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product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Podophyllotoxin
catalog :
P4405
citations: 175
Reference
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Hochegger P, Faist J, Seebacher W, Saf R, Maser P, Kaiser M, et al. Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity. Bioorg Med Chem. 2019;27:2052-2065 pubmed publisher
Hochegger P, Faist J, Seebacher W, Saf R, Maser P, Kaiser M, et al. Antiprotozoal Activities of Tetrazole-quinolines with Aminopiperidine Linker. Med Chem. 2019;15:409-416 pubmed publisher
Verma S, Debnath U, Agarwal P, Srivastava K, Prabhakar Y. In Silico Exploration for New Antimalarials: Arylsulfonyloxy Acetimidamides as Prospective Agents. J Chem Inf Model. 2015;55:1708-19 pubmed publisher
Vasudevan S, Thomas S, Sivakumar K, Komalam R, Sreerekha K, Rajasekharan K, et al. Diaminothiazoles evade multidrug resistance in cancer cells and xenograft tumour models and develop transient specific resistance: understanding the basis of broad-spectrum versus specific resistance. Carcinogenesis. 2015;36:883-93 pubmed publisher
Roy A, Ernsting M, Undzys E, Li S. A highly tumor-targeted nanoparticle of podophyllotoxin penetrated tumor core and regressed multidrug resistant tumors. Biomaterials. 2015;52:335-46 pubmed publisher
Houël E, Fleury M, Odonne G, Nardella F, Bourdy G, Vonthron Sénécheau C, et al. Antiplasmodial and anti-inflammatory effects of an antimalarial remedy from the Wayana Amerindians, French Guiana: takamalaimë (Psidium acutangulum Mart. ex DC., Myrtaceae). J Ethnopharmacol. 2015;166:279-85 pubmed publisher
Zi C, Yang D, Dong F, Li G, Li Y, Ding Z, et al. Synthesis and antitumor activity of novel per-butyrylated glycosides of podophyllotoxin and its derivatives. Bioorg Med Chem. 2015;23:1437-46 pubmed publisher
Och M, Och A, Cieśla Ł, Kubrak T, Pecio Ł, Stochmal A, et al. Study of cytotoxic activity, podophyllotoxin, and deoxypodophyllotoxin content in selected Juniperus species cultivated in Poland. Pharm Biol. 2015;53:831-7 pubmed publisher
Keiser J, Panić G, Vargas M, Wang C, Dong Y, Gautam N, et al. Aryl hydantoin Ro 13-3978, a broad-spectrum antischistosomal. J Antimicrob Chemother. 2015;70:1788-97 pubmed publisher
Kumar P, Pal T, Sharma N, Kumar V, Sood H, Chauhan R. Expression analysis of biosynthetic pathway genes vis-à-vis podophyllotoxin content in Podophyllum hexandrum Royle. Protoplasma. 2015;252:1253-62 pubmed publisher
Kumari A, Singh H, Jha A, Swarnkar M, Shankar R, Kumar S. Transcriptome sequencing of rhizome tissue of Sinopodophyllum hexandrum at two temperatures. BMC Genomics. 2014;15:871 pubmed publisher
Cantrell C, Zheljazkov V, Carvalho C, Astatkie T, Jeliazkova E, Rosa L. Dual extraction of essential oil and podophyllotoxin from creeping juniper (Juniperus horizontalis). PLoS ONE. 2014;9:e106057 pubmed publisher
Zhao J, Wang Y, Luan L. Star-shaped polycaprolactone-polyethyleneglycol copolymer micelle-like nanoparticles for picropodophyllin delivery. J Biomed Nanotechnol. 2014;10:1627-34 pubmed
Hinojosa W, Quiróz M, Álvarez I, Castañeda P, Villarreal M, Taketa A. Anti-Helicobacter pylori, gastroprotective, anti-inflammatory, and cytotoxic activities of methanolic extracts of five different populations of Hippocratea celastroides collected in Mexico. J Ethnopharmacol. 2014;155:1156-63 pubmed publisher
Yin S, Guo W, Tao Z. Picropodophyllin inhibits tumor growth of human nasopharyngeal carcinoma in a mouse model. Biochem Biophys Res Commun. 2013;439:1-5 pubmed publisher
Liu J, Cao B, Gao Y, Bai M, Mei X, Chen H, et al. Design, synthesis, and antitumor activity of novel podophyllotoxin derivatives as potent anticancer agents. J Asian Nat Prod Res. 2013;15:985-92 pubmed publisher
Lee S. Humibacter antri sp. nov., an actinobacterium isolated from a natural cave, and emended description of the genus Humibacter. Int J Syst Evol Microbiol. 2013;63:4315-4319 pubmed publisher
Dong Z, Yao M, Wang L, Yan X, Gu X, Shi Y, et al. Abnormal expression of insulin-like growth factor-I receptor in hepatoma tissue and its inhibition to promote apoptosis of tumor cells. Tumour Biol. 2013;34:3397-405 pubmed
Mohan R, Katrukha E, Doodhi H, Smal I, Meijering E, Kapitein L, et al. End-binding proteins sensitize microtubules to the action of microtubule-targeting agents. Proc Natl Acad Sci U S A. 2013;110:8900-5 pubmed publisher
Lu X, Wang L, Mei J, Wang X, Zhu X, Zhang Q, et al. Picropodophyllin inhibits epithelial ovarian cancer cells in vitro and in vivo. Biochem Biophys Res Commun. 2013;435:385-90 pubmed publisher
Kruczynski A, Pillon A, Creancier L, Vandenberghe I, Gomes B, Brel V, et al. F14512, a polyamine-vectorized anti-cancer drug, currently in clinical trials exhibits a marked preclinical anti-leukemic activity. Leukemia. 2013;27:2139-48 pubmed publisher
Rostoker R, Bitton Worms K, Caspi A, Shen Orr Z, LeRoith D. Investigating new therapeutic strategies targeting hyperinsulinemia's mitogenic effects in a female mouse breast cancer model. Endocrinology. 2013;154:1701-10 pubmed publisher
Feng G, Zhang J, Yang L, Liu Y, Zhang Z, Tian X, et al. Antifeedant activity of spin-labeled derivatives of deoxypodophyllotoxin against Brontispa longissima larvae. Nat Prod Commun. 2013;8:199-202 pubmed
Wu Z, Zhou P, Li X, Wang H, Luo D, Qiao H, et al. Structural characterization of a recombinant fusion protein by instrumental analysis and molecular modeling. PLoS ONE. 2013;8:e57642 pubmed publisher
Yang Z, Liu X, Wang K, Cao X, Wu S. Novel linear and step-gradient counter-current chromatography for bio-guided isolation and purification of cytotoxic podophyllotoxins from Dysosma versipellis (Hance). J Sep Sci. 2013;36:1022-8 pubmed publisher
Steben M, Ouhoummane N, Rodier C, Brassard P. Temporal trends in genital warts among individuals covered by the public prescription drug insurance plan in the province of Quebec, Canada, from 1998 to 2007. J Low Genit Tract Dis. 2013;17:147-53 pubmed publisher
Wang B, Chen L, Zhen H, Zhou L, Shi P, Huang Z. Proteomic changes induced by podophyllotoxin in human cervical carcinoma HeLa cells. Am J Chin Med. 2013;41:163-75 pubmed publisher
Kim K, Cho H, Yu S, Kim S, Yu H, Park Y, et al. Interplay of reactive oxygen species, intracellular Ca2+ and mitochondrial homeostasis in the apoptosis of prostate cancer cells by deoxypodophyllotoxin. J Cell Biochem. 2013;114:1124-34 pubmed publisher
Kamal A, Tamboli J, Vishnuvardhan M, Adil S, Nayak V, Ramakrishna S. Synthesis and anticancer activity of heteroaromatic linked 4β-amido podophyllotoxins as apoptotic inducing agents. Bioorg Med Chem Lett. 2013;23:273-80 pubmed publisher
. [Item 149--Epithelial and melanotic skin tumors: human papillomavirus (HPV) tumors]. Ann Dermatol Venereol. 2012;139:A144-9 pubmed publisher
Marques J, Kim K, Lee C, Costa M, May G, Crow J, et al. Next generation sequencing in predicting gene function in podophyllotoxin biosynthesis. J Biol Chem. 2013;288:466-79 pubmed publisher
Saiz Jimenez C, Miller A, Martin Sanchez P, Hernandez Marine M. Uncovering the origin of the black stains in Lascaux Cave in France. Environ Microbiol. 2012;14:3220-31 pubmed publisher
Li J, Dai C, Sun H, Jin L, Guo C, Cao W, et al. Protective effects and mechanisms of curcumin on podophyllotoxin toxicity in vitro and in vivo. Toxicol Appl Pharmacol. 2012;265:190-9 pubmed publisher
Merzouki A, Buschmann M, Jean M, Young R, Liao S, Gal S, et al. Adva-27a, a novel podophyllotoxin derivative found to be effective against multidrug resistant human cancer cells. Anticancer Res. 2012;32:4423-32 pubmed
Liu Y, Wei D, Zhao Y, Cheng W, Lu Y, Ma Y, et al. Synthesis and biological evaluation of a series of podophyllotoxins derivatives as a class of potent antitubulin agents. Bioorg Med Chem. 2012;20:6285-95 pubmed publisher
Joerger M. Prevention and handling of acute allergic and infusion reactions in oncology. Ann Oncol. 2012;23 Suppl 10:x313-9 pubmed
Magedov I, Evdokimov N, Karki M, Peretti A, Lima D, Frolova L, et al. Reengineered epipodophyllotoxin. Chem Commun (Camb). 2012;48:10416-8 pubmed
Hammarlund K, Nystrom M, Jomeen J. Young women's experiences of managing self-treatment for anogenital warts. Sex Reprod Healthc. 2012;3:117-21 pubmed publisher
Vose J, Bierman P, Loberiza F, Enke C, Hankins J, Bociek R, et al. Phase II trial of 131-Iodine tositumomab with high-dose chemotherapy and autologous stem cell transplantation for relapsed diffuse large B cell lymphoma. Biol Blood Marrow Transplant. 2013;19:123-8 pubmed publisher
Zhu Q, Liu F, Xu M, Lin X, Wang X. Ultrahigh pressure extraction of lignan compounds from Dysosma versipellis and purification by high-speed counter-current chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2012;905:145-9 pubmed publisher
Thanh V, Pham V, Mai H, Litaudon M, Guéritte F, Retailleau P, et al. Cytotoxic lignans from fruits of Cleistanthus indochinensis: synthesis of cleistantoxin derivatives. J Nat Prod. 2012;75:1578-83 pubmed
Ferreri A, Bruno Ventre M, Donadoni G, Cattaneo C, Fumagalli L, Foppoli M, et al. Safety and activity of a new intensive short-term chemoimmunotherapy in HIV-positive patients with Burkitt lymphoma. Br J Haematol. 2012;159:252-5 pubmed publisher
O Meara A, Halter J, Heim D, Gerull S, Bucher C, Passweg J, et al. Allogeneic stem cell transplantation for relapsed or refractory lymphoma after conditioning with BEAM/fludarabine/TBI. Biol Blood Marrow Transplant. 2013;19:82-6 pubmed publisher
Rojas Sepúlveda A, Mendieta Serrano M, Mojica M, Salas Vidal E, Marquina S, Villarreal M, et al. Cytotoxic podophyllotoxin type-lignans from the steam bark of Bursera fagaroides var. fagaroides. Molecules. 2012;17:9506-19 pubmed publisher
McCracken S, Kaiser M, Boshoff H, Boyd P, Copp B. Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers. Bioorg Med Chem. 2012;20:1482-93 pubmed publisher
Huang W, Liu J, Liu J, Hui L, Ding Y, Chen S. Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7. Eur J Med Chem. 2012;49:48-54 pubmed publisher
Dürüst Y, Karakuş H, Kaiser M, Tasdemir D. Synthesis and anti-protozoal activity of novel dihydropyrrolo[3,4-d][1,2,3]triazoles. Eur J Med Chem. 2012;48:296-304 pubmed publisher
Avupati V, Yejella R, Guntuku G, Gunta P. Synthesis, characterization and in vitro biological evaluation of some novel diarylsulfonylureas as potential cytotoxic and antimicrobial agents. Bioorg Med Chem Lett. 2012;22:1031-5 pubmed publisher
Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W. Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS Comput Biol. 2011;7:e1002310 pubmed publisher
Kamal A, Mallareddy A, Suresh P, Lakshma Nayak V, Shetti R, Sankara Rao N, et al. Synthesis and anticancer activity of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxins as apoptotic inducing agents. Eur J Med Chem. 2012;47:530-45 pubmed publisher
Mayence A, Vanden Eynde J, Kaiser M, Brun R, Yarlett N, Huang T. Bis(oxyphenylene)benzimidazoles: a novel class of anti-Plasmodium falciparum agents. Bioorg Med Chem. 2011;19:7493-500 pubmed publisher
Bouchikhi F, Anizon F, Brun R, Moreau P. Biological evaluation of glycosyl-isoindigo derivatives against the pathogenic agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis). Bioorg Med Chem Lett. 2011;21:6319-21 pubmed publisher
Semenova M, Kiselyov A, Tsyganov D, Konyushkin L, Firgang S, Semenov R, et al. Polyalkoxybenzenes from plants. 5. Parsley seed extract in synthesis of azapodophyllotoxins featuring strong tubulin destabilizing activity in the sea urchin embryo and cell culture assays. J Med Chem. 2011;54:7138-49 pubmed publisher
Shi X, Ge J, Liu B, Kaiser M, Wittlin S, Brun R, et al. Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives. Bioorg Med Chem Lett. 2011;21:5804-7 pubmed publisher
Chan S, Pearce A, Page M, Kaiser M, Copp B. Antimalarial β-carbolines from the New Zealand ascidian Pseudodistoma opacum. J Nat Prod. 2011;74:1972-9 pubmed publisher
Lu W, Fu C, Zhao Y. [Review on biosynthesis of podophyllotoxin]. Zhongguo Zhong Yao Za Zhi. 2011;36:1109-14 pubmed
Kumar A, Kumar V, Alegria A, Malhotra S. Synthetic and application perspectives of azapodophyllotoxins: alternative scaffolds of podophyllotoxin. Curr Med Chem. 2011;18:3853-70 pubmed
Chen H, Zuo S, Wang X, Tang X, Zhao M, Lu Y, et al. Synthesis of 4β-triazole-podophyllotoxin derivatives by azide-alkyne cycloaddition and biological evaluation as potential antitumor agents. Eur J Med Chem. 2011;46:4709-14 pubmed publisher
Kamal A, Suresh P, Janaki Ramaiah M, Mallareddy A, Kumar B, Raju P, et al. Synthesis and biological evaluation of 4β-acrylamidopodophyllotoxin congeners as DNA damaging agents. Bioorg Med Chem. 2011;19:4589-600 pubmed publisher
Prinz H, Schmidt P, Böhm K, Baasner S, Muller K, Gerlach M, et al. Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization. Bioorg Med Chem. 2011;19:4183-91 pubmed publisher
Singh P, Sachdeva S, Raj R, Kumar V, Mahajan M, Nasser S, et al. Antiplasmodial and cytotoxicity evaluation of 3-functionalized 2-azetidinone derivatives. Bioorg Med Chem Lett. 2011;21:4561-3 pubmed publisher
Ndakala A, Gessner R, Gitari P, October N, White K, Hudson A, et al. Antimalarial pyrido[1,2-a]benzimidazoles. J Med Chem. 2011;54:4581-9 pubmed publisher
Magedov I, Frolova L, Manpadi M, Bhoga U, Tang H, Evdokimov N, et al. Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis. J Med Chem. 2011;54:4234-46 pubmed publisher
Sun Y, Li Z, Chen H, Liu X, Zhou W, Hua H. Three new cytotoxic aryltetralin lignans from Sinopodophyllum emodi. Bioorg Med Chem Lett. 2011;21:3794-7 pubmed publisher
Prinz H, Chamasmani B, Vogel K, Böhm K, Aicher B, Gerlach M, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011;54:4247-63 pubmed publisher
Okanya P, Mohr K, Gerth K, Jansen R, Muller R. Marinoquinolines A-F, pyrroloquinolines from Ohtaekwangia kribbensis (Bacteroidetes). J Nat Prod. 2011;74:603-8 pubmed publisher
Gachet M, Kunert O, Kaiser M, Brun R, Zehl M, Keller W, et al. Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense. J Nat Prod. 2011;74:559-66 pubmed publisher
Baragaña B, McCarthy O, Sanchez P, Bosch Navarrete C, Kaiser M, Brun R, et al. ?-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. Bioorg Med Chem. 2011;19:2378-91 pubmed publisher
Kamal A, Suresh P, Mallareddy A, Kumar B, Reddy P, Raju P, et al. Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents. Bioorg Med Chem. 2011;19:2349-58 pubmed publisher
Finlayson R, Pearce A, Page M, Kaiser M, Bourguet Kondracki M, Harper J, et al. Didemnidines A and B, indole spermidine alkaloids from the New Zealand ascidian Didemnum sp. J Nat Prod. 2011;74:888-92 pubmed publisher
Kamal A, Kumar B, Suresh P, Shankaraiah N, Kumar M. An efficient one-pot synthesis of benzothiazolo-4β-anilino-podophyllotoxin congeners: DNA topoisomerase-II inhibition and anticancer activity. Bioorg Med Chem Lett. 2011;21:350-3 pubmed publisher
Reid C, Patrick D, He S, Fotie J, Premalatha K, Tidwell R, et al. Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation. Bioorg Med Chem. 2011;19:513-23 pubmed publisher
Tasdemir D, Sanabria D, Lauinger I, Tarun A, Herman R, Perozzo R, et al. 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Bioorg Med Chem. 2010;18:7475-85 pubmed publisher
Bringmann G, Bischof S, Muller S, Gulder T, Winter C, Stich A, et al. QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids. Eur J Med Chem. 2010;45:5370-83 pubmed publisher
Vantikommu J, Palle S, Reddy P, Ramanatham V, Khagga M, Pallapothula V. Synthesis and cytotoxicity evaluation of novel 1,4-disubstituted 1,2,3-triazoles via CuI catalysed 1,3-dipolar cycloaddition. Eur J Med Chem. 2010;45:5044-50 pubmed publisher
Regalado E, Tasdemir D, Kaiser M, Cachet N, Amade P, Thomas O. Antiprotozoal steroidal saponins from the marine sponge Pandaros acanthifolium. J Nat Prod. 2010;73:1404-10 pubmed publisher
Surkau G, Böhm K, Muller K, Prinz H. Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives. Eur J Med Chem. 2010;45:3354-64 pubmed publisher
Nickel H, Schmidt P, Böhm K, Baasner S, Muller K, Gerlach M, et al. Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety. Eur J Med Chem. 2010;45:3420-38 pubmed publisher
Gachet M, Kunert O, Kaiser M, Brun R, Munoz R, Bauer R, et al. Jacaranone-derived glucosidic esters from Jacaranda glabra and their activity against Plasmodium falciparum. J Nat Prod. 2010;73:553-6 pubmed publisher
Lee K. Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. J Nat Prod. 2010;73:500-16 pubmed publisher
Holloway G, Parisot J, Novello P, Watson K, Armstrong T, Thompson R, et al. Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi. Bioorg Med Chem Lett. 2010;20:1816-8 pubmed publisher
Uddin M, Smithson D, Brown K, Crews B, Connelly M, Zhu F, et al. Podophyllotoxin analogues active versus Trypanosoma brucei. Bioorg Med Chem Lett. 2010;20:1787-91 pubmed publisher
Kiselyov A, Semenova M, Chernyshova N, Leitao A, Samet A, Kislyi K, et al. Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays. Eur J Med Chem. 2010;45:1683-97 pubmed publisher
Castro M, del Corral J, Garcia P, Rojo M, de la Iglesia Vicente J, Mollinedo F, et al. Synthesis and biological evaluation of new podophyllic aldehyde derivatives with cytotoxic and apoptosis-inducing activities. J Med Chem. 2010;53:983-93 pubmed publisher
Fotie J, Kaiser M, Delfin D, Manley J, Reid C, Paris J, et al. Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives. J Med Chem. 2010;53:966-82 pubmed publisher
Fourches D, Barnes J, Day N, Bradley P, Reed J, Tropsha A. Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chem Res Toxicol. 2010;23:171-83 pubmed publisher
Pagliero R, Lusvarghi S, Pierini A, Brun R, Mazzieri M. Synthesis, stereoelectronic characterization and antiparasitic activity of new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinolines. Bioorg Med Chem. 2010;18:142-50 pubmed publisher
Bakunov S, Bakunova S, Wenzler T, Ghebru M, Werbovetz K, Brun R, et al. Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles. J Med Chem. 2010;53:254-72 pubmed publisher
Passarella D, Peretto B, Blasco y Yepes R, Cappelletti G, Cartelli D, Ronchi C, et al. Synthesis and biological evaluation of novel thiocolchicine-podophyllotoxin conjugates. Eur J Med Chem. 2010;45:219-26 pubmed publisher
Van Baelen G, Hostyn S, Dhooghe L, Tapolcsányi P, Matyus P, Lemiere G, et al. Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues. Bioorg Med Chem. 2009;17:7209-17 pubmed publisher
Yuan J, Johnson R, Huang R, Wichterman J, Jiang H, Hayton K, et al. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat Chem Biol. 2009;5:765-71 pubmed publisher
Bakunova S, Bakunov S, Wenzler T, Barszcz T, Werbovetz K, Brun R, et al. Synthesis and antiprotozoal activity of pyridyl analogues of pentamidine. J Med Chem. 2009;52:4657-67 pubmed publisher
Cavalli A, Lizzi F, Bongarzone S, Brun R, Luise Krauth Siegel R, Bolognesi M. Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase. Bioorg Med Chem Lett. 2009;19:3031-5 pubmed publisher
Patrick D, Bakunov S, Bakunova S, Kumar E, Chen H, Jones S, et al. Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes. Eur J Med Chem. 2009;44:3543-51 pubmed publisher
Wolfgang G, Shibata R, Wang J, Ray A, Wu S, Doerrfler E, et al. GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. Antimicrob Agents Chemother. 2009;53:2777-84 pubmed publisher
Holloway G, Charman W, Fairlamb A, Brun R, Kaiser M, Kostewicz E, et al. Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity. Antimicrob Agents Chemother. 2009;53:2824-33 pubmed publisher
Chen S, Xiang R, Liu J, Tian X. Synthesis and biological evaluation of novel conjugates of podophyllotoxin and 5-FU as antineoplastic agents. Bioorg Med Chem. 2009;17:3111-7 pubmed publisher
Bakunova S, Bakunov S, Patrick D, Kumar E, Ohemeng K, Bridges A, et al. Structure-activity study of pentamidine analogues as antiprotozoal agents. J Med Chem. 2009;52:2016-35 pubmed publisher
Prinz H, Schmidt P, Böhm K, Baasner S, Muller K, Unger E, et al. 10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2009;52:1284-94 pubmed publisher
Efange S, Brun R, Wittlin S, Connolly J, Hoye T, McAkam T, et al. Okundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from Scleria striatinux with antiplasmodial activity. J Nat Prod. 2009;72:280-3 pubmed publisher
Delfin D, Morgan R, Zhu X, Werbovetz K. Redox-active dinitrodiphenylthioethers against Leishmania: synthesis, structure-activity relationships and mechanism of action studies. Bioorg Med Chem. 2009;17:820-9 pubmed publisher
Sturm N, Hu Y, Zimmermann H, Fritz Wolf K, Wittlin S, Rahlfs S, et al. Compounds structurally related to ellagic acid show improved antiplasmodial activity. Antimicrob Agents Chemother. 2009;53:622-30 pubmed publisher
Alp M, Goker H, Brun R, Yildiz S. Synthesis and antiparasitic and antifungal evaluation of 2'-arylsubstituted-1H,1'H-[2,5']bisbenzimidazolyl-5-carboxamidines. Eur J Med Chem. 2009;44:2002-8 pubmed publisher
Bakunov S, Bakunova S, Wenzler T, Barszcz T, Werbovetz K, Brun R, et al. Synthesis and antiprotozoal activity of cationic 2-phenylbenzofurans. J Med Chem. 2008;51:6927-44 pubmed publisher
Pontius A, Krick A, Kehraus S, Brun R, König G. Antiprotozoal activities of heterocyclic-substituted xanthones from the marine-derived fungus Chaetomium sp. J Nat Prod. 2008;71:1579-84 pubmed publisher
Nussbaumer P, Winiski A. Structure-activity relationship studies on a novel class of antiproliferative agents derived from Lavendustin A. Part I: Ring A modifications. Bioorg Med Chem. 2008;16:7552-60 pubmed publisher
Saxena H, Faridi U, Srivastava S, Kumar J, Darokar M, Luqman S, et al. Gallic acid-based indanone derivatives as anticancer agents. Bioorg Med Chem Lett. 2008;18:3914-8 pubmed publisher
Schlapper C, Seebacher W, Faist J, Kaiser M, Brun R, Saf R, et al. Antiplasmodial and antitrypanosomal activities of aminobicyclo[2.2.2]octyl omega-aminoalkanoates. Eur J Med Chem. 2009;44:736-44 pubmed publisher
Ge J, Arai C, Kaiser M, Wittlin S, Brun R, Ihara M. Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive 3,7-bis(dialkylamino)phenoxazin-5-ium derivatives. J Med Chem. 2008;51:3654-8 pubmed publisher
Passarella D, Giardini A, Peretto B, Fontana G, Sacchetti A, Silvani A, et al. Inhibitors of tubulin polymerization: synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III. Bioorg Med Chem. 2008;16:6269-85 pubmed publisher
Saitoh T, Kuramochi K, Imai T, Takata K, Takehara M, Kobayashi S, et al. Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro. Bioorg Med Chem. 2008;16:5815-25 pubmed publisher
Magedov I, Manpadi M, Ogasawara M, Dhawan A, Rogelj S, Van Slambrouck S, et al. Structural simplification of bioactive natural products with multicomponent synthesis. 2. antiproliferative and antitubulin activities of pyrano[3,2-c]pyridones and pyrano[3,2-c]quinolones. J Med Chem. 2008;51:2561-70 pubmed publisher
Raghavan B, Balasubramanian R, Steele J, Sackett D, Fecik R. Cytotoxic simplified tubulysin analogues. J Med Chem. 2008;51:1530-3 pubmed publisher
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product information
Catalog Number :
P4405
Product Name :
Podophyllotoxin
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA