
Frezzatti R, Silveira P. Allopurinol reduces the lethality associated with acute renal failure induced by Crotalus durissus terrificus snake venom: comparison with probenecid. PLoS Negl Trop Dis. 2011;5:e1312 pubmed publisher
Fookes M, Schroeder G, Langridge G, Blondel C, Mammina C, Connor T, et al. Salmonella bongori provides insights into the evolution of the Salmonellae. PLoS Pathog. 2011;7:e1002191 pubmed publisher
Raisch D, Straight T, Holodniy M. Thrombocytopenia from combination treatment with oseltamivir and probenecid: case report, MedWatch data summary, and review of the literature. Pharmacotherapy. 2009;29:988-92 pubmed publisher
Leffler A, Ahlstedt I, Engberg S, Svensson A, Billger M, Oberg L, et al. Characterization of species-related differences in the pharmacology of tachykinin NK receptors 1, 2 and 3. Biochem Pharmacol. 2009;77:1522-30 pubmed publisher
Prat C, Schmid S, Farrugia F, Cenac N, Le Masson G, Schwemmle M, et al. Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity. PLoS Pathog. 2009;5:e1000425 pubmed publisher
Sheffler D, Williams R, Bridges T, Xiang Z, Kane A, BYUN N, et al. A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning. Mol Pharmacol. 2009;76:356-68 pubmed publisher
Andjelic C, Planelles V, Barrows L. Characterizing the anti-HIV activity of papuamide A. Mar Drugs. 2008;6:528-49 pubmed publisher
Nduati E, Diriye A, Ommeh S, Mwai L, Kiara S, Masseno V, et al. Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer. Parasitol Res. 2008;102:1227-34 pubmed publisher
Cox V, Zed P. Once-daily cefazolin and probenecid for skin and soft tissue infections. Ann Pharmacother. 2004;38:458-63 pubmed
Brown G. Cephalosporin-probenecid drug interactions. Clin Pharmacokinet. 1993;24:289-300 pubmed
Cunningham R, Israili Z, Dayton P. Clinical pharmacokinetics of probenecid. Clin Pharmacokinet. 1981;6:135-51 pubmed
Cowdry R, Ebert M, van Kammen D, Post R, Goodwin F. Cerebrospinal fluid probenecid studies: a reinterpretation. Biol Psychiatry. 1983;18:1287-99 pubmed
Vanderheyden J, Dekoninck W, Lefevre A, Mendlewicz J. [Use of the probenecid test for the diagnosis and treatment of Parkinsonism. Review of the literature and personal experience (author's transl)]. Encephale. 1980;6:349-66 pubmed
Gutman A. Uricosuric drugs, with special reference to probenecid and sulfinpyrazone. Adv Pharmacol. 1966;4:91-142 pubmed
Krasil nikov I. [On the therapeutic use of ethamide and benemid (probenecid)]. Sov Med. 1968;31:128-31 pubmed
product information
Catalog Number :
P8761
Product Name :
Probenecid
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA