This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Prostratin
catalog :
P0077
citations: 29
Reference
Zhang W, Svensson Akusjärvi S, Sonnerborg A, Neogi U. Characterization of Inducible Transcription and Translation-Competent HIV-1 Using the RNAscope ISH Technology at a Single-Cell Resolution. Front Microbiol. 2018;9:2358 pubmed publisher
Saayman S, Lazar D, Scott T, Hart J, Takahashi M, Burnett J, et al. Potent and Targeted Activation of Latent HIV-1 Using the CRISPR/dCas9 Activator Complex. Mol Ther. 2016;24:488-98 pubmed publisher
Power D, Santoso N, Dieringer M, Yu J, Huang H, Simpson S, et al. IFI44 suppresses HIV-1 LTR promoter activity and facilitates its latency. Virology. 2015;481:142-50 pubmed publisher
Shen X, Xiong G, Jing Y, Xiao H, Cui Y, Zhang Y, et al. The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents. Cancer Lett. 2015;356:686-96 pubmed publisher
Murry J, Godoy J, Mukim A, Swann J, Bruce J, Ahlquist P, et al. Sulfonation pathway inhibitors block reactivation of latent HIV-1. Virology. 2014;471-473:1-12 pubmed publisher
Bourjot M, Delang L, Nguyen V, Neyts J, Guéritte F, Leyssen P, et al. Prostratin and 12-O-tetradecanoylphorbol 13-acetate are potent and selective inhibitors of Chikungunya virus replication. J Nat Prod. 2012;75:2183-7 pubmed publisher
Chan C, McMonagle E, Hosie M, Willett B. Prostratin exhibits both replication enhancing and inhibiting effects on FIV infection of feline CD4+ T-cells. Virus Res. 2013;171:121-8 pubmed publisher
Ying H, Zhang Y, Zhou X, Qu X, Wang P, Liu S, et al. Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB. PLoS ONE. 2012;7:e48832 pubmed publisher
Li Z, Guo J, Wu Y, Zhou Q. The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation. Nucleic Acids Res. 2013;41:277-87 pubmed publisher
Zhu J, Gaiha G, John S, Pertel T, Chin C, Gao G, et al. Reactivation of latent HIV-1 by inhibition of BRD4. Cell Rep. 2012;2:807-16 pubmed publisher
DeChristopher B, Loy B, Marsden M, Schrier A, Zack J, Wender P. Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro. Nat Chem. 2012;4:705-10 pubmed publisher
Tang Y, Jiang W, Wu Q, Yu L, Zhang L, Tao W, et al. Comparative characteristic of the inflammatory diterpenes in the roots of Euphorbia fischeriana with different preparation method using HPLC-ELSD. Fitoterapia. 2012;83:427-33 pubmed publisher
Barrero R, Chapman B, Yang Y, Moolhuijzen P, Keeble Gagnère G, Zhang N, et al. De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes. BMC Genomics. 2011;12:600 pubmed publisher
Tripathy M, Abbas W, Herbein G. Epigenetic regulation of HIV-1 transcription. Epigenomics. 2011;3:487-502 pubmed publisher
Yu L, Jiang B, Luo D, Shen X, Guo S, Duan J, et al. Bioactive components in the fruits of Ziziphus jujuba Mill. against the inflammatory irritant action of Euphorbia plants. Phytomedicine. 2012;19:239-44 pubmed publisher
Ying H, Zhang Y, Lin S, Han Y, Zhu H. Histone deacetylase inhibitor Scriptaid reactivates latent HIV-1 promoter by inducing histone modification in in vitro latency cell lines. Int J Mol Med. 2010;26:265-72 pubmed
Reuse S, Calao M, Kabeya K, Guiguen A, Gatot J, Quivy V, et al. Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection. PLoS ONE. 2009;4:e6093 pubmed publisher
JOHNSON H, Banack S, Cox P. Variability in content of the anti-AIDS drug candidate prostratin in Samoan populations of Homalanthus nutans. J Nat Prod. 2008;71:2041-4 pubmed publisher
Marsden M, Xu J, Hamer D, Zack J. Short communication: Activating stimuli enhance immunotoxin-mediated killing of HIV-infected macrophages. AIDS Res Hum Retroviruses. 2008;24:1399-404 pubmed publisher
Cox P, JOHNSON H, Tavana G. Giving Samoan healers credit for prostratin. Science. 2008;320:1589 pubmed publisher
Katz R, Jack Scott E, Narezkina A, Palagin I, Boimel P, Kulkosky J, et al. High-frequency epigenetic repression and silencing of retroviruses can be antagonized by histone deacetylase inhibitors and transcriptional activators, but uniform reactivation in cell clones is restricted by additional mechanisms. J Virol. 2007;81:2592-604 pubmed
Sung T, Rice A. Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells. Retrovirology. 2006;3:66 pubmed
Warrilow D, Gardner J, Darnell G, Suhrbier A, Harrich D. HIV type 1 inhibition by protein kinase C modulatory compounds. AIDS Res Hum Retroviruses. 2006;22:854-64 pubmed
Hezareh M. Prostratin as a new therapeutic agent targeting HIV viral reservoirs. Drug News Perspect. 2005;18:496-500 pubmed
Brown H, McBride W, Zack J, Sun R. Prostratin and bortezomib are novel inducers of latent Kaposi's sarcoma-associated herpesvirus. Antivir Ther. 2005;10:745-51 pubmed
Hezareh M, Moukil M, Szanto I, Pondarzewski M, Mouche S, Cherix N, et al. Mechanisms of HIV receptor and co-receptor down-regulation by prostratin: role of conventional and novel PKC isoforms. Antivir Chem Chemother. 2004;15:207-22 pubmed
Rullas J, Bermejo M, Garcia Perez J, Beltán M, González N, Hezareh M, et al. Prostratin induces HIV activation and downregulates HIV receptors in peripheral blood lymphocytes. Antivir Ther. 2004;9:545-54 pubmed
Biancotto A, Grivel J, Gondois Rey F, Bettendroffer L, Vigne R, Brown S, et al. Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue. J Virol. 2004;78:10507-15 pubmed
Williams S, Chen L, Kwon H, Fenard D, Bisgrove D, Verdin E, et al. Prostratin antagonizes HIV latency by activating NF-kappaB. J Biol Chem. 2004;279:42008-17 pubmed
product information
Catalog Number :
P0077
Product Name :
Prostratin
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC)
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA