Reference |
---|
Bala Bhaskara Rao K, Katragunta K, Sarma U, Jain N. Abundance of d-2-hydroxyglutarate in G2/M is determined by FOXM1 in mutant IDH1-expressing cells. FEBS Lett. 2019;: pubmed publisher
|
Hochegger P, Faist J, Seebacher W, Saf R, Maser P, Kaiser M, et al. Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity. Bioorg Med Chem. 2019;27:2052-2065 pubmed publisher
|
Hochegger P, Faist J, Seebacher W, Saf R, Maser P, Kaiser M, et al. Antiprotozoal Activities of Tetrazole-quinolines with Aminopiperidine Linker. Med Chem. 2019;15:409-416 pubmed publisher
|
Verma S, Debnath U, Agarwal P, Srivastava K, Prabhakar Y. In Silico Exploration for New Antimalarials: Arylsulfonyloxy Acetimidamides as Prospective Agents. J Chem Inf Model. 2015;55:1708-19 pubmed publisher
|
Vasudevan S, Thomas S, Sivakumar K, Komalam R, Sreerekha K, Rajasekharan K, et al. Diaminothiazoles evade multidrug resistance in cancer cells and xenograft tumour models and develop transient specific resistance: understanding the basis of broad-spectrum versus specific resistance. Carcinogenesis. 2015;36:883-93 pubmed publisher
|
Roy A, Ernsting M, Undzys E, Li S. A highly tumor-targeted nanoparticle of podophyllotoxin penetrated tumor core and regressed multidrug resistant tumors. Biomaterials. 2015;52:335-46 pubmed publisher
|
Houël E, Fleury M, Odonne G, Nardella F, Bourdy G, Vonthron Sénécheau C, et al. Antiplasmodial and anti-inflammatory effects of an antimalarial remedy from the Wayana Amerindians, French Guiana: takamalaimë (Psidium acutangulum Mart. ex DC., Myrtaceae). J Ethnopharmacol. 2015;166:279-85 pubmed publisher
|
Zi C, Yang D, Dong F, Li G, Li Y, Ding Z, et al. Synthesis and antitumor activity of novel per-butyrylated glycosides of podophyllotoxin and its derivatives. Bioorg Med Chem. 2015;23:1437-46 pubmed publisher
|
Och M, Och A, Cieśla Ł, Kubrak T, Pecio Ł, Stochmal A, et al. Study of cytotoxic activity, podophyllotoxin, and deoxypodophyllotoxin content in selected Juniperus species cultivated in Poland. Pharm Biol. 2015;53:831-7 pubmed publisher
|
Keiser J, Panić G, Vargas M, Wang C, Dong Y, Gautam N, et al. Aryl hydantoin Ro 13-3978, a broad-spectrum antischistosomal. J Antimicrob Chemother. 2015;70:1788-97 pubmed publisher
|
Kumar P, Pal T, Sharma N, Kumar V, Sood H, Chauhan R. Expression analysis of biosynthetic pathway genes vis-à-vis podophyllotoxin content in Podophyllum hexandrum Royle. Protoplasma. 2015;252:1253-62 pubmed publisher
|
Kumari A, Singh H, Jha A, Swarnkar M, Shankar R, Kumar S. Transcriptome sequencing of rhizome tissue of Sinopodophyllum hexandrum at two temperatures. BMC Genomics. 2014;15:871 pubmed publisher
|
Cantrell C, Zheljazkov V, Carvalho C, Astatkie T, Jeliazkova E, Rosa L. Dual extraction of essential oil and podophyllotoxin from creeping juniper (Juniperus horizontalis). PLoS ONE. 2014;9:e106057 pubmed publisher
|
Zhao J, Wang Y, Luan L. Star-shaped polycaprolactone-polyethyleneglycol copolymer micelle-like nanoparticles for picropodophyllin delivery. J Biomed Nanotechnol. 2014;10:1627-34 pubmed
|
Hinojosa W, Quiróz M, Álvarez I, Castañeda P, Villarreal M, Taketa A. Anti-Helicobacter pylori, gastroprotective, anti-inflammatory, and cytotoxic activities of methanolic extracts of five different populations of Hippocratea celastroides collected in Mexico. J Ethnopharmacol. 2014;155:1156-63 pubmed publisher
|
Yin S, Guo W, Tao Z. Picropodophyllin inhibits tumor growth of human nasopharyngeal carcinoma in a mouse model. Biochem Biophys Res Commun. 2013;439:1-5 pubmed publisher
|
Liu J, Cao B, Gao Y, Bai M, Mei X, Chen H, et al. Design, synthesis, and antitumor activity of novel podophyllotoxin derivatives as potent anticancer agents. J Asian Nat Prod Res. 2013;15:985-92 pubmed publisher
|
Lee S. Humibacter antri sp. nov., an actinobacterium isolated from a natural cave, and emended description of the genus Humibacter. Int J Syst Evol Microbiol. 2013;63:4315-4319 pubmed publisher
|
Dong Z, Yao M, Wang L, Yan X, Gu X, Shi Y, et al. Abnormal expression of insulin-like growth factor-I receptor in hepatoma tissue and its inhibition to promote apoptosis of tumor cells. Tumour Biol. 2013;34:3397-405 pubmed
|
Mohan R, Katrukha E, Doodhi H, Smal I, Meijering E, Kapitein L, et al. End-binding proteins sensitize microtubules to the action of microtubule-targeting agents. Proc Natl Acad Sci U S A. 2013;110:8900-5 pubmed publisher
|
Lu X, Wang L, Mei J, Wang X, Zhu X, Zhang Q, et al. Picropodophyllin inhibits epithelial ovarian cancer cells in vitro and in vivo. Biochem Biophys Res Commun. 2013;435:385-90 pubmed publisher
|
Kruczynski A, Pillon A, Creancier L, Vandenberghe I, Gomes B, Brel V, et al. F14512, a polyamine-vectorized anti-cancer drug, currently in clinical trials exhibits a marked preclinical anti-leukemic activity. Leukemia. 2013;27:2139-48 pubmed publisher
|
Rostoker R, Bitton Worms K, Caspi A, Shen Orr Z, LeRoith D. Investigating new therapeutic strategies targeting hyperinsulinemia's mitogenic effects in a female mouse breast cancer model. Endocrinology. 2013;154:1701-10 pubmed publisher
|
Feng G, Zhang J, Yang L, Liu Y, Zhang Z, Tian X, et al. Antifeedant activity of spin-labeled derivatives of deoxypodophyllotoxin against Brontispa longissima larvae. Nat Prod Commun. 2013;8:199-202 pubmed
|
Wu Z, Zhou P, Li X, Wang H, Luo D, Qiao H, et al. Structural characterization of a recombinant fusion protein by instrumental analysis and molecular modeling. PLoS ONE. 2013;8:e57642 pubmed publisher
|
Yang Z, Liu X, Wang K, Cao X, Wu S. Novel linear and step-gradient counter-current chromatography for bio-guided isolation and purification of cytotoxic podophyllotoxins from Dysosma versipellis (Hance). J Sep Sci. 2013;36:1022-8 pubmed publisher
|
Steben M, Ouhoummane N, Rodier C, Brassard P. Temporal trends in genital warts among individuals covered by the public prescription drug insurance plan in the province of Quebec, Canada, from 1998 to 2007. J Low Genit Tract Dis. 2013;17:147-53 pubmed publisher
|
Wang B, Chen L, Zhen H, Zhou L, Shi P, Huang Z. Proteomic changes induced by podophyllotoxin in human cervical carcinoma HeLa cells. Am J Chin Med. 2013;41:163-75 pubmed publisher
|
Kim K, Cho H, Yu S, Kim S, Yu H, Park Y, et al. Interplay of reactive oxygen species, intracellular Ca2+ and mitochondrial homeostasis in the apoptosis of prostate cancer cells by deoxypodophyllotoxin. J Cell Biochem. 2013;114:1124-34 pubmed publisher
|
Kamal A, Tamboli J, Vishnuvardhan M, Adil S, Nayak V, Ramakrishna S. Synthesis and anticancer activity of heteroaromatic linked 4β-amido podophyllotoxins as apoptotic inducing agents. Bioorg Med Chem Lett. 2013;23:273-80 pubmed publisher
|
. [Item 149--Epithelial and melanotic skin tumors: human papillomavirus (HPV) tumors]. Ann Dermatol Venereol. 2012;139:A144-9 pubmed publisher
|
Marques J, Kim K, Lee C, Costa M, May G, Crow J, et al. Next generation sequencing in predicting gene function in podophyllotoxin biosynthesis. J Biol Chem. 2013;288:466-79 pubmed publisher
|
Saiz Jimenez C, Miller A, Martin Sanchez P, Hernandez Marine M. Uncovering the origin of the black stains in Lascaux Cave in France. Environ Microbiol. 2012;14:3220-31 pubmed publisher
|
Li J, Dai C, Sun H, Jin L, Guo C, Cao W, et al. Protective effects and mechanisms of curcumin on podophyllotoxin toxicity in vitro and in vivo. Toxicol Appl Pharmacol. 2012;265:190-9 pubmed publisher
|
Merzouki A, Buschmann M, Jean M, Young R, Liao S, Gal S, et al. Adva-27a, a novel podophyllotoxin derivative found to be effective against multidrug resistant human cancer cells. Anticancer Res. 2012;32:4423-32 pubmed
|
Liu Y, Wei D, Zhao Y, Cheng W, Lu Y, Ma Y, et al. Synthesis and biological evaluation of a series of podophyllotoxins derivatives as a class of potent antitubulin agents. Bioorg Med Chem. 2012;20:6285-95 pubmed publisher
|
Joerger M. Prevention and handling of acute allergic and infusion reactions in oncology. Ann Oncol. 2012;23 Suppl 10:x313-9 pubmed
|
Magedov I, Evdokimov N, Karki M, Peretti A, Lima D, Frolova L, et al. Reengineered epipodophyllotoxin. Chem Commun (Camb). 2012;48:10416-8 pubmed
|
Hammarlund K, Nystrom M, Jomeen J. Young women's experiences of managing self-treatment for anogenital warts. Sex Reprod Healthc. 2012;3:117-21 pubmed publisher
|
Vose J, Bierman P, Loberiza F, Enke C, Hankins J, Bociek R, et al. Phase II trial of 131-Iodine tositumomab with high-dose chemotherapy and autologous stem cell transplantation for relapsed diffuse large B cell lymphoma. Biol Blood Marrow Transplant. 2013;19:123-8 pubmed publisher
|
Zhu Q, Liu F, Xu M, Lin X, Wang X. Ultrahigh pressure extraction of lignan compounds from Dysosma versipellis and purification by high-speed counter-current chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2012;905:145-9 pubmed publisher
|
Thanh V, Pham V, Mai H, Litaudon M, Guéritte F, Retailleau P, et al. Cytotoxic lignans from fruits of Cleistanthus indochinensis: synthesis of cleistantoxin derivatives. J Nat Prod. 2012;75:1578-83 pubmed
|
Ferreri A, Bruno Ventre M, Donadoni G, Cattaneo C, Fumagalli L, Foppoli M, et al. Safety and activity of a new intensive short-term chemoimmunotherapy in HIV-positive patients with Burkitt lymphoma. Br J Haematol. 2012;159:252-5 pubmed publisher
|
O Meara A, Halter J, Heim D, Gerull S, Bucher C, Passweg J, et al. Allogeneic stem cell transplantation for relapsed or refractory lymphoma after conditioning with BEAM/fludarabine/TBI. Biol Blood Marrow Transplant. 2013;19:82-6 pubmed publisher
|
Rojas Sepúlveda A, Mendieta Serrano M, Mojica M, Salas Vidal E, Marquina S, Villarreal M, et al. Cytotoxic podophyllotoxin type-lignans from the steam bark of Bursera fagaroides var. fagaroides. Molecules. 2012;17:9506-19 pubmed publisher
|
McCracken S, Kaiser M, Boshoff H, Boyd P, Copp B. Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers. Bioorg Med Chem. 2012;20:1482-93 pubmed publisher
|
Huang W, Liu J, Liu J, Hui L, Ding Y, Chen S. Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7. Eur J Med Chem. 2012;49:48-54 pubmed publisher
|
Dürüst Y, Karakuş H, Kaiser M, Tasdemir D. Synthesis and anti-protozoal activity of novel dihydropyrrolo[3,4-d][1,2,3]triazoles. Eur J Med Chem. 2012;48:296-304 pubmed publisher
|
Avupati V, Yejella R, Guntuku G, Gunta P. Synthesis, characterization and in vitro biological evaluation of some novel diarylsulfonylureas as potential cytotoxic and antimicrobial agents. Bioorg Med Chem Lett. 2012;22:1031-5 pubmed publisher
|
Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W. Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS Comput Biol. 2011;7:e1002310 pubmed publisher
|
Kamal A, Mallareddy A, Suresh P, Lakshma Nayak V, Shetti R, Sankara Rao N, et al. Synthesis and anticancer activity of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxins as apoptotic inducing agents. Eur J Med Chem. 2012;47:530-45 pubmed publisher
|
Mayence A, Vanden Eynde J, Kaiser M, Brun R, Yarlett N, Huang T. Bis(oxyphenylene)benzimidazoles: a novel class of anti-Plasmodium falciparum agents. Bioorg Med Chem. 2011;19:7493-500 pubmed publisher
|
Bouchikhi F, Anizon F, Brun R, Moreau P. Biological evaluation of glycosyl-isoindigo derivatives against the pathogenic agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis). Bioorg Med Chem Lett. 2011;21:6319-21 pubmed publisher
|
Semenova M, Kiselyov A, Tsyganov D, Konyushkin L, Firgang S, Semenov R, et al. Polyalkoxybenzenes from plants. 5. Parsley seed extract in synthesis of azapodophyllotoxins featuring strong tubulin destabilizing activity in the sea urchin embryo and cell culture assays. J Med Chem. 2011;54:7138-49 pubmed publisher
|
Shi X, Ge J, Liu B, Kaiser M, Wittlin S, Brun R, et al. Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives. Bioorg Med Chem Lett. 2011;21:5804-7 pubmed publisher
|
Chan S, Pearce A, Page M, Kaiser M, Copp B. Antimalarial β-carbolines from the New Zealand ascidian Pseudodistoma opacum. J Nat Prod. 2011;74:1972-9 pubmed publisher
|
Lu W, Fu C, Zhao Y. [Review on biosynthesis of podophyllotoxin]. Zhongguo Zhong Yao Za Zhi. 2011;36:1109-14 pubmed
|
Kumar A, Kumar V, Alegria A, Malhotra S. Synthetic and application perspectives of azapodophyllotoxins: alternative scaffolds of podophyllotoxin. Curr Med Chem. 2011;18:3853-70 pubmed
|
Chen H, Zuo S, Wang X, Tang X, Zhao M, Lu Y, et al. Synthesis of 4β-triazole-podophyllotoxin derivatives by azide-alkyne cycloaddition and biological evaluation as potential antitumor agents. Eur J Med Chem. 2011;46:4709-14 pubmed publisher
|
Kamal A, Suresh P, Janaki Ramaiah M, Mallareddy A, Kumar B, Raju P, et al. Synthesis and biological evaluation of 4β-acrylamidopodophyllotoxin congeners as DNA damaging agents. Bioorg Med Chem. 2011;19:4589-600 pubmed publisher
|
Prinz H, Schmidt P, Böhm K, Baasner S, Muller K, Gerlach M, et al. Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization. Bioorg Med Chem. 2011;19:4183-91 pubmed publisher
|
Singh P, Sachdeva S, Raj R, Kumar V, Mahajan M, Nasser S, et al. Antiplasmodial and cytotoxicity evaluation of 3-functionalized 2-azetidinone derivatives. Bioorg Med Chem Lett. 2011;21:4561-3 pubmed publisher
|
Ndakala A, Gessner R, Gitari P, October N, White K, Hudson A, et al. Antimalarial pyrido[1,2-a]benzimidazoles. J Med Chem. 2011;54:4581-9 pubmed publisher
|
Magedov I, Frolova L, Manpadi M, Bhoga U, Tang H, Evdokimov N, et al. Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis. J Med Chem. 2011;54:4234-46 pubmed publisher
|
Sun Y, Li Z, Chen H, Liu X, Zhou W, Hua H. Three new cytotoxic aryltetralin lignans from Sinopodophyllum emodi. Bioorg Med Chem Lett. 2011;21:3794-7 pubmed publisher
|
Prinz H, Chamasmani B, Vogel K, Böhm K, Aicher B, Gerlach M, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011;54:4247-63 pubmed publisher
|
Okanya P, Mohr K, Gerth K, Jansen R, Muller R. Marinoquinolines A-F, pyrroloquinolines from Ohtaekwangia kribbensis (Bacteroidetes). J Nat Prod. 2011;74:603-8 pubmed publisher
|
Gachet M, Kunert O, Kaiser M, Brun R, Zehl M, Keller W, et al. Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense. J Nat Prod. 2011;74:559-66 pubmed publisher
|
Baragaña B, McCarthy O, Sanchez P, Bosch Navarrete C, Kaiser M, Brun R, et al. ?-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. Bioorg Med Chem. 2011;19:2378-91 pubmed publisher
|
Kamal A, Suresh P, Mallareddy A, Kumar B, Reddy P, Raju P, et al. Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents. Bioorg Med Chem. 2011;19:2349-58 pubmed publisher
|
Finlayson R, Pearce A, Page M, Kaiser M, Bourguet Kondracki M, Harper J, et al. Didemnidines A and B, indole spermidine alkaloids from the New Zealand ascidian Didemnum sp. J Nat Prod. 2011;74:888-92 pubmed publisher
|
Kamal A, Kumar B, Suresh P, Shankaraiah N, Kumar M. An efficient one-pot synthesis of benzothiazolo-4β-anilino-podophyllotoxin congeners: DNA topoisomerase-II inhibition and anticancer activity. Bioorg Med Chem Lett. 2011;21:350-3 pubmed publisher
|
Reid C, Patrick D, He S, Fotie J, Premalatha K, Tidwell R, et al. Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation. Bioorg Med Chem. 2011;19:513-23 pubmed publisher
|
Tasdemir D, Sanabria D, Lauinger I, Tarun A, Herman R, Perozzo R, et al. 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Bioorg Med Chem. 2010;18:7475-85 pubmed publisher
|
Bringmann G, Bischof S, Muller S, Gulder T, Winter C, Stich A, et al. QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids. Eur J Med Chem. 2010;45:5370-83 pubmed publisher
|
Vantikommu J, Palle S, Reddy P, Ramanatham V, Khagga M, Pallapothula V. Synthesis and cytotoxicity evaluation of novel 1,4-disubstituted 1,2,3-triazoles via CuI catalysed 1,3-dipolar cycloaddition. Eur J Med Chem. 2010;45:5044-50 pubmed publisher
|
Regalado E, Tasdemir D, Kaiser M, Cachet N, Amade P, Thomas O. Antiprotozoal steroidal saponins from the marine sponge Pandaros acanthifolium. J Nat Prod. 2010;73:1404-10 pubmed publisher
|
Surkau G, Böhm K, Muller K, Prinz H. Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives. Eur J Med Chem. 2010;45:3354-64 pubmed publisher
|
Nickel H, Schmidt P, Böhm K, Baasner S, Muller K, Gerlach M, et al. Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety. Eur J Med Chem. 2010;45:3420-38 pubmed publisher
|
Gachet M, Kunert O, Kaiser M, Brun R, Munoz R, Bauer R, et al. Jacaranone-derived glucosidic esters from Jacaranda glabra and their activity against Plasmodium falciparum. J Nat Prod. 2010;73:553-6 pubmed publisher
|
Lee K. Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach. J Nat Prod. 2010;73:500-16 pubmed publisher
|
Holloway G, Parisot J, Novello P, Watson K, Armstrong T, Thompson R, et al. Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi. Bioorg Med Chem Lett. 2010;20:1816-8 pubmed publisher
|
Uddin M, Smithson D, Brown K, Crews B, Connelly M, Zhu F, et al. Podophyllotoxin analogues active versus Trypanosoma brucei. Bioorg Med Chem Lett. 2010;20:1787-91 pubmed publisher
|
Kiselyov A, Semenova M, Chernyshova N, Leitao A, Samet A, Kislyi K, et al. Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays. Eur J Med Chem. 2010;45:1683-97 pubmed publisher
|
Castro M, del Corral J, Garcia P, Rojo M, de la Iglesia Vicente J, Mollinedo F, et al. Synthesis and biological evaluation of new podophyllic aldehyde derivatives with cytotoxic and apoptosis-inducing activities. J Med Chem. 2010;53:983-93 pubmed publisher
|
Fotie J, Kaiser M, Delfin D, Manley J, Reid C, Paris J, et al. Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives. J Med Chem. 2010;53:966-82 pubmed publisher
|
Fourches D, Barnes J, Day N, Bradley P, Reed J, Tropsha A. Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chem Res Toxicol. 2010;23:171-83 pubmed publisher
|
Pagliero R, Lusvarghi S, Pierini A, Brun R, Mazzieri M. Synthesis, stereoelectronic characterization and antiparasitic activity of new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinolines. Bioorg Med Chem. 2010;18:142-50 pubmed publisher
|
Bakunov S, Bakunova S, Wenzler T, Ghebru M, Werbovetz K, Brun R, et al. Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles. J Med Chem. 2010;53:254-72 pubmed publisher
|
Passarella D, Peretto B, Blasco y Yepes R, Cappelletti G, Cartelli D, Ronchi C, et al. Synthesis and biological evaluation of novel thiocolchicine-podophyllotoxin conjugates. Eur J Med Chem. 2010;45:219-26 pubmed publisher
|
Van Baelen G, Hostyn S, Dhooghe L, Tapolcsányi P, Matyus P, Lemiere G, et al. Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues. Bioorg Med Chem. 2009;17:7209-17 pubmed publisher
|
Yuan J, Johnson R, Huang R, Wichterman J, Jiang H, Hayton K, et al. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat Chem Biol. 2009;5:765-71 pubmed publisher
|
Bakunova S, Bakunov S, Wenzler T, Barszcz T, Werbovetz K, Brun R, et al. Synthesis and antiprotozoal activity of pyridyl analogues of pentamidine. J Med Chem. 2009;52:4657-67 pubmed publisher
|
Cavalli A, Lizzi F, Bongarzone S, Brun R, Luise Krauth Siegel R, Bolognesi M. Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase. Bioorg Med Chem Lett. 2009;19:3031-5 pubmed publisher
|
Patrick D, Bakunov S, Bakunova S, Kumar E, Chen H, Jones S, et al. Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes. Eur J Med Chem. 2009;44:3543-51 pubmed publisher
|
Wolfgang G, Shibata R, Wang J, Ray A, Wu S, Doerrfler E, et al. GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. Antimicrob Agents Chemother. 2009;53:2777-84 pubmed publisher
|
Holloway G, Charman W, Fairlamb A, Brun R, Kaiser M, Kostewicz E, et al. Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity. Antimicrob Agents Chemother. 2009;53:2824-33 pubmed publisher
|
Chen S, Xiang R, Liu J, Tian X. Synthesis and biological evaluation of novel conjugates of podophyllotoxin and 5-FU as antineoplastic agents. Bioorg Med Chem. 2009;17:3111-7 pubmed publisher
|
Bakunova S, Bakunov S, Patrick D, Kumar E, Ohemeng K, Bridges A, et al. Structure-activity study of pentamidine analogues as antiprotozoal agents. J Med Chem. 2009;52:2016-35 pubmed publisher
|
Prinz H, Schmidt P, Böhm K, Baasner S, Muller K, Unger E, et al. 10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2009;52:1284-94 pubmed publisher
|
Efange S, Brun R, Wittlin S, Connolly J, Hoye T, McAkam T, et al. Okundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from Scleria striatinux with antiplasmodial activity. J Nat Prod. 2009;72:280-3 pubmed publisher
|
Delfin D, Morgan R, Zhu X, Werbovetz K. Redox-active dinitrodiphenylthioethers against Leishmania: synthesis, structure-activity relationships and mechanism of action studies. Bioorg Med Chem. 2009;17:820-9 pubmed publisher
|
Sturm N, Hu Y, Zimmermann H, Fritz Wolf K, Wittlin S, Rahlfs S, et al. Compounds structurally related to ellagic acid show improved antiplasmodial activity. Antimicrob Agents Chemother. 2009;53:622-30 pubmed publisher
|
Alp M, Goker H, Brun R, Yildiz S. Synthesis and antiparasitic and antifungal evaluation of 2'-arylsubstituted-1H,1'H-[2,5']bisbenzimidazolyl-5-carboxamidines. Eur J Med Chem. 2009;44:2002-8 pubmed publisher
|
Bakunov S, Bakunova S, Wenzler T, Barszcz T, Werbovetz K, Brun R, et al. Synthesis and antiprotozoal activity of cationic 2-phenylbenzofurans. J Med Chem. 2008;51:6927-44 pubmed publisher
|
Pontius A, Krick A, Kehraus S, Brun R, König G. Antiprotozoal activities of heterocyclic-substituted xanthones from the marine-derived fungus Chaetomium sp. J Nat Prod. 2008;71:1579-84 pubmed publisher
|
Nussbaumer P, Winiski A. Structure-activity relationship studies on a novel class of antiproliferative agents derived from Lavendustin A. Part I: Ring A modifications. Bioorg Med Chem. 2008;16:7552-60 pubmed publisher
|
Saxena H, Faridi U, Srivastava S, Kumar J, Darokar M, Luqman S, et al. Gallic acid-based indanone derivatives as anticancer agents. Bioorg Med Chem Lett. 2008;18:3914-8 pubmed publisher
|
Schlapper C, Seebacher W, Faist J, Kaiser M, Brun R, Saf R, et al. Antiplasmodial and antitrypanosomal activities of aminobicyclo[2.2.2]octyl omega-aminoalkanoates. Eur J Med Chem. 2009;44:736-44 pubmed publisher
|
Ge J, Arai C, Kaiser M, Wittlin S, Brun R, Ihara M. Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive 3,7-bis(dialkylamino)phenoxazin-5-ium derivatives. J Med Chem. 2008;51:3654-8 pubmed publisher
|
Passarella D, Giardini A, Peretto B, Fontana G, Sacchetti A, Silvani A, et al. Inhibitors of tubulin polymerization: synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III. Bioorg Med Chem. 2008;16:6269-85 pubmed publisher
|
Saitoh T, Kuramochi K, Imai T, Takata K, Takehara M, Kobayashi S, et al. Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro. Bioorg Med Chem. 2008;16:5815-25 pubmed publisher
|
Magedov I, Manpadi M, Ogasawara M, Dhawan A, Rogelj S, Van Slambrouck S, et al. Structural simplification of bioactive natural products with multicomponent synthesis. 2. antiproliferative and antitubulin activities of pyrano[3,2-c]pyridones and pyrano[3,2-c]quinolones. J Med Chem. 2008;51:2561-70 pubmed publisher
|
Raghavan B, Balasubramanian R, Steele J, Sackett D, Fecik R. Cytotoxic simplified tubulysin analogues. J Med Chem. 2008;51:1530-3 pubmed publisher
|
Friebolin W, Jannack B, Wenzel N, Furrer J, Oeser T, Sanchez C, et al. Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum. J Med Chem. 2008;51:1260-77 pubmed publisher
|
Magedov I, Luchetti G, Evdokimov N, Manpadi M, Steelant W, Van Slambrouck S, et al. Novel three-component synthesis and antiproliferative properties of diversely functionalized pyrrolines. Bioorg Med Chem Lett. 2008;18:1392-6 pubmed publisher
|
Vicente E, Lima L, Bongard E, Charnaud S, Villar R, Solano B, et al. Synthesis and structure-activity relationship of 3-phenylquinoxaline 1,4-di-N-oxide derivatives as antimalarial agents. Eur J Med Chem. 2008;43:1903-10 pubmed publisher
|
Bringmann G, Gampe C, Reichert Y, Bruhn T, Faber J, Mikyna M, et al. Synthesis and pharmacological evaluation of fluorescent and photoactivatable analogues of antiplasmodial naphthylisoquinolines. J Med Chem. 2007;50:6104-15 pubmed
|
Bhat B, Reddy P, Agrawal S, Saxena A, Kumar H, Qazi G. Studies on novel 4beta-[(4-substituted)-1,2,3-triazol-1-yl] podophyllotoxins as potential anticancer agents. Eur J Med Chem. 2008;43:2067-72 pubmed
|
Hu L, Li Z, Li J, Qu J, Jiang J, Boykin D. 3-(2'-Bromopropionylamino)-benzamides as novel S-phase arrest agents. Bioorg Med Chem Lett. 2007;17:6847-52 pubmed
|
Zuse A, Schmidt P, Baasner S, Böhm K, Muller K, Gerlach M, et al. Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2007;50:6059-66 pubmed
|
Kuettel S, Zambon A, Kaiser M, Brun R, Scapozza L, Perozzo R. Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives. J Med Chem. 2007;50:5833-9 pubmed
|
Bakunova S, Bakunov S, Wenzler T, Barszcz T, Werbovetz K, Brun R, et al. Synthesis and in vitro antiprotozoal activity of bisbenzofuran cations. J Med Chem. 2007;50:5807-23 pubmed
|
Senn M, Gunzenhauser S, Brun R, Séquin U. Antiprotozoal polyacetylenes from the Tanzanian medicinal plant Cussonia zimmermannii. J Nat Prod. 2007;70:1565-9 pubmed
|
Magedov I, Manpadi M, Slambrouck S, Steelant W, Rozhkova E, Przheval skii N, et al. Discovery and investigation of antiproliferative and apoptosis-inducing properties of new heterocyclic podophyllotoxin analogues accessible by a one-step multicomponent synthesis. J Med Chem. 2007;50:5183-92 pubmed
|
Imperio D, Pirali T, Galli U, Pagliai F, Cafici L, Canonico P, et al. Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry. Bioorg Med Chem. 2007;15:6748-57 pubmed
|
Tasdemir D, Topaloglu B, Perozzo R, Brun R, O Neill R, Carballeira N, et al. Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli. Bioorg Med Chem. 2007;15:6834-45 pubmed
|
Cammerer S, Jimenez C, Jones S, Gros L, Lorente S, Rodrigues C, et al. Quinuclidine derivatives as potential antiparasitics. Antimicrob Agents Chemother. 2007;51:4049-61 pubmed
|
George T, Endeshaw M, Morgan R, Mahasenan K, Delfin D, Mukherjee M, et al. Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4,N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents. Bioorg Med Chem. 2007;15:6071-9 pubmed
|
Too K, Brown D, Bongard E, Yardley V, Vivas L, Loakes D. Anti-malarial activity of N6-modified purine analogues. Bioorg Med Chem. 2007;15:5551-62 pubmed
|
Hu L, Jiang J, Qu J, Li Y, Jin J, Li Z, et al. Novel potent antimitotic heterocyclic ketones: synthesis, antiproliferative activity, and structure-activity relationships. Bioorg Med Chem Lett. 2007;17:3613-7 pubmed
|
Bringmann G, Brun R, Kaiser M, Neumann S. Synthesis and antiprotozoal activities of simplified analogs of naphthylisoquinoline alkaloids. Eur J Med Chem. 2008;43:32-42 pubmed
|
Patrick D, Bakunov S, Bakunova S, Kumar E, Lombardy R, Jones S, et al. Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles. J Med Chem. 2007;50:2468-85 pubmed
|
Diamandis P, Wildenhain J, Clarke I, Sacher A, Graham J, Bellows D, et al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol. 2007;3:268-73 pubmed
|
Chen S, Wang Y, Jin Y, Tian X, Zheng Y, Luo D, et al. Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives. Bioorg Med Chem Lett. 2007;17:2091-5 pubmed
|
Jiang R, Zhou J, Hon P, Li S, Zhou Y, Li L, et al. Lignans from Dysosma versipellis with inhibitory effects on prostate cancer cell lines. J Nat Prod. 2007;70:283-6 pubmed
|
Hay A, Ioset J, Ahua K, Diallo D, Brun R, Hostettmann K. Limonoid orthoacetates and antiprotozoal compounds from the roots of Pseudocedrela kotschyi. J Nat Prod. 2007;70:9-13 pubmed
|
Castro M, Miguel Del Corral J, Gordaliza M, Garcia P, Gómez Zurita M, San Feliciano A. Synthesis and cytotoxic evaluation of C-9 oxidized podophyllotoxin derivatives. Bioorg Med Chem. 2007;15:1670-8 pubmed
|
Hu L, Li Z, Wang Y, Wu Y, Jiang J, Boykin D. Novel pyridinyl and pyrimidinylcarbazole sulfonamides as antiproliferative agents. Bioorg Med Chem Lett. 2007;17:1193-6 pubmed
|
Magedov I, Manpadi M, Rozhkova E, Przheval skii N, Rogelj S, Shors S, et al. Structural simplification of bioactive natural products with multicomponent synthesis: dihydropyridopyrazole analogues of podophyllotoxin. Bioorg Med Chem Lett. 2007;17:1381-5 pubmed
|
Zuse A, Schmidt P, Baasner S, Böhm K, Muller K, Gerlach M, et al. 9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2006;49:7816-25 pubmed
|
Hu L, Li Z, Li Y, Qu J, Ling Y, Jiang J, et al. Synthesis and structure-activity relationships of carbazole sulfonamides as a novel class of antimitotic agents against solid tumors. J Med Chem. 2006;49:6273-82 pubmed
|
Gros L, Lorente S, Jimenez C, Yardley V, Rattray L, Wharton H, et al. Evaluation of azasterols as anti-parasitics. J Med Chem. 2006;49:6094-103 pubmed
|
Mahboobi S, Sellmer A, Höcher H, Eichhorn E, Bär T, Schmidt M, et al. [4-(imidazol-1-yl)thiazol-2-yl]phenylamines. A novel class of highly potent colchicine site binding tubulin inhibitors: synthesis and cytotoxic activity on selected human cancer cell lines. J Med Chem. 2006;49:5769-76 pubmed
|
Eyberger A, Dondapati R, Porter J. Endophyte fungal isolates from Podophyllum peltatum produce podophyllotoxin. J Nat Prod. 2006;69:1121-4 pubmed
|
Nguyen C, Ruda G, Schipani A, Kasinathan G, Leal I, Musso Buendia A, et al. Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. J Med Chem. 2006;49:4183-95 pubmed
|
Romagnoli R, Baraldi P, Pavani M, Tabrizi M, Preti D, Fruttarolo F, et al. Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents. J Med Chem. 2006;49:3906-15 pubmed
|
Mc Carthy O, Schipani A, Buendía A, Ruiz Perez L, Kaiser M, Brun R, et al. Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase. Bioorg Med Chem Lett. 2006;16:3809-12 pubmed
|
Hallur G, Jimeno A, Dalrymple S, Zhu T, Jung M, Hidalgo M, et al. Benzoylphenylurea sulfur analogues with potent antitumor activity. J Med Chem. 2006;49:2357-60 pubmed
|
Hartmann J, Lipp H. Camptothecin and podophyllotoxin derivatives: inhibitors of topoisomerase I and II - mechanisms of action, pharmacokinetics and toxicity profile. Drug Saf. 2006;29:209-30 pubmed
|
Salem M, Werbovetz K. Isoflavonoids and other compounds from Psorothamnus arborescens with antiprotozoal activities. J Nat Prod. 2006;69:43-9 pubmed
|
Coro J, Atherton R, Little S, Wharton H, Yardley V, Alvarez A, et al. Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents. Bioorg Med Chem Lett. 2006;16:1312-5 pubmed
|
Lee B, Bauer H, Melchers J, Ruppert T, Rattray L, Yardley V, et al. Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate. J Med Chem. 2005;48:7400-10 pubmed
|
Li P, Xiao Z, Hu Z, Pandit B, Sun Y, Sackett D, et al. Conformationally restricted analogs of Combretastatin A-4 derived from SU5416. Bioorg Med Chem Lett. 2005;15:5382-5 pubmed
|
Van Miert S, Hostyn S, Maes B, Cimanga K, Brun R, Kaiser M, et al. Isoneocryptolepine, a synthetic indoloquinoline alkaloid, as an antiplasmodial lead compound. J Nat Prod. 2005;68:674-7 pubmed
|
You Y. Podophyllotoxin derivatives: current synthetic approaches for new anticancer agents. Curr Pharm Des. 2005;11:1695-717 pubmed
|
Fang X, Shao L, Zhang H, Wang S. CHMIS-C: a comprehensive herbal medicine information system for cancer. J Med Chem. 2005;48:1481-8 pubmed
|
Farkya S, Bisaria V, Srivastava A. Biotechnological aspects of the production of the anticancer drug podophyllotoxin. Appl Microbiol Biotechnol. 2004;65:504-19 pubmed
|
Gordaliza M, Garcia P, del Corral J, Castro M, Gómez Zurita M. Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives. Toxicon. 2004;44:441-59 pubmed
|
Lafuma A, Monsonego J, Moyal Barracco M, Pribil C. [A model-based comparison of cost effectiveness of imiquimod versus podophyllotoxin for the treatment of external anogenital warts in France]. Ann Dermatol Venereol. 2003;130:731-6 pubmed
|
Desbène S, Giorgi Renault S. Drugs that inhibit tubulin polymerization: the particular case of podophyllotoxin and analogues. Curr Med Chem Anticancer Agents. 2002;2:71-90 pubmed
|
Longstaff E, von Krogh G. Condyloma eradication: self-therapy with 0.15-0.5% podophyllotoxin versus 20-25% podophyllin preparations--an integrated safety assessment. Regul Toxicol Pharmacol. 2001;33:117-37 pubmed
|
Gordaliza M, Castro M, del Corral J, Feliciano A. Antitumor properties of podophyllotoxin and related compounds. Curr Pharm Des. 2000;6:1811-39 pubmed
|
Canel C, Moraes R, Dayan F, Ferreira D. Podophyllotoxin. Phytochemistry. 2000;54:115-20 pubmed
|
Prasad V, Chaudhuri A, Curcio M, Tomita I, Mizuhashi F, Murata K, et al. Podophyllotoxin and nocodazole counter the effect of IKP104 on tubulin decay. J Protein Chem. 1998;17:663-8 pubmed
|
Damayanthi Y, Lown J. Podophyllotoxins: current status and recent developments. Curr Med Chem. 1998;5:205-52 pubmed
|
. Sarah Cannon Cancer Center Consensus Conference on Novel Developments with Podophyllotoxin Therapy. Semin Oncol. 1996;23:1-60 pubmed
|
Beutner K. Podophyllotoxin in the treatment of genital warts. Curr Probl Dermatol. 1996;24:227-32 pubmed
|
Sackett D. Podophyllotoxin, steganacin and combretastatin: natural products that bind at the colchicine site of tubulin. Pharmacol Ther. 1993;59:163-228 pubmed
|
D INCALCI M, Garattini S. Podophyllotoxin derivatives VP-16 and VM-26. Cancer Chemother Biol Response Modif. 1987;9:67-70 pubmed
|
D INCALCI M, Garattini S. Podophyllotoxin derivatives VP-16 and VM-26. Cancer Chemother Biol Response Modif. 1988;10:57-63 pubmed
|
Stahelin H, von Wartburg A. From podophyllotoxin glucoside to etoposide. Prog Drug Res. 1989;33:169-266 pubmed
|
D INCALCI M, Garattini S. Podophyllotoxin derivatives. Cancer Chemother Biol Response Modif. 1990;11:82-9 pubmed
|
Beutner K, von Krogh G. Current status of podophyllotoxin for the treatment of genital warts. Semin Dermatol. 1990;9:148-51 pubmed
|
Stähelin H, von Wartburg A. The chemical and biological route from podophyllotoxin glucoside to etoposide: ninth Cain memorial Award lecture. Cancer Res. 1991;51:5-15 pubmed
|