This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Prazosin hydrochloride
catalog :
P7791
citations: 94
Reference
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Sugama S, Takenouchi T, Hashimoto M, Ohata H, Takenaka Y, Kakinuma Y. Stress-induced microglial activation occurs through β-adrenergic receptor: noradrenaline as a key neurotransmitter in microglial activation. J Neuroinflammation. 2019;16:266 pubmed publisher
Lubberding A, Thomsen M. Low-Dose Adrenaline Reduces Blood Pressure Acutely in Anesthetized Pigs Through a β2-Adrenergic Pathway. J Cardiovasc Pharmacol. 2019;74:38-43 pubmed publisher
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García Junco Clemente P, Tring E, Ringach D, Trachtenberg J. State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex. Cell Rep. 2019;26:2282-2288.e3 pubmed publisher
Yim Y, Betke K, McDonald W, Gilsbach R, Chen Y, Hyde K, et al. The in vivo specificity of synaptic Gβ and Gγ subunits to the α2a adrenergic receptor at CNS synapses. Sci Rep. 2019;9:1718 pubmed publisher
Kuo H, Chang C, Cheng W. Tyramine's modulation of immune resistance functions in Litopenaeus vannamei and its signal pathway. Dev Comp Immunol. 2019;95:68-76 pubmed publisher
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Lo Martire V, Silvani A, Alvente S, Bastianini S, Berteotti C, Valli A, et al. Modulation of sympathetic vasoconstriction is critical for the effects of sleep on arterial pressure in mice. J Physiol. 2018;596:591-608 pubmed publisher
Harris D, Park J, Lee K, Xu C, Stella N, Hague C. Label-Free Dynamic Mass Redistribution Reveals Low-Density, Prosurvival α1B-Adrenergic Receptors in Human SW480 Colon Carcinoma Cells. J Pharmacol Exp Ther. 2017;361:219-228 pubmed publisher
Fabre Nys C, Chanvallon A, Dupont J, Lardic L, Lomet D, Martinet S, et al. The "Ram Effect": A "Non-Classical" Mechanism for Inducing LH Surges in Sheep. PLoS ONE. 2016;11:e0158530 pubmed publisher
Monai H, Ohkura M, Tanaka M, Oe Y, Konno A, Hirai H, et al. Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain. Nat Commun. 2016;7:11100 pubmed publisher
Singh C, Oikonomou G, Prober D. Norepinephrine is required to promote wakefulness and for hypocretin-induced arousal in zebrafish. elife. 2015;4:e07000 pubmed publisher
Sheng Z, Cui X, Cui S, Yu B, Zhang X, Li S, et al. Involvement of adrenoceptors, dopamine receptors and AMPA receptors in antidepressant-like action of 7-O-ethylfangchinoline in mice. Acta Pharmacol Sin. 2015;36:949-56 pubmed publisher
Froehlich J, Hausauer B, Fischer S, WISE B, Rasmussen D. Prazosin Reduces Alcohol Intake in an Animal Model of Alcohol Relapse. Alcohol Clin Exp Res. 2015;39:1538-46 pubmed publisher
Cummins Jacklin E, Boughner E, Kent K, Kwiatkowski D, MacDonald T, Leri F. Memory of a drug lapse: Role of noradrenaline. Neuropharmacology. 2015;99:98-105 pubmed publisher
Colby Milley J, Cavanagh C, Jego S, Breitner J, Quirion R, Adamantidis A. Sleep-Wake Cycle Dysfunction in the TgCRND8 Mouse Model of Alzheimer's Disease: From Early to Advanced Pathological Stages. PLoS ONE. 2015;10:e0130177 pubmed publisher
Lowe J, Sanderson H, Cooke A, Ostovar M, Tsisanova E, Withey S, et al. Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization. Mol Pharmacol. 2015;88:347-56 pubmed publisher
Hasebe S, Ago Y, Nishiyama S, Oka S, Hashimoto H, Takuma K, et al. Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice. Behav Pharmacol. 2015;26:681-90 pubmed publisher
Harada K, Kitaguchi T, Tsuboi T. Integrative function of adrenaline receptors for glucagon-like peptide-1 exocytosis in enteroendocrine L cell line GLUTag. Biochem Biophys Res Commun. 2015;460:1053-8 pubmed publisher
Verplaetse T, Czachowski C. Low-dose prazosin alone and in combination with propranolol or naltrexone: effects on ethanol and sucrose seeking and self-administration in the P rat. Psychopharmacology (Berl). 2015;232:2647-57 pubmed publisher
Galea C, Mangelings D, Heyden Y. Method development for impurity profiling in SFC: The selection of a dissimilar set of stationary phases. J Pharm Biomed Anal. 2015;111:333-43 pubmed publisher
Fuchs R, Schwach G, Stracke A, Meier Allard N, Absenger M, Ingolic E, et al. The anti-hypertensive drug prazosin induces apoptosis in the medullary thyroid carcinoma cell line TT. Anticancer Res. 2015;35:31-38 pubmed
Sekio M, Seki K. Lipopolysaccharide-induced depressive-like behavior is associated with α₁-adrenoceptor dependent downregulation of the membrane GluR1 subunit in the mouse medial prefrontal cortex and ventral tegmental area. Int J Neuropsychopharmacol. 2014;18: pubmed publisher
Ishola I, Ochieng C, Olayemi S, Jimoh M, Lawal S. Potential of novel phytoecdysteroids isolated from Vitex doniana in the treatment depression: involvement of monoaminergic systems. Pharmacol Biochem Behav. 2014;127:90-100 pubmed publisher
Maïga A, Dupont M, Blanchet G, Marcon E, Gilquin B, Servent D, et al. Molecular exploration of the α(1A)-adrenoceptor orthosteric site: binding site definition for epinephrine, HEAT and prazosin. FEBS Lett. 2014;588:4613-9 pubmed publisher
Abraham R, Nirogi R, Shinde A, Irupannanavar S. Low-dose prazosin in combination with 5-HT6 antagonist PRX-07034 has antipsychotic effects. Can J Physiol Pharmacol. 2015;93:13-21 pubmed publisher
Chen X, Zhao C, Li X, Wang T, Li Y, Cao C, et al. Terazosin activates Pgk1 and Hsp90 to promote stress resistance. Nat Chem Biol. 2015;11:19-25 pubmed publisher
Murahata Y, Miki Y, Hikasa Y. Antagonistic effects of atipamezole, yohimbine, and prazosin on xylazine-induced diuresis in clinically normal cats. Can J Vet Res. 2014;78:304-15 pubmed
Akerstrom T, Laub L, Vedel K, Brand C, Pedersen B, Lindqvist A, et al. Increased skeletal muscle capillarization enhances insulin sensitivity. Am J Physiol Endocrinol Metab. 2014;307:E1105-16 pubmed publisher
Ragnarsson L, Andersson Ã, Thomas W, Lewis R. Extracellular surface residues of the α1B-adrenoceptor critical for G protein-coupled receptor function. Mol Pharmacol. 2015;87:121-9 pubmed publisher
Velásquez Martínez M, Vázquez Torres R, Rojas L, SANABRIA P, Jiménez Rivera C. Alpha-1 adrenoreceptors modulate GABA release onto ventral tegmental area dopamine neurons. Neuropharmacology. 2015;88:110-21 pubmed publisher
Naylor A, McGettrick H, Maynard W, May P, Barone F, Croft A, et al. A differential role for CD248 (Endosialin) in PDGF-mediated skeletal muscle angiogenesis. PLoS ONE. 2014;9:e107146 pubmed publisher
Lippiello P, Hoxha E, Volpicelli F, Lo Duca G, Tempia F, Miniaci M. Noradrenergic modulation of the parallel fiber-Purkinje cell synapse in mouse cerebellum. Neuropharmacology. 2015;89:33-42 pubmed publisher
Stolz E, Hasse D, von Poser G, Rates S. Uliginosin B, a natural phloroglucinol derivative, presents a multimediated antinociceptive effect in mice. J Pharm Pharmacol. 2014;66:1774-85 pubmed publisher
Perin M, Longordo F, Massonnet C, Welker E, Lüthi A. Diurnal inhibition of NMDA-EPSCs at rat hippocampal mossy fibre synapses through orexin-2 receptors. J Physiol. 2014;592:4277-95 pubmed publisher
Freitas A, Egea J, Buendia I, Navarro E, Rada P, Cuadrado A, et al. Agmatine induces Nrf2 and protects against corticosterone effects in hippocampal neuronal cell line. Mol Neurobiol. 2015;51:1504-19 pubmed publisher
. Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle. J Pharmacol Exp Ther. 2014;350:681-90 pubmed publisher
Silvani A, Berteotti C, Bastianini S, Cohen G, Lo Martire V, Mazza R, et al. Cardiorespiratory anomalies in mice lacking CB1 cannabinoid receptors. PLoS ONE. 2014;9:e100536 pubmed publisher
Brunet I, Gordon E, Han J, Cristofaro B, Broqueres You D, Liu C, et al. Netrin-1 controls sympathetic arterial innervation. J Clin Invest. 2014;124:3230-40 pubmed publisher
Mori T, Uzawa N, Kazawa H, Watanabe H, Mochizuki A, Shibasaki M, et al. Differential substitution for the discriminative stimulus effects of 3,4-methylenedioxymethamphetamine and methylphenidate in rats. J Pharmacol Exp Ther. 2014;350:403-11 pubmed publisher
Rasmussen D, Beckwith L, Kincaid C, Froehlich J. Combining the α1 -adrenergic receptor antagonist, prazosin, with the β-adrenergic receptor antagonist, propranolol, reduces alcohol drinking more effectively than either drug alone. Alcohol Clin Exp Res. 2014;38:1532-9 pubmed publisher
Kikuchi N, Irifune M, Shimizu Y, Yoshida K, Morita K, Kanematsu T, et al. Selective blockade of N-methyl-D-aspartate channels in combination with dopamine receptor antagonism induces loss of the righting reflex in mice, but not immobility. Psychopharmacology (Berl). 2015;232:39-46 pubmed publisher
Ho J, Anekonda V, Thompson B, Zhu M, Curry R, Hwang B, et al. Hindbrain oxytocin receptors contribute to the effects of circulating oxytocin on food intake in male rats. Endocrinology. 2014;155:2845-57 pubmed publisher
Shen X, Xu Q, Xu S, Li J, Zhang N, Zhang L. Preparation and transdermal diffusion evaluation of the prazosin hydrochloride-loaded electrospun poly(vinyl alcohol) fiber mats. J Nanosci Nanotechnol. 2014;14:5258-65 pubmed
Kwon G, Kim H, Park S, Lee H, Woo H, Ahn Y, et al. Anxiolytic-like effect of danshensu [(3-(3,4-dihydroxyphenyl)-lactic acid)] in mice. Life Sci. 2014;101:73-8 pubmed publisher
Hermes E, Harpaz Rotem I, Rosenheck R. Diffusion of prazosin treatment for PTSD. Am J Psychiatry. 2014;171:117 pubmed publisher
Shrestha S, Liow J, Lu S, Jenko K, Gladding R, Svenningsson P, et al. (11)C-CUMI-101, a PET radioligand, behaves as a serotonin 1A receptor antagonist and also binds to α(1) adrenoceptors in brain. J Nucl Med. 2014;55:141-6 pubmed publisher
Kobuchi S, Tanaka R, Funai A, Suzuki R, Yazawa M, Tsutsui H, et al. Involvement of renal sympathetic nerve overactivation in the progression of chronic kidney disease in rats. J Cardiovasc Pharmacol. 2014;63:9-15 pubmed publisher
Friedman M. Toward rational pharmacotherapy for posttraumatic stress disorder: reprise. Am J Psychiatry. 2013;170:944-6 pubmed publisher
Lanteri C, Doucet E, Hernández Vallejo S, Godeheu G, Bobadilla A, Salomon L, et al. Repeated exposure to MDMA triggers long-term plasticity of noradrenergic and serotonergic neurons. Mol Psychiatry. 2014;19:823-33 pubmed publisher
Wang M, Tanida M, Shibamoto T, Kurata Y. Alpha-adrenoceptor antagonists and chemical sympathectomy exacerbate anaphylaxis-induced hypotension, but not portal hypertension, in anesthetized rats. Am J Physiol Regul Integr Comp Physiol. 2013;305:R900-7 pubmed publisher
Polack P, Friedman J, GOLSHANI P. Cellular mechanisms of brain state-dependent gain modulation in visual cortex. Nat Neurosci. 2013;16:1331-9 pubmed publisher
Raskind M, Peterson K, Williams T, Hoff D, Hart K, Holmes H, et al. A trial of prazosin for combat trauma PTSD with nightmares in active-duty soldiers returned from Iraq and Afghanistan. Am J Psychiatry. 2013;170:1003-10 pubmed publisher
Deweerdt S. Mood disorders: the dark night. Nature. 2013;497:S14-5 pubmed publisher
Kristek F, Malekova M, Cacanyiova S. Long-term effect of prazosin and losartan administration on blood pressure, heart, carotid artery, and acetylcholine induced dilation of cardiovascular system of young Wistar rats and SHR. Gen Physiol Biophys. 2013;32:235-43 pubmed publisher
Adewoye E, Ige A. Effect of magnesium on gastrointestinal transit time in normal and diabetic rats: possible mechanism of action. Afr J Med Med Sci. 2012;41:373-8 pubmed
Adedapo A, Sikuade O, Adeleke S, Okechukwu R. Drug utilization and blood pressure control in a population where antihypertensives are given free: effect of policy change. Afr J Med Med Sci. 2012;41:349-56 pubmed
Versnaeyen L, Debien C, Warembourg F, Ducrocq F, Vaiva G. [Prazosin for sleep disturbance and nightmares in post-traumatic stress disorder]. Presse Med. 2013;42:1276-9 pubmed publisher
Shore J. Telepsychiatry: videoconferencing in the delivery of psychiatric care. Am J Psychiatry. 2013;170:256-62 pubmed publisher
Kitazawa T. Contractile signaling pathways in mouse prostate smooth muscle. Prostate. 2013;73:996-1006 pubmed publisher
Coutsos M, Sala Mercado J, Ichinose M, Li Z, Dawe E, O Leary D. Muscle metaboreflex-induced coronary vasoconstriction limits ventricular contractility during dynamic exercise in heart failure. Am J Physiol Heart Circ Physiol. 2013;304:H1029-37 pubmed publisher
Friedrich M. Researchers seek new ways to counter the harmful toll of stress on the brain. JAMA. 2013;309:330-2 pubmed publisher
Romero T, Resende L, Guzzo L, Duarte I. CB1 and CB2 cannabinoid receptor agonists induce peripheral antinociception by activation of the endogenous noradrenergic system. Anesth Analg. 2013;116:463-72 pubmed publisher
Wang L, Liang P, Yang W, Zhou P, Huang X, Liu J, et al. [Efficacy of compound Xuanju capsule in the treatment of chronic prostatitis with erectile dysfunction]. Zhonghua Nan Ke Xue. 2012;18:950-2 pubmed
Kumar L, Meena C, Pawar Y, Wahlang B, Tikoo K, Jain R, et al. Effect of counterions on physicochemical properties of prazosin salts. AAPS PharmSciTech. 2013;14:141-50 pubmed publisher
Miyazato M, Oshiro T, Chancellor M, de Groat W, Yoshimura N, Saito S. An alpha1-adrenoceptor blocker terazosin improves urine storage function in the spinal cord in spinal cord injured rats. Life Sci. 2013;92:125-30 pubmed publisher
Lewis N, Ainslie P, Atkinson G, Jones H, Grant E, Lucas S. Initial orthostatic hypotension and cerebral blood flow regulation: effect of ?1-adrenoreceptor activity. Am J Physiol Regul Integr Comp Physiol. 2013;304:R147-54 pubmed publisher
Pelletier A, Delanaud S, Décima P, Thuroczy G, de Seze R, Cerri M, et al. Effects of chronic exposure to radiofrequency electromagnetic fields on energy balance in developing rats. Environ Sci Pollut Res Int. 2013;20:2735-46 pubmed publisher
Johnson K, Rosen J. Re-emergence of posttraumatic stress disorder nightmares with nursing home admission: treatment with prazosin. J Am Med Dir Assoc. 2013;14:130-1 pubmed publisher
Bernardi R, Lattal K. Prazosin differentially affects extinction of cocaine conditioned place preference on the basis of dose and initial preference. Neuroreport. 2012;23:1048-51 pubmed publisher
Lin Z, Chuang W. High therapeutic concentration of prazosin up-regulates angiogenic IL6 and CCL2 genes in hepatocellular carcinoma cells. Biomed Pharmacother. 2012;66:583-6 pubmed publisher
Dhingra D, Chhillar R. Antidepressant-like activity of ellagic acid in unstressed and acute immobilization-induced stressed mice. Pharmacol Rep. 2012;64:796-807 pubmed
Oluwabusi O, Sedky K, Bennett D. Prazosin treatment of nightmares and sleep disturbances associated with posttraumatic stress disorder: two adolescent cases. J Child Adolesc Psychopharmacol. 2012;22:399-402 pubmed publisher
Novielli N, Al Khazraji B, Medeiros P, Goldman D, Jackson D. Pre-diabetes augments neuropeptide Y1- and ?1-receptor control of basal hindlimb vascular tone in young ZDF rats. PLoS ONE. 2012;7:e46659 pubmed publisher
Katsouri L, Vizcaychipi M, McArthur S, Harrison I, Suarez Calvet M, Lleo A, et al. Prazosin, an α(1)-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease. Neurobiol Aging. 2013;34:1105-15 pubmed publisher
Augedal A, Hansen K, Kronhaug C, Harvey A, Pallesen S. Randomized controlled trials of psychological and pharmacological treatments for nightmares: a meta-analysis. Sleep Med Rev. 2013;17:143-52 pubmed publisher
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Purkayastha S, Saxena A, Eubank W, Hoxha B, Raven P. ?1-Adrenergic receptor control of the cerebral vasculature in humans at rest and during exercise. Exp Physiol. 2013;98:451-61 pubmed publisher
Köse M, Erdem S, Peșkircioğlu C, Caylak B. Effects of angiogenesis inhibition by spironolactone on isolated vas deferens contractility in an experimental varicocele model in rats. Urology. 2012;80:816-21 pubmed publisher
Yu S, Wang D. Enhanced salt sensitivity following shRNA silencing of neuronal TRPV1 in rat spinal cord. Acta Pharmacol Sin. 2011;32:845-52 pubmed publisher
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product information
Catalog Number :
P7791
Product Name :
Prazosin hydrochloride
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥99.0% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA