This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Ouabain octahydrate
catalog :
O3125
citations: 71
Reference
Hossain K, Li X, Zhang T, Paula S, Cornelius F, Clarke R. Polarity of the ATP binding site of the Na+,K+-ATPase, gastric H+,K+-ATPase and sarcoplasmic reticulum Ca2+-ATPase. Biochim Biophys Acta Biomembr. 2020;1862:183138 pubmed publisher
Shen J, Zhan Y, Li H, Wang Z. Ouabain impairs cancer metabolism and activates AMPK-Src signaling pathway in human cancer cell lines. Acta Pharmacol Sin. 2020;41:110-118 pubmed publisher
Skogestad J, Aronsen J, Tovsrud N, Wanichawan P, Hougen K, Stokke M, et al. Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes. Cardiovasc Res. 2020;116:78-90 pubmed publisher
Laube M, Riedel D, Ackermann B, Haase M, H Thome U. Glucocorticoids Equally Stimulate Epithelial Na+ Transport in Male and Female Fetal Alveolar Cells. Int J Mol Sci. 2019;21: pubmed publisher
Ryan A, Chan C, Graner F, Hiiragi T. Lumen Expansion Facilitates Epiblast-Primitive Endoderm Fate Specification during Mouse Blastocyst Formation. Dev Cell. 2019;51:684-697.e4 pubmed publisher
Karageorgi M, Groen S, Sumbul F, Pelaez J, Verster K, Aguilar J, et al. Genome editing retraces the evolution of toxin resistance in the monarch butterfly. Nature. 2019;574:409-412 pubmed publisher
Chan C, Costanzo M, Ruiz Herrero T, Mönke G, Petrie R, Bergert M, et al. Hydraulic control of mammalian embryo size and cell fate. Nature. 2019;: pubmed publisher
Gross N, Abad N, Lichtstein D, Taron S, Aparicio L, Fonteh A, et al. Endogenous Na+, K+-ATPase inhibitors and CSF [Na+] contribute to migraine formation. PLoS ONE. 2019;14:e0218041 pubmed publisher
Lin L, Xu L, Lv W, Han L, Xiang Y, Fu L, et al. An NLRP3 inflammasome-triggered cytokine storm contributes to Streptococcal toxic shock-like syndrome (STSLS). PLoS Pathog. 2019;15:e1007795 pubmed publisher
Solarski M, Williams D, Mehrabian M, Wang H, Wille H, Schmitt Ulms G. The human brain somatostatin interactome: SST binds selectively to P-type family ATPases. PLoS ONE. 2019;14:e0217392 pubmed publisher
Estevez P, Castro D, Pequeño Valtierra A, Leao J, Vilariño Ó, Diogène J, et al. An Attempt to Characterize the Ciguatoxin Profile in Seriola fasciata Causing Ciguatera Fish Poisoning in Macaronesia. Toxins (Basel). 2019;11: pubmed publisher
Mitchell D, Sun C, Hunter S, New D, Stenkamp D. Regeneration associated transcriptional signature of retinal microglia and macrophages. Sci Rep. 2019;9:4768 pubmed publisher
Muraglia K, Chorghade R, Kim B, Tang X, Shah V, Grillo A, et al. Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia. Nature. 2019;567:405-408 pubmed publisher
Shih Y, Shang H, Chen Y, Hsueh S, Chou H, Lu H, et al. Ouabain promotes immune responses in WEHI-3 cells to generate leukemia mice through enhancing phagocytosis and natural killer cell activities in vivo. Environ Toxicol. 2019;34:659-665 pubmed publisher
Williamson L, Flyak A, Kose N, Bombardi R, Branchizio A, Reddy S, et al. Early Human B Cell Response to Ebola Virus in Four U.S. Survivors of Infection. J Virol. 2019;93: pubmed publisher
Baeza Lehnert F, Saab A, Gutierrez R, Larenas V, Díaz E, Horn M, et al. Non-Canonical Control of Neuronal Energy Status by the Na+ Pump. Cell Metab. 2019;29:668-680.e4 pubmed publisher
Mayr C, Beyreis M, Dobias H, Gaisberger M, Fuchs J, Pichler M, et al. Continuous, label-free, 96-well-based determination of cell migration using confluence measurement. Cell Adh Migr. 2019;13:76-82 pubmed publisher
Delpiano L, Thomas J, Yates A, Rice S, Gray M, Saint Criq V. Esomeprazole Increases Airway Surface Liquid pH in Primary Cystic Fibrosis Epithelial Cells. Front Pharmacol. 2018;9:1462 pubmed publisher
Mitchell D, Lovel A, Stenkamp D. Dynamic changes in microglial and macrophage characteristics during degeneration and regeneration of the zebrafish retina. J Neuroinflammation. 2018;15:163 pubmed publisher
Racine M, Crecelius A, Luckasen G, Larson D, Dinenno F. Inhibition of Na+ /K+ -ATPase and KIR channels abolishes hypoxic hyperaemia in resting but not contracting skeletal muscle of humans. J Physiol. 2018;596:3371-3389 pubmed publisher
Lim M, Louie B, Ford D, Heath K, Cha P, Betts LaCroix J, et al. Development of the Digital Arthritis Index, a Novel Metric to Measure Disease Parameters in a Rat Model of Rheumatoid Arthritis. Front Pharmacol. 2017;8:818 pubmed publisher
Khunweeraphong N, Stockner T, Kuchler K. The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion. Sci Rep. 2017;7:13767 pubmed publisher
Billon P, Bryant E, Joseph S, Nambiar T, Hayward S, Rothstein R, et al. CRISPR-Mediated Base Editing Enables Efficient Disruption of Eukaryotic Genes through Induction of STOP Codons. Mol Cell. 2017;67:1068-1079.e4 pubmed publisher
Nozaki Y, Honda Y, Watanabe H, Saiki S, Koyabu K, Itoh T, et al. CSAHi study-2: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes: Assessment of reference compounds and comparison with non-clinical studies and clinical . Regul Toxicol Pharmacol. 2017;88:238-251 pubmed publisher
Li Z, Li S, Hu L, Li F, Cheung A, Shao W, et al. MECHANISMS UNDERLYING ACTION OF XINMAILONG INJECTION, A TRADITIONAL CHINESE MEDICINE IN CARDIAC FUNCTION IMPROVEMENT. Afr J Tradit Complement Altern Med. 2017;14:241-252 pubmed publisher
Bagh M, Peng S, Chandra G, Zhang Z, Singh S, Pattabiraman N, et al. Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model. Nat Commun. 2017;8:14612 pubmed publisher
La J, Reed E, Chan L, Smolyaninova L, Akomova O, Mutlu G, et al. Downregulation of TGF-β Receptor-2 Expression and Signaling through Inhibition of Na/K-ATPase. PLoS ONE. 2016;11:e0168363 pubmed publisher
de Oliveira J, Abdalla F, Dornelles G, Adefegha S, Palma T, Signor C, et al. Berberine protects against memory impairment and anxiogenic-like behavior in rats submitted to sporadic Alzheimer's-like dementia: Involvement of acetylcholinesterase and cell death. Neurotoxicology. 2016;57:241-250 pubmed publisher
Miyazaki H, Wangemann P, Marcus D. The gastric H,K-ATPase in stria vascularis contributes to pH regulation of cochlear endolymph but not to K secretion. BMC Physiol. 2016;17:1 pubmed publisher
Sapparapu G, Czakó R, Alvarado G, Shanker S, Prasad B, Atmar R, et al. Frequent Use of the IgA Isotype in Human B Cells Encoding Potent Norovirus-Specific Monoclonal Antibodies That Block HBGA Binding. PLoS Pathog. 2016;12:e1005719 pubmed publisher
Tokuda S, Kim Y, Matsumoto H, Muro S, Hirai T, Mishima M, et al. Effects of Hydrostatic Pressure on Carcinogenic Properties of Epithelia. PLoS ONE. 2015;10:e0145522 pubmed publisher
Hanuska A, Szénási G, Albert M, Köles L, Varga A, Szabo A, et al. Some Operational Characteristics of Glycine Release in Rat Retina: The Role of Reverse Mode Operation of Glycine Transporter Type-1 (GlyT-1) in Ischemic Conditions. Neurochem Res. 2016;41:73-85 pubmed publisher
Kaltofen T, Haase M, Thome U, Laube M. Male Sex is Associated with a Reduced Alveolar Epithelial Sodium Transport. PLoS ONE. 2015;10:e0136178 pubmed publisher
Thete D, Danthi P. Conformational changes required for reovirus cell entry are sensitive to pH. Virology. 2015;483:291-301 pubmed publisher
Lynch C, Zhao J, Huang R, Xiao J, Li L, Heyward S, et al. Quantitative high-throughput identification of drugs as modulators of human constitutive androstane receptor. Sci Rep. 2015;5:10405 pubmed publisher
Crecelius A, Kirby B, Hearon C, Luckasen G, Larson D, Dinenno F. Contracting human skeletal muscle maintains the ability to blunt α1 -adrenergic vasoconstriction during KIR channel and Na(+) /K(+) -ATPase inhibition. J Physiol. 2015;593:2735-51 pubmed publisher
Shin H, Ryu B, Choi S, Kim S, Lee K. Inactivation of Src-to-ezrin pathway: a possible mechanism in the ouabain-mediated inhibition of A549 cell migration. Biomed Res Int. 2015;2015:537136 pubmed publisher
Tsuchiya Y, Fujita R, Saitou A, Wajima N, Aizawa F, Iinuma A. [6]-gingerol induces electrogenic sodium absorption in the rat colon via the capsaicin receptor TRPV1. J Nutr Sci Vitaminol (Tokyo). 2014;60:403-7 pubmed publisher
Flyak A, Ilinykh P, Murin C, Garron T, Shen X, Fusco M, et al. Mechanism of human antibody-mediated neutralization of Marburg virus. Cell. 2015;160:893-903 pubmed publisher
Carvalho F, Gutierres J, Bohnert C, Zago A, Abdalla F, Vieira J, et al. Anthocyanins suppress the secretion of proinflammatory mediators and oxidative stress, and restore ion pump activities in demyelination. J Nutr Biochem. 2015;26:378-90 pubmed publisher
García Dorival I, Wu W, Dowall S, Armstrong S, Touzelet O, Wastling J, et al. Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host-cell protein function. J Proteome Res. 2014;13:5120-35 pubmed publisher
Nickless A, Jackson E, Marasa J, Nugent P, Mercer R, Piwnica Worms D, et al. Intracellular calcium regulates nonsense-mediated mRNA decay. Nat Med. 2014;20:961-6 pubmed publisher
Epstein T, Xu L, Gillies R, Gatenby R. Separation of metabolic supply and demand: aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane. Cancer Metab. 2014;2:7 pubmed publisher
Crecelius A, Luckasen G, Larson D, Dinenno F. KIR channel activation contributes to onset and steady-state exercise hyperemia in humans. Am J Physiol Heart Circ Physiol. 2014;307:H782-91 pubmed publisher
Rana S, Rajakumar A, Geahchan C, Salahuddin S, Cerdeira A, Burke S, et al. Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1? pathway. FASEB J. 2014;28:4324-34 pubmed publisher
Sepp M, Sokolova N, Jugai S, Mandel M, Peterson P, Vendelin M. Tight coupling of Na+/K+-ATPase with glycolysis demonstrated in permeabilized rat cardiomyocytes. PLoS ONE. 2014;9:e99413 pubmed publisher
Katz A, Tal D, Heller D, Haviv H, Rabah B, Barkana Y, et al. Digoxin derivatives with enhanced selectivity for the ?2 isoform of Na,K-ATPase: effects on intraocular pressure in rabbits. J Biol Chem. 2014;289:21153-62 pubmed publisher
Mattes C, Laube M, Thome U. Rapid elevation of sodium transport through insulin is mediated by AKT in alveolar cells. Physiol Rep. 2014;2:e00269 pubmed publisher
Xie C, Liu X, Yu S, Cheng C. Cardiac glycosides block cancer growth through HIF-1?- and NF-?B-mediated Plk1. Carcinogenesis. 2013;34:1870-80 pubmed publisher
Kapri Pardes E, Katz A, Haviv H, Mahmmoud Y, Ilan M, Khalfin Penigel I, et al. Stabilization of the α2 isoform of Na,K-ATPase by mutations in a phospholipid binding pocket. J Biol Chem. 2011;286:42888-99 pubmed publisher
Wang Q, Green S. Functional role of neurotrophin-3 in synapse regeneration by spiral ganglion neurons on inner hair cells after excitotoxic trauma in vitro. J Neurosci. 2011;31:7938-49 pubmed publisher
Laohapitakworn S, Thongbunchoo J, Nakkrasae L, Krishnamra N, Charoenphandhu N. Parathyroid hormone (PTH) rapidly enhances CFTR-mediated HCO?? secretion in intestinal epithelium-like Caco-2 monolayer: a novel ion regulatory action of PTH. Am J Physiol Cell Physiol. 2011;301:C137-49 pubmed publisher
Schmalhofer W, Swensen A, Thomas B, Felix J, Haedo R, Solly K, et al. A pharmacologically validated, high-capacity, functional thallium flux assay for the human Ether-à-go-go related gene potassium channel. Assay Drug Dev Technol. 2010;8:714-26 pubmed publisher
Katz A, Lifshitz Y, Bab Dinitz E, Kapri Pardes E, Goldshleger R, Tal D, et al. Selectivity of digitalis glycosides for isoforms of human Na,K-ATPase. J Biol Chem. 2010;285:19582-92 pubmed publisher
Belogus T, Haviv H, Karlish S. Neutralization of the charge on Asp 369 of Na+,K+-ATPase triggers E1 <--> E2 conformational changes. J Biol Chem. 2009;284:31038-51 pubmed publisher
Gaitanaki C, Mastri M, Aggeli I, Beis I. Differential roles of p38-MAPK and JNKs in mediating early protection or apoptosis in the hyperthermic perfused amphibian heart. J Exp Biol. 2008;211:2524-32 pubmed publisher
Bawankule D, Sathishkumar K, Sardar K, Chanda D, Krishna A, Prakash V, et al. BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine]-induced dilation in ovine pulmonary artery: role of sodium pump. J Pharmacol Exp Ther. 2005;314:207-13 pubmed
Karle C, Gehrig T, Wodopia R, Höschele S, Kreye V, Katus H, et al. Hypoxia-induced inhibition of whole cell membrane currents and ion transport of A549 cells. Am J Physiol Lung Cell Mol Physiol. 2004;286:L1154-60 pubmed
Baudouin Legros M, Brouillard F, Tondelier D, Hinzpeter A, Edelman A. Effect of ouabain on CFTR gene expression in human Calu-3 cells. Am J Physiol Cell Physiol. 2003;284:C620-6 pubmed
Capella L, Gefé M, Silva E, Morales M, Affonso Mitidieri O, Lopes A, et al. Reduced glutathione protect cells from ouabain toxicity. Biochim Biophys Acta. 2001;1526:293-300 pubmed
Patchornik G, Goldshleger R, Karlish S. The complex ATP-Fe(2+) serves as a specific affinity cleavage reagent in ATP-Mg(2+) sites of Na,K-ATPase: altered ligation of Fe(2+) (Mg(2+)) ions accompanies the E(1)-->E(2) conformational change. Proc Natl Acad Sci U S A. 2000;97:11954-9 pubmed
Veerasingham S, Leenen F. Ouabain- and central sodium-induced hypertension depend on the ventral anteroventral third ventricle region. Am J Physiol. 1999;276:H63-70 pubmed publisher
McDougall J, Yates N. Natriuresis and inhibition of Na+/K(+)-ATPase: modulation of response by physiological manipulation. Clin Exp Pharmacol Physiol Suppl. 1998;25:S57-60 pubmed
Lingrel J, Croyle M, Woo A, Arguello J. Ligand binding sites of Na,K-ATPase. Acta Physiol Scand Suppl. 1998;643:69-77 pubmed
Blaustein M, Juhaszova M, Golovina V. The cellular mechanism of action of cardiotonic steroids: a new hypothesis. Clin Exp Hypertens. 1998;20:691-703 pubmed
Van Huysse J, Leenen F. Role of endogenous brain "ouabain" in the sympathoexcitatory and pressor effects of sodium. Clin Exp Hypertens. 1998;20:657-67 pubmed
Hamlyn J, Lu Z, Manunta P, Ludens J, Kimura K, Shah J, et al. Observations on the nature, biosynthesis, secretion and significance of endogenous ouabain. Clin Exp Hypertens. 1998;20:523-33 pubmed
Doris P, Bagrov A. Endogenous sodium pump inhibitors and blood pressure regulation: an update on recent progress. Proc Soc Exp Biol Med. 1998;218:156-67 pubmed
Juhaszova M, Blaustein M. Na+ pump low and high ouabain affinity alpha subunit isoforms are differently distributed in cells. Proc Natl Acad Sci U S A. 1997;94:1800-5 pubmed
Guh J, Ko F, Chueh S, Lai M, Teng C. Ouabain-induced increases in resting tone of human hyperplastic prostate following repeated noradrenaline and electrical field stimulation. Br J Pharmacol. 1996;117:1716-20 pubmed
Peng M, Huang L, Xie Z, Huang W, Askari A. Partial inhibition of Na+/K+-ATPase by ouabain induces the Ca2+-dependent expressions of early-response genes in cardiac myocytes. J Biol Chem. 1996;271:10372-8 pubmed
product information
Catalog Number :
O3125
Product Name :
Ouabain octahydrate
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥95% (HPLC), powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA