This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Pindolol
catalog :
P0778
citations: 98
Reference
Liu W, Holdsworth C, Ye L. Synthesis of molecularly imprinted polymers using a functionalized initiator for chiral-selective recognition of propranolol. Chirality. 2020;32:370-377 pubmed publisher
Fornells E, Fuguet E, Mañé M, Ruiz R, Box K, Bosch E, et al. Effect of vinylpyrrolidone polymers on the solubility and supersaturation of drugs; a study using the Cheqsol method. Eur J Pharm Sci. 2018;117:227-235 pubmed publisher
Okamoto H, Hamaguchi R, Kuroda Y. Hydrophilic interaction chromatography with a focus on the drug-phosphate interaction in drug screening to determine the phospholipidosis induction risk. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1051:33-40 pubmed publisher
Teixeira Castro A, Jalles A, Esteves S, Kang S, da Silva Santos L, Silva Fernandes A, et al. Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. Brain. 2015;138:3221-37 pubmed publisher
Alvarez Segura T, Gómez Díaz A, Ortiz Bolsico C, Torres Lapasió J, García Alvarez Coque M. A chromatographic objective function to characterise chromatograms with unknown compounds or without standards available. J Chromatogr A. 2015;1409:79-88 pubmed publisher
Peris García E, Ortiz Bolsico C, Baeza Baeza J, García Álvarez Coque M. Isocratic and gradient elution in micellar liquid chromatography with Brij-35. J Sep Sci. 2015;38:2059-67 pubmed publisher
Nakamura Y, Ishii J, Kondo A. Applications of yeast-based signaling sensor for characterization of antagonist and analysis of site-directed mutants of the human serotonin 1A receptor. Biotechnol Bioeng. 2015;112:1906-15 pubmed publisher
Al Majed A, Hefnawy M, Mohammed M, Attia S, Lehmann J. Selective microemulsion liquid chromatography analysis of dopamine receptor antagonist LE300 and its N-methyl metabolite in mouse sera by using a monolithic silica column. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;989:104-11 pubmed publisher
Santos M, Tavares I, Boralli V, Figueiredo E. Direct doping analysis of beta-blocker drugs from urinary samples by on-line molecularly imprinted solid-phase extraction coupled to liquid chromatography/mass spectrometry. Analyst. 2015;140:2696-703 pubmed publisher
Galea C, Mangelings D, Heyden Y. Method development for impurity profiling in SFC: The selection of a dissimilar set of stationary phases. J Pharm Biomed Anal. 2015;111:333-43 pubmed publisher
Rocchi S, Rocco A, Pesek J, Matyska M, Capitani D, Fanali S. Enantiomers separation by nano-liquid chromatography: use of a novel sub-2 μm vancomycin silica hydride stationary phase. J Chromatogr A. 2015;1381:149-59 pubmed publisher
Ubeda Torres M, Ortiz Bolsico C, García Alvarez Coque M, Ruiz Angel M. Gaining insight in the behaviour of imidazolium-based ionic liquids as additives in reversed-phase liquid chromatography for the analysis of basic compounds. J Chromatogr A. 2015;1380:96-103 pubmed publisher
Udy A, Jarrett P, Stuart J, Lassig Smith M, Starr T, Dunlop R, et al. Determining the mechanisms underlying augmented renal drug clearance in the critically ill: use of exogenous marker compounds. Crit Care. 2014;18:657 pubmed publisher
Mandic M, Drinovec L, Glisic S, Veljkovic N, Nøhr J, Vrecl M. Demonstration of a direct interaction between β2-adrenergic receptor and insulin receptor by BRET and bioinformatics. PLoS ONE. 2014;9:e112664 pubmed publisher
Freitas A, Egea J, Buendia I, Navarro E, Rada P, Cuadrado A, et al. Agmatine induces Nrf2 and protects against corticosterone effects in hippocampal neuronal cell line. Mol Neurobiol. 2015;51:1504-19 pubmed publisher
Hsieh M, Chau L, Hon Y. Single-step approach for fabrication of vancomycin-bonded silica monolith as chiral stationary phase. J Chromatogr A. 2014;1358:208-16 pubmed publisher
Periat A, Kohler I, Bugey A, Bieri S, Versace F, Staub C, et al. Hydrophilic interaction chromatography versus reversed phase liquid chromatography coupled to mass spectrometry: effect of electrospray ionization source geometry on sensitivity. J Chromatogr A. 2014;1356:211-20 pubmed publisher
Vlčková H, Ježková K, Stětková K, Tomšíková H, Solich P, Novakova L. Study of the retention behavior of small polar molecules on different types of stationary phases used in hydrophilic interaction liquid chromatography. J Sep Sci. 2014;37:1297-307 pubmed publisher
Agius A, Jones N, Muscat R. Serial blood serotonin levels in a randomized controlled trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in patients with chronic tension-type facial pain. Rhinology. 2013;51:236-42 pubmed publisher
Tan C, Tan E, Luo B, Huang C, Loo J, Choong C, et al. SMAD3 deficiency promotes inflammatory aortic aneurysms in angiotensin II-infused mice via activation of iNOS. J Am Heart Assoc. 2013;2:e000269 pubmed publisher
Agius A, Jones N, Muscat R. A Randomized Controlled Trial comparing the efficacy of low-dose amitriptyline, amitriptyline with pindolol and surrogate placebo in the treatment of chronic tension-type facial pain. Rhinology. 2013;51:143-53 pubmed publisher
Wang C, Jiang Y, Ma J, Wu H, Wacker D, KATRITCH V, et al. Structural basis for molecular recognition at serotonin receptors. Science. 2013;340:610-4 pubmed publisher
Skelin I, Fikre Merid M, Diksic M. Both acute and subchronic treatments with pindolol, a 5-HT(1A) and ?? and ?? adrenoceptor antagonist, elevate regional serotonin synthesis in the rat brain: an autoradiographic study. Neurochem Int. 2012;61:1417-23 pubmed publisher
Erkinaro T, Haapsamo M, Kavasmaa T, Mäkikallio K, Acharya G, Rasanen J. Fetal cardiac function after labetalol or pindolol for maternal hypertension in a sheep model of increased placental vascular resistance. Eur J Obstet Gynecol Reprod Biol. 2013;166:18-22 pubmed publisher
Saijo T, Maeda J, Okauchi T, Maeda J, Morio Y, Kuwahara Y, et al. Presynaptic selectivity of a ligand for serotonin 1A receptors revealed by in vivo PET assays of rat brain. PLoS ONE. 2012;7:e42589 pubmed publisher
Morante Zarcero S, Sierra I. Simultaneous enantiomeric determination of propranolol, metoprolol, pindolol, and atenolol in natural waters by HPLC on new polysaccharide-based stationary phase using a highly selective molecularly imprinted polymer extraction. Chirality. 2012;24:860-6 pubmed publisher
Belal F, Sharaf el Din M, Aly F, Hefnawy M, el Awady M. Fluorometric determination of bopindolol and celiprolol in pharmaceutical preparations and biological fluids. J Fluoresc. 2012;22:1141-50 pubmed publisher
Martiny K, Lunde M, Bech P, Plenge P. A short-term double-blind randomized controlled pilot trial with active or placebo pindolol in patients treated with venlafaxine for major depression. Nord J Psychiatry. 2012;66:147-54 pubmed publisher
Abdelkrim M, Mallem M, Chatagnon G, Gogny M, Desfontis J, Noireaud J. Autoantibodies against cardiac β(1)-adrenoceptor do not affect the low-affinity state β(1)-adrenoceptor-mediated inotropy in rat cardiomyocytes. Can J Physiol Pharmacol. 2012;90:407-14 pubmed publisher
Silva S, Ribeiro C. Tachyphylaxis to the sumatriptan-induced contractile effect in the human uterine artery but not in human cerebral blood vessels: pharmacological demonstration of the 5-HT(1B) receptor functionality loss. Pharmacology. 2012;89:29-36 pubmed publisher
Jin Y, Chen C, Meng L, Chen J, Li M, Zhu Z. Simultaneous and sensitive capillary electrophoretic enantioseparation of three ?-blockers with the combination of achiral ionic liquid and dual CD derivatives. Talanta. 2012;89:149-54 pubmed publisher
Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W. Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS Comput Biol. 2011;7:e1002310 pubmed publisher
Terao T. Can pindolol really enhance antidepressant effect?. J Clin Psychiatry. 2011;72:1558; author reply 1558 pubmed publisher
Newman W, McDermott B. Beta blockers for violence prophylaxis: case reports. J Clin Psychopharmacol. 2011;31:785-7 pubmed publisher
Bao J, Krylova S, Wilson D, Reinstein O, Johnson P, Krylov S. Kinetic capillary electrophoresis with mass-spectrometry detection (KCE-MS) facilitates label-free solution-based kinetic analysis of protein-small molecule binding. Chembiochem. 2011;12:2551-4 pubmed publisher
Block F, Dafotakis M. [Drug-induced tremor]. Fortschr Neurol Psychiatr. 2011;79:570-5 pubmed publisher
Miller J, Tate C. Engineering an ultra-thermostable β(1)-adrenoceptor. J Mol Biol. 2011;413:628-38 pubmed publisher
Baker J, Adams L, Salchow K, Mistry S, Middleton R, Hill S, et al. Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human ?-adrenoceptors. J Med Chem. 2011;54:6874-87 pubmed publisher
Bode M, Gravestock D, Moleele S, van der Westhuyzen C, Pelly S, Steenkamp P, et al. Imidazo[1,2-a]pyridin-3-amines as potential HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorg Med Chem. 2011;19:4227-37 pubmed publisher
Goral V, Jin Y, Sun H, Ferrie A, Wu Q, Fang Y. Agonist-directed desensitization of the β2-adrenergic receptor. PLoS ONE. 2011;6:e19282 pubmed publisher
Zielińska Pisklak M, Pisklak D, Wawer I. 1H and 13C NMR characteristics of ?-blockers. Magn Reson Chem. 2011;49:284-90 pubmed publisher
Gozalbes R, Jacewicz M, Annand R, Tsaioun K, Pineda Lucena A. QSAR-based permeability model for drug-like compounds. Bioorg Med Chem. 2011;19:2615-24 pubmed publisher
Sela V, Biesdorf C, Ramos D, Zangrossi H, Graeff F, Audi E. Serotonin-1A receptors in the dorsal periaqueductal gray matter mediate the panicolytic-like effect of pindolol and paroxetine combination in the elevated T-maze. Neurosci Lett. 2011;495:63-6 pubmed publisher
Herold F, Chodkowski A, Izbicki Ł, Turło J, Dawidowski M, Kleps J, et al. Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT(1A) activity. part 3. Eur J Med Chem. 2011;46:142-9 pubmed publisher
Portella M, de Diego Adeliño J, Ballesteros J, Puigdemont D, Oller S, Santos B, et al. Can we really accelerate and enhance the selective serotonin reuptake inhibitor antidepressant effect? A randomized clinical trial and a meta-analysis of pindolol in nonresistant depression. J Clin Psychiatry. 2011;72:962-9 pubmed publisher
Buttar D, Colclough N, Gerhardt S, Macfaul P, Phillips S, Plowright A, et al. A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions. Bioorg Med Chem. 2010;18:7486-96 pubmed publisher
Ekins S, Williams A, Xu J. A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug Metab Dispos. 2010;38:2302-8 pubmed publisher
Sela V, Roncon C, Zangrossi H, Graeff F, Audi E. Pindolol potentiates the panicolytic effect of paroxetine in the elevated T-maze. Life Sci. 2010;87:445-50 pubmed publisher
Del Giaccio A, Eblen Zajjur A. Cardiovascular drugs in human mechanical nociception: digoxin, amlodipine, propranolol, pindolol and atenolol. Invest Clin. 2010;51:77-86 pubmed
Gozalbes R, Pineda Lucena A. QSAR-based solubility model for drug-like compounds. Bioorg Med Chem. 2010;18:7078-84 pubmed publisher
Balaraman G, Bhattacharya S, Vaidehi N. Structural insights into conformational stability of wild-type and mutant beta1-adrenergic receptor. Biophys J. 2010;99:568-77 pubmed publisher
Greene N, Fisk L, Naven R, Note R, Patel M, Pelletier D. Developing structure-activity relationships for the prediction of hepatotoxicity. Chem Res Toxicol. 2010;23:1215-22 pubmed publisher
Hysek C, Vollenweider F, Liechti M. Effects of a beta-blocker on the cardiovascular response to MDMA (Ecstasy). Emerg Med J. 2010;27:586-9 pubmed publisher
Giacomini K, Huang S, Tweedie D, Benet L, Brouwer K, Chu X, et al. Membrane transporters in drug development. Nat Rev Drug Discov. 2010;9:215-36 pubmed publisher
Varma M, Obach R, Rotter C, Miller H, Chang G, Steyn S, et al. Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. J Med Chem. 2010;53:1098-108 pubmed publisher
Guerra A, Campillo N, Paez J. Neural computational prediction of oral drug absorption based on CODES 2D descriptors. Eur J Med Chem. 2010;45:930-40 pubmed publisher
Kruhlak N, Choi S, Contrera J, Weaver J, Willard J, Hastings K, et al. Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicol Mech Methods. 2008;18:217-27 pubmed publisher
Fridén M, Winiwarter S, Jerndal G, Bengtsson O, Wan H, Bredberg U, et al. Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. J Med Chem. 2009;52:6233-43 pubmed publisher
Langham J, Cleves A, Spitzer R, Kirshner D, Jain A. Physical binding pocket induction for affinity prediction. J Med Chem. 2009;52:6107-25 pubmed publisher
Du Cuny L, Song Z, Moses S, Powis G, Mash E, Meuillet E, et al. Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorg Med Chem. 2009;17:6983-92 pubmed publisher
Varma M, Feng B, Obach R, Troutman M, Chupka J, Miller H, et al. Physicochemical determinants of human renal clearance. J Med Chem. 2009;52:4844-52 pubmed publisher
Bard B, Carrupt P, Martel S. Lipophilicity of basic drugs measured by hydrophilic interaction chromatography. J Med Chem. 2009;52:3416-9 pubmed publisher
Wan H, Ahman M, Holmén A. Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. J Med Chem. 2009;52:1693-700 pubmed publisher
Whale R, Terao T, Cowen P, Freemantle N, Geddes J. Pindolol augmentation of serotonin reuptake inhibitors for the treatment of depressive disorder: a systematic review. J Psychopharmacol. 2010;24:513-20 pubmed publisher
Li H, Sun J, Sui X, Liu J, Yan Z, Liu X, et al. First-principle, structure-based prediction of hepatic metabolic clearance values in human. Eur J Med Chem. 2009;44:1600-6 pubmed publisher
Groszek G, Bednarski M, Dybała M, Filipek B. Synthesis and adrenolytic activity of 1-(1H-indol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol and its enantiomers. Part 1. Eur J Med Chem. 2009;44:809-17 pubmed publisher
Obach R, Lombardo F, Waters N. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug Metab Dispos. 2008;36:1385-405 pubmed publisher
Henchoz Y, Guillarme D, Rudaz S, Veuthey J, Carrupt P. High-throughput log P determination by ultraperformance liquid chromatography: a convenient tool for medicinal chemists. J Med Chem. 2008;51:396-9 pubmed publisher
Krushinski J, Schaus J, Thompson D, Calligaro D, Nelson D, Luecke S, et al. Indoloxypropanolamine analogues as 5-HT(1A) receptor antagonists. Bioorg Med Chem Lett. 2007;17:5600-4 pubmed
Abraham M, Ibrahim A, Acree W. Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. Eur J Med Chem. 2008;43:478-85 pubmed
Fujikawa M, Nakao K, Shimizu R, Akamatsu M. QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorg Med Chem. 2007;15:3756-67 pubmed
Diamandis P, Wildenhain J, Clarke I, Sacher A, Graham J, Bellows D, et al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol. 2007;3:268-73 pubmed
Artigas F, Adell A, Celada P. Pindolol augmentation of antidepressant response. Curr Drug Targets. 2006;7:139-47 pubmed
Morphy R, Rankovic Z. Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005;48:6523-43 pubmed
Caron G, Ermondi G. Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). J Med Chem. 2005;48:3269-79 pubmed
Matsson P, Bergström C, Nagahara N, Tavelin S, Norinder U, Artursson P. Exploring the role of different drug transport routes in permeability screening. J Med Chem. 2005;48:604-13 pubmed
Segrave R, Nathan P. Pindolol augmentation of selective serotonin reuptake inhibitors: accounting for the variability of results of placebo-controlled double-blind studies in patients with major depression. Hum Psychopharmacol. 2005;20:163-74 pubmed
Brousse G, Schmitt A, Chereau I, Eschalier A, Dubray C, Llorca P. [Interest of the use of pindolol in the treatment of depression: review]. Encephale. 2003;29:338-50 pubmed
Kinney G, Taber M, Gribkoff V. The augmentation hypothesis for improvement of antidepressant therapy: is pindolol a suitable candidate for testing the ability of 5HT1A receptor antagonists to enhance SSRI efficacy and onset latency?. Mol Neurobiol. 2000;21:137-52 pubmed
Artigas F, Celada P, Laruelle M, Adell A. How does pindolol improve antidepressant action?. Trends Pharmacol Sci. 2001;22:224-8 pubmed
Olver J, Cryan J, Burrows G, Norman T. Pindolol augmentation of antidepressants: a review and rationale. Aust N Z J Psychiatry. 2000;34:71-9 pubmed
Martinez D, Broft A, Laruelle M. Pindolol augmentation of antidepressant treatment: recent contributions from brain imaging studies. Biol Psychiatry. 2000;48:844-53 pubmed
Ichikawa J, Meltzer H. The effect of ipsapirone and S(-)-pindolol on dopamine release in rat striatum and nucleus accumbens. Brain Res. 1999;842:445-51 pubmed
Fornal C, Martin F, Metzler C, Jacobs B. Pindolol suppresses serotonergic neuronal activity and does not block the inhibition of serotonergic neurons produced by 8-hydroxy-2-(di-n-propylamino)tetralin in awake cats. J Pharmacol Exp Ther. 1999;291:229-38 pubmed
Millan M, Gobert A. (-)-Pindolol increases dialysate concentrations of dopamine and noradrenaline, but not serotonin, in the frontal cortex of freely-moving rats. Neuropharmacology. 1999;38:909-12 pubmed
Puzantian T, Kawase K. Does the addition of pindolol accelerate or enhance the response to selective serotonin reuptake inhibitor antidepressants?. Pharmacotherapy. 1999;19:205-12 pubmed
McAskill R, Mir S, Taylor D. Pindolol augmentation of antidepressant therapy. Br J Psychiatry. 1998;173:203-8 pubmed
Blier P, Bergeron R. The use of pindolol to potentiate antidepressant medication. J Clin Psychiatry. 1998;59 Suppl 5:16-23; discussion 24-5 pubmed
Watkins D, Lawrence A, Lewis S, Jarrott B. Loss of [125I]-pindolol binding to beta-adrenoceptors on rat nodose ganglion after chronic isoprenaline treatment. J Auton Nerv Syst. 1996;60:12-6 pubmed
Krupp P, Fanchamps A. Pindolol: experience gained in 10 years of safety monitoring. Am Heart J. 1982;104:486-90 pubmed
Gonasun L. Antihypertensive effects of pindolol. Am Heart J. 1982;104:374-87 pubmed
Frishman W. Drug therapy. Pindolol: a new beta-adrenoceptor antagonist with partial agonist activity. N Engl J Med. 1983;308:940-4 pubmed
Fanchamps A. Therapeutic trials of pindolol in hypertension: comparison and combination with other drugs. Am Heart J. 1982;104:388-406 pubmed
Aellig W. Clinical pharmacology of pindolol. Am Heart J. 1982;104:346-56 pubmed
Duner H. Reversibility of structural changes in the resistance vessels in hypertension: a review of studies with pindolol. Br J Clin Pharmacol. 1987;24 Suppl 1:51S-54S pubmed
Herpin D, Guillard O, Piriou A, Amiel A, Boutaud P, Ciber M, et al. [Comparative effects of pindolol and atenolol on blood pressure and lipids in mild to moderate arterial hypertension]. Ann Med Interne (Paris). 1988;139:484-7 pubmed
Aellig W, Clark B. Is the ISA of pindolol beta 2-adrenoceptor selective?. Br J Clin Pharmacol. 1987;24 Suppl 1:21S-28S pubmed
. Effects of pindolol, or a pindolol/clopamide combination preparation, on plasma lipid levels in essential hypertension. Hunter Hypertension Research Group. Med J Aust. 1989;150:646, 648, 651-2 pubmed
product information
Catalog Number :
P0778
Product Name :
Pindolol
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (TLC), powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA