| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; mouse; 1:1000; loading ...; fig 7c
| Juenemann K, Jansen A, van Riel L, Merkx R, Mulder M, An H, et al. Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies. Sci Rep. 2018;8:1405 pubmed publisher |
- western blot; mouse; loading ...; fig 5c
| Culver B, DeClercq J, Dolgalev I, Yu M, Ma B, Heguy A, et al. Huntington's Disease Protein Huntingtin Associates with its own mRNA. J Huntingtons Dis. 2016;5:39-51 pubmed publisher |
- western blot; mouse; 1:1000; fig 1
| Yao Y, Cui X, Al Ramahi I, Sun X, Li B, Hou J, et al. A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity. elife. 2015;4: pubmed publisher |
- immunoprecipitation; mouse
| Sathasivam K, Neueder A, Gipson T, Landles C, Benjamin A, Bondulich M, et al. Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease. Proc Natl Acad Sci U S A. 2013;110:2366-70 pubmed publisher |
| Aviolat H, Pinto R, Godschall E, Murtha R, Richey H, Sapp E, et al. Assessing average somatic CAG repeat instability at the protein level. Sci Rep. 2019;9:19152 pubmed publisher |
| Li Z, Wang C, Wang Z, Zhu C, Li J, Sha T, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019;: pubmed publisher |
| Kourkouta E, Weij R, González Barriga A, Mulder M, Verheul R, Bosgra S, et al. Suppression of Mutant Protein Expression in SCA3 and SCA1 Mice Using a CAG Repeat-Targeting Antisense Oligonucleotide. Mol Ther Nucleic Acids. 2019;17:601-614 pubmed publisher |
| Imanikia S, Sheng M, Castro C, Griffin J, Taylor R. XBP-1 Remodels Lipid Metabolism to Extend Longevity. Cell Rep. 2019;28:581-589.e4 pubmed publisher |
| Imanikia S, Özbey N, Krueger C, Casanueva M, Taylor R. Neuronal XBP-1 Activates Intestinal Lysosomes to Improve Proteostasis in C. elegans. Curr Biol. 2019;29:2322-2338.e7 pubmed publisher |
| Franich N, Hickey M, Zhu C, Osborne G, Ali N, Chu T, et al. Phenotype onset in Huntington's disease knock-in mice is correlated with the incomplete splicing of the mutant huntingtin gene. J Neurosci Res. 2019;97:1590-1605 pubmed publisher |
| Tousley A, Iuliano M, Weisman E, Sapp E, Zhang N, Vodicka P, et al. Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington's Disease. J Huntingtons Dis. 2019;8:53-69 pubmed publisher |
| Baldo B, Sajjad M, Cheong R, Bigarreau J, Vijayvargia R, McLean C, et al. Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA Assay. Eneuro. 2018;5: pubmed publisher |
| Neueder A, Dumas A, Benjamin A, Bates G. Regulatory mechanisms of incomplete huntingtin mRNA splicing. Nat Commun. 2018;9:3955 pubmed publisher |
| Mani R, Gupta M, Malik A, Tandon R, Prasad R, Bhatnagar R, et al. Adjuvant Potential of Poly-α-l-Glutamine from the Cell Wall of Mycobacterium tuberculosis. Infect Immun. 2018;86: pubmed publisher |
| Ghosh D, Roy A, Ranjan A. The ATPase VCP/p97 functions as a disaggregase against toxic Huntingtin-exon1 aggregates. FEBS Lett. 2018;592:2680-2692 pubmed publisher |
| Vidinska D, Vochozková P, Šmatlíková P, Ardan T, Klima J, Juhás S, et al. Gradual Phenotype Development in Huntington Disease Transgenic Minipig Model at 24 Months of Age. Neurodegener Dis. 2018;18:107-119 pubmed publisher |
| Clift D, McEwan W, Labzin L, Konieczny V, Mogessie B, James L, et al. A Method for the Acute and Rapid Degradation of Endogenous Proteins. Cell. 2017;171:1692-1706.e18 pubmed publisher |
| Yu M, Fu Y, Liang Y, Song H, Yao Y, Wu P, et al. Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models. Cell Res. 2017;27:1441-1465 pubmed publisher |
| Rindt H, Tom C, Lorson C, Mattis V. Optimization of trans-Splicing for Huntington's Disease RNA Therapy. Front Neurosci. 2017;11:544 pubmed publisher |
| Lee A, Ung H, Sands L, Kikis E. A new Caenorhabditis elegans model of human huntingtin 513 aggregation and toxicity in body wall muscles. PLoS ONE. 2017;12:e0173644 pubmed publisher |
| Pavel M, Imarisio S, Menzies F, Jimenez Sanchez M, Siddiqi F, Wu X, et al. CCT complex restricts neuropathogenic protein aggregation via autophagy. Nat Commun. 2016;7:13821 pubmed publisher |
| Zhang X, Abels E, Redzic J, Margulis J, Finkbeiner S, Breakefield X. Potential Transfer of Polyglutamine and CAG-Repeat RNA in Extracellular Vesicles in Huntington's Disease: Background and Evaluation in Cell Culture. Cell Mol Neurobiol. 2016;36:459-70 pubmed publisher |
| Stroedicke M, Bounab Y, Strempel N, Klockmeier K, Yigit S, Friedrich R, et al. Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity. Genome Res. 2015;25:701-13 pubmed publisher |
| Fodale V, Kegulian N, Verani M, Cariulo C, Azzollini L, Petricca L, et al. Polyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopy. PLoS ONE. 2014;9:e112262 pubmed publisher |
| Landles C, Weiss A, Franklin S, Howland D, Bates G. Caspase-6 does not contribute to the proteolysis of mutant huntingtin in the HdhQ150 knock-in mouse model of Huntington's disease. PLoS Curr. 2012;4:e4fd085bfc9973 pubmed publisher |
| Vidal R, Figueroa A, Court F, Thielen P, Molina C, Wirth C, et al. Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy. Hum Mol Genet. 2012;21:2245-62 pubmed publisher |
| Prahlad V, Morimoto R. Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins. Proc Natl Acad Sci U S A. 2011;108:14204-9 pubmed publisher |
| Thompson L, Aiken C, Kaltenbach L, Agrawal N, Illes K, Khoshnan A, et al. IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J Cell Biol. 2009;187:1083-99 pubmed publisher |
| Wacker J, Zareie M, Fong H, Sarikaya M, Muchowski P. Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer. Nat Struct Mol Biol. 2004;11:1215-22 pubmed |
| Brooks E, Arrasate M, Cheung K, Finkbeiner S. Using antibodies to analyze polyglutamine stretches. Methods Mol Biol. 2004;277:103-28 pubmed |
