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product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Pentylenetetrazole
catalog :
P6500
citations: 175
Reference
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Kilinc E, Gunes H. Modulatory effects of neuropeptides on pentylenetetrazol-induced epileptic seizures and neuroinflammation in rats. Rev Assoc Med Bras (1992). 2019;65:1188-1192 pubmed publisher
Reichert S, Pavón Arocas O, Rihel J. The Neuropeptide Galanin Is Required for Homeostatic Rebound Sleep following Increased Neuronal Activity. Neuron. 2019;104:370-384.e5 pubmed publisher
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Zamyad M, Abbasnejad M, Esmaeili Mahani S, Mostafavi A, Sheibani V. The anticonvulsant effects of Ducrosia anethifolia (Boiss) essential oil are produced by its main component alpha-pinene in rats. Arq Neuropsiquiatr. 2019;77:106-114 pubmed publisher
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Sahin S, Gürgen S, Yazar U, Ince I, Kamaşak T, Acar Arslan E, et al. Vitamin D protects against hippocampal apoptosis related with seizures induced by kainic acid and pentylenetetrazol in rats. Epilepsy Res. 2019;149:107-116 pubmed publisher
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Jin M, Sheng W, Han L, He Q, Ji X, Liu K. Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish. Fish Shellfish Immunol. 2018;83:26-36 pubmed publisher
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Benneh C, Biney R, Tandoh A, Ampadu F, Adongo D, Jato J, et al. Maerua angolensis DC. (Capparaceae) Stem Bark Extract Protects against Pentylenetetrazole-Induced Oxidative Stress and Seizures in Rats. Evid Based Complement Alternat Med. 2018;2018:9684138 pubmed publisher
Acker D, Wong I, Kang M, Paradis S. Semaphorin 4D promotes inhibitory synapse formation and suppresses seizures in vivo. Epilepsia. 2018;59:1257-1268 pubmed publisher
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Wang B, Gupta G, Singh M, Veerabhadrappa K, Mishra A, Chinnaboina G. Pharmacological Evaluation of Novel Flavone from Morus alba in Pentylenetetrazole-Induced Kindling and Oxidative Stress. J Environ Pathol Toxicol Oncol. 2018;37:43-52 pubmed publisher
Huang W, Lin S, Chen H, Chen Y, Chen T, Hsu K, et al. NADPH oxidases as potential pharmacological targets against increased seizure susceptibility after systemic inflammation. J Neuroinflammation. 2018;15:140 pubmed publisher
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Kawaharada S, Nakanishi M, Nakanishi N, Hazama K, Higashino M, Yasuhiro T, et al. ONO-8590580, a Novel GABAA?5 Negative Allosteric Modulator Enhances Long-Term Potentiation and Improves Cognitive Deficits in Preclinical Models. J Pharmacol Exp Ther. 2018;366:58-65 pubmed publisher
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Vashishta A, Slomnicki L, Pietrzak M, Smith S, Kolikonda M, Naik S, et al. RNA Polymerase 1 Is Transiently Regulated by Seizures and Plays a Role in a Pharmacological Kindling Model of Epilepsy. Mol Neurobiol. 2018;55:8374-8387 pubmed publisher
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Hamada N, Ashour R, Shalaby A, El Beltagi H. Calcitonin potentiates the anticonvulsant and antinociceptive effects of valproic acid and pregabalin in pentylenetetrazole-kindled mice. Eur J Pharmacol. 2018;818:351-355 pubmed publisher
Soares D, Portela J, Roos D, Rodrigues N, Gomes K, Macedo G, et al. Treatment with pentylenetetrazole (PTZ) and 4-aminopyridine (4-AP) differently affects survival, locomotor activity, and biochemical markers in Drosophila melanogaster. Mol Cell Biochem. 2018;442:129-142 pubmed publisher
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Zabinyakov N, Bullivant G, Cao F, Fernandez Ojeda M, Jia Z, Wen X, et al. Characterization of the first knock-out aldh7a1 zebrafish model for pyridoxine-dependent epilepsy using CRISPR-Cas9 technology. PLoS ONE. 2017;12:e0186645 pubmed publisher
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Vilela L, Lima I, Kunsch Ã, Pinto H, de Miranda A, Vieira Ã, et al. Anticonvulsant effect of cannabidiol in the pentylenetetrazole model: Pharmacological mechanisms, electroencephalographic profile, and brain cytokine levels. Epilepsy Behav. 2017;75:29-35 pubmed publisher
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Abdel Zaher A, Farghaly H, Farrag M, Abdel Rahman M, Abdel Wahab B. A potential mechanism for the ameliorative effect of thymoquinone on pentylenetetrazole-induced kindling and cognitive impairments in mice. Biomed Pharmacother. 2017;88:553-561 pubmed publisher
Kalantaripour T, Esmaeili Mahani S, Sheibani V, Najafipour H, Asadi Shekaari M M. Apelin-13 protects rat primary cortical glia-neuron co-culture against pentylenetetrazole-induced toxicity. Biomed Pharmacother. 2017;87:661-668 pubmed publisher
Abd Elghafour B, El Sayed N, Ahmed A, Zaitone S, Moustafa Y. Aspirin and (or) omega-3 polyunsaturated fatty acids protect against corticohippocampal neurodegeneration and downregulate lipoxin A4 production and formyl peptide receptor-like 1 expression in pentylenetetrazole-kindled rats. Can J Physiol Pharmacol. 2017;95:340-348 pubmed publisher
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Mao K, You C, Lei D, Zhang H. High dosage of cannabidiol (CBD) alleviates pentylenetetrazole-induced epilepsy in rats by exerting an anticonvulsive effect. Int J Clin Exp Med. 2015;8:8820-7 pubmed
Joshi R, Reeta K, Sharma S, Tripathi M, Gupta Y. Panchagavya Ghrita, an Ayurvedic formulation attenuates seizures, cognitive impairment and oxidative stress in pentylenetetrazole induced seizures in rats. Indian J Exp Biol. 2015;53:446-51 pubmed
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product information
Catalog Number :
P6500
Product Name :
Pentylenetetrazole
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA