This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
protein
product name :
Protein Disulfide Isomerase from bovine liver
catalog :
P3818
citations: 89
Reference
Cook G, Sousa C, Schaeffer J, Wiles K, Jareonsettasin P, Kalyanasundaram A, et al. Regulation of nerve growth and patterning by cell surface protein disulphide isomerase. elife. 2020;9: pubmed publisher
Obermeier A, Schneider J, Harrasser N, Tübel J, Mühlhofer H, Pförringer D, et al. Viable adhered Staphylococcus aureus highly reduced on novel antimicrobial sutures using chlorhexidine and octenidine to avoid surgical site infection (SSI). PLoS ONE. 2018;13:e0190912 pubmed publisher
Roehl K, Jankowski M, Hofmeister E. ANTIDOG IgG SECONDARY ANTIBODY SUCCESSFULLY DETECTS IgG IN A VARIETY OF AQUATIC MAMMALS. J Zoo Wildl Med. 2016;47:970-976 pubmed publisher
Doroudi M, Plaisance M, Boyan B, Schwartz Z. Membrane actions of 1α,25(OH)2D3 are mediated by Ca(2+)/calmodulin-dependent protein kinase II in bone and cartilage cells. J Steroid Biochem Mol Biol. 2015;145:65-74 pubmed publisher
Flaumenhaft R, Furie B, Zwicker J. Therapeutic implications of protein disulfide isomerase inhibition in thrombotic disease. Arterioscler Thromb Vasc Biol. 2015;35:16-23 pubmed publisher
Wu X, Wang A, Chen L, Huang E, Xie W, Liu C, et al. S-Nitrosylating protein disulphide isomerase mediates α-synuclein aggregation caused by methamphetamine exposure in PC12 cells. Toxicol Lett. 2014;230:19-27 pubmed publisher
Iqbal A, Paviani V, Moretti A, Laurindo F, Augusto O. Oxidation, inactivation and aggregation of protein disulfide isomerase promoted by the bicarbonate-dependent peroxidase activity of human superoxide dismutase. Arch Biochem Biophys. 2014;557:72-81 pubmed publisher
Riener M, Thiesler T, Hellerbrand C, Amann T, Cathomas G, Fritzsche F, et al. Loss of anterior gradient-2 expression is an independent prognostic factor in colorectal carcinomas. Eur J Cancer. 2014;50:1722-1730 pubmed publisher
Shepherd C, Oka O, Bulleid N. Inactivation of mammalian Ero1? is catalysed by specific protein disulfide-isomerases. Biochem J. 2014;461:107-13 pubmed publisher
Yoon B, Kim J, Um S, Jo I, Yoo J, Lee K, et al. Periplasmic disulfide isomerase DsbC is involved in the reduction of copper binding protein CueP from Salmonella enterica serovar Typhimurium. Biochem Biophys Res Commun. 2014;446:971-6 pubmed publisher
Higa A, Taouji S, Lhomond S, Jensen D, Fernandez Zapico M, Simpson J, et al. Endoplasmic reticulum stress-activated transcription factor ATF6? requires the disulfide isomerase PDIA5 to modulate chemoresistance. Mol Cell Biol. 2014;34:1839-49 pubmed publisher
Malojcic G, Owen R, Glockshuber R. Structural and mechanistic insights into the PAPS-independent sulfotransfer catalyzed by bacterial aryl sulfotransferase and the role of the DsbL/Dsbl system in its folding. Biochemistry. 2014;53:1870-7 pubmed publisher
Di Jeso B, Morishita Y, Treglia A, Lofrumento D, Nicolardi G, Beguinot F, et al. Transient covalent interactions of newly synthesized thyroglobulin with oxidoreductases of the endoplasmic reticulum. J Biol Chem. 2014;289:11488-96 pubmed publisher
Grillo C, Chichiarelli S, Gaucci E, Altieri F, Turano C, Cervoni L. The binding of silibinin to ERp57. Chem Biol Interact. 2014;213:37-43 pubmed publisher
Eletto D, Eletto D, Dersh D, Gidalevitz T, Argon Y. Protein disulfide isomerase A6 controls the decay of IRE1? signaling via disulfide-dependent association. Mol Cell. 2014;53:562-576 pubmed publisher
Leonhardt R, Abrahimi P, Mitchell S, Cresswell P. Three tapasin docking sites in TAP cooperate to facilitate transporter stabilization and heterodimerization. J Immunol. 2014;192:2480-94 pubmed publisher
McMahon R, Premkumar L, Martin J. Four structural subclasses of the antivirulence drug target disulfide oxidoreductase DsbA provide a platform for design of subclass-specific inhibitors. Biochim Biophys Acta. 2014;1844:1391-401 pubmed publisher
Yang P, Lüpken T, Habekuss A, Hensel G, Steuernagel B, Kilian B, et al. PROTEIN DISULFIDE ISOMERASE LIKE 5-1 is a susceptibility factor to plant viruses. Proc Natl Acad Sci U S A. 2014;111:2104-9 pubmed publisher
Sobierajska K, Skurzynski S, Stasiak M, Kryczka J, Cierniewski C, Swiatkowska M. Protein disulfide isomerase directly interacts with ?-actin Cys374 and regulates cytoskeleton reorganization. J Biol Chem. 2014;289:5758-73 pubmed publisher
Sun C, Li J, Gu J, Liu J, Huang B. Proteomic studies of multiple myeloma in RPMI8226 cell line treated with bendamustine. J BUON. 2013;18:996-1005 pubmed
França L, Freitas L, Chagas V, Coêlho C, Barroso W, Costa G, et al. Mechanisms underlying hypertriglyceridemia in rats with monosodium L-glutamate-induced obesity: evidence of XBP-1/PDI/MTP axis activation. Biochem Biophys Res Commun. 2014;443:725-30 pubmed publisher
Premkumar L, Kurth F, Neyer S, Schembri M, Martin J. The multidrug resistance IncA/C transferable plasmid encodes a novel domain-swapped dimeric protein-disulfide isomerase. J Biol Chem. 2014;289:2563-76 pubmed publisher
Gibbins J. Platelets using proteins creatively. Blood. 2013;122:3553-4 pubmed publisher
Fujii T, Awaka S, Takahashi Y, Fujita K, Tsuji H, Shimizu T, et al. Modulation of H(+),K(+)-ATPase activity by the molecular chaperone ERp57 highly expressed in gastric parietal cells. FEBS Lett. 2013;587:3898-905 pubmed publisher
Watson L, Long B, Demartino A, Brittian K, Readnower R, Brainard R, et al. Cardiomyocyte Ogt is essential for postnatal viability. Am J Physiol Heart Circ Physiol. 2014;306:H142-53 pubmed publisher
Uehara T. [Regulation of intracellular signal pathways via sensor proteins by oxidative stress]. Clin Calcium. 2013;23:1613-9 pubmed publisher
Yazawa K, Furusawa H, Okahata Y. Real-time monitoring of intermediates reveals the reaction pathway in the thiol-disulfide exchange between disulfide bond formation protein A (DsbA) and B (DsbB) on a membrane-immobilized quartz crystal microbalance (QCM) system. J Biol Chem. 2013;288:35969-81 pubmed publisher
Wijeyesakere S, Rizvi S, Raghavan M. Glycan-dependent and -independent interactions contribute to cellular substrate recruitment by calreticulin. J Biol Chem. 2013;288:35104-16 pubmed publisher
Xu L, Liu X, Chen J, Liang Y. Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization. PLoS ONE. 2013;8:e76657 pubmed publisher
Kadokura H, Saito M, Tsuru A, Hosoda A, Iwawaki T, Inaba K, et al. Identification of the redox partners of ERdj5/JPDI, a PDI family member, from an animal tissue. Biochem Biophys Res Commun. 2013;440:245-50 pubmed publisher
Araki K, Iemura S, Kamiya Y, Ron D, Kato K, Natsume T, et al. Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases. J Cell Biol. 2013;202:861-74 pubmed publisher
Ishikawa Y, Bachinger H. An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1·cartilage-associated protein·cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro. J Biol Chem. 2013;288:31437-46 pubmed publisher
Wang L, Wu Y, Zhou J, Ahmad S, Mutus B, Garbi N, et al. Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the ?IIb?3 integrin. Blood. 2013;122:3642-50 pubmed publisher
Park M, Kim S, Shin H, Lee S, Chung J. TXNDC5 gene polymorphism contributes to increased risk of hepatocellular carcinoma in the Korean male population. Anticancer Res. 2013;33:3983-7 pubmed
Sha C, Yu X, Zhang M, Xu Y. Efficient secretion of lipase r27RCL in Pichia pastoris by enhancing the disulfide bond formation pathway in the endoplasmic reticulum. J Ind Microbiol Biotechnol. 2013;40:1241-9 pubmed publisher
Kakihana T, Araki K, Vavassori S, Iemura S, Cortini M, Fagioli C, et al. Dynamic regulation of Ero1? and peroxiredoxin 4 localization in the secretory pathway. J Biol Chem. 2013;288:29586-94 pubmed publisher
Prado G, Romero J, Rivera A. Endothelin-1 receptor antagonists regulate cell surface-associated protein disulfide isomerase in sickle cell disease. FASEB J. 2013;27:4619-29 pubmed publisher
Reinstein J. Proximity effects on the protein domain level: engineering prolyl isomerases through combinatorial biochemistry. J Mol Biol. 2013;425:4065-6 pubmed publisher
Chen Y, Ho C, Chen P, Chen Y, Chang C. Anterior gradient 2: a novel sensitive tumor marker for metastatic oral cancer. Cancer Lett. 2013;339:270-8 pubmed publisher
Rutledge A, Qiu W, Zhang R, Urade R, Adeli K. Role of cysteine-protease CGHC motifs of ER-60, a protein disulfide isomerase, in hepatic apolipoprotein B100 degradation. Arch Biochem Biophys. 2013;537:104-12 pubmed publisher
Jain K, Suryakumar G, Prasad R, Singh S, Ganju L. Myocardial ER chaperone activation and protein degradation occurs due to synergistic, not individual, cold and hypoxic stress. Biochimie. 2013;95:1897-908 pubmed publisher
Wang F, Reece E, Yang P. Superoxide dismutase 1 overexpression in mice abolishes maternal diabetes-induced endoplasmic reticulum stress in diabetic embryopathy. Am J Obstet Gynecol. 2013;209:345.e1-7 pubmed publisher
O Hara J, Mantis N. Neutralizing monoclonal antibodies against ricin's enzymatic subunit interfere with protein disulfide isomerase-mediated reduction of ricin holotoxin in vitro. J Immunol Methods. 2013;395:71-8 pubmed publisher
Pace P, Peskin A, Han M, Hampton M, Winterbourn C. Hyperoxidized peroxiredoxin 2 interacts with the protein disulfide- isomerase ERp46. Biochem J. 2013;453:475-85 pubmed publisher
Trnková L, Ricci D, Grillo C, Colotti G, Altieri F. Green tea catechins can bind and modify ERp57/PDIA3 activity. Biochim Biophys Acta. 2013;1830:2671-82 pubmed
Zarbock A. β2-integrin activity: the role of thiols. Blood. 2013;121:3779-80 pubmed publisher
Khairnar N, Joe M, Misra H, Lim S, Kim D. FrnE, a cadmium-inducible protein in Deinococcus radiodurans, is characterized as a disulfide isomerase chaperone in vitro and for its role in oxidative stress tolerance in vivo. J Bacteriol. 2013;195:2880-6 pubmed publisher
Aureli C, Gaucci E, Arcangeli V, Grillo C, Eufemi M, Chichiarelli S. ERp57/PDIA3 binds specific DNA fragments in a melanoma cell line. Gene. 2013;524:390-5 pubmed publisher
Bernardoni P, Fazi B, Costanzi A, Nardacci R, Montagna C, Filomeni G, et al. Reticulon1-C modulates protein disulphide isomerase function. Cell Death Dis. 2013;4:e581 pubmed publisher
Parakh S, Spencer D, Halloran M, Soo K, Atkin J. Redox regulation in amyotrophic lateral sclerosis. Oxid Med Cell Longev. 2013;2013:408681 pubmed publisher
Benham A, van Lith M, Sitia R, Braakman I. Ero1-PDI interactions, the response to redox flux and the implications for disulfide bond formation in the mammalian endoplasmic reticulum. Philos Trans R Soc Lond B Biol Sci. 2013;368:20110403 pubmed publisher
Beutler N, Hauka S, Niepel A, Kowalewski D, Uhlmann J, Ghanem E, et al. A natural tapasin isoform lacking exon 3 modifies peptide loading complex function. Eur J Immunol. 2013;43:1459-69 pubmed publisher
Schlegel S, Rujas E, Ytterberg A, Zubarev R, Luirink J, de Gier J. Optimizing heterologous protein production in the periplasm of E. coli by regulating gene expression levels. Microb Cell Fact. 2013;12:24 pubmed publisher
Li S, Yang Z, Hu J, Gordon W, Bazan N, Haas A, et al. Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP). J Biol Chem. 2013;288:11395-406 pubmed publisher
Heckler E, Crassous P, Baskaran P, Beuve A. Protein disulfide-isomerase interacts with soluble guanylyl cyclase via a redox-based mechanism and modulates its activity. Biochem J. 2013;452:161-9 pubmed publisher
Brophy T, Coller B, Ahamed J. Identification of the thiol isomerase-binding peptide, mastoparan, as a novel inhibitor of shear-induced transforming growth factor ?1 (TGF-?1) activation. J Biol Chem. 2013;288:10628-39 pubmed publisher
Hahm E, Li J, Kim K, Huh S, Rogelj S, Cho J. Extracellular protein disulfide isomerase regulates ligand-binding activity of ?M?2 integrin and neutrophil recruitment during vascular inflammation. Blood. 2013;121:3789-800, S1-15 pubmed publisher
Bosello Travain V, Conrad M, Cozza G, Negro A, Quartesan S, Rossetto M, et al. Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7. Biochim Biophys Acta. 2013;1830:3846-57 pubmed publisher
Kpadeh Z, Jameson Lee M, Yeh A, Chertihin O, Shumilin I, Dey R, et al. Disulfide bond oxidoreductase DsbA2 of Legionella pneumophila exhibits protein disulfide isomerase activity. J Bacteriol. 2013;195:1825-33 pubmed publisher
Ivanova A, Tereshina M, Ermakova G, Belousov V, Zaraisky A. Agr genes, missing in amniotes, are involved in the body appendages regeneration in frog tadpoles. Sci Rep. 2013;3:1279 pubmed publisher
Santana A, Guerrero C, Acosta O. Implication of Hsc70, PDI and integrin ?v?3 involvement during entry of the murine rotavirus ECwt into small-intestinal villi of suckling mice. Arch Virol. 2013;158:1323-36 pubmed publisher
Boyle L, Hermann C, Boname J, Porter K, Patel P, Burr M, et al. Tapasin-related protein TAPBPR is an additional component of the MHC class I presentation pathway. Proc Natl Acad Sci U S A. 2013;110:3465-70 pubmed publisher
Gao M, Yang Q, Wang M, Miller K, Sledge G, Zheng Q. Synthesis of radiolabeled protein disulfide isomerase (PDI) inhibitors as new potential PET agents for imaging of the enzyme PDI in neurological disorders and cancer. Appl Radiat Isot. 2013;74:61-9 pubmed publisher
Funkner A, Parthier C, Schutkowski M, Zerweck J, Lilie H, Gyrych N, et al. Peptide binding by catalytic domains of the protein disulfide isomerase-related protein ERp46. J Mol Biol. 2013;425:1340-62 pubmed publisher
Taylor S, Crawley Snowdon H, Wagstaff J, Rowe M, Shepherd M, Williamson R, et al. Measuring protein reduction potentials using 15N HSQC NMR spectroscopy. Chem Commun (Camb). 2013;49:1847-9 pubmed publisher
Hrstka R, Murray E, Brychtova V, Fabian P, Hupp T, Vojtesek B. Identification of an AKT-dependent signalling pathway that mediates tamoxifen-dependent induction of the pro-metastatic protein anterior gradient-2. Cancer Lett. 2013;333:187-93 pubmed publisher
Wearsch P, Cresswell P. In vitro reconstitution of the MHC class I peptide-loading complex. Methods Mol Biol. 2013;960:67-79 pubmed publisher
Bae J, Koo B, Ryu H, Song J, Nguyen M, Vu T, et al. Cu/Zn incorporation during purification of soluble human EC-SOD from E. coli stabilizes proper disulfide bond formation. Appl Biochem Biotechnol. 2013;169:1633-47 pubmed publisher
Wang L, Zheng Y, Xu H, Yan X, Chang X. Investigate pathogenic mechanism of TXNDC5 in rheumatoid arthritis. PLoS ONE. 2013;8:e53301 pubmed publisher
Young C, Raden D, Robinson A. Analysis of ER resident proteins in Saccharomyces cerevisiae: implementation of H/KDEL retrieval sequences. Traffic. 2013;14:365-81 pubmed publisher
Zhao X, Tang R, Wang M, Guo W, Liu J, Li L, et al. Distribution of PDIA3 transcript and protein in rat testis and sperm cells. Reprod Domest Anim. 2013;48:59-63 pubmed publisher
Langer F, Spath B, Fischer C, Stolz M, Ayuk F, Kroger N, et al. Rapid activation of monocyte tissue factor by antithymocyte globulin is dependent on complement and protein disulfide isomerase. Blood. 2013;121:2324-35 pubmed publisher
Bu H, Schweiger M, Manke T, Wunderlich A, Timmermann B, Kerick M, et al. Anterior gradient 2 and 3--two prototype androgen-responsive genes transcriptionally upregulated by androgens and by oestrogens in prostate cancer cells. FEBS J. 2013;280:1249-66 pubmed publisher
Patel P, Clarke C, Barraclough D, Jowitt T, Rudland P, Barraclough R, et al. Metastasis-promoting anterior gradient 2 protein has a dimeric thioredoxin fold structure and a role in cell adhesion. J Mol Biol. 2013;425:929-43 pubmed publisher
Galligan J, Petersen D. The human protein disulfide isomerase gene family. Hum Genomics. 2012;6:6 pubmed publisher
Amin N, Wallis A, Wells S, Rowe M, Williamson R, Howard M, et al. High-resolution NMR studies of structure and dynamics of human ERp27 indicate extensive interdomain flexibility. Biochem J. 2013;450:321-32 pubmed publisher
Stegmann M, Metcalfe C, Barclay A. Immunoregulation through membrane proteins modified by reducing conditions induced by immune reactions. Eur J Immunol. 2013;43:15-21 pubmed publisher
Brymora A, Duggin I, Berven L, van Dam E, Roufogalis B, Robinson P. Identification and characterisation of the RalA-ERp57 interaction: evidence for GDI activity of ERp57. PLoS ONE. 2012;7:e50879 pubmed publisher
Ryu J, Park S, Lee P, Cho S, Lee D, Kim G, et al. Dimerization of pro-oncogenic protein Anterior Gradient 2 is required for the interaction with BiP/GRP78. Biochem Biophys Res Commun. 2013;430:610-5 pubmed publisher
Stantchev T, Paciga M, Lankford C, Schwartzkopff F, Broder C, Clouse K. Cell-type specific requirements for thiol/disulfide exchange during HIV-1 entry and infection. Retrovirology. 2012;9:97 pubmed publisher
Sato Y, Inaba K. [Protein disulfide bond formation system in mammalian cells]. Seikagaku. 2012;84:767-72 pubmed
Kober F, Koelmel W, Kuper J, Drechsler J, Mais C, Hermanns H, et al. The crystal structure of the protein-disulfide isomerase family member ERp27 provides insights into its substrate binding capabilities. J Biol Chem. 2013;288:2029-39 pubmed publisher
Kenche H, Baty C, Vedagiri K, Shapiro S, Blumental Perry A. Cigarette smoking affects oxidative protein folding in endoplasmic reticulum by modifying protein disulfide isomerase. FASEB J. 2013;27:965-77 pubmed publisher
Santos C, Stolf B, Takemoto P, Amanso A, Lopes L, Souza E, et al. Protein disulfide isomerase (PDI) associates with NADPH oxidase and is required for phagocytosis of Leishmania chagasi promastigotes by macrophages. J Leukoc Biol. 2009;86:989-98 pubmed publisher
Smith A, Chan J, Oksenberg D, Urfer R, Wexler D, Ow A, et al. A high-throughput turbidometric assay for screening inhibitors of protein disulfide isomerase activity. J Biomol Screen. 2004;9:614-20 pubmed
Hillson D, Lambert N, Freedman R. Formation and isomerization of disulfide bonds in proteins: protein disulfide-isomerase. Methods Enzymol. 1984;107:281-94 pubmed
Fuchs S, De Lorenzo F, Anfinsen C. Studies on the mechanism of the enzymic catalysis of disulfide interchange in proteins. J Biol Chem. 1967;242:398-402 pubmed
De Lorenzo F, Goldberger R, Steers E, Givol D, Anfinsen B. Purification and properties of an enzyme from beef liver which catalyzes sulfhydryl-disulfide interchange in proteins. J Biol Chem. 1966;241:1562-7 pubmed
Gething M, Sambrook J. Protein folding in the cell. Nature. 1992;355:33-45 pubmed
product information
Catalog Number :
P3818
Product Name :
Protein Disulfide Isomerase from bovine liver
Product Type :
PROTEINS & ENZYMES
Product Group :
Protein & Pathway Technologies
Product Description :
>95% (SDS-PAGE), ?100 units/mg protein, lyophilized powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA