This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Piracetam
catalog :
P5295
citations: 81
Reference
Park S, Ahn Y, Lee H, Hong E, Ryu J. Standardized Prunella vulgaris var. lilacina Extract Enhances Cognitive Performance in Normal Naive Mice. Phytother Res. 2015;29:1814-21 pubmed publisher
Gao Q, Jeon S, Jung H, Lee H, Park S, Lee Y, et al. Nodakenin Enhances Cognitive Function and Adult Hippocampal Neurogenesis in Mice. Neurochem Res. 2015;40:1438-47 pubmed publisher
Bang S, Ambavade S, Jagdale P, Adkar P, Waghmare A, Ambavade P. Lacosamide reduces HDAC levels in the brain and improves memory: Potential for treatment of Alzheimer's disease. Pharmacol Biochem Behav. 2015;134:65-9 pubmed publisher
Sendrowski K, Sobaniec W, Stasiak Barmuta A, Sobaniec P, Popko J. Study of the protective effects of nootropic agents against neuronal damage induced by amyloid-beta (fragment 25-35) in cultured hippocampal neurons. Pharmacol Rep. 2015;67:326-31 pubmed publisher
Li B, Calvet A, Casamayou Boucau Y, Morris C, Ryder A. Low-content quantification in powders using Raman spectroscopy: a facile chemometric approach to sub 0.1% limits of detection. Anal Chem. 2015;87:3419-28 pubmed publisher
Palit P, Mukherjee D, Mandal S. Reconstituted mother tinctures of Gelsemium sempervirens L. improve memory and cognitive impairment in mice scopolamine-induced dementia model. J Ethnopharmacol. 2015;159:274-84 pubmed publisher
Tóth A, Tóth A, Walter F, Kiss L, Veszelka S, Ózsvári B, et al. Compounds blocking methylglyoxal-induced protein modification and brain endothelial injury. Arch Med Res. 2014;45:753-64 pubmed publisher
Mrozikiewicz P, Bogacz A, Bartkowiak Wieczorek J, Kujawski R, Mikolajczak P, Ozarowski M, et al. Screening for impact of popular herbs improving mental abilities on the transcriptional level of brain transporters. Acta Pharm. 2014;64:223-32 pubmed publisher
Zaccara G, Almas M, Pitman V, Knapp L, Posner H. Efficacy and safety of pregabalin versus levetiracetam as adjunctive therapy in patients with partial seizures: a randomized, double-blind, noninferiority trial. Epilepsia. 2014;55:1048-57 pubmed publisher
Mehta A, Bhati Y, Tripathi C, Sharma K. Analgesic effect of piracetam on peripheral neuropathic pain induced by chronic constriction injury of sciatic nerve in rats. Neurochem Res. 2014;39:1433-9 pubmed publisher
Burakgazi E, Bashir S, Doss V, Pellock J. The safety and tolerability of different intravenous administrations of levetiracetam, bolus versus infusion, in intensive care unit patients. Clin EEG Neurosci. 2014;45:89-91 pubmed publisher
Iyoda K, Ogawa K, Okazaki T. [Efficacy and psychiatric adverse events as short-term adjunctive levetiracetam for epileptic children with refractory convulsive seizures]. No To Hattatsu. 2013;45:463-4 pubmed
Wakita M, Kotani N, Kogure K, Akaike N. Inhibition of excitatory synaptic transmission in hippocampal neurons by levetiracetam involves Zn²⁺-dependent GABA type A receptor-mediated presynaptic modulation. J Pharmacol Exp Ther. 2014;348:246-59 pubmed publisher
Kikuchi T, Kato M, Takahashi N, Nakamura K, Hayasaka K. [Epileptic encephalopathy associated with forced normalization after administration of levetiracetam]. No To Hattatsu. 2013;45:375-8 pubmed
Kwiecińska P, WROBEL A, Taubøll E, Gregoraszczuk E. Valproic acid, but not levetiracetam, selectively decreases HDAC7 and HDAC2 expression in human ovarian cancer cells. Toxicol Lett. 2014;224:225-32 pubmed publisher
Nakamura H, Osawa M, Yokoyama T, Yoshida K, Suzuki A. [Efficacy and safety of levetiracetam as adjunctive therapy in Japanese children with uncontrolled partial-onset seizures: multicenter and open-label study (N01223), short term evaluation]. Brain Nerve. 2013;65:1083-92 pubmed
Bleck T, Cock H, Chamberlain J, Cloyd J, Connor J, Elm J, et al. The established status epilepticus trial 2013. Epilepsia. 2013;54 Suppl 6:89-92 pubmed publisher
Kang B, Moon H, Kim Y, Lee S, Jung K, Chu K, et al. The long-term efficacy and safety of levetiracetam in a tertiary epilepsy centre. Epileptic Disord. 2013;15:302-10 pubmed publisher
Kim D, Lee S, Shon Y, Kim J. Effects of new antiepileptic drugs on circulatory markers for vascular risk in patients with newly diagnosed epilepsy. Epilepsia. 2013;54:e146-9 pubmed publisher
Pearl P, McCarter R, McGavin C, Yu Y, Sandoval F, Trzcinski S, et al. Results of phase II levetiracetam trial following acute head injury in children at risk for posttraumatic epilepsy. Epilepsia. 2013;54:e135-7 pubmed publisher
Barrera Bailón B, Oliveira J, Lopez D, Muñoz L, Garcia Cairasco N, Sancho C. Pharmacological and neuroethological studies of three antiepileptic drugs in the Genetic Audiogenic Seizure Hamster (GASH:Sal). Epilepsy Behav. 2013;28:413-25 pubmed publisher
Connor J, Elm J, Broglio K. Bayesian adaptive trials offer advantages in comparative effectiveness trials: an example in status epilepticus. J Clin Epidemiol. 2013;66:S130-7 pubmed publisher
Tanaka S, Tanaka T. Levetiracetam add-on therapy in Japanese patients with refractory partial epilepsy. Epileptic Disord. 2013;15:132-41 pubmed publisher
Tiurenkov I, Samotrueva M, Priluchnyĭ S. [Psychomodulating activity of phenotropil in experimental hyperthyroidism]. Eksp Klin Farmakol. 2013;76:18-21 pubmed
Muley M, Thakare V, Patil R, Bafna P, Naik S. Amelioration of cognitive, motor and endogenous defense functions with silymarin, piracetam and protocatechuic acid in the cerebral global ischemic rat model. Life Sci. 2013;93:51-7 pubmed publisher
Palermo A, Giglia G, Cosentino G, Raieli V, Brighina F, Fierro B. Two cases of cluster headache effectively treated with levetiracetam. Funct Neurol. 2013;28:63-4 pubmed
Garbossa D, Panciani P, Angeleri R, Battaglia L, Tartara F, Ajello M, et al. A retrospective two-center study of antiepileptic prophylaxis in patients with surgically treated high-grade gliomas. Neurol India. 2013;61:131-7 pubmed publisher
Dedea L. Phenytoin or levetiracetam for seizure prophylaxis in TBI. JAAPA. 2012;25:11 pubmed
Phabphal K, Geater A, Limapichat K, Sathirapanya P, Setthawatcharawanich S, Leelawattana R. Effect of switching hepatic enzyme-inducer antiepileptic drug to levetiracetam on bone mineral density, 25 hydroxyvitamin D, and parathyroid hormone in young adult patients with epilepsy. Epilepsia. 2013;54:e94-8 pubmed publisher
Mahmoud A, Rizk T, Mansy A, Ali J, Al Tannir M. Ineffectiveness of topiramate and levetiracetam in infantile spasms non-responsive to steroids. Open labeled randomized prospective study. Neurosciences (Riyadh). 2013;18:143-6 pubmed
Yesilova Y, Turan E, Sonmez A, Ozardali I. A case of erythema multiforme developing after levetiracetam therapy. Dermatol Online J. 2013;19:12 pubmed
Nakken K, Sætre E, Markhus R, Lossius M. [Epilepsy in the elderly]. Tidsskr Nor Laegeforen. 2013;133:528-31 pubmed publisher
Inaba K, Menaker J, Branco B, Gooch J, Okoye O, Herrold J, et al. A prospective multicenter comparison of levetiracetam versus phenytoin for early posttraumatic seizure prophylaxis. J Trauma Acute Care Surg. 2013;74:766-71; discussion 771-3 pubmed publisher
Sethi N, Sethi P, Torgovnick J, Arsura E, Cukierwar F. Asymptomatic elevation of liver enzymes due to levetiracetam: a case report. Drug Metabol Drug Interact. 2013;28:123-4 pubmed publisher
Kazoka H, Koliškina O, Veinberg G, Vorona M. Separation of piracetam derivatives on polysaccharide-based chiral stationary phases. J Chromatogr A. 2013;1281:160-5 pubmed publisher
Chukanova E, Khodzhamzharov B, Chukanova A. [Current possibilities of the correction of oxidative stress in acute brain ischaemia]. Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112:79-82 pubmed
Bjørnæs H, Bakke K, Larsson P, Heminghyt E, Rytter E, Brager Larsen L, et al. Subclinical epileptiform activity in children with electrical status epilepticus during sleep: effects on cognition and behavior before and after treatment with levetiracetam. Epilepsy Behav. 2013;27:40-8 pubmed publisher
Hubs kyĭ I, Bielenichev I, Kovalenko S, Goriushko H, Bukhtiiarova N, Litvinova N, et al. [Antioxidant and cerebroprotective action of N-,S-chinazolone derivative under rat brain ischemia]. Ukr Biokhim Zh (1999). 2012;84:89-96 pubmed
Costa R, Fernandes M, de Souza Pinto N, Vercesi A. Protective effects of l-carnitine and piracetam against mitochondrial permeability transition and PC3 cell necrosis induced by simvastatin. Eur J Pharmacol. 2013;701:82-6 pubmed publisher
Amieva H, Meillon C, Helmer C, Barberger Gateau P, Dartigues J. Ginkgo biloba extract and long-term cognitive decline: a 20-year follow-up population-based study. PLoS ONE. 2013;8:e52755 pubmed publisher
Duong T, Haddad C, Valeyrie Allanore L, Sbidian E, Chosidow O, Wolkenstein P. Levetiracetam: a possible new inducer of toxic epidermal necrolysis and Stevens-Johnson syndrome in 2 cases. JAMA Dermatol. 2013;149:113-5 pubmed publisher
Mawhinney E, Craig J, Morrow J, Russell A, Smithson W, Parsons L, et al. Levetiracetam in pregnancy: results from the UK and Ireland epilepsy and pregnancy registers. Neurology. 2013;80:400-5 pubmed publisher
Lee G, Kim B, Kang J, Lee S. Loss of the initial efficacy of levetiracetam in patients with refractory epilepsy. Seizure. 2013;22:185-8 pubmed publisher
Steinhoff B, Maren Staack A, Wisniewski I. Seizure control with antiepileptic drug therapy in 517 consecutive adult outpatients at the Kork Epilepsy Centre. Epileptic Disord. 2012;14:379-87 pubmed publisher
Almeida D, Jean M, Chystsiakova A, Monahan E, Oliveira S, Monteiro I. Levetiracetam-associated acute pancreatitis in an adolescent with autism: a case report. Pancreas. 2013;42:177-8 pubmed publisher
Asadullaev M, Saidvaliev F, Shermukhamedova F, Rizvonov Z, Vakhabova N. [Assessment of multimodal effect of cytoflavin in the acute brain stroke in patients with metabolic syndrome]. Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112:24-7 pubmed
Zaitone S, Abo Elmatty D, Elshazly S. Piracetam and vinpocetine ameliorate rotenone-induced Parkinsonism in rats. Indian J Pharmacol. 2012;44:774-9 pubmed publisher
Martikainen M, Päivärinta M, Jääskeläinen S, Majamaa K. Successful treatment of POLG-related mitochondrial epilepsy with antiepileptic drugs and low glycaemic index diet. Epileptic Disord. 2012;14:438-41 pubmed publisher
Maschio M, Dinapoli L, Sperati F, Pace A, Fabi A, Vidiri A, et al. Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study. Epileptic Disord. 2012;14:388-97 pubmed publisher
Sönnichsen A. The problem of non-superiority: what do we know after KOMET?. J Neurol Neurosurg Psychiatry. 2013;84:1067 pubmed publisher
Ricci S, Celani M, Cantisani T, Righetti E. Piracetam for acute ischaemic stroke. Cochrane Database Syst Rev. 2012;:CD000419 pubmed publisher
Trinka E, Marson A, Van Paesschen W, Kälviäinen R, Marovac J, Duncan B, et al. KOMET: an unblinded, randomised, two parallel-group, stratified trial comparing the effectiveness of levetiracetam with controlled-release carbamazepine and extended-release sodium valproate as monotherapy in patients with newly diagnosed epilepsy. J Neurol Neurosurg Psychiatry. 2013;84:1138-47 pubmed publisher
Hofmeyr G, Kulier R. Piracetam for fetal distress in labour. Cochrane Database Syst Rev. 2012;:CD001064 pubmed publisher
Guandalini L, Martini E, Di Cesare Mannelli L, Dei S, Manetti D, Scapecchi S, et al. Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs. Bioorg Med Chem Lett. 2012;22:1936-9 pubmed publisher
Martini E, Di Cesare Mannelli L, Bartolucci G, Bertucci C, Dei S, Ghelardini C, et al. Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs. J Med Chem. 2011;54:2512-6 pubmed publisher
Malykh A, Sadaie M. Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders. Drugs. 2010;70:287-312 pubmed publisher
Ahmed A, Oswald R. Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors. J Med Chem. 2010;53:2197-203 pubmed publisher
Martini E, Salvicchi A, Ghelardini C, Manetti D, Dei S, Guandalini L, et al. Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. Bioorg Med Chem. 2009;17:7606-14 pubmed publisher
Martini E, Norcini M, Ghelardini C, Manetti D, Dei S, Guandalini L, et al. Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. Bioorg Med Chem. 2008;16:10034-42 pubmed publisher
Wheble P, Sena E, Macleod M. A systematic review and meta-analysis of the efficacy of piracetam and piracetam-like compounds in experimental stroke. Cerebrovasc Dis. 2008;25:5-11 pubmed
Marwaha A, Goel R, Mahajan M. PASS-predicted design, synthesis and biological evaluation of cyclic nitrones as nootropics. Bioorg Med Chem Lett. 2007;17:5251-5 pubmed
Al Hajeri A, Fedorowicz Z, Omran A, Tadmouri G. Piracetam for reducing the incidence of painful sickle cell disease crises. Cochrane Database Syst Rev. 2007;:CD006111 pubmed
Diamandis P, Wildenhain J, Clarke I, Sacher A, Graham J, Bellows D, et al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol. 2007;3:268-73 pubmed
Ricci S, Celani M, Cantisani A, Righetti E. Piracetam for acute ischaemic stroke. Cochrane Database Syst Rev. 2006;:CD000419 pubmed
Winnicka K, Tomasiak M, Bielawska A. Piracetam--an old drug with novel properties?. Acta Pol Pharm. 2005;62:405-9 pubmed
Winblad B. Piracetam: a review of pharmacological properties and clinical uses. CNS Drug Rev. 2005;11:169-82 pubmed
Ricci S, Celani M, Cantisani A, Righetti E. Piracetam for acute ischaemic stroke. Cochrane Database Syst Rev. 2002;:CD000419 pubmed
Kondakor I. [Effects of piracetam on the cognitive functions verified by electrophysiologic methods]. Orv Hetil. 2002;143:1129-33 pubmed
Hofmeyr G, Kulier R. Piracetam for fetal distress in labour. Cochrane Database Syst Rev. 2002;:CD001064 pubmed
Gualtieri F, Manetti D, Romanelli M, Ghelardini C. Design and study of piracetam-like nootropics, controversial members of the problematic class of cognition-enhancing drugs. Curr Pharm Des. 2002;8:125-38 pubmed
Flicker L, Grimley Evans G. Piracetam for dementia or cognitive impairment. Cochrane Database Syst Rev. 2001;:CD001011 pubmed
Tajima K, Nanri M. [A pharmacological profile of piracetam (Myocalm), a drug for myoclonus]. Nihon Yakurigaku Zasshi. 2000;116:209-14 pubmed
Genton P, Van Vleymen B. Piracetam and levetiracetam: close structural similarities but different pharmacological and clinical profiles. Epileptic Disord. 2000;2:99-105 pubmed
Flicker L, Grimley Evans J. Piracetam for dementia or cognitive impairment. Cochrane Database Syst Rev. 2000;:CD001011 pubmed
Ricci S, Celani M, Cantisani A, Righetti E. Piracetam for acute ischaemic stroke. Cochrane Database Syst Rev. 2000;:CD000419 pubmed
Hofmeyr G, Kulier R. Piracetam for fetal distress in labour. Cochrane Database Syst Rev. 2000;:CD001064 pubmed
Noorbala A, Akhondzadeh S, Davari Ashtiani R, Amini Nooshabadi H. Piracetam in the treatment of schizophrenia: implications for the glutamate hypothesis of schizophrenia. J Clin Pharm Ther. 1999;24:369-74 pubmed
Ruthrich H, Grecksch G, Krug M. Effects of piracetam on pentylenetetrazol-kindling development, hippocampal potentiation phenomena and kindling-induced learning deficit. Naunyn Schmiedebergs Arch Pharmacol. 1999;360:413-20 pubmed
Gallinat J, Moller H, Hegerl U. [Piracetam in anesthesia for prevention of postoperative delirium]. Anasthesiol Intensivmed Notfallmed Schmerzther. 1999;34:520-7 pubmed
Oosterveld W. The effectiveness of piracetam in vertigo. Pharmacopsychiatry. 1999;32 Suppl 1:54-60 pubmed
Gouliaev A, Senning A. Piracetam and other structurally related nootropics. Brain Res Brain Res Rev. 1994;19:180-222 pubmed
product information
Catalog Number :
P5295
Product Name :
Piracetam
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA