product summary
company name :
MilliporeSigma
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, FLUKA, Sigma-Aldrich, Novabiochem, Guava, Roche Applied Science
product type :
antibody
product name :
Anti-p62/SQSTM1 antibody produced in rabbit
catalog :
P0067
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, fruit fly
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section, proximity ligation assay
more info or order :
citations: 276
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; loading ...; fig 3f
Wani A, Zhu J, ULRICH J, Eteleeb A, Sauerbeck A, Reitz S, et al. Neuronal VCP loss of function recapitulates FTLD-TDP pathology. Cell Rep. 2021;36:109399 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5a
Park G, Lee J, Han H, An H, Jin Z, Jeong E, et al. Ablation of dynamin-related protein 1 promotes diabetes-induced synaptic injury in the hippocampus. Cell Death Dis. 2021;12:445 pubmed publisher
  • proximity ligation assay; human; fig 8j
  • immunoprecipitation; human; 1:100; loading ...; fig 7h
  • immunocytochemistry; human; fig 7m
Cui Y, Yang S, Wei J, Shea C, Zhong W, Wang F, et al. Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis. Nat Commun. 2021;12:2183 pubmed publisher
  • western blot; mouse; fig 1e
Lim Y, Kim S, Kim E. Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells. Mol Brain. 2021;14:65 pubmed publisher
  • immunohistochemistry - paraffin section; rat; loading ...; fig 1d
  • immunohistochemistry - frozen section; human; loading ...; fig 5a
Shin H, Park H, Shin N, Kwon H, Yin Y, Hwang J, et al. Pink1-Mediated Chondrocytic Mitophagy Contributes to Cartilage Degeneration in Osteoarthritis. J Clin Med. 2019;8: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7b
Jung S, Choe S, Woo H, Jeong H, An H, Moon H, et al. Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits. Autophagy. 2019;:1-19 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:500; loading ...; fig 5
  • immunohistochemistry; mouse; 1:500; loading ...; fig 6c
  • western blot; mouse; 1:1000; loading ...; fig 7a
Duan W, Guo M, Yi L, Zhang J, Bi Y, Liu Y, et al. Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice. Aging (Albany NY). 2019;11:2457-2476 pubmed publisher
  • western blot; mouse; loading ...; fig s6d
Ao Y, Zhang J, Liu Z, Qian M, Li Y, Wu Z, et al. Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model. Sci Adv. 2019;5:eaav5078 pubmed publisher
  • western blot; human; fig 4a
Park H, Chung K, An H, Gim J, Hong J, Woo H, et al. Parkin Promotes Mitophagic Cell Death in Adult Hippocampal Neural Stem Cells Following Insulin Withdrawal. Front Mol Neurosci. 2019;12:46 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 5a
Pajares M, Rojo A, Arias E, Díaz Carretero A, Cuervo A, Cuadrado A. Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A. Autophagy. 2018;14:1310-1322 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:50; loading ...; fig 6a
  • western blot; mouse; 1:1000; loading ...; fig 5a
Liu H, Jiang W, Chen X, Chang G, Zhao L, Li X, et al. Skeletal muscle-specific Sidt2 knockout in mice induced muscular dystrophy-like phenotype. Metabolism. 2018;85:259-270 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7a
  • western blot; fruit fly ; 1:1000; loading ...; fig 5c
Kovacs T, Billes V, Komlos M, Hotzi B, Manzéger A, Tarnóci A, et al. The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms. Sci Rep. 2017;7:42014 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 5b
  • immunocytochemistry; human; loading ...; fig 5c
  • western blot; human; loading ...; fig 1a
  • western blot; mouse; loading ...; fig 1k
Feng L, Zhang J, Zhu N, Ding Q, Zhang X, Yu J, et al. Ubiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant/?-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy. Autophagy. 2017;13:686-702 pubmed publisher
  • western blot; human; fig 2a
Kim M, Deng H, Wong Y, Siddique T, Krainc D. The Parkinson's disease-linked protein TMEM230 is required for Rab8a-mediated secretory vesicle trafficking and retromer trafficking. Hum Mol Genet. 2017;26:729-741 pubmed publisher
  • immunoprecipitation; human; fig 5c
  • western blot; human; 1:1000; fig 3b
López de Maturana R, Lang V, Zubiarrain A, Sousa A, Vázquez N, Gorostidi A, et al. Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons. J Neuroinflammation. 2016;13:295 pubmed
  • immunocytochemistry; human; loading ...; fig 1c
  • western blot; human; loading ...; fig 1b
Watanabe Y, Tsujimura A, Taguchi K, Tanaka M. HSF1 stress response pathway regulates autophagy receptor SQSTM1/p62-associated proteostasis. Autophagy. 2017;13:133-148 pubmed publisher
  • western blot; human; loading ...; fig 2d
Wang J, Zhang J, Lee Y, Koh P, Ng S, Bao F, et al. Quantitative chemical proteomics profiling of de novo protein synthesis during starvation-mediated autophagy. Autophagy. 2016;12:1931-1944 pubmed
  • immunohistochemistry - free floating section; mouse; 1:250; loading ...; fig 3b
  • immunohistochemistry - paraffin section; mouse; 1:250; loading ...; fig 3b
  • western blot; mouse; 1:2000; loading ...; fig 2b
  • immunohistochemistry - free floating section; human; 1:250; loading ...; fig 7c
  • immunohistochemistry - paraffin section; human; 1:250; loading ...; fig 7c
  • western blot; human; 1:2000; loading ...; fig 7a
Pajares M, Jiménez Moreno N, García Yagüe A, Escoll M, De Ceballos M, Van Leuven F, et al. Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes. Autophagy. 2016;12:1902-1916 pubmed
  • western blot; human; 1:1000; fig s5
Tosco A, De Gregorio F, Esposito S, De Stefano D, Sana I, Ferrari E, et al. A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR. Cell Death Differ. 2016;23:1380-93 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 5f
Son S, Cha M, Choi H, Kang S, Choi H, Lee M, et al. Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease. Autophagy. 2016;12:784-800 pubmed publisher
  • immunohistochemistry - frozen section; mouse
  • western blot; human
García Prat L, Martínez Vicente M, Perdiguero E, Ortet L, Rodríguez Ubreva J, Rebollo E, et al. Autophagy maintains stemness by preventing senescence. Nature. 2016;529:37-42 pubmed publisher
  • immunohistochemistry; human; fig 9
Xie C, Ginet V, Sun Y, Koike M, Zhou K, Li T, et al. Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury. Autophagy. 2016;12:410-23 pubmed publisher
Catalani E, Fanelli G, Silvestri F, Cherubini A, Del Quondam S, Bongiorni S, et al. Nutraceutical Strategy to Counteract Eye Neurodegeneration and Oxidative Stress in Drosophila melanogaster Fed with High-Sugar Diet. Antioxidants (Basel). 2021;10: pubmed publisher
Actis C, Muzio G, Autelli R. Autophagy Triggers Tamoxifen Resistance in Human Breast Cancer Cells by Preventing Drug-Induced Lysosomal Damage. Cancers (Basel). 2021;13: pubmed publisher
Napolitano F, Bruno G, Terracciano C, Franzese G, Palomba N, Scotto di Carlo F, et al. Rare Variants in Autophagy and Non-Autophagy Genes in Late-Onset Pompe Disease: Suggestions of Their Disease-Modifying Role in Two Italian Families. Int J Mol Sci. 2021;22: pubmed publisher
Escoll M, Lastra D, Robledinos Antón N, Wandosell F, Anton I, Cuadrado A. WIP Modulates Oxidative Stress through NRF2/KEAP1 in Glioblastoma Cells. Antioxidants (Basel). 2020;9: pubmed publisher
Cai C, Yang C, Zhuang X, Yuan N, Wu M, Tan J, et al. NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation. Autophagy. 2020;:1-19 pubmed publisher
Kim Y, Kim J, Hanh B, Kim S, Kim H, Kim Y, et al. The Peroxisome Proliferator-Activated Receptor α- Agonist Gemfibrozil Promotes Defense Against Mycobacterium abscessus Infections. Cells. 2020;9: pubmed publisher
Yang C, Zhu Z, Tong B, Iyaswamy A, Xie W, Zhu Y, et al. A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38. Redox Biol. 2020;32:101445 pubmed publisher
Wang Y, Zaitsev K, Lu Q, Li S, Schaiff W, Kim K, et al. Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes. Nat Microbiol. 2020;5:272-281 pubmed publisher
Hong C, Yeon J, Yeo B, Woo H, An H, Heo W, et al. Fas-apoptotic inhibitory molecule 2 localizes to the lysosome and facilitates autophagosome-lysosome fusion through the LC3 interaction region motif-dependent interaction with LC3. FASEB J. 2020;34:161-179 pubmed publisher
Li Y, Xie J, Li X, Fang J. Poly (ADP-ribosylation) of HMGB1 facilitates its acetylation and promotes HMGB1 translocation-associated chemotherapy-induced autophagy in leukaemia cells. Oncol Lett. 2020;19:368-378 pubmed publisher
Zou H, Wang T, Yuan J, Sun J, Yuan Y, Gu J, et al. Cadmium-induced cytotoxicity in mouse liver cells is associated with the disruption of autophagic flux via inhibiting the fusion of autophagosomes and lysosomes. Toxicol Lett. 2020;321:32-43 pubmed publisher
Carloni S, Balduini W. Simvastatin preconditioning confers neuroprotection against hypoxia-ischemia induced brain damage in neonatal rats via autophagy and silent information regulator 1 (SIRT1) activation. Exp Neurol. 2020;324:113117 pubmed publisher
Odeh M, Tamir Livne Y, Haas T, Bengal E. P38α MAPK coordinates the activities of several metabolic pathways that together induce atrophy of denervated muscles. FEBS J. 2020;287:73-93 pubmed publisher
Wang X, Yue J, Hu L, Tian Z, Zhang K, Yang L, et al. Activation of G protein-coupled receptor 30 protects neurons by regulating autophagy in astrocytes. Glia. 2020;68:27-43 pubmed publisher
Busquets S, Pérez Peiró M, Salazar Degracia A, Argiles J, Serpe R, Rojano Toimil A, et al. Differential structural features in soleus and gastrocnemius of carnitine-treated cancer cachectic rats. J Cell Physiol. 2020;235:526-537 pubmed publisher
Mustafa R, Kreiner G, Kaminska K, Wood A, Kirsch J, Tucker K, et al. Targeted Depletion of Primary Cilia in Dopaminoceptive Neurons in a Preclinical Mouse Model of Huntington's Disease. Front Cell Neurosci. 2019;13:565 pubmed publisher
Song J, Malampati S, Zeng Y, Durairajan S, Yang C, Tong B, et al. A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models. Aging Cell. 2019;:e13069 pubmed publisher
Ucci S, Renzini A, Russi V, Mangialardo C, Cammarata I, Cavioli G, et al. Thyroid Hormone Protects from Fasting-Induced Skeletal Muscle Atrophy by Promoting Metabolic Adaptation. Int J Mol Sci. 2019;20: pubmed publisher
Jiao D, Yang Z, Wang L, Hu B, Wang J, Xu A, et al. Endogenous leptin promotes autophagy in EBSS-induced PFCs. Anim Cells Syst (Seoul). 2019;23:318-325 pubmed publisher
Nettesheim A, Shim M, Hirt J, Liton P. Transcriptome analysis reveals autophagy as regulator of TGFβ/Smad-induced fibrogenesis in trabecular meshwork cells. Sci Rep. 2019;9:16092 pubmed publisher
Akpinar H, Kahraman H, Yaman I. Ochratoxin A Sequentially Activates Autophagy and the Ubiquitin-Proteasome System. Toxins (Basel). 2019;11: pubmed publisher
Sharaf A, Mensching L, Keller C, Rading S, Scheffold M, Palkowitsch L, et al. Systematic Affinity Purification Coupled to Mass Spectrometry Identified p62 as Part of the Cannabinoid Receptor CB2 Interactome. Front Mol Neurosci. 2019;12:224 pubmed publisher
Chollat Namy M, Ben Safta Saadoun T, Haferssas D, Meurice G, Chouaib S, Thiery J. The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy. Cell Death Dis. 2019;10:695 pubmed publisher
Balan E, Schwalm C, Naslain D, Nielens H, Francaux M, Deldicque L. Regular Endurance Exercise Promotes Fission, Mitophagy, and Oxidative Phosphorylation in Human Skeletal Muscle Independently of Age. Front Physiol. 2019;10:1088 pubmed publisher
Ding J, Li F, Cong Y, Miao J, Wu D, Liu B, et al. Trichostatin A inhibits skeletal muscle atrophy induced by cigarette smoke exposure in mice. Life Sci. 2019;235:116800 pubmed publisher
Sitaraman S, Na C, Yang L, Filuta A, Bridges J, Weaver T. Proteasome dysfunction in alveolar type 2 epithelial cells is associated with acute respiratory distress syndrome. Sci Rep. 2019;9:12509 pubmed publisher
Wang T, Wang J, Wang J, Mao L, Tang B, Vanderklish P, et al. HAP1 is an in vivo UBE3A target that augments autophagy in a mouse model of Angelman syndrome. Neurobiol Dis. 2019;132:104585 pubmed publisher
Koerver L, Papadopoulos C, Liu B, Kravic B, Rota G, Brecht L, et al. The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage. EMBO Rep. 2019;20:e48014 pubmed publisher
Liu C, Peng M, Zheng L, Zhao Y, Wang R, Su Q, et al. Enhanced autophagy alleviates injury during hindlimb ischemia/reperfusion in mice. Exp Ther Med. 2019;18:1669-1676 pubmed publisher
Liu X, Tu B, Jiang X, Xu G, Bai L, Zhang L, et al. Lysosomal dysfunction is associated with persistent lung injury in dams caused by pregnancy exposure to carbon black nanoparticles. Life Sci. 2019;233:116741 pubmed publisher
Orvedahl A, McAllaster M, Sansone A, Dunlap B, Desai C, Wang Y, et al. Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock. Proc Natl Acad Sci U S A. 2019;116:16497-16506 pubmed publisher
Moulis M, Grousset E, Faccini J, Richetin K, Thomas G, Vindis C. The Multifunctional Sorting Protein PACS-2 Controls Mitophagosome Formation in Human Vascular Smooth Muscle Cells through Mitochondria-ER Contact Sites. Cells. 2019;8: pubmed publisher
Yi M, Shin J, Shin N, Yin Y, Lee S, Kim C, et al. PINK1 mediates spinal cord mitophagy in neuropathic pain. J Pain Res. 2019;12:1685-1699 pubmed publisher
Vihola A, Palmio J, Danielsson O, Penttilä S, Louiselle D, Pittman S, et al. Novel mutation in TNPO3 causes congenital limb-girdle myopathy with slow progression. Neurol Genet. 2019;5:e337 pubmed publisher
Huang Y, Wang Y, Feng Y, Wang P, He X, Ren H, et al. Role of Endoplasmic Reticulum Stress-Autophagy Axis in Severe Burn-Induced Intestinal Tight Junction Barrier Dysfunction in Mice. Front Physiol. 2019;10:606 pubmed publisher
Sikder S, Kumari S, Mustafi P, Ramdas N, Padhi S, Saha A, et al. Nonhistone human chromatin protein PC4 is critical for genomic integrity and negatively regulates autophagy. FEBS J. 2019;: pubmed publisher
Oonthonpan L, Rauckhorst A, Gray L, Boutron A, Taylor E. Two human patient mitochondrial pyruvate carrier mutations reveal distinct molecular mechanisms of dysfunction. JCI Insight. 2019;5: pubmed publisher
Ha S, Jeong S, Yi K, Chu J, Kim S, Kim E, et al. Autophagy Mediates Astrogenesis in Adult Hippocampal Neural Stem Cells. Exp Neurobiol. 2019;28:229-246 pubmed publisher
Carrino M, Quotti Tubi L, Fregnani A, Canovas Nunes S, Barilà G, Trentin L, et al. Prosurvival autophagy is regulated by protein kinase CK1 alpha in multiple myeloma. Cell Death Discov. 2019;5:98 pubmed publisher
Qin P, Du E, Luo W, Yang Y, Zhang Y, Wang B, et al. Characteristics of the Life Cycle of Porcine Deltacoronavirus (PDCoV) In Vitro: Replication Kinetics, Cellular Ultrastructure and Virion Morphology, and Evidence of Inducing Autophagy. Viruses. 2019;11: pubmed publisher
Reyes Fermín L, Avila Rojas S, Aparicio Trejo O, Tapia E, Rivero I, Pedraza Chaverri J. The Protective Effect of Alpha-Mangostin against Cisplatin-Induced Cell Death in LLC-PK1 Cells is Associated to Mitochondrial Function Preservation. Antioxidants (Basel). 2019;8: pubmed publisher
Zhou X, Wan X, Fu X, Xie C. Puerarin prevents cadmium-induced hepatic cell damage by suppressing apoptosis and restoring autophagic flux. Biomed Pharmacother. 2019;115:108929 pubmed publisher
Jo M, Lee S, Kim K, Lee S, Kim S, Kim H. Inhibition of MEK5 suppresses TDP-43 toxicity via the mTOR-independent activation of the autophagy-lysosome pathway. Biochem Biophys Res Commun. 2019;513:925-932 pubmed publisher
Neubert P, Weichselbaum A, Reitinger C, Schatz V, Schröder A, Ferdinand J, et al. HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting. Autophagy. 2019;15:1899-1916 pubmed publisher
Lee D, Ahn J, Jang Y, Ha T, Jung C. Oleic acid-induced defective autolysosome shows impaired lipid degradation. Biochem Biophys Res Commun. 2019;513:553-559 pubmed publisher
Wang B, Maxwell B, Joo J, Gwon Y, Messing J, Mishra A, et al. ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97. Mol Cell. 2019;74:742-757.e8 pubmed publisher
Devorkin L, Pavey N, Carleton G, Comber A, Ho C, Lim J, et al. Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity. Cell Rep. 2019;27:502-513.e5 pubmed publisher
Chu Q, Zhang S, Chen M, Han W, Jia R, Chen W, et al. Cherry Anthocyanins Regulate NAFLD by Promoting Autophagy Pathway. Oxid Med Cell Longev. 2019;2019:4825949 pubmed publisher
Alyodawi K, Vermeij W, Omairi S, Kretz O, Hopkinson M, Solagna F, et al. Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling. J Cachexia Sarcopenia Muscle. 2019;10:662-686 pubmed publisher
Chen S, Li Y, Yin X, Li S, Zhu Y, Fan Y, et al. Recombinant adenoviruses expressing apoptin suppress the growth of MCF‑7 breast cancer cells and affect cell autophagy. Oncol Rep. 2019;41:2818-2832 pubmed publisher
Zhang X, Wang L, Ireland S, Ahat E, Li J, Bekier Ii M, et al. GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion. Autophagy. 2019;:1-14 pubmed publisher
Wani A, Gupta M, Ahmad M, Shah A, Ahsan A, Qazi P, et al. Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway. Autophagy. 2019;:1-19 pubmed publisher
Fedeli C, Filadi R, Rossi A, Mammucari C, Pizzo P. PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis. Autophagy. 2019;15:2044-2062 pubmed publisher
Lynch M, Tran M, Ralto K, Zsengellér Z, Raman V, Bhasin S, et al. TFEB-driven lysosomal biogenesis is pivotal for PGC1α-dependent renal stress resistance. JCI Insight. 2019;5: pubmed publisher
Xu C, Wang J, Jing Pan -, Min Liao -. Tph2 Genetic Ablation Contributes to Senile Plaque Load and Astrogliosis in APP/PS1 Mice. Curr Alzheimer Res. 2019;16:219-232 pubmed publisher
Chaurasia M, Gupta S, Das A, Dwarakanath B, Simonsen A, Sharma K. Radiation induces EIF2AK3/PERK and ERN1/IRE1 mediated pro-survival autophagy. Autophagy. 2019;15:1391-1406 pubmed publisher
Ryzhikov M, Ehlers A, Steinberg D, Xie W, Oberlander E, Brown S, et al. Diurnal Rhythms Spatially and Temporally Organize Autophagy. Cell Rep. 2019;26:1880-1892.e6 pubmed publisher
Zhao X, Wei S, Li Z, Lin C, Zhu Z, Sun D, et al. Autophagic flux blockage in alveolar epithelial cells is essential in silica nanoparticle-induced pulmonary fibrosis. Cell Death Dis. 2019;10:127 pubmed publisher
Feng H, Zhao X, Guo Q, Feng Y, Ma M, Guo W, et al. Autophagy resists EMT process to maintain retinal pigment epithelium homeostasis. Int J Biol Sci. 2019;15:507-521 pubmed publisher
Li J, Pan S, Wang J, Lu J. Changes in Autophagy Levels in Rat Myocardium During Exercise Preconditioning-Initiated Cardioprotective Effects. Int Heart J. 2019;60:419-428 pubmed publisher
Nahapetyan H, Moulis M, Grousset E, Faccini J, Grazide M, Mucher E, et al. Altered mitochondrial quality control in Atg7-deficient VSMCs promotes enhanced apoptosis and is linked to unstable atherosclerotic plaque phenotype. Cell Death Dis. 2019;10:119 pubmed publisher
Trajkovic K, Valdez C, Ysselstein D, Krainc D. Fluctuations in cell density alter protein markers of multiple cellular compartments, confounding experimental outcomes. PLoS ONE. 2019;14:e0211727 pubmed publisher
Pigna E, Simonazzi E, Sanna K, Bernadzki K, Proszynski T, Heil C, et al. Histone deacetylase 4 protects from denervation and skeletal muscle atrophy in a murine model of amyotrophic lateral sclerosis. EBioMedicine. 2019;40:717-732 pubmed publisher
Terra L, Wailemann R, Dos Santos A, Gomes V, Silva R, Laporte A, et al. Heat shock protein B1 is a key mediator of prolactin-induced beta-cell cytoprotection against oxidative stress. Free Radic Biol Med. 2019;134:394-405 pubmed publisher
Bai Y, Chen Y, Chen X, Jiang J, Wang X, Wang L, et al. Trichostatin A activates FOXO1 and induces autophagy in osteosarcoma. Arch Med Sci. 2019;15:204-213 pubmed publisher
Agrotis A, Pengo N, Burden J, Ketteler R. Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells. Autophagy. 2019;15:976-997 pubmed publisher
Arhzaouy K, Papadopoulos C, Schulze N, Pittman S, Meyer H, Weihl C. VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle. Autophagy. 2019;:1-18 pubmed publisher
Gong Z, Wang X, Wang J, Fan R, Wang L. Trehalose prevents cadmium-induced hepatotoxicity by blocking Nrf2 pathway, restoring autophagy and inhibiting apoptosis. J Inorg Biochem. 2019;192:62-71 pubmed publisher
Barreiro E, Salazar Degracia A, Sancho Muñoz A, Gea J. Endoplasmic reticulum stress and unfolded protein response profile in quadriceps of sarcopenic patients with respiratory diseases. J Cell Physiol. 2019;234:11315-11329 pubmed publisher
Wang R, Tan J, Chen T, Han H, Tian R, Tan Y, et al. ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome-lysosome fusion. J Cell Biol. 2019;218:267-284 pubmed publisher
Nie X, Wang W, Wang Q, Zhu D, Song H. Intranasal erythropoietin ameliorates neurological function impairments and neural pathology in mice with chronic alcoholism by regulating autophagy‑related Nrf2 degradation. Mol Med Rep. 2019;19:1139-1149 pubmed publisher
Wang M, Fan R, Li W, Zhang D, Yang D, Wang Z, et al. Activation of PERK-eIF2α-ATF4-CHOP axis triggered by excessive ER stress contributes to lead-induced nephrotoxicity. Biochim Biophys Acta Mol Cell Res. 2019;1866:713-726 pubmed publisher
Sironi J, Aranda E, Nordstrøm L, Schwartz E. Lysosome Membrane Permeabilization and Disruption of the Molecular Target of Rapamycin (mTOR)-Lysosome Interaction Are Associated with the Inhibition of Lung Cancer Cell Proliferation by a Chloroquinoline Analog. Mol Pharmacol. 2019;95:127-138 pubmed publisher
Wang L, Fan R, Yang D, Zhang D, Wang L. Puerarin reverses cadmium-induced lysosomal dysfunction in primary rat proximal tubular cells via inhibiting Nrf2 pathway. Biochem Pharmacol. 2019;162:132-141 pubmed publisher
Xu Y, Zhang S, Zheng H. The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau). Autophagy. 2019;15:583-598 pubmed publisher
Zhang L, Qiang P, Yu J, Miao Y, Chen Z, Qu J, et al. Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer. Autophagy. 2019;15:391-406 pubmed publisher
Ezquerro S, Mocha F, Fruhbeck G, Guzmán Ruiz R, Valenti V, Mugueta C, et al. Ghrelin Reduces TNF-α-Induced Human Hepatocyte Apoptosis, Autophagy, and Pyroptosis: Role in Obesity-Associated NAFLD. J Clin Endocrinol Metab. 2019;104:21-37 pubmed publisher
Vantaggiato C, Panzeri E, Castelli M, Citterio A, Arnoldi A, Santorelli F, et al. ZFYVE26/SPASTIZIN and SPG11/SPATACSIN mutations in hereditary spastic paraplegia types AR-SPG15 and AR-SPG11 have different effects on autophagy and endocytosis. Autophagy. 2019;15:34-57 pubmed publisher
Li B, Wang Z, Xie J, Wang G, Qian L, Guan X, et al. TIGAR knockdown enhanced the anticancer effect of aescin via regulating autophagy and apoptosis in colorectal cancer cells. Acta Pharmacol Sin. 2019;40:111-121 pubmed publisher
Knyazeva A, Krutikov A, Golovkin A, Mishanin A, Pavlov G, Smolina N, et al. Time- and Ventricular-Specific Expression Profiles of Genes Encoding Z-Disk Proteins in Pressure Overload Model of Left Ventricular Hypertrophy. Front Genet. 2018;9:684 pubmed publisher
De Luca E, Pedone D, Moglianetti M, Pulcini D, Perrelli A, Retta S, et al. Multifunctional Platinum@BSA-Rapamycin Nanocarriers for the Combinatorial Therapy of Cerebral Cavernous Malformation. ACS Omega. 2018;3:15389-15398 pubmed publisher
Qin C, Liu Q, Hu Z, Zhou L, Shang K, Bosco D, et al. Microglial TLR4-dependent autophagy induces ischemic white matter damage via STAT1/6 pathway. Theranostics. 2018;8:5434-5451 pubmed publisher
Relic B, Charlier E, Deroyer C, Malaise O, Crine Y, Neuville S, et al. Serum starvation raises turnover of phosphorylated p62/SQSTM1 (Serine 349), reveals expression of proteasome and N-glycanase1 interactive protein RAD23B and sensitizes human synovial fibroblasts to BAY 11-7085-induced cell death. Oncotarget. 2018;9:35830-35843 pubmed publisher
Zhao B, Shen C, Zheng Z, Wang X, Zhao W, Chen X, et al. Peiminine Inhibits Glioblastoma in Vitro and in Vivo Through Cell Cycle Arrest and Autophagic Flux Blocking. Cell Physiol Biochem. 2018;51:1566-1583 pubmed publisher
Shan Y, Sun S, Yang F, Shang N, Liu H. Dexmedetomidine protects the developing rat brain against the neurotoxicity wrought by sevoflurane: role of autophagy and Drp1-Bax signaling. Drug Des Devel Ther. 2018;12:3617-3624 pubmed publisher
Zhu W, Qu H, Xu K, Jia B, Li H, Du Y, et al. Differences in the starvation-induced autophagy response in MDA-MB-231 and MCF-7 breast cancer cells. Anim Cells Syst (Seoul). 2017;21:190-198 pubmed publisher
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product information
Product No. :
P0067
Product Name :
Anti-p62/SQSTM1 antibody produced in rabbit
Host :
rabbit
Conjugate :
unconjugated
Antibody Type :
polyclonal
Applications/Description :
Suitable for immunoprecipitation (IP): 1-2 μg using lysate of NIH-3T3 cells; western blot: 1-2 μg/mL using whole extracts of rat PC12 cells; indirect immunofluorescence: 1-2 μg/mL using human A549 cells
Species Reactivity :
rat, mouse, human
Concentration :
~1 mg/mL
Storage :
Store at -20°C
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA