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product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Phencyclidine hydrochloride
catalog :
P3029
citations: 41
Reference
Asif Malik A, Dautan D, Young A, Gerdjikov T. Altered cortico-striatal crosstalk underlies object recognition memory deficits in the sub-chronic phencyclidine model of schizophrenia. Brain Struct Funct. 2017;222:3179-3190 pubmed publisher
Hamouda A, Wang Z, Stewart D, Jain A, Glennon R, Cohen J. Desformylflustrabromine (dFBr) and [3H]dFBr-Labeled Binding Sites in a Nicotinic Acetylcholine Receptor. Mol Pharmacol. 2015;88:1-11 pubmed publisher
Swalve N, Pittenger S, Bevins R, Li M. Behavioral effects of phencyclidine on nicotine self-administration and reinstatement in the presence or absence of a visual stimulus in rats. Psychopharmacology (Berl). 2015;232:2877-87 pubmed publisher
Popik P, Holuj M, Nikiforuk A, Kos T, Trullas R, Skolnick P. 1-aminocyclopropanecarboxylic acid (ACPC) produces procognitive but not antipsychotic-like effects in rats. Psychopharmacology (Berl). 2015;232:1025-38 pubmed publisher
Ingallinesi M, Le Bouil L, Biguet N, Thi A, Mannoury la Cour C, Millan M, et al. Local inactivation of Gpr88 in the nucleus accumbens attenuates behavioral deficits elicited by the neonatal administration of phencyclidine in rats. Mol Psychiatry. 2015;20:951-8 pubmed publisher
Hiyoshi T, Kambe D, Karasawa J, Chaki S. Differential effects of NMDA receptor antagonists at lower and higher doses on basal gamma band oscillation power in rat cortical electroencephalograms. Neuropharmacology. 2014;85:384-96 pubmed publisher
Swedberg M, Ellgren M, Raboisson P. mGluR5 antagonist-induced psychoactive properties: MTEP drug discrimination, a pharmacologically selective non-NMDA effect with apparent lack of reinforcing properties. J Pharmacol Exp Ther. 2014;349:155-64 pubmed publisher
Gaskin P, Alexander S, Fone K. Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of 'schizophrenia-like' behaviour in the rat. Psychopharmacology (Berl). 2014;231:2533-45 pubmed publisher
Piyabhan P, Wetchateng T, Sireeratawong S. Cognitive enhancement effects of Bacopa monnieri (Brahmi) on novel object recognition and NMDA receptor immunodensity in the prefrontal cortex and hippocampus of sub-chronic phencyclidine rat model of schizophrenia. J Med Assoc Thai. 2013;96:231-8 pubmed
Rengarajan A, Mullins M. How often do false-positive phencyclidine urine screens occur with use of common medications?. Clin Toxicol (Phila). 2013;51:493-6 pubmed publisher
Kjaerby C, Bundgaard C, Fejgin K, Kristiansen U, Dalby N. Repeated potentiation of the metabotropic glutamate receptor 5 and the alpha 7 nicotinic acetylcholine receptor modulates behavioural and GABAergic deficits induced by early postnatal phencyclidine (PCP) treatment. Neuropharmacology. 2013;72:157-68 pubmed publisher
Roth B, Gibbons S, Arunotayanun W, Huang X, Setola V, Treble R, et al. The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor. PLoS ONE. 2013;8:e59334 pubmed publisher
Hida H, Mouri A, Noda Y. Behavioral phenotypes in schizophrenic animal models with multiple combinations of genetic and environmental factors. J Pharmacol Sci. 2013;121:185-91 pubmed
Santini M, Ratner C, Aznar S, Klein A, Knudsen G, Mikkelsen J. Enhanced prefrontal serotonin 2A receptor signaling in the subchronic phencyclidine mouse model of schizophrenia. J Neurosci Res. 2013;91:634-41 pubmed publisher
Price J. Creatinine normalization of workplace urine drug tests: does it make a difference?. J Addict Med. 2013;7:129-32 pubmed publisher
Stanojlovic O, Nikolic T, Hrnčić D, Radonjic N, Rašić Marković A, Mladenović D, et al. Ontogenetic influence on rat susceptibility to lindane seizure after pretreatment with phencyclidine. Environ Toxicol Pharmacol. 2013;35:161-70 pubmed publisher
Enkel T, Thomas M, Bartsch D. Differential effects of subchronic phencyclidine on anxiety in the light-enhanced startle-, light/dark exploration- and open field tests. Behav Brain Res. 2013;243:61-5 pubmed publisher
Hajikhani R, Ahmadi A, Naderi N, Yaghoobi K, Shirazizand Z, Rezaee N, et al. Effect of phencyclidine derivatives on anxiety-like behavior using an elevated-plus maze test in mice. Adv Clin Exp Med. 2012;21:307-12 pubmed
Lutgen V, Qualmann K, Resch J, Kong L, Choi S, Baker D. Reduction in phencyclidine induced sensorimotor gating deficits in the rat following increased system xc? activity in the medial prefrontal cortex. Psychopharmacology (Berl). 2013;226:531-40 pubmed publisher
Airado Rodríguez D, Cruces Blanco C, García Campaña A. Dispersive liquid-liquid microextraction prior to field-amplified sample injection for the sensitive analysis of 3,4-methylenedioxymethamphetamine, phencyclidine and lysergic acid diethylamide by capillary electrophoresis in human urine. J Chromatogr A. 2012;1267:189-97 pubmed publisher
Feng M, Sui N, Li M. Environmental and behavioral controls of the expression of clozapine tolerance: evidence from a novel across-model transfer paradigm. Behav Brain Res. 2013;238:178-87 pubmed publisher
Kaalund S, Riise J, Broberg B, Fabricius K, Karlsen A, Secher T, et al. Differential expression of parvalbumin in neonatal phencyclidine-treated rats and socially isolated rats. J Neurochem. 2013;124:548-57 pubmed publisher
Zimnisky R, Chang G, Gyertyán I, Kiss B, Adham N, Schmauss C. Cariprazine, a dopamine D(3)-receptor-preferring partial agonist, blocks phencyclidine-induced impairments of working memory, attention set-shifting, and recognition memory in the mouse. Psychopharmacology (Berl). 2013;226:91-100 pubmed publisher
Moriya F. [Preliminary comparative study on the usefulness of instant-view'TM M-1 and Triage DOA in testing for drugs-of-abuse in forensic urine samples]. Chudoku Kenkyu. 2012;25:243-6 pubmed
Horiguchi M, Hannaway K, Adelekun A, Huang M, Jayathilake K, Meltzer H. D(1) receptor agonists reverse the subchronic phencyclidine (PCP)-induced novel object recognition (NOR) deficit in female rats. Behav Brain Res. 2013;238:36-43 pubmed publisher
Köhler J, Bergander K, Fabian J, Schepmann D, Wünsch B. Enantiomerically pure 1,3-dioxanes as highly selective NMDA and σ₁ receptor ligands. J Med Chem. 2012;55:8953-7 pubmed publisher
Misselbrook G, Hamilton E. Out with the old, in with the new? Case reports of the clinical features and acute management of two novel designer drugs. Acute Med. 2012;11:157-60 pubmed
Javitt D, Zukin S, Heresco Levy U, Umbricht D. Has an angel shown the way? Etiological and therapeutic implications of the PCP/NMDA model of schizophrenia. Schizophr Bull. 2012;38:958-66 pubmed publisher
Javitt D. Twenty-five years of glutamate in schizophrenia: are we there yet?. Schizophr Bull. 2012;38:911-3 pubmed publisher
Clifton N, Morisot N, Girardon S, Millan M, Loiseau F. Enhancement of social novelty discrimination by positive allosteric modulators at metabotropic glutamate 5 receptors: adolescent administration prevents adult-onset deficits induced by neonatal treatment with phencyclidine. Psychopharmacology (Berl). 2013;225:579-94 pubmed publisher
Macneal J, Cone D, Sinha V, Tomassoni A. Use of haloperidol in PCP-intoxicated individuals. Clin Toxicol (Phila). 2012;50:851-3 pubmed publisher
King A, Pugh J, Menke N, Krasowski M, Lynch M, Pizon A. Nonfatal tramadol overdose may cause false-positive phencyclidine on Emit-II assay. Am J Emerg Med. 2013;31:444.e5-9 pubmed publisher
Okamoto M, Katayama T, Suzuki Y, Hoshino K, Yamada H, Matsuoka N, et al. Neonatal administration of phencyclidine decreases the number of putative inhibitory interneurons and increases neural excitability to auditory paired clicks in the hippocampal CA3 region of freely moving adult mice. Neuroscience. 2012;224:268-81 pubmed publisher
Spano M, Fattore L, Cadeddu F, Fratta W, Fadda P. Chronic cannabinoid exposure reduces phencyclidine-induced schizophrenia-like positive symptoms in adult rats. Psychopharmacology (Berl). 2013;225:531-42 pubmed publisher
Moghaddam B, Krystal J. Capturing the angel in "angel dust": twenty years of translational neuroscience studies of NMDA receptor antagonists in animals and humans. Schizophr Bull. 2012;38:942-9 pubmed publisher
Chen X, Sassano M, Zheng L, Setola V, Chen M, Bai X, et al. Structure-functional selectivity relationship studies of ?-arrestin-biased dopamine D? receptor agonists. J Med Chem. 2012;55:7141-53 pubmed publisher
Horio M, Fujita Y, Hashimoto K. Therapeutic effects of metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on phencyclidine-induced cognitive deficits in mice. Fundam Clin Pharmacol. 2013;27:483-8 pubmed publisher
O DONNELL P, Grace A. Phencyclidine interferes with the hippocampal gating of nucleus accumbens neuronal activity in vivo. Neuroscience. 1998;87:823-30 pubmed
Nakazawa M, Matsuno K, Mita S. Activation of sigma1 receptor subtype leads to neuroprotection in the rat primary neuronal cultures. Neurochem Int. 1998;32:337-43 pubmed
Sharp J. Phencyclidine (PCP) acts at sigma sites to induce c-fos gene expression. Brain Res. 1997;758:51-8 pubmed
Porter R, Greenamyre J. Regional variations in the pharmacology of NMDA receptor channel blockers: implications for therapeutic potential. J Neurochem. 1995;64:614-23 pubmed
product information
Catalog Number :
P3029
Product Name :
Phencyclidine hydrochloride
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA