This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Progesterone-Water Soluble
catalog :
P7556
citations: 80
Reference
El Mayet F, Sawant L, Wijesekera N, Jones C. Progesterone increases the incidence of bovine herpesvirus 1 reactivation from latency and stimulates productive infection. Virus Res. 2020;276:197803 pubmed publisher
Zhang Y, Yan L, Liu J, Cui S, Qiu J. cGMP-dependent protein kinase II determines β-catenin accumulation that is essential for uterine decidualization in mice. Am J Physiol Cell Physiol. 2019;317:C1115-C1127 pubmed publisher
Roesler M, Lombino F, Freitag S, Schweizer M, Hermans Borgmeyer I, Schwarz J, et al. Myosin XVI Regulates Actin Cytoskeleton Dynamics in Dendritic Spines of Purkinje Cells and Affects Presynaptic Organization. Front Cell Neurosci. 2019;13:330 pubmed publisher
Yoder P, Ruiz Cortés T, Castro J, Hanigan M. Effects of varying extracellular amino acid profile on intracellular free amino acid concentrations and cell signaling in primary mammary epithelial cells. J Dairy Sci. 2019;102:8977-8985 pubmed publisher
Wagner W, Lippmann K, Heisler F, Gromova K, Lombino F, Roesler M, et al. Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression. Cell Rep. 2019;28:11-20.e9 pubmed publisher
Sabbir M. Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1. J Steroid Biochem Mol Biol. 2019;191:105376 pubmed publisher
O Shea L, Fair T, Hensey C. X-linked α-thalassemia with mental retardation is downstream of protein kinase A in the meiotic cell cycle signaling cascade in Xenopus oocytes and is dynamically regulated in response to DNA damage†. Biol Reprod. 2019;100:1238-1249 pubmed publisher
El Mayet F, El Habbaa A, d Offay J, Jones C. Synergistic Activation of Bovine Herpesvirus 1 Productive Infection and Viral Regulatory Promoters by the Progesterone Receptor and Krüppel-Like Transcription Factor 15. J Virol. 2019;93: pubmed publisher
Rodríguez Muñoz M, Onetti Y, Cortés Montero E, Garzón J, Sánchez Blázquez P. Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor. Mol Brain. 2018;11:51 pubmed publisher
Devadas K, Biswas S, Ragupathy V, Lee S, Dayton A, Hewlett I. Modulation of HIV replication in monocyte derived macrophages (MDM) by steroid hormones. PLoS ONE. 2018;13:e0191916 pubmed publisher
Turco M, Gardner L, Hughes J, Cindrova Davies T, Gomez M, Farrell L, et al. Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium. Nat Cell Biol. 2017;19:568-577 pubmed publisher
Weber F, Endesfelder S, Buhrer C, Berns M. Effects of progesterone on hyperoxia-induced damage in mouse C8-D1A astrocytes. Brain Behav. 2016;6:e00435 pubmed publisher
Jo Y, Lee G, Nam S, Kim S. Progesterone Inhibits Leptin-Induced Invasiveness of BeWo Cells. Int J Med Sci. 2015;12:773-9 pubmed publisher
Rodríguez Muñoz M, Cortés Montero E, Pozo Rodrigálvarez A, Sánchez Blázquez P, Garzón Niño J. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders. Oncotarget. 2015;6:35458-77 pubmed publisher
Mittelman Smith M, Wong A, Kathiresan A, Micevych P. Classical and membrane-initiated estrogen signaling in an in vitro model of anterior hypothalamic kisspeptin neurons. Endocrinology. 2015;156:2162-73 pubmed publisher
Nguyen G, Gokhan S, Molero A, Yang S, Kim B, Skoultchi A, et al. The role of H1 linker histone subtypes in preserving the fidelity of elaboration of mesendodermal and neuroectodermal lineages during embryonic development. PLoS ONE. 2014;9:e96858 pubmed publisher
O Shea L, Fair T, Hensey C. Aven is dynamically regulated during Xenopus oocyte maturation and is required for oocyte survival. Cell Death Dis. 2013;4:e908 pubmed publisher
Nguyen G, Molero A, Gokhan S, Mehler M. Functions of huntingtin in germ layer specification and organogenesis. PLoS ONE. 2013;8:e72698 pubmed publisher
Tingling J, Bake S, Holgate R, Rawlings J, Nagsuk P, Chandrasekharan J, et al. CD24 expression identifies teratogen-sensitive fetal neural stem cell subpopulations: evidence from developmental ethanol exposure and orthotopic cell transfer models. PLoS ONE. 2013;8:e69560 pubmed publisher
Nguyen G, Gokhan S, Molero A, Mehler M. Selective roles of normal and mutant huntingtin in neural induction and early neurogenesis. PLoS ONE. 2013;8:e64368 pubmed publisher
Schmidt F, Van Den Eijnden M, Pescini Gobert R, Saborio G, Carboni S, Alliod C, et al. Identification of VHY/Dusp15 as a regulator of oligodendrocyte differentiation through a systematic genomics approach. PLoS ONE. 2012;7:e40457 pubmed publisher
Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W. Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS Comput Biol. 2011;7:e1002310 pubmed publisher
Nagata N, Miyakawa M, Amano S, Furuya K, Yamamoto N, Nejishima H, et al. Tetrahydroquinolines as a novel series of nonsteroidal selective androgen receptor modulators: structural requirements for better physicochemical and biological properties. Bioorg Med Chem Lett. 2011;21:6310-3 pubmed publisher
Schläger T, Schepmann D, Lehmkuhl K, Holenz J, Vela J, Buschmann H, et al. Combination of two pharmacophoric systems: synthesis and pharmacological evaluation of spirocyclic pyranopyrazoles with high σ₁ receptor affinity. J Med Chem. 2011;54:6704-13 pubmed publisher
Gozalbes R, Jacewicz M, Annand R, Tsaioun K, Pineda Lucena A. QSAR-based permeability model for drug-like compounds. Bioorg Med Chem. 2011;19:2615-24 pubmed publisher
González Muñoz G, Arce M, Lopez B, Perez C, Romero A, del Barrio L, et al. N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. Eur J Med Chem. 2011;46:2224-35 pubmed publisher
Nagata N, Miyakawa M, Amano S, Furuya K, Yamamoto N, Inoguchi K. Design and synthesis of tricyclic tetrahydroquinolines as a new series of nonsteroidal selective androgen receptor modulators (SARMs). Bioorg Med Chem Lett. 2011;21:1744-7 pubmed publisher
Alvarez L, Dansey M, Marti M, Bertucci P, Di Chenna P, Pecci A, et al. Biological activity and ligand binding mode to the progesterone receptor of A-homo analogues of progesterone. Bioorg Med Chem. 2011;19:1683-91 pubmed publisher
Ekins S, Williams A, Xu J. A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug Metab Dispos. 2010;38:2302-8 pubmed publisher
Puri N, Prakash O, Manoharlal R, Sharma M, Ghosh I, Prasad R. Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. Eur J Med Chem. 2010;45:4813-26 pubmed publisher
Singh P, Kaur J, Yadav B, Komath S. Targeting efflux pumps-In vitro investigations with acridone derivatives and identification of a lead molecule for MDR modulation. Bioorg Med Chem. 2010;18:4212-23 pubmed publisher
Greene N, Fisk L, Naven R, Note R, Patel M, Pelletier D. Developing structure-activity relationships for the prediction of hepatotoxicity. Chem Res Toxicol. 2010;23:1215-22 pubmed publisher
Du Y, Li Q, Xiong B, Hui X, Wang X, Feng Y, et al. Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists. Bioorg Med Chem. 2010;18:4255-68 pubmed publisher
Tsuji H, Miyoshi S, Ikegami Y, Hida N, Asada H, Togashi I, et al. Xenografted human amniotic membrane-derived mesenchymal stem cells are immunologically tolerated and transdifferentiated into cardiomyocytes. Circ Res. 2010;106:1613-23 pubmed publisher
Zeinyeh W, Alameh G, Radix S, Grenot C, Dumontet C, Walchshofer N. Design, synthesis and evaluation of progesterone-adenine hybrids as bivalent inhibitors of P-glycoprotein-mediated multidrug efflux. Bioorg Med Chem Lett. 2010;20:3165-8 pubmed publisher
Siemieniuch M, Bowolaksono A, Skarzynski D, Okuda K. Ovarian steroids regulate prostaglandin secretion in the feline endometrium. Anim Reprod Sci. 2010;120:142-50 pubmed publisher
Zeinyeh W, Xia H, Lawton P, Radix S, Marminon C, Nebois P, et al. Synthesis and modulation properties of imidazo[4,5-b]pyridin-7-one and indazole-4,7-dione derivatives towards the Cryptosporidium parvum CpABC3 transporter. Eur J Med Chem. 2010;45:2480-8 pubmed publisher
Prado Prado F, Garcia Mera X, González Díaz H. Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorg Med Chem. 2010;18:2225-2231 pubmed publisher
Guerra A, Campillo N, Paez J. Neural computational prediction of oral drug absorption based on CODES 2D descriptors. Eur J Med Chem. 2010;45:930-40 pubmed publisher
Fourches D, Barnes J, Day N, Bradley P, Reed J, Tropsha A. Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chem Res Toxicol. 2010;23:171-83 pubmed publisher
Lee P, Conradi R, Shanmugasundaram V. Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. Bioorg Med Chem Lett. 2010;20:69-73 pubmed publisher
Dexheimer T, Gediya L, Stephen A, Weidlich I, Antony S, Marchand C, et al. 4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors. J Med Chem. 2009;52:7122-31 pubmed publisher
Roll D, Barbieri L, Bigelis R, McDonald L, Arias D, Chang L, et al. The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144. J Nat Prod. 2009;72:1944-8 pubmed publisher
Arce M, Rodríguez Franco M, González Muñoz G, Perez C, Lopez B, Villarroya M, et al. Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. J Med Chem. 2009;52:7249-57 pubmed publisher
MacNevin C, Atif F, Sayeed I, Stein D, Liotta D. Development and screening of water-soluble analogues of progesterone and allopregnanolone in models of brain injury. J Med Chem. 2009;52:6012-23 pubmed publisher
Bellavance E, Luu The V, Poirier D. Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone. J Med Chem. 2009;52:7488-502 pubmed publisher
Yuan J, Johnson R, Huang R, Wichterman J, Jiang H, Hayton K, et al. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat Chem Biol. 2009;5:765-71 pubmed publisher
Du Cuny L, Song Z, Moses S, Powis G, Mash E, Meuillet E, et al. Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorg Med Chem. 2009;17:6983-92 pubmed publisher
Camps P, Formosa X, Galdeano C, Muñoz Torrero D, Ramírez L, Gomez E, et al. Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. J Med Chem. 2009;52:5365-79 pubmed publisher
Thompson S, Washburn D, Frazee J, Madauss K, Hoang T, Lapinski L, et al. Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists. Bioorg Med Chem Lett. 2009;19:4777-80 pubmed publisher
Goldman S, Lovett D, Shalev E. Mechanisms of matrix metalloproteinase-2 (mmp-2) transcriptional repression by progesterone in jar choriocarcinoma cells. Reprod Biol Endocrinol. 2009;7:41 pubmed publisher
Marco Contelles J, Leon R, de Los Rios C, Samadi A, Bartolini M, Andrisano V, et al. Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. J Med Chem. 2009;52:2724-32 pubmed publisher
Vaught D, Chen J, Brantley Sieders D. Regulation of mammary gland branching morphogenesis by EphA2 receptor tyrosine kinase. Mol Biol Cell. 2009;20:2572-81 pubmed publisher
Singh P, Kaur J, Kaur P, Kaur S. Search for MDR modulators: design, syntheses and evaluations of N-substituted acridones for interactions with p-glycoprotein and Mg2+. Bioorg Med Chem. 2009;17:2423-7 pubmed publisher
Gobert R, Joubert L, Curchod M, Salvat C, Foucault I, Jorand Lebrun C, et al. Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Mol Cell Biol. 2009;29:1538-53 pubmed publisher
Ahlin G, Karlsson J, Pedersen J, Gustavsson L, Larsson R, Matsson P, et al. Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. J Med Chem. 2008;51:5932-42 pubmed publisher
Kern J, Terefenko E, Fensome A, Unwalla R, Wrobel J, Cohen J, et al. 1,5-Dihydro-benzo[e][1,4]oxazepin-2(1H)-ones containing a 7-(5'-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators. Bioorg Med Chem Lett. 2008;18:5015-7 pubmed publisher
Pick A, Müller H, Wiese M. Structure-activity relationships of new inhibitors of breast cancer resistance protein (ABCG2). Bioorg Med Chem. 2008;16:8224-36 pubmed publisher
Pedram B, van Oeveren A, Mais D, Marschke K, Verbost P, Groen M, et al. A tissue-selective nonsteroidal progesterone receptor modulator: 7,9-difluoro-5-(3-methylcyclohex-2-enyl)-2,2,4-trimethyl-1,2-dihydrochromeno[3,4-f]quinoline. J Med Chem. 2008;51:3696-9 pubmed publisher
Chuang S, Velkov T, Horne J, Porter C, Scanlon M. Characterization of the drug binding specificity of rat liver fatty acid binding protein. J Med Chem. 2008;51:3755-64 pubmed publisher
Pedersen J, Matsson P, Bergström C, Norinder U, Hoogstraate J, Artursson P. Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). J Med Chem. 2008;51:3275-87 pubmed publisher
Cherkasov A, Ban F, Santos Filho O, Thorsteinson N, Fallahi M, Hammond G. An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin. J Med Chem. 2008;51:2047-56 pubmed publisher
Fong W, Shen X, Globisch C, Wiese M, Chen G, Zhu G, et al. Methoxylation of 3',4'-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells. Bioorg Med Chem. 2008;16:3694-703 pubmed publisher
Sato H, Macchiarulo A, Thomas C, Gioiello A, Une M, Hofmann A, et al. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem. 2008;51:1831-41 pubmed publisher
Young D, Bender A, Hoyt J, McWhinnie E, Chirn G, Tao C, et al. Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat Chem Biol. 2008;4:59-68 pubmed
Müller H, Klinkhammer W, Globisch C, Kassack M, Pajeva I, Wiese M. New functional assay of P-glycoprotein activity using Hoechst 33342. Bioorg Med Chem. 2007;15:7470-9 pubmed
Baert B, Deconinck E, Van Gele M, Slodicka M, Stoppie P, Bodé S, et al. Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds. Bioorg Med Chem. 2007;15:6943-55 pubmed
Kapfhammer J, Xu H, Raper J. The detection and quantification of growth cone collapsing activities. Nat Protoc. 2007;2:2005-11 pubmed
Zhang P, Terefenko E, Kern J, Fensome A, Trybulski E, Unwalla R, et al. 5-(3-Cyclopentyl-2-thioxo-2,3-dihydro-1H-benzimidazol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile: A novel, highly potent, selective, and orally active non-steroidal progesterone receptor agonist. Bioorg Med Chem. 2007;15:6556-64 pubmed
Pelczar H, Caulet S, Thibier C, Aubet G, Poulhe R, Vallianou I, et al. Characterization and expression of a maternal axolotl cyclin B1 during oogenesis and early development. Dev Growth Differ. 2007;49:407-19 pubmed
Diamandis P, Wildenhain J, Clarke I, Sacher A, Graham J, Bellows D, et al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol. 2007;3:268-73 pubmed
Prock T, Miranda R. Embryonic cerebral cortical progenitors are resistant to apoptosis, but increase expression of suicide receptor DISC-complex genes and suppress autophagy following ethanol exposure. Alcohol Clin Exp Res. 2007;31:694-703 pubmed
Ottaviani G, Martel S, Carrupt P. In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. J Med Chem. 2007;50:742-8 pubmed
Ekins S, Mankowski D, Hoover D, Lawton M, Treadway J, Harwood H. Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. Drug Metab Dispos. 2007;35:493-500 pubmed
Söderholm A, Lehtovuori P, Nyrönen T. Docking and three-dimensional quantitative structure-activity relationship (3D QSAR) analyses of nonsteroidal progesterone receptor ligands. J Med Chem. 2006;49:4261-8 pubmed
Ottaviani G, Martel S, Carrupt P. Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability. J Med Chem. 2006;49:3948-54 pubmed
Lill M, Winiger F, Vedani A, Ernst B. Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals. J Med Chem. 2005;48:5666-74 pubmed
Laggner C, Schieferer C, Fiechtner B, Poles G, Hoffmann R, Glossmann H, et al. Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening. J Med Chem. 2005;48:4754-64 pubmed
Zhao L, Brinton R. Structure-based virtual screening for plant-based ERbeta-selective ligands as potential preventative therapy against age-related neurodegenerative diseases. J Med Chem. 2005;48:3463-6 pubmed
Caron G, Ermondi G. Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). J Med Chem. 2005;48:3269-79 pubmed
product information
Catalog Number :
P7556
Product Name :
Progesterone-Water Soluble
Product Type :
CELL CULTURE REAGENT
Product Group :
Cell Biology
Product Description :
powder, BioReagent, suitable for cell culture
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA