Chang M, Pan Y, Wu H, Lu Y, Liao W, Yeh C, et al. Stimulation of MMP-9 of oral epithelial cells by areca nut extract is related to TGF-β/Smad2-dependent and -independent pathways and prevented by betel leaf extract, hydroxychavicol and melatonin. Aging (Albany NY). 2019;11:11624-11639 pubmed publisher

Weiterer S, Meier Soelch J, Georgomanolis T, Mizi A, Beyerlein A, Weiser H, et al. Distinct IL-1α-responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner. EMBO J. 2019;:e101533 pubmed publisher

Costa Mendonça Natividade F, Duque Lopes C, Ricci Azevedo R, Sardinha Silva A, Figueiredo Pinzan C, Paiva Alegre Maller A, et al. Receptor Heterodimerization and Co-Receptor Engagement in TLR2 Activation Induced by MIC1 and MIC4 from Toxoplasma gondii. Int J Mol Sci. 2019;20: pubmed publisher

Shin K, Park J, Hong Y, Aziz N, Park S, Kim S, et al. Anti-Inflammatory Effects of Licania macrocarpa Cuatrec Methanol Extract Target Src- and TAK1-Mediated Pathways. Evid Based Complement Alternat Med. 2019;2019:4873870 pubmed publisher

Sheng T, Sun Y, Sun J, Prinz R, Peng D, Liu X, et al. Role of TGF-β-activated kinase 1 (TAK1) activation in H5N1 influenza A virus-induced c-Jun terminal kinase activation and virus replication. Virology. 2019;537:263-271 pubmed publisher

Tang Y, Tu H, Zhang J, Zhao X, Wang Y, Qin J, et al. K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation. Nat Commun. 2019;10:4157 pubmed publisher

Newton K, Wickliffe K, Dugger D, Maltzman A, Roose Girma M, Dohse M, et al. Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis. Nature. 2019;574:428-431 pubmed publisher

Abe K, Yano T, Tanno M, Miki T, Kuno A, Sato T, et al. mTORC1 inhibition attenuates necroptosis through RIP1 inhibition-mediated TFEB activation. Biochim Biophys Acta Mol Basis Dis. 2019;1865:165552 pubmed publisher

Wang Y, Mao Y, Zhang X, Liu H, Peng W, Liang L, et al. TAK1 may promote the development of diabetic nephropathy by reducing the stability of SnoN protein. Life Sci. 2019;228:1-10 pubmed publisher

Krishna Subramanian S, Singer S, Armaka M, Banales J, Hölzer K, Schirmacher P, et al. RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury. Cell Death Differ. 2019;: pubmed publisher

Rogers C, Erkes D, Nardone A, Aplin A, Fernandes Alnemri T, Alnemri E. Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation. Nat Commun. 2019;10:1689 pubmed publisher

Olianas M, Dedoni S, Onali P. Inhibition of TNF-α-induced neuronal apoptosis by antidepressants acting through the lysophosphatidic acid receptor LPA1. Apoptosis. 2019;24:478-498 pubmed publisher

Nighot M, Rawat M, Al Sadi R, Castillo E, Nighot P, Ma T. Lipopolysaccharide-Induced Increase in Intestinal Permeability Is Mediated by TAK-1 Activation of IKK and MLCK/MYLK Gene. Am J Pathol. 2019;189:797-812 pubmed publisher

Zhou J, Qiu T, Wang T, Chen Z, Ma X, Zhang L, et al. USP4 deficiency exacerbates hepatic ischaemia/reperfusion injury via TAK1 signalling. Clin Sci (Lond). 2019;133:335-349 pubmed publisher

Bendrick J, Eldredge L, Williams E, Haight N, Dubash A. Desmoplakin Harnesses Rho GTPase and p38 Mitogen-Activated Protein Kinase Signaling to Coordinate Cellular Migration. J Invest Dermatol. 2019;139:1227-1236 pubmed publisher

Yang L, Wang W, Wang X, Zhao J, Xiao L, Gui W, et al. Creg in Hepatocytes Ameliorates Liver Ischemia/Reperfusion Injury in a TAK1-Dependent Manner in Mice. Hepatology. 2019;69:294-313 pubmed publisher

Deng Y, Lu J, Li W, Wu A, Zhang X, Tong W, et al. Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation. Nat Commun. 2018;9:4564 pubmed publisher

Choo M, Kraft S, Missero C, Park J. The protein kinase p38α destabilizes p63 to limit epidermal stem cell frequency and tumorigenic potential. Sci Signal. 2018;11: pubmed publisher

Prinz E, Aviram S, Aronheim A. WDR62 mediates TNFα-dependent JNK activation via TRAF2-MLK3 axis. Mol Biol Cell. 2018;29:2470-2480 pubmed publisher

Wu T, Xu K, Martinek J, Young R, Banchereau R, George J, et al. IL1 Receptor Antagonist Controls Transcriptional Signature of Inflammation in Patients with Metastatic Breast Cancer. Cancer Res. 2018;78:5243-5258 pubmed publisher

Zhang B, Fu D, Xu Q, Cong X, Wu C, Zhong X, et al. The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1. Nat Commun. 2018;9:1723 pubmed publisher

Zhu K, Liang W, Ma Z, Xu D, Cao S, Lu X, et al. Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression. Cell Death Dis. 2018;9:500 pubmed publisher

Ghorpade D, Ozcan L, Zheng Z, Nicoloro S, Shen Y, Chen E, et al. Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance. Nature. 2018;555:673-677 pubmed publisher

Zhou J, Fan Y, Zhong J, Huang Z, Huang T, Lin S, et al. TAK1 mediates excessive autophagy via p38 and ERK in cisplatin-induced acute kidney injury. J Cell Mol Med. 2018;22:2908-2921 pubmed publisher

Meng H, Liu Z, Li X, Wang H, Jin T, Wu G, et al. Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis. Proc Natl Acad Sci U S A. 2018;115:E2001-E2009 pubmed publisher

Fan Z, Xu X, Qi X, Wu Y. Role of TGF-β activated kinase-1 inhibitor on the interaction between macrophages and mesangial cells on the condition of high glucose. Immunol Invest. 2018;47:303-314 pubmed publisher

Zheng R, Liu H, Zhou Y, Yan D, Chen J, Ma D, et al. Notch4 Negatively Regulates the Inflammatory Response to Mycobacterium tuberculosis Infection by Inhibiting TAK1 Activation. J Infect Dis. 2018;218:312-323 pubmed publisher

Kobayashi A, Kobayashi S, Miyai K, Osawa Y, Horiuchi T, Kato S, et al. TAK1 inhibition ameliorates survival from graft-versus-host disease in an allogeneic murine marrow transplantation model. Int J Hematol. 2018;107:222-229 pubmed publisher

Chang M, Chang H, Lin P, Huang Y, Chan C, Tsai Y, et al. Effects of TGF-β1 on plasminogen activation in human dental pulp cells: Role of ALK5/Smad2, TAK1 and MEK/ERK signalling. J Tissue Eng Regen Med. 2018;12:854-863 pubmed publisher

Zinecker H, Ouaret D, Ebner D, Gaidt M, Taylor S, Aulicino A, et al. ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect. Oncotarget. 2017;8:106764-106777 pubmed publisher

Lu L, Zhang X, Tong H, Zhang W, Xu P, Qu S. Central Administration of 5Z-7-Oxozeaenol Protects Experimental Autoimmune Encephalomyelitis Mice by Inhibiting Microglia Activation. Front Pharmacol. 2017;8:789 pubmed publisher

Wang H, Meng H, Li X, Zhu K, Dong K, Mookhtiar A, et al. PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP. Proc Natl Acad Sci U S A. 2017;114:11944-11949 pubmed publisher

Jiao H, Ye Y, Yang R, Sun H, Wang S, Wang Y, et al. Downregulation of SAFB Sustains the NF-?B Pathway by Targeting TAK1 during the Progression of Colorectal Cancer. Clin Cancer Res. 2017;23:7108-7118 pubmed publisher

An S, Zhao L, Shen L, Wang S, Zhang K, Qi Y, et al. USP18 protects against hepatic steatosis and insulin resistance through its deubiquitinating activity. Hepatology. 2017;66:1866-1884 pubmed publisher

Shen H, Li L, Yang S, Wang D, Zhou S, Chen X, et al. Regulatory role of tumor necrosis factor receptor-associated factor 6 in breast cancer by activating the protein kinase B/glycogen synthase kinase 3β signaling pathway. Mol Med Rep. 2017;16:2269-2273 pubmed publisher

Proença C, Ribeiro D, Soares T, Tomé S, Silva A, Lima J, et al. Chlorinated Flavonoids Modulate the Inflammatory Process in Human Blood. Inflammation. 2017;40:1155-1165 pubmed publisher

Xu X, Sun J, Song R, Doscas M, Williamson A, Zhou J, et al. Inhibition of p70 S6 kinase (S6K1) activity by A77 1726, the active metabolite of leflunomide, induces autophagy through TAK1-mediated AMPK and JNK activation. Oncotarget. 2017;8:30438-30454 pubmed publisher

Wang H, Zhang X, Zuo Z, Zhang Q, Pan Y, Zeng B, et al. Rip2 Is Required for Nod2-Mediated Lysozyme Sorting in Paneth Cells. J Immunol. 2017;198:3729-3736 pubmed publisher

Olianas M, Dedoni S, Onali P. The GABAB positive allosteric modulators CGP7930 and GS39783 stimulate ERK1/2 signalling in cells lacking functional GABAB receptors. Eur J Pharmacol. 2017;794:135-146 pubmed publisher

Darvin P, Joung Y, Kang D, Sp N, Byun H, Hwang T, et al. Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells. J Cell Mol Med. 2017;21:720-734 pubmed publisher

Bo L, Cui H, Fang Z, Qun T, Xia C. Inactivation of transforming growth factor-?-activated kinase 1 promotes taxol efficacy in ovarian cancer cells. Biomed Pharmacother. 2016;84:917-924 pubmed publisher

Guo X, Yin H, Chen Y, Li L, Li J, Liu Q. TAK1 regulates caspase 8 activation and necroptotic signaling via multiple cell death checkpoints. Cell Death Dis. 2016;7:e2381 pubmed publisher

Zhang Y, O Keefe R, Jonason J. BMP-TAK1 (MAP3K7) Induces Adipocyte Differentiation Through PPARγ Signaling. J Cell Biochem. 2017;118:204-210 pubmed publisher

Wang P, Zhang X, Luo P, Jiang X, Zhang P, Guo J, et al. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun. 2016;7:10592 pubmed publisher

Lin P, Niu W, Peng C, Zhang Z, Niu J. The role of TAK1 expression in thyroid cancer. Int J Clin Exp Pathol. 2015;8:14449-56 pubmed

Xu X, Qi X, Shao Y, Li Y, Fu X, Feng S, et al. Blockade of TGF-β-activated kinase 1 prevents advanced glycation end products-induced inflammatory response in macrophages. Cytokine. 2016;78:62-8 pubmed publisher

Refaat A, Abdelhamed S, Saiki I, Sakurai H. Inhibition of p38 mitogen-activated protein kinase potentiates the apoptotic effect of berberine/tumor necrosis factor-related apoptosis-inducing ligand combination therapy. Oncol Lett. 2015;10:1907-1911 pubmed

Canli Ã, AlankuÅŸ Y, Grootjans S, Vegi N, Hültner L, Hoppe P, et al. Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors. Blood. 2016;127:139-48 pubmed publisher

Ota K, Kawaguchi M, Fujita J, Kokubu F, Huang S, Morishima Y, et al. Synthetic double-stranded RNA induces interleukin-32 in bronchial epithelial cells. Exp Lung Res. 2015;41:335-43 pubmed publisher

Hrabe J, O Leary B, Fath M, Rodman S, Button A, Domann F, et al. Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells. Redox Biol. 2015;5:319-327 pubmed publisher

Onodera Y, Teramura T, Takehara T, Shigi K, Fukuda K. Reactive oxygen species induce Cox-2 expression via TAK1 activation in synovial fibroblast cells. FEBS Open Bio. 2015;5:492-501 pubmed publisher

Refaat A, Aminullah -, Zhou Y, Kawanishi M, Tomaru R, Abdelhamed S, et al. Role of tyrosine kinase-independent phosphorylation of EGFR with activating mutation in cisplatin-treated lung cancer cells. Biochem Biophys Res Commun. 2015;458:856-61 pubmed publisher

Huang C, Sheu W, Chiang A. Docosahexaenoic acid and eicosapentaenoic acid suppress adhesion molecule expression in human aortic endothelial cells via differential mechanisms. Mol Nutr Food Res. 2015;59:751-62 pubmed publisher

Ribeiro D, Freitas M, Tomé S, Silva A, Laufer S, Lima J, et al. Flavonoids inhibit COX-1 and COX-2 enzymes and cytokine/chemokine production in human whole blood. Inflammation. 2015;38:858-70 pubmed publisher

Dvashi Z, Green Y, Pollack A. TAK1 inhibition accelerates cellular senescence of retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2014;55:5679-86 pubmed publisher

Hashimoto M, Nasser H, Chihara T, Suzu S. Macropinocytosis and TAK1 mediate anti-inflammatory to pro-inflammatory macrophage differentiation by HIV-1 Nef. Cell Death Dis. 2014;5:e1267 pubmed publisher

Beppu L, Anilkumar A, Newbury R, Dohil R, Broide D, Aceves S. TGF-β1-induced phospholamban expression alters esophageal smooth muscle cell contraction in patients with eosinophilic esophagitis. J Allergy Clin Immunol. 2014;134:1100-1107.e4 pubmed publisher

McEwan W, Tam J, Watkinson R, Bidgood S, Mallery D, James L. Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21. Nat Immunol. 2013;14:327-36 pubmed publisher

Strickson S, Campbell D, Emmerich C, Knebel A, Plater L, Ritorto M, et al. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. Biochem J. 2013;451:427-37 pubmed publisher

Arcipowski K, Bishop G. Roles of the kinase TAK1 in TRAF6-dependent signaling by CD40 and its oncogenic viral mimic, LMP1. PLoS ONE. 2012;7:e42478 pubmed publisher

Chang Y, Lee T, Chiang A. Quercetin enhances ABCA1 expression and cholesterol efflux through a p38-dependent pathway in macrophages. J Lipid Res. 2012;53:1840-50 pubmed publisher

Wang Z, Yang Y, Yang H, Capó Aponte J, Tachado S, Wolosin J, et al. NF-?B feedback control of JNK1 activation modulates TRPV1-induced increases in IL-6 and IL-8 release by human corneal epithelial cells. Mol Vis. 2011;17:3137-46 pubmed

Rzeczkowski K, Beuerlein K, Müller H, Dittrich Breiholz O, Schneider H, Kettner Buhrow D, et al. c-Jun N-terminal kinase phosphorylates DCP1a to control formation of P bodies. J Cell Biol. 2011;194:581-96 pubmed publisher